Hypoxia induced myocytes cardiac. Medical search. Frequent questions

It has previously been demonstrated that phosphatidylinositol‑3‑kinase (PI3K)/Akt and cleaved caspase‑3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. (spandidos-publications.com)
Our group reported that severe chronic hypoxia alone does not cause apoptosis of cardiac myocytes in culture. (biomedres.us)

The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
Persistent myocardial ischemia and hypoxia will cause malignant cardiac remodeling and subsequent heart failure. (hindawi.com)
Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
Scarabelli TM, Stephanou A, Pasini E, et al: Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. (spandidos-publications.com)
Townsend PA, Scarabelli TM, Pasini E, et al: Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. (spandidos-publications.com)
oxidative stress that occurs during reperfusion injury has been shown to induce apoptosis, over and above that induced by ischemia. (latestfashiontips.com)
It leads to the death of myocyte cells due to loss of blood flow, anemia, and ischemia [ 3 ]. (scitechnol.com)
During extended myocardial ischemia combinations of hypoxia and acidosis drive cardiac cell loss by apoptosis and necrosis that contribute importantly to myocardial infarction (MI). (biomedres.us)
The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
Important roles of inflammatory mediators in cardiac cell death by ischemia with or without reperfusion are well established [12-14]. (biomedres.us)
Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
We found that wild type (WT) C57BL/6 mice, subjected to hind limb ischemia (HLI) and supplemented with carnosine (1g/L) in drinking water, had improved blood flow recovery and limb function, enhanced revascularization and regeneration of myocytes compared with HLI mice placed on water alone. (frontiersin.org)
The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)

During the initial hospital admission, he developed signs of meningitis and sepsis including photophobia, headache, fever and nuchal rigidity as well as acute hypoxia. (omicsonline.org)
In acute lung injury (ALI), a severe insult induces a hyperinflammatory state in the lungs. (bvsalud.org)
Acute hypoxia stimulates fatty acid transport by regulating subcellular distribution of FAT/CD36 and FABPpm. (edu.pl)
The acute as oxidizing liniments profoundly are two cardiac tests and are been from integrated heart( single homoserine) by the region released in the acidosis. (siriuspixels.com)
Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)

PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy. (wikipedia.org)
However, questions remain as to whether apoptosis is a critical event in the transition from compensated to decompensated cardiac hypertrophy and the onset of ventricular dysfunction. (latestfashiontips.com)
Expression levels of RCAN homologs are responsive to external stressors such as reactive oxygen species, Ca 2+ , amyloid β, and hormonal changes and upregulated in pathological conditions, including Alzheimer's disease, cardiac hypertrophy, diabetes, and degenerative neuropathy. (molcells.org)
This study was undertaken to investigate whether Res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (ISO), and whether the protective effect is mediated by endoplasmic reticulum (ER) stress. (karger.com)
Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
During the pathological development of cardiovascular diseases, cardiac hypertrophy plays a critical role. (karger.com)
Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
Especially, Dr. Chen would like, but not limited, to elucidate how noncoding RNA regulates cardiac hypertrophy and cardiac regeneration during the cardiovascular diseases. (z2hospital.com)

Wang GW, Zhou Z, Klein JB and Kang YJ: Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardio-myocytes. (spandidos-publications.com)
High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function. (uchicago.edu)

We aimed to investigate the effect of PLCA on hypoxia/reoxygenation (H/R) in neonatal rat ventricular myocytes (NRVM) and on myocardial I/R in rats. (biomedcentral.com)

Cardiac myocyte apoptosis may be induced by tumor necrosis factor-a, oxidative stress, atrial natriuretic peptide, hypoxia, and stretching. (latestfashiontips.com)
However, administration of Ocimum sanctum (100 and 200 mg/kg p.o. ) and its saponin rich fraction (100 and 200 mg/kg p.o. ) for 14 days significantly attenuated vincristine-induced neuropathic pain along with decrease in oxidative stress and calcium levels. (biomedcentral.com)
It may be concluded that Ocimum sanctum has ameliorative potential in attenuating chemotherapy induced-painful neuropathic state, which may be attributed to decrease in oxidative stress and calcium levels. (biomedcentral.com)
One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)

When the cardiac myocytes were incubated in the medium contained the mitochondrial respiratory inhibitor potassium cyanide (chemically-induced hypoxia)the spontaneous contractility was ceased. (edu.pl)
Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
Intralipid was as efficient as cyclosporine-A in inhibiting the mitochondrial permeability transition pore opening (calcium retention capacity = 280 ± 8.2 vs. 260.3 ± 2.9 nmol/mg mitochondria protein in cyclosporine-A, P = 0.454, n = 6) and in reducing cardiac mitochondrial superoxide production. (silverchair.com)
Although intralipid inhibits the opening of the mitochondrial permeability transition pore as efficiently as cyclosporine-A, intralipid is more effective in reducing the infarct size and improving the cardiac functional recovery. (silverchair.com)

In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. (hindawi.com)
Wnt11 inactivation was sufficient to induce myocyte proliferation in perinatal mouse hearts and reduced Rb1 protein and phosphorylation in neonatal cardiomyocytes. (jci.org)
Hypoxia regulates neonatal cardiomyocyte proliferation in a chamber-specific manner. (jci.org)
Neonatal pups were reared with their dams in either normoxia or hypoxia (10% FIO 2 ) and maintained until the predecided end points (P0, P3, or P7). (jci.org)

Stephanou A, Brar B, Liao Z, et al: Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury. (spandidos-publications.com)

These studies were further supported by those performed in isolated, skinned cardiac muscle fibers, showing that in vitro phosphorylation of cTnI by PKCε or Serine-43/45 mutation to Glutamate to mimic phosphorylation desensitized myofilaments to calcium and decreased maximal tension and filament sliding speed. (wikipedia.org)
Acidosis with or without hypoxia increased apoptosis that was paralleled by elevated miR-126, increased phosphorylation of p38-MAPK and JNK, enhanced expression of IL-6, IL-8, and TNF, and downregulation of Bcl-2. (biomedres.us)
2005. Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. (badrilla.com)
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure. (badrilla.com)
2007. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. (badrilla.com)
2008. Adenylyl Cyclase Type VI Increases Akt Activity and Phospholamban Phosphorylation in Cardiac Myocytes. (badrilla.com)

EGCG and/or zinc were perfused prior to induced hypoxic stress. (spandidos-publications.com)
Methods The present study used a chronic hypoxia rat model to simulate the hypoxic state of CCHD patients. (cams.cn)
Hypoxic cardiac myocytes generate excess H+ through increased anaerobic glycolysis, net hydrolysis of ATP, and CO2 retention. (biomedres.us)
Acclimation to hypoxia did not influence resting (basal) in situ cardiac performance during oxygenated or hypoxic conditions. (biologists.com)
This study showed that cod acclimated to hypoxia ( P w O 2 8-9 kPa, 40% air saturation) had significantly lower values for resting and maximum stroke volume and cardiac output, and a significantly lower scope for stroke volume when swimming in hypoxic water as compared with normoxia-acclimated fish. (biologists.com)

Its conductance is increased in response to hypoxia, isotonic stress, NMDA R activation, and Caspase-3 and -7 activation during apopotosis. (rndsystems.com)
This function influences the chamber-specific development and pathogenesis in response to hypoxia and cyanotic CHDs. (jci.org)

TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)

The p53-associated signaling pathway has been demonstrated to regulate hypoxia-induced apoptosis and senescence [ 5 ]. (hindawi.com)

Two groups of Sprague-Dawley rats ( n =6 per group) were either exposed to hypoxia (10% O 2 ) or normoxia (21% O 2 ) for 3 weeks. (cams.cn)

Objective Many physiological and pathological conditions, including cyanotic congenital heart diseases (CCHD), are accompanied by chronic hypoxia, which might interfere with the transcription process. (cams.cn)
The present work aimed to explore the transcriptional profile alteration of peripheral blood in chronic hypoxia. (cams.cn)
Conclusions Our study demonstrated the transcriptional profile alteration in peripheral blood of chronic hypoxia rat model. (cams.cn)
Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia[J].Chinese Medical Sciences Journal, 2020, 35(1): 54-64. (cams.cn)
In contrast, only one study has investigated the effect of chronic (weeks of) hypoxia on fish in vivo cardiovascular function ( Petersen and Gamperl, 2010 ). (biologists.com)

While this work has provided novel insights into how fish cardiorespiratory physiology is impacted by prolonged exposure to hypoxia, the reason(s) for the diminished cardiac function in hypoxia-acclimated cod is not clear. (biologists.com)

Since EGCG + Zn2+ may, at least in part, protect cardiac myocytes against H/R‑induced apoptotic cell death, the PI3K/Akt pathway of EGCG may be enhanced by its interactions with zinc during H/R injury. (spandidos-publications.com)
Heart failure is characterized by a significant increase in apoptotic myocyte death in spite of the enhanced expression of antiapoptotic gene products in the cells. (latestfashiontips.com)
This anatomic condition is characterized by diastolic overloading, sarcomere stretching, apoptotic cell death, and side-to-side slippage of myocytes within the wall. (latestfashiontips.com)

reported that KYQG possesses anti-inflammatory activity and promotes the healing of phenol-induced oral ulcers in rats [ 7 ]. (biomedcentral.com)
The accumulation of cardiac lactate was attenuated by PLCA during myocardial I/R, and infarct size was smaller in rats treated with PLCA (1 mg/kg) than in those treated with caffeic acid (1 mg/kg). (biomedcentral.com)
The present study was designed to investigate the ameliorative potential of Ocimum sanctum and its saponin rich fraction in vincristine-induced peripheral neuropathic pain in rats. (biomedcentral.com)
Peripheral neuropathy was induced in rats by administration of vincristine sulfate (50 μg/kg i.p. ) for 10 consecutive days. (biomedcentral.com)
Cardioprotective effects of rutin via alteration in TNF-alpha, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats. (cusabio.com)

The molecular mechanisms of cardiac remodeling during IHD are complex [ 2 - 4 ]. (hindawi.com)
Molecular cardiology, cell biology, cardiac regeneration. (z2hospital.com)
In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)
2011. SR-targeted CaMKII inhibition improves SR Ca2+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKII delta(C). Journal of Molecular and Cellular Cardiology. (badrilla.com)

The contractility partly recovered that during chemical hypoxia, in which cellular ATP is decreased (37% of control), the respponsiveness of myocytes to muscarinic cholinergic stimulation significantly increase. (edu.pl)
The in vivo results showed that per-treatment of PEMF could significantly improve the cardiac function in I/R injury group. (pemfglobal.com)

PKCε translocates to cardiac muscle sarcomeres and modulates contractility of the myocardium. (wikipedia.org)

There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. (wikipedia.org)

Epigallocatechin‑3‑gallate (EGCG), the predominant catechin component of green tea, has been reported to have potential cardioprotective effects in primary cultures of cardiac myocytes exposed to I/R injury, mediated through inhibition of signal transducers and activators of transcription‑1 activity. (spandidos-publications.com)
Inhibition of Na+/H+ exchange is protective against ischemic injury, while inhibition of the vacuolar ATPase promotes apoptosis, in part by shifting the proton load toward the Na+/H+ transporter and thus increasing Ca2+ uptake, and in part by reducing the myocyte capacity to control [pH]i. (biomedres.us)
2008. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. (badrilla.com)

Dr. Chen's researches have been focused on cardiovascular diseases from development, adult heart remodeling and cardiac regeneration. (z2hospital.com)
Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. (z2hospital.com)

Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts. (edu.pl)

2011. Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure. (badrilla.com)

A ) Schematic illustration of experimental design for perinatal systemic hypoxia exposure. (jci.org)
Longer exposure to H2S may also help induce the protective hibernation-like state. (gotomydoctor.com)
On a more macroscopic level it could represent the amount of whole-body radiation received due to an exposure event or to the amount of exposure to carbon monoxide or to stress due to being at high altitude (hypoxia). (anti-agingfirewalls.com)
2011. Influence of Taurine on Cardiac Remodeling Induced by Tobacco Smoke Exposure. (badrilla.com)

Further support was gained from in vivo studies in which mice expressing a mutant cTnI (Serine43/45Alanine) exhibited enhanced cardiac contractility. (wikipedia.org)
Indeed, MSCs ex vivo pre-conditioning by hypoxia, inflammatory stimulus, or other factors/conditions may stimulate their survival, proliferation, migration, exosome secretion, and pro-angiogenic and anti-inflammatory characteristics in vivo. (biomedcentral.com)

Sirius Pixels UHDe HEVC Encoder Fiscal buy christian anarchism a political commentary: An nonpregnant production in which a dissection of ligands( a cardiomyopathy), all cardiac of a 41(1 mm and using in their atom to a contractile deletion rate, potentiates admitted over a bedfast magnesium of percentage to form the agent regulators of the heart in the alpha-1-adrenergic and damaged esters. (siriuspixels.com)
This relationship concerns the central and autonomic nervous systems, and their impairment can adversely affect cardiovascular system and induce stress-related cardiomyopathy (SRC) [ 2 ]. (springeropen.com)
Septic cardiomyopathy is primarily assessed using hemodynamic devices such as a pulmonary artery floating catheter (PAC) and pulsed continuous cardiac output (PiCCO) monitoring. (balkanmedicaljournal.org)

The role of a huge increase in endogenous and/or exogenous catecholamine level in critically ill patients (severe sepsis, post cardiac resuscitation, post tachycardia) to explain the onset of myocardial dysfunction was discussed. (springeropen.com)

Echocardiography showed normal systolic and diastolic left and right ventricular function and no evidence of intra-cardiac shunt or valvular disease. (rcjournal.com)
However, PAC and PiCCO suffer several drawbacks including an inability to monitor cardiac diastolic function and right heart function, invasiveness, potential catheter-related infection, and difficulty with data measurement and interpretation. (balkanmedicaljournal.org)

The process is present during normal myocyte development and is activated in response to cell injury and results in the removal of the injured cell without damaging surrounding tissue. (latestfashiontips.com)
The clinical definition of cardiogenic shock is decreased cardiac output and evidence of tissue hypoxia in the presence of adequate intravascular volume. (medscape.com)
For instance, because it is less likely to be affected by cardiac preload and afterload, tissue Doppler imaging can measure cardiac function more accurately, objectively, and quantitatively (8). (balkanmedicaljournal.org)

Hypoxia-induced fatty acid transporter translocation increases fatty acid transport and contributes to lipid accumulation in the heart. (edu.pl)

Obligatory roles for acidosis in promoting apoptosis confirmed our previous reports that hypoxia alone does not confer a lethal signal. (biomedres.us)

In contrast to adrenaline, exogenously administrated cholinergic agonist, carbachol have very little effect on the contractility of rat cardiac myocytes, unless its contracitle has been increased by adrenergic agonist. (edu.pl)
Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. (frontiersin.org)
In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. (frontiersin.org)

Perinatal hypoxia treatment in mice suppressed Wnt11 expression and induced myocyte proliferation more robustly in the right ventricle, modulating Rb1 protein activity. (jci.org)

Several small doses are best because high doses may induce tachycardia. (msdmanuals.com)

2008. Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. (badrilla.com)

NT-proBNP and BNP are potential early biomarkers for 2-DG-induced cardiac toxicity that can be useful to monitor 2-DG therapy in clinical trials. (cusabio.com)
Cardiac toxicity was mediated more by catecholamines released directly into the heart via neural connection than by those reaching the heart via the bloodstream. (springeropen.com)

A lower heart rate, if not extreme, means reduced cardiac workload and possibly reduced infarct size. (msdmanuals.com)

Moreover, none of the medications, assessed in randomized controlled studies conducted, has been found to be effective in injury induced and chemotherapy-induced neuropathic pain [ 7 ]. (biomedcentral.com)

Methamphetamine induces transcriptional changes in cultured HIV-infected mature monocytes that may contribute to HIV neuropathogenesis. (academictree.org)
MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)

MI-induced necrosis stimulates the hypothalamic-pituitary-adrenal axis and, as a stressor, increases cortisol (CORT) and catecholamine levels [ 5 , 6 ]. (scitechnol.com)

cavity dilatation correlates with deterioration of cardiac pump function and poor survival in the myopathic heart. (latestfashiontips.com)
These data show that acclimation to hypoxia has a direct effect on cod myocardial function and/or physiology, and suggest that the cod heart shows some adaptations to prolonged hypoxia. (biologists.com)

PLCA at 1 μM and metformin at 30 μM exerted similar effects on the improvement of cell viability and the alleviation of cell apoptosis in NRVM after H/R. PLCA promoted p-AMPK, p-AKT, and GLUT4 upregulation to induce a cardioprotective effect in both cell and animal model. (biomedcentral.com)

And Schisandra chinensis is a commonly used TCM that has been clinically proven to alleviate the damage of myocytes after the onset of AMI. (frontiersin.org)

Dr. Chen's team use cardiac cell system, mouse genetic model and AAV system to study the cardiovascular diseases. (z2hospital.com)

Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation. (frontierspartnerships.org)

Plasma histones, cardiac troponin I, and N-terminal pro-brain natriuretic peptide were measured using ELISA. (balkanmedicaljournal.org)

In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. (hindawi.com)

Even though the exact mechanisms underlying ischemic injury in the muscle are not completely understood, hypoxia-inducible factor-1 alpha (HIF-1α) has emerged as an attractive target to enhance post ischemic angiogenesis. (frontiersin.org)

However, the transcriptome profile in peripheral blood under hypoxia is still unidentified. (cams.cn)
Peripheral blood was collected and total RNA was extracted for RNA-Seq at the end of the hypoxia treatment. (cams.cn)

RSV treatment decreased mortality and improved cardiac hemodynamics. (hindawi.com)

Inhibiting malignant cardiac remodeling has been considered an efficient strategy for preventing the occurrence and development of heart failure. (hindawi.com)
Cardiac myocyte cell death by apoptosis accompanies heart disease of both ischemic and nonischemic origin [1-3]. (biomedres.us)
Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)
Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial. (msdmanuals.com)
These have been in continual use by the entire cardiac excitation-contraction coupling research community since that time, and have underpinned a series of discoveries concerning the aetiology and potential management of heart failure. (badrilla.com)
2011. Impaired beta-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure. (badrilla.com)
2014. Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart FailureThe CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b). (badrilla.com)
Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. (journaltocs.ac.uk)

Aversano T, Aversano LT, Passamani E, et al: Thrombolytic therapy vs. primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery: a randomized controlled trial. (spandidos-publications.com)

An eligible Das perfekte Fotobuch of solutions normal for cardiac name hormone and complex occurs the state ulcers, or MMPs. (augenta.net)

Hormesis is a process through which moderate stress induces a body response that is protective against insults, confers health and possibly even longevity benefits. (anti-agingfirewalls.com)

Patients with disturbances of cardiac rhythm are evaluated for hypoxia and electrolyte abnormalities, which can be causative or contributory. (msdmanuals.com)

Anatomy31

Organisms12

Diseases37

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes55

Disciplines and Occupations3

Information Science1

Health Care7

Apoptosis of cardiac myocytes2

Ischemia15

Acute5

Hypertrophy8

Reoxygenation-induced2

Ventricular myocytes1

Oxidative stress4

Mitochondrial4

Neonatal4

Reperfusion injury1

Phosphorylation6

Hypoxic5

Response to hypoxia2

Pathways1

Signaling pathway1

Normoxia1

Chronic5

Diminished cardiac function1

Apoptotic3

Rats5

Molecular4

Significantly2

Myocardium1

Progenitor cells1

Modulates cardiac1

Inhibition3

Regeneration2

Activation2

Proteins1

Exposure4

Vivo2

Cardiomyopathy3

Severe1

Diastolic2

Tissue3

Translocation1

Acidosis1

Contractility3

Mice1

Tachycardia1

Intracellular1

Toxicity2

Infarct size1

Injury induced1

Transcriptional2

Stimulates1

Function2

Cardioprotective1

Onset1

Cardiovascular diseases1

Fibrosis1

Troponin1

Vitro1

Ischemic injury1

Peripheral2

Mortality1

Heart8

Therapy1

Ulcers1

Moderate1

Patients1