Potently inhibits inosine monophosphate dehydrogenase (IMPDH), thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. (tocris.com)
Xanthylic acid is an important metabolic intermediate in the purine metabolism, and is a product or substrate of the enzymes inosine monophosphate dehydrogenase (EC 1.1.1.205), hypoxanthine phosphoribosyltransferase (EC 2.4.2.8), xanthine phosphoribosyltransferase (EC 2.4.2.22), 5'-ribonucleotide phosphohydrolase (EC 3.1.3.5), Ap4A hydrolase (EC 3.6.1.17), nucleoside-triphosphate diphosphatase (EC 3.6.1.19), phosphoribosylamine-glycine ligase (EC 6.3.4.1), and glutamine amidotransferase (EC 6.3.5.2). (ecmdb.ca)
IMPDH5
Inosine-5′-monophosphate dehydrogenase (IMPDH) is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide (NAD+)-dependent oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP), the first committed and rate-limiting step towards the de novo biosynthesis of guanine nucleotides from IMP. (wikipedia.org)
Most IMPDH monomers contain two domains: a catalytic (β/α)8 barrel domain with an active site located in the loops at the C-terminal end of the barrel, and a subdomain consisting of two, repeated cystathionine beta synthetase (CBS) domains that are inserted within the dehydrogenase sequence. (wikipedia.org)
In cell culture, C. albicans is sensitive to mycophenolic acid (MPA) and mizoribine, both natural product inhibitors of IMP dehydrogenase (IMPDH). (okstate.edu)
Host inosine-5'- monophosphate dehydrogenase (IMPDH) involved in the synthesis of guanine nucleotides, is known to be a potential target to inhibit the replication of viruses. (biomedcentral.com)
While in the de novo synthesis of GTP, IMPDH catalyzes the oxidation of inosine monophosphate (IMP) to xanthosine monophosphate (XMP) which is the rate-limiting step. (biomedcentral.com)
Inhibitors1
Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine. (aspetjournals.org)
IMPDH21
Here we show that IMP dehydrogenase-2 (IMPDH2), the rate-limiting enzyme for de novo guanine nucleotide biosynthesis, is overexpressed in the highly lethal brain cancer glioblastoma. (elsevierpure.com)
GTP is involved in the synthesis of IMP to AMP , while ATP is involved in the synthesis of IMP to GMP ! (amboss.com)
Subunit1
Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase). (umbc.edu)
Mycophenolate1
13. Hyle J.W., Shaw R.J., Reines D. Functional distinctions bet ween IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. (org.ua)
Activity2
A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. (csic.es)
Wright DG, Boosalis MS, Waraska K, Oshry LJ, Weintraub LR, Vosburgh E. Tiazofurin effects on IMP-dehydrogenase activity and expression in the leukemia cells of patients with CML blast crisis. (bu.edu)
Amino1
Mechanistically, p38α signaling increases expression of inosine-5′-monophosphate dehydrogenase 2 in HSPCs, leading to altered levels of amino acids and purine-related metabolites and changes in cell-cycle progression in vitro and in vivo. (elsevierpure.com)
Mycophenolate and ribavirin2
The latter reaction is especially important, as the drugs mycophenolate and ribavirin inhibit the enzyme IMP dehydrogenase, which converts IMP to GMP. (pixorize.com)
Inosine monophosphate (IMP) dehydrogenase had previously been determined to be a likely target enzyme for the sesquiterpene lactones, a class of potential anti-neoplastic drugs. (nih.gov)
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. (nih.gov)
These substances include two aromatic moieties: one which interacts using the hypoxanthine bottom of IMP and one which interacts with Tyr358 in the adjacent subunit (Schu S4 (this enzyme is here now denoted ought to be susceptible to Schu S4. (cancer8.info)
Ribavirin1
16. Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs. (nih.gov)
The first step is the conversion of ribose-6-phosphate to PRPP(PRPP stands for phosphoribosyl pyrophosphate), In the next step, PRPP is converted into IMP. (marquardtadvogados.com.br)
PRPP + Nitrogen base = Mono-nucleotide (OMP for pyrimidine and IMP for purine) 3.1. (marquardtadvogados.com.br)
Purine3
IMP binds to the active site and a conserved cysteine residue attacks the 2-position of the purine ring. (wikipedia.org)
De novo synthesis involves a complex, energy-expensive pathway that yields inosine 5'-monophosphate (IMP), a purine ribonucleotide. (marquardtadvogados.com.br)
Synthesis of the purine ring de novo is required especially when DNA is replicated so that, although present in most tissues, the activity of the metabolic pathway is … The conversion of PRPP to IMP can be inhibited by the drug 6-MP (6-mercaptopurine) as well as by its prodrug azathioprine. (marquardtadvogados.com.br)
Binds1
In individual and various other eukaryotic IMPDHs, the cofactor binds in the normal extended conformation noticed for some dehydrogenases, as well as the cofactor binding site is basically contained inside the same monomer as IMP (31). (cancer8.info)
Bound1
In prokaryotic IMPDHs, the cofactor is normally bound within an uncommon compressed conformation, as well as the adenosine subsite is situated in the monomer next to the IMP and nicotinamide binding sites (32). (cancer8.info)
Assembly1
2. Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments. (nih.gov)
Complex1
The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex. (yeastrc.org)
Nicotinamide1
As the IMP and nicotinamide binding servings of the energetic site are extremely conserved, the rest from the cofactor binding site is quite 58558-08-0 IC50 different in individual and bacterial IMPDHs. (cancer8.info)
Reaction1
The first-order rate constants for the reaction of the sesquiterpene lactones with IMP dehydrogenase (k1) and the second-order rate constants for the reaction of the sesquiterpene lactones with glutathione (k2) were also determined. (nih.gov)
Drugs1
Binding of the drugs by IMP dehydrogenase increased as the size of the drug increased. (nih.gov)
Human1
Genetic expression differences of 11 beta-hydroxysteroid dehydrogenase in the bone microvascular endothelial cells derived from different regions of the human femoral head]. (nih.gov)
Conversion1
The conversion of PRPP to IMP can be inhibited by the drug 6-MP (6-mercaptopurine) as well as by its prodrug azathioprine. (pixorize.com)