• IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. (wikipedia.org)
  • WWP2 interacts with transcription factor IRF7, promoting its non-degradative mono-ubiquitination, nuclear translocation and transcriptional activity, leading to upregulation of Ccl5 at transcriptional level. (nature.com)
  • Exposed C57BL/6 mice exhibited a specific network of type I interferon signaling in blood cells and aorta from 4hr to 28d post-exposure The central component of the network was the transcription factor interferon regulatory factor 7 (Irf7), the master regulator of the type I interferon response. (cdc.gov)
  • Interferon regulatory aspect 7 (IRF7) is an interferon (IFN)-inducible transcription factor required for activation of a subset of IFN-α genes that are expressed with delayed kinetics following viral contamination. (healthdisparitiesks.org)
  • ATF2_HUMAN Cyclic-AMP-dependent transcription factor ATF-2[61. (pdbj.org)
  • TF65_HUMAN IRF7_HUMAN IRF3_HUMAN Transcription factor p65/Interferon regulatory fac. (pdbj.org)
  • Candidate genes showing distinctive expression patterns in response to ethanol were clustered by pattern and further analyzed for related function, pathway membership and common transcription factor binding within and across clusters. (biomedcentral.com)
  • Analysis showed function-based networks, shared transcription factor binding sites and signaling pathways for members of the clusters. (biomedcentral.com)
  • The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). (biomedcentral.com)
  • Activated STING then serves Fenretinide as a platform for the inducible recruitment of the TBK1 kinase, which phosphorylates and activates the transcription factor IRF3, leading to the induction of the type I interferon mediated antiviral response (7). (woofahs.com)
  • Unterholzner L, Sumner RP, Baran M, Ren H, Mansur DS, Bourke NM, Randow F, Smith GL, Bowie AG (2011) Vaccinia Virus Protein C6 is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7. (cam.ac.uk)
  • Finally, we tested whether the antiviral response to DNA was dependent on the transcription factors IRF3 and IRF7, which together are essential for the IFN response to all other known nucleic acid detection pathways (12). (woofahs.com)
  • Third, IRF3 and IRF7 are essential for both DNA-activated antiviral responses in human cells. (woofahs.com)
  • Also, IRF7 has been shown to interact with Aryl Hydrocarbon Receptor Interacting Protein (AIP), which is a negative regulator for the antiviral pathway. (wikipedia.org)
  • An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. (umassmed.edu)
  • The inherited form of factor VII deficiency, known as congenital factor VII deficiency, is caused by mutations in the F7 gene, which provides instructions for making a protein called coagulation factor VII. (medlineplus.gov)
  • Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)
  • The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. (umassmed.edu)
  • Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
  • 2012)]. In addition to ifngr1 and ifrd1, many other immune-relevant transcripts [e.g. encoding double stranded RNA activated protein kinase (PKR) type 2, and several complement factors] were highly, and similarly, expressed in fertilized eggs of all 3 females included in the microarray study ( Supplemental Table 8). (camkkinases.com)
  • Among these proteins, heat shock protein 70 (HSP70) is the most conserved protein, which has a variety of biological functions including molecular chaperone, regulation of immune response, anti-apoptosis, and improvement of cell tolerance to stressors [ 7 ]. (biomedcentral.com)
  • The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected. (wikipedia.org)
  • Regulation of the promoter activity of interferon regulatory factor-7 gene. (wikipedia.org)
  • Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (medlineplus.gov)
  • Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. (rcsb.org)
  • A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
  • Rapamycin was found to block the interaction of TLR with myeloid differentiation primary response gene 88 (MyD88), resulting in reduced interferon regulatory factor-7 (IRF-7) phosphorylation [16]. (c-kitinhibitors.com)
  • As part of civil aviation safety research into aeromedical factors impacting flight safety, we have undertaken a time course study on the effects of acute ethanol exposure to the legal intoxication level of blood alcohol concentration (BAC), 0.08 g/dL (0.08% wt/vol), on human gene expression in non-chronic users. (biomedcentral.com)
  • Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
  • This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. (umassmed.edu)
  • These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. (rcsb.org)
  • To establish a productive infection viruses must counteract the immune system, in particular the early host innate response and VACV encodes an arsenal of proteins that inhibit innate immune signalling (in particular the activation of key transcription factors such as NF-κB and IRF3). (cam.ac.uk)
  • Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
  • The expression of IFNs is governed by a family of transcription factors known as interferon regulatory factors (IRFs) (24 64 In particular the transcription of type I IFN (IFN-α/β) relies on the activation of IRF-3 and IRF-7 highly homologous proteins that become activated via C-terminal phosphorylation (58). (health-ground.com)
  • Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. (wikipedia.org)
  • Luciferase assays in THP1 showed dramatically reduced TLR3-driven IRF3 promoter activity in response to poly(I:C) with IRF7 and UNC93B1 variants (Fig. 2 & 3). (childrensmercy.org)
  • Conclusion(s): We identified 2 variants (IRF7, UNC93B1) that disrupted the TLR3-response to HSV in vitro and in vivo in an infant with recurrent HSV. (childrensmercy.org)
  • Our study aimed to examine potentially functional genetic variants in interferon regulatory factor 3 (IRF3), IRF5, IRF7, type I and type II IFN and their receptor genes with respect to colorectal cancer (CRC) risk and clinical outcome. (cancerindex.org)
  • Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. (wikipedia.org)
  • Interferon Regulatory Factor-7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Interferon Regulatory Factor-7" by people in this website by year, and whether "Interferon Regulatory Factor-7" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Interferon Regulatory Factor-7" by people in Profiles. (umassmed.edu)
  • 2009). In addition, IFN regulatory factor 7 (IRF7) is deregulated by directly interacting with CSFV N^pro, thus inhibiting the production of IFN-alpha and decreasing the anti-viral cellular response (Fiebach et al. (usda.gov)
  • 2011). Also, N^pro promotes proteosomal degradation of IFN regulatory factor 3 (IRF3) (Bauhofer et al. (usda.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interferon Regulatory Factor 4 (IRF4) in Tissue homogenates, cell lysates and other biological fluids. (operatiebrp.nl)
  • Description: A sandwich ELISA kit for detection of Interferon Regulatory Factor 4 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
  • Wild type and mutated alleles were transfected into THP1 monocyte cell line stably expressing an interferon regulatory factor 3 (IRF3) promoter-driven luciferase reporter. (childrensmercy.org)
  • Results: We identified rare missense mutations in interferon regulatory factor 7 (IRF7) (p.Arg100Pro) and UNC-93 Homolog B1 (UNC93B1) (p.Pro404Ser) genes. (childrensmercy.org)
  • An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
  • An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. (lookformedical.com)
  • In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
  • In this paper we examine evidence for a direct crosstalk of the NF-κB and IRF3 signaling pathways at the lowest level, between main transcription factors and genes coding for these transcription factors. (biomedcentral.com)
  • We identify a pro-fibrogenic macrophage subtype in non-ischemic cardiomyopathy, and demonstrate that WWP2 is a key regulator of IRF7-mediated Ccl5/Ly6c high monocyte axis in heart fibrosis. (nature.com)
  • Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. (umassmed.edu)
  • Recurrent neonatal herpes simplex virus infection associated with IRF7" by Venkatesh Sampath, Megan H. Tucker et al. (childrensmercy.org)
  • We knew that specific transcription factors regulate innate immune responses to bacterial infection and that the outcome of infection be beneficial or destructive, depending on how these regulators work'' says Lund University Professor Catharina Svanborg. (drugtargetreview.com)
  • Using mice lacking the closely related transcription factors IRF-3 or IRF-7, the researchers were surprised to find that IRF-3 and IRF-7 control different facets of the immune response to kidney infection and that this determines the susceptibility to acute pyelonephritis, which is a severe, potentially life-threatening bacterial infection of the urinary tract. (drugtargetreview.com)
  • In contrast to mice lacking IRF-3, which became very ill, Irf7-/- mice were protected from infection and chronic inflammation, suggesting that suppression of Irf7 might be beneficial. (drugtargetreview.com)
  • In the canonical model, IFN regulation, after RNA virus infection, is conducted by IRF-3 and IRF-7. (biomedcentral.com)
  • Therefore, study on factors and mechanisms that limit the in vivo persistence of CAR T cells is crucial for developing strategies to reduce the probability of tumor relapse and improve the long-term disease-free survival for patients who are treated with CAR T cells. (biomedcentral.com)
  • Four latency types (0, I, II, III) are defined depending on the expression pattern of EBV latent genes, and at the same time are linked to a particular tumor type [ 6 , 7 ]. (ijbs.com)
  • 1 This is due to multiple factors, including tumor heterogeneity, the immunosuppressive nature of the tumor microenvironment (TME) and innate or acquired resistance to treatment. (bmj.com)
  • IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES. (umassmed.edu)
  • We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to assemble a complete picture of enhanceosome architecture in the vicinity of the DNA. (rcsb.org)
  • We conclude that members of the NF-κB family may directly impact regulation of IRF family, while IRF members impact regulation of NF-κB family rather indirectly, via other transcription factors such as AP-1 and SP1. (biomedcentral.com)
  • According to the results of MI/IHC immunoprofiles, we further investigated the correlation of these immune cells with breast cancer using the TCGA database, and proposed the potential transcription factors or metabolism-related genes as targets in immune cell regulation. (researchsquare.com)
  • This is the first report of human HSV disease associated with IRF7 mutation. (childrensmercy.org)
  • Suschak JJ, Wang S, Fitzgerald KA, Lu S. A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. (umassmed.edu)
  • The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. (wikipedia.org)
  • Five of the seven clusters showed links to the p38 MAPK pathway. (biomedcentral.com)
  • For the 5 microarray-identified and qPCR-confirmed genes and 3 IFN pathway genes of interest (irf7, ifngr1, and ifrd1), the qPCR results for fertilized and unfertilized eggs are shown in Fig. 3 and Fig. 4, old respectively. (camkkinases.com)
  • BLASTx information, and functional annotation (if available) associated with putative human orthologues of Atlantic cod ifngr1 and ifrd1 and irf7 are provided in Supplemental Table 14. (camkkinases.com)
  • IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. (wikipedia.org)
  • Because of this extensive presence, IRF-3 function is widely targeted by viruses [ 11 ], and thus its activity has to be aided by IRF-7 which takes a major part in amplification of the antiviral response. (biomedcentral.com)
  • NF-κB also controls expression of the downstream IFN auto-amplification loop through STAT1, IRF-1, −5, and −7 transcription factors. (biomedcentral.com)
  • Most commonly, clinically relevant viral encephalitis affects children, young adults, or elderly patients, but the spectrum of involvement depends on the specific viral agent, host immune status, and genetic and environmental factors. (medscape.com)
  • To do this, we used a previously described clonal line of IRF3/IRF7 double knockout human THP1 monocytes (13). (woofahs.com)
  • we used siRNA therapy to silence Irf7 and were able to demonstrate protection in susceptible mice," says Manoj Puthia, researcher at Lund University. (drugtargetreview.com)
  • Atherosclerosis severity, determined by plaque area and intensity in the aorta (en face), was increased. (cdc.gov)
  • Further studies have shown that Th1 cells promote atherosclerosis initiation and progression [ 6 , 7 ]. (hindawi.com)
  • Treg cells produce anti-inflammatory cytokines such as interleukin 10 (IL-10) and transforming growth factor-β (TGF- β). (biomedcentral.com)
  • Hormone-dependent dimerization of chimeric IRF7-ER stimulated DNA binding and transcriptional transactivation of endogenous target genes. (healthdisparitiesks.org)
  • TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. (umassmed.edu)
  • Similarly, IFNα and IFNβ expression induced by poly(I:C) was enhanced by wild type IRF7 and UNC93B1 alleles, but strongly suppressed by mutant IRF7 and UNC93B1 alleles (Fig. 2 & 3). (childrensmercy.org)
  • Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. (wikipedia.org)
  • In apoE-/- mice, pulmonary inflammation, serum levels of IL-1â and MAC-3 and blood cell expression of Irf7 were increased post-GMA-SS exposure. (cdc.gov)
  • The candidate genes of interest (GOI) identified from the microarray analysis and clustered by expression pattern across the five BAC points showed seven coordinately expressed groups. (biomedcentral.com)
  • Certainly 3 from the 4 vIRFs encoded within KSHV can separately inhibit the induction of IFN and IFN-induced signaling by disrupting the features of mobile IRF-1 IRF-3 IRF-5 and IRF-7 (9 10 20 29 43 71 76 The inhibitory systems employed by each one of the vIRFs are assorted suggesting AS703026 that every vIRF plays a distinctive and significant part. (health-ground.com)
  • Therefore, study on factors and mechanisms that limit the in vivo persistence of CAR T cells is crucial for developing strategies to overcome these limitations. (biomedcentral.com)
  • In this review, we summarize the rapidly developing knowledge regarding the factors that influence CAR T cells in vivo persistence and the underlying mechanisms. (biomedcentral.com)
  • In this review, we summarize the rapidly developing knowledge regarding the influence factors and mechanisms of poor CAR T cells persistence, and also the potential strategies to overcome these limitations. (biomedcentral.com)
  • miRNA family enrichment of interacting miRNA partners of selected RNAs indicated the enrichment of let-7 family. (cancerindex.org)
  • Supplemental Table 6b), 5 genes were selected for qPCR studies involving 7 hpf fertilized egg samples from 15 different females (kpna7, hacd1, srd5a3, cnih, and trappc3). (camkkinases.com)
  • Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models. (wikipedia.org)