Hypoxia inducible factor 1 alpha subunit. Medical search. Frequent questions

The analysis of the Hif1α pathway in SDHD-ESR tissues and in two newly derived cell lines after complete SdhD loss -a requirement for hereditary paraganglioma type-1 tumor formation in humans- partially recapitulated the "pseudo-hypoxic" response and rendered inconsistent results. (ed.ac.uk)
Hypoxic conditions further increased GLUT1 expression levels in HCC cells, and this induction was dependent on the activation of the transcription factor hypoxia-inducible factor-1alpha. (uni-regensburg.de)
Pulmonary endothelial deletion of arginase-1, a downstream target of HIF-2α, likewise attenuated many of the pathophysiological symptoms associated with hypoxic pulmonary hypertension. (cam.ac.uk)
Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF-1 alpha. (bio-techne.com)
Here, we identify LIMD1 as a HIF-1 target gene, which mediates a previously uncharacterised, negative regulatory feedback mechanism for hypoxic HIF-α degradation by modulating PHD2-LIMD1-VHL complex formation. (york.ac.uk)
Hypoxic induction of LIMD1 expression results in increased HIF-α protein degradation, inhibiting HIF-1 target gene expression, tumour growth and vascularisation. (york.ac.uk)
It is stabilized only at O 2 concentrations below 5% and upon stabilization under hypoxic conditions HIF-1 translocates to the nucleus. (abcam.cn)
Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (abcam.cn)
pVHL and HIF alpha-subunits co-immunoprecipitate, and pVHL is present in the hypoxic HIF-1 DNA-binding complex. (ncl.ac.uk)
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. (ox.ac.uk)
The most important of these, although not capable of driving hypoxic induction in isolation, had the consensus of a hypoxia-inducible factor 1 (HIF-1) site, and cross-competed for the binding of HIF-1 with functionally active Epo and phosphoglycerate kinase-1 sequences. (ox.ac.uk)
The second domain was positioned close to the HIF-1 site, in an analogous position to one of the critical regions in the Epo 3' hypoxic enhancer. (ox.ac.uk)
Hypoxic preconditioning was mimicked by treatment with two types of hypoxia-inducible factor (HIF) prolyl-4-hydroxylase inhibitors (PHDIs): dimethyloxaloylglycine (DMOG) and 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (BIC). (ox.ac.uk)
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. (ox.ac.uk)
In a normal cell, the alpha subunits of HIF-1 are degraded by the proteasome, whereas in a hypoxic cell they are stabilized. (czytelniamedyczna.pl)
These studies define a new class of HIF-1-responsive gene, the activation of which has implications for the understanding of hypoxic tumor metabolism and which may provide endogenous markers for tumor hypoxia. (ox.ac.uk)
We undertook integrated genomic analyses of both non-coding and coding transcripts using massively parallel sequencing and interfaced this data with pan-genomic analyses of hypoxia-inducible factor (HIF) and RNApol2 binding in hypoxic cells. (ox.ac.uk)
Hypoxia induced HIF-1 expression, but cobaltous ions and desferrioxamine did not mimic hypoxic IL-8 induction. (ox.ac.uk)
Estrogen treated TG1-1 cells secreted higher levels of VEGF which were comparable to secreted levels from cells grown under hypoxic conditions. (biomedcentral.com)

The HIF DNA binding complex consists of 2 basic-helix-loop-helix PAS proteins designated alpha and beta subunits. (ox.ac.uk)
Interestingly, estrogen is also capable of contributing to breast cancer progression by a novel role, via modulation of proteins involved in hypoxia signaling, namely hypoxia inducible factor 1 (HIF-1). (biomedcentral.com)

The stability and activity of hypoxia-inducible factor (HIF) are regulated by the post-translational hydroxylation of specific prolyl and asparaginyl residues. (ox.ac.uk)

In this study, a rat model of wound ischemia was used to test the hypothesis that HBO enhances wound healing by modulating hypoxia-inducible factor-1alpha (HIF-1alpha) signaling. (nih.gov)
Recently, prolyl hydroxylation was identified as a key regulatory event that targets the HIF-1alpha subunit for proteasomal degradation via the pVHL ubiquitination complex. (nih.gov)
The degradation process of its alpha subunit, the hypoxia inducible factor-1alpha (HIF-1alpha), is directly regulated by oxygen concentration. (aiche.org)
In this study, we present the characterization of the two transfected cell lines by demonstrating that differential expression of measurable quantities of the EGFP-HIF-1alpha fusion is achieved with prolonged exposure to hypoxia. (aiche.org)
In addition, Akt activation leads to HIF-1alpha stabilization, whereas PTEN attenuates hypoxia-mediated HIF-1alpha stabilization. (ox.ac.uk)
Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1alpha expression. (ox.ac.uk)
Tumors with exclusively cytoplasmic expression of FOXP1 were linked with deep myometrial invasion and hypoxia-inducible factors 1alpha (HIF-1alpha) expression. (ox.ac.uk)
This study provides evidence on pathways to be investigated to elucidate the interplay between FOXP1, ER-alpha and HIF-1alpha in hormone dependent cancers. (ox.ac.uk)
Mitochondria are an important source of ROS, and in one model it has been proposed that hypoxia increases the generation of ROS at complex III in the mitochondrion and that this signal acts through a transduction pathway to stabilize HIF-1alpha and to activate HIF. (ox.ac.uk)
To test this model the induction of the HIF-1alpha subunit and the HIF target gene, glucose-transporter-1, was examined in a variety of mutant cells that lacked mitochondrial DNA (rho0) or had other genetic defects in mitochondrial respiration. (ox.ac.uk)
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. (cnrs.fr)

However, regulation of BAT by dietary factors remains largely unexplored at the mechanistic level. (ttu.edu)
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in energy metabolism, angiogenesis and apoptosis. (ncl.ac.uk)
Here we demonstrate a critical role for the von Hippel-Lindau (VHL) tumour suppressor gene product pVHL in HIF-1 regulation. (ncl.ac.uk)
Using cDNA arrays and serial analysis of gene expression, we found that hypoxia induces up-regulation of BNIP3 and its homologue, Nip3-like protein X. Analysis of human carcinoma cell lines showed that they are hypoxically regulated in many tumor types, as well as in endothelial cells and macrophages. (ox.ac.uk)
Regulation was hypoxia inducible factor-1-dependent, and hypoxia inducible factor-1 expression was suppressed by von Hippel-Lindau protein in normoxic cells. (ox.ac.uk)
Two alpha-ketoglutarate dependent non-heme iron dioxygenases are responsible for the regulation of HIF-1 through hydroxylation of residues on the HIF-1a subunit. (umass.edu)
A VHL protein is mandatory for the process of hypoxia-inducible factor 1 (HIF-1) regulation (4). (czytelniamedyczna.pl)
In renal carcinoma cells that are defective for the von Hippel-Lindau (VHL) tumor suppressor, up-regulation of these CAs is associated with loss of regulation by hypoxia, consistent with the critical function of pVHL in the regulation of HIF-1. (ox.ac.uk)
Further studies of CA9 defined a HIF-1-dependent hypoxia response element in the minimal promoter and demonstrated that tight regulation by the HIF/pVHL system was reflected in the pattern of CA IX expression within tumors. (ox.ac.uk)
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. (ox.ac.uk)
Regulation occurs principally through the alpha subunits, which are stabilized and activated in hypoxia. (ox.ac.uk)
Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. (ox.ac.uk)
The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS). (ox.ac.uk)
Using the murine mammary cell line TG1-1 we observed estrogen (E 2 ) lead to an up regulation of hypoxia inducible factor-1 (HIF-1), an effect abrogated by the anti-estrogen Fulvestrant and the HIF-1 inhibitor YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole) suggesting the interchangeability of hypoxia and estrogen mediated effects. (biomedcentral.com)

Hypoxia-inducible factor 1-alpha inhibitor is a protein that in humans is encoded by the HIF1AN gene. (wikipedia.org)
In this work, we made use of the inducible SDHD-ESR mouse, a conditional mutant in the SdhD gene, which encodes the small subunit of MCII, and that acts as a tumor suppressor gene in humans. (ed.ac.uk)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)
The glucose transporter isoform 1 (GLUT1) gene encodes a key rate-limiting factor in glucose transport into cancer cells. (uni-regensburg.de)
TREATMENT: The plasmid carrying neuropilin-1 (NRP1) gene was transfected into ESC for overexpression. (bvsalud.org)
Loss of PTEN facilitates HIF-1-mediated gene expression. (ox.ac.uk)
However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene expression by regulating Akt activation of HIF-1 activity. (ox.ac.uk)
We propose that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt activity and HIF-1-regulated gene expression. (ox.ac.uk)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
To understand the organization of cis-acting sequences that are responsible for oxygen-regulated gene expression, we have studied the 5' flanking region of the mouse gene encoding the hypoxically inducible enzyme lactate dehydrogenase A (LDH). (ox.ac.uk)
Under hypoxia, the CDC proliferation rate increased by 1.4-fold, generating 6 × 10(6) CDCs with higher expression of cardiac stem cell and pluripotency gene markers compared to normoxia. (ox.ac.uk)
HIF-1 induces expression of VEGF gene. (czytelniamedyczna.pl)
The FOXP1 gene has been identified as a new member of the winged helix family of transcription factors that have important roles in cellular transformation, differentiation and proliferation. (ox.ac.uk)
The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important mediator of gene expression patterns in tumors, although the range of responding genes is still incompletely defined. (ox.ac.uk)
The von Hippel-Lindau tumour suppressor gene (VHL) targets hypoxia inducible factor (HIF)-alpha subunits for ubiquitin dependent proteolysis. (ox.ac.uk)
The tumor suppressor p53, encoded by the TP53 gene and known as "the guardian of the genome" [ 1 ] , performs a variety of functions in cancer prevention. (encyclopedia.pub)

Cell response to hypoxia is primarily controlled by the hypoxia inducible factor-1 (HIF-1). (aiche.org)
however, the specific role of pulmonary endothelial HIF expression in this process, and in the physiological process of vasoconstriction in response to hypoxia, remains unclear. (cam.ac.uk)
These data offer new insight into the role of pulmonary endothelial HIF-2α in regulating the pulmonary vascular response to hypoxia. (cam.ac.uk)
Functions as a master transcriptional regulator of the adaptive response to hypoxia. (abcam.cn)
Activation of cAMP by forskolin had no effect on the level of LDH mRNA in normoxia, but produced a magnified response to hypoxia that was dependent upon the integrity of the CRE, indicating an interaction between inducible factors binding the HIF-1 and CRE sites. (ox.ac.uk)
However, the non-coding transcriptional response to hypoxia is largely uncharacterized. (ox.ac.uk)
These findings indicate that the transcriptional response to hypoxia is substantially more extensive than previously considered. (ox.ac.uk)

The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha) is the regulated member of the transcription factor heterodimer HIF-1. (bio-techne.com)
In studies during the early 1990's, Gregg Semenza identified, and then in 1995 purified and cloned, a transcription factor that regulates these oxygen-dependent responses. (nobelprize.org)
The control of oxygen delivery to cells in the body is the result of a small group of primary oxygen sensors, one of the most important of which is the hypoxia-inducible transcription factor-1 (HIF-1). (umass.edu)
Both the pattern of cytokine expression and transcription factor activation by hypoxia was different to that seen with endotoxin.ConclusionsRapidly raised intrapulmonary IL-8 levels are associated with ARDS progression in patients with major trauma. (ox.ac.uk)
Acute hypoxia, a clinically relevant stimulus, rapidly and selectively upregulates IL-8 in macrophages associated with a novel pattern of transcription factor activation. (ox.ac.uk)
Once formed, the complex translocates to the nucleus where it acts as a transcription factor by binding to the estrogen response elements (EREs) at the promoters of estrogen responsive genes[ 9 , 10 ]. (biomedcentral.com)
HIF-1 is also a heterodimeric transcription factor, consisting of the oxygen dependent alpha subunit and the constitutively expressed beta subunit. (biomedcentral.com)

In addition, we evaluated the expression of VEGF-A, VEGF-R2 and NRP-1 at the protein level. (amsterdamumc.org)
Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) is a cell death factor that is a member of the Bcl-2 proapoptotic family recently shown to induce necrosis rather than apoptosis. (ox.ac.uk)
In the absence of VHL protein, alpha subunits of HIF-1 are constitutively stabilized despite the normal oxygenation. (czytelniamedyczna.pl)
VEGF protein is a potent proangiogenic factor that binds to its receptor on endothelial cells. (czytelniamedyczna.pl)
Genes newly defined as targets of the VHL/hypoxia pathway (conditionally downregulated by VHL in normoxic cells) include aminopeptidase A, collagen type V, alpha 1, cyclin G2, DEC1/Stra13, endothelin 1, low density lipoprotein receptor-related protein 1, MIC2/CD99, and transglutaminase 2. (ox.ac.uk)
In human monocyte derived macrophages hypoxia rapidly upregulated IL-8 protein (within 2 hours) and mRNA expression (within 30 mins). (ox.ac.uk)
B and T lymphocyte attenuator (BTLA) is an inhibitory receptor, similar to cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD1), that negatively regulates the immune response. (cnrs.fr)
The basic unit of the p53 protein consists of three major functional domains such as an N-terminal transactivation domain (TAD), a core DNA-binding domain (DBD)-the main target for mutations, and a C-terminal regulatory domain (CTD) ( Figure 1 A) [ 2 ] . (encyclopedia.pub)
Estrogen modulation of HIF-1 and subsequent effects on endothelial cells is dependent on the Akt/PI3K pathway and protein synthesis as validated by the use of the inhibitors wortmannin and cycloheximide which abrogated estrogen's effects respectively. (biomedcentral.com)

Hypoxia-inducible factors (HIFs) are nuclear transcriptional factors that regulate the transcription of genes that mediate cellular and tissue homeostatic responses to altered oxygenation. (ox.ac.uk)
Hypoxia-inducible factor (HIF) mediates a large number of transcriptional responses to hypoxia and has an important role in processes that include angiogenesis and erythropoiesis. (ox.ac.uk)

LIMD1 complexes with PHD2 and VHL in physiological oxygen levels (normoxia) to facilitate proteasomal degradation of the HIF-α subunit. (york.ac.uk)
These findings indicate that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF alpha-subunits. (ncl.ac.uk)

Additionally, asparaginyl hydroxylation of HIF1α by FIH-1 (HIF1AN) at N803 impairs its interaction with CBP/P300. (wikipedia.org)
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. (ox.ac.uk)
We show that the HIF asparaginyl hydroxylase, factor inhibiting HIF (FIH), also catalyzes hydroxylation of highly conserved asparaginyl residues within ankyrin repeat (AR) domains (ARDs) of endogenous Notch receptors. (ox.ac.uk)

Furthermore, concentrations of rotenone that maximally inhibited respiration did not affect HIF activation by hypoxia. (ox.ac.uk)

Genes negatively correlated with thermogenesis such as hypoxia inducible factor 1 alpha subunit inhibitor (Hif1an), were downregulated by EPA. (ttu.edu)

The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. (york.ac.uk)

RESULTS: In atherosclerotic plaque, HIF-1α was localized in macrophages and smooth muscle cells bordering the necrotic core. (ox.ac.uk)
In pulmonary hypertension, HIF-1α contributes to the increase of intracellular K(+) and Ca(2+) leading to vasoconstriction of pulmonary smooth muscle cells. (ox.ac.uk)
Here, we show that hypoxia induces corticosteroid-insensitive inflammation via reduced transcription of histone deacetylase-2 (HDAC2) in lung epithelial and macrophage cells. (tmu.edu.tw)
Moderate-to strong HIF-1α nuclear staining in >10% and cell surface PD-L1 expression in >5% of OSCC cells were recorded as a positive result. (ntu.edu.tw)
Pathways related to thermogenesis such as peroxisome proliferator-activated receptor (PPAR) were upregulated by EPA while pathways associated with obesity and inflammation such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were downregulated by EPA. (ttu.edu)
In VHL-defective cells, HIF alpha-subunits are constitutively stabilized and HIF-1 is activated. (ncl.ac.uk)
In cells exposed to iron chelation or cobaltous ions, HIF-1 is dissociated from pVHL. (ncl.ac.uk)
The oxygen-regulated control system responsible for the induction of erythropoietin (Epo) by hypoxia is present in most (if not all) cells and operates on other genes, including those involved in energy metabolism. (ox.ac.uk)
Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. (ox.ac.uk)
However, current protocols used to expand CDCs require at least 1 month in vitro to obtain sufficient cells for transplantation. (ox.ac.uk)
We report that CDC culture can be optimized by preconditioning the cells under hypoxia (2% oxygen), which may reflect the physiological oxygen level of the stem cell niche. (ox.ac.uk)
In conclusion, cells cultured under hypoxia could have potentially enhanced therapeutic potential, which can be mimicked, in part, by PHDIs. (ox.ac.uk)
Solid tumors contain regions of hypoxia, a physiological stress that can activate cell death pathways and, thus, result in the selection of cells resistant to death signals and anticancer therapy. (ox.ac.uk)
HIF induction by hypoxia was essentially normal in all cells tested. (ox.ac.uk)
Hydrogen peroxide production was measured by the luminol/peroxidase method and found to be reduced in rho0 versus wild-type cells and reduced by hypoxia in both rho0 and wild-type cells. (ox.ac.uk)
Previously we found that estrogen aided in this neovasculogenesis via recruitment of bone marrow derived endothelial progenitor cells (BM-EPCs), leading to increased vessel formation and vascular endothelial growth factor (VEGF) production in vivo . (biomedcentral.com)
Soluble factors in conditioned media from E 2 treated breast cancer cells also lead to migration and tube formation of human umbilical vein endothelial cells (HUVEC) in vitro . (biomedcentral.com)

The RVSP of mice lacking HIF-2α in pulmonary endothelium after exposure to hypoxia was not significantly different from normoxic WT mice and much lower than the RVSP values seen in WT littermate controls and mice with pulmonary endothelial deletion of HIF-1α exposed to hypoxia. (cam.ac.uk)

It was hypothesized that there would be a difference in inhibition of FIH-1 from the other HIF-1 regulating enzyme, the prolyl hydroxylase domain-2 (PHD2), when testing a series of ten small molecule inhibitors. (umass.edu)

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. (ox.ac.uk)

Smoking, obesity, and hypertension are the 3 most well-established risk factors associated with development of sporadic renal cell carcinoma (RCC). (medscape.com)

These recruited monocyte-derived macrophages also protect lung function by their heightened production of antipathogen factors and active phagocytosis of cellular debris (Aegerter et al. (biomedcentral.com)

Combined the network analysis, molecular docking and in-vitro experiments, the results firstly demonstrated that the treatment effect of DGP on ONFH may be closely related to HIF-1α, VEGFA and HIF-1 signaling pathway. (researchsquare.com)
The results indicated that DGP may exert the effect on ONFH targeting on HIF-1α and VEGFA via HIF-1 signaling pathway. (researchsquare.com)
Hypoxia-inducible factor pathway and diseases of the vascular wall. (ox.ac.uk)
Increased activation of the HIF pathway causes aberrant expression of angiogenic factors contributing to the formation and maintenance of vascular malformations. (ox.ac.uk)
Some viruses hijack cellular machinery to translate some of their mRNAs through a noncanonical initiation pathway using internal ribosome entry site (IRES), a highly structured RNAs which can directly recruit the ribosome with a restricted set of initiation factors, and in some cases even without cap and initiator tRNA. (cnrs.fr)
Our data provide evidence that estrogen signaling mediates the tumor vasculogenic process required for breast cancer progression and involves a key regulator of the hypoxia signaling pathway. (biomedcentral.com)

To confirm tumor hypoxia, partial oxygen pressure (pO 2 ) is an important factor of physiological state, and it indicates the balance between oxygen delivery and consumption [ 21 ]. (hindawi.com)

The alpha subunits of HIF are rapidly degraded by the proteasome under normal conditions, but are stabilized by hypoxia. (ncl.ac.uk)

Here we show that pulmonary endothelial HIF-2α is a critical regulator of hypoxia-induced pulmonary arterial hypertension. (cam.ac.uk)

The change for HIF-1 alpha has been detected in colorectal cancer (CRC) [ 11 , 12 ] and several authors have described its importance in angiogenesis and CRC growth [ 13 , 14 ]. (hindawi.com)
Increased HIF-1α may contribute to atherosclerosis through alteration of smooth muscle cell proliferation and migration, angiogenesis, and lipid metabolism. (ox.ac.uk)
Furthermore, telomerase (TERT), cytokines/ligands involved in stem cell trafficking (SDF/CXCR-4), erythropoiesis (EPO), and angiogenesis (VEGF) were increased under hypoxia. (ox.ac.uk)
In such case, HIF-1 promotes angiogenesis and other typical cellular responses for hypoxia. (czytelniamedyczna.pl)

Immunohistochemistry (IHC) staining was conducted by using the avidin-biotin complex technique for detecting the antibodies to hypoxia inducible factor-1 (HIF-1) alpha, cytokeratin 20 (CK20), and cell proliferation factor Ki67. (hindawi.com)
Paired paraffin-embedded primary tumor and metastatic lymph nodes (LN) sections were stained with antibodies against hypoxia-inducible factor-1α (HIF-1α) and PD-L1. (ntu.edu.tw)
Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. (uchicago.edu)

Hypoxia-Mediated In Vivo Tumor Glucose Uptake Measurement and Analysis. (ouhsc.edu)

Vascular endothelial growth factor, cyclooxygenase-2, and neutrophil infiltration were reduced in ischemic wounds treated with HBO. (nih.gov)
We analysed the mRNA expression levels of all known vascular endothelial growth factor (VEGF) ligands and receptors in human endometrium collected in the menstrual and proliferative phases of the menstrual cycle. (amsterdamumc.org)
The two most important molecular targets for new drugs in renal cancer are vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. (czytelniamedyczna.pl)
In comparison with vascular endothelial growth factor mRNA, expression of CA IX demonstrated a similar, although more tightly circumscribed, pattern of expression around regions of necrosis and showed substantial although incomplete overlap with activation of the hypoxia marker pimonidazole. (ox.ac.uk)

Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1-regulated genes. (ox.ac.uk)

1-8 (2017). (tohoku.ac.jp)
61 (1), 1654-1661 (2017). (tohoku.ac.jp)

Placental expression of angiogenic factors in Trisomy 13. (uchicago.edu)
Angiogenic factors in diagnosis, management, and research in preeclampsia. (uchicago.edu)
Circulating Angiogenic Factors and the Risk of Adverse Outcomes among Haitian Women with Preeclampsia. (uchicago.edu)
The course of angiogenic factors in early- vs. late-onset preeclampsia and HELLP syndrome. (uchicago.edu)
The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes. (uchicago.edu)
Circulating levels of the antiangiogenic marker soluble FMS-like tyrosine kinase 1 are elevated in women with pregestational diabetes and preeclampsia: angiogenic markers in preeclampsia and preexisting diabetes. (uchicago.edu)
Abnormal placentation, angiogenic factors, and the pathogenesis of preeclampsia. (uchicago.edu)
Angiogenic factors in preeclampsia: potential for diagnosis and treatment. (uchicago.edu)
Angiogenic factors and pregnant woman with new onset seizures. (uchicago.edu)
Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia. (uchicago.edu)
Modeling risk for severe adverse outcomes using angiogenic factor measurements in women with suspected preterm preeclampsia. (uchicago.edu)
KRYPTOR-automated angiogenic factor assays and risk of preeclampsia-related adverse outcomes. (uchicago.edu)
Household air pollution and angiogenic factors in pregnant Nigerian women: A randomized controlled ethanol cookstove intervention. (uchicago.edu)
Myocardial performance index in hypertensive disorders of pregnancy: The relationship between blood pressures and angiogenic factors. (uchicago.edu)
Thus, constitutive HIF-1 activation may underlie the angiogenic phenotype of VHL-associated tumours. (ncl.ac.uk)

These analyses revealed that all classes of RNA are profoundly regulated by hypoxia and implicated HIF as a major direct regulator of both the non-coding and coding transcriptome, acting predominantly through release of pre-bound promoter-paused RNApol2. (ox.ac.uk)

Except for endothelial VEGF-R2 expression in CDs 6-8, there were no significant differences in the expression of VEGF, VEGF-R2 or NRP-1 in any of the cell compartments. (amsterdamumc.org)
Changes in VEGF ligands and receptors were associated with elevated expression of the hypoxia markers HIF1alpha and CA-IX in the menstrual and early proliferative phases. (amsterdamumc.org)
Furthermore, VEGF-A production appears to be triggered by hypoxia in the menstrual phase and subsequently suppressed by estrogen during the late proliferative phase. (amsterdamumc.org)

Estrogen mediates its effects by binding to its cognate estrogen receptor(s), either estrogen receptor alpha (ERα) or estrogen receptor beta (ERβ), leading to ER dimerization and association with various co-factors. (biomedcentral.com)

The only two modestly active agents were interleukin 2 and interferon alpha but very few patients benefited from immunotherapy. (czytelniamedyczna.pl)

Translation initiation, in both eukaryotes and bacteria, requires essential elements such as mRNA, ribosome, initiator tRNA, and a set of initiation factors. (cnrs.fr)

Endothelial HIF-2α deletion also protected mice from hypoxia remodeling. (cam.ac.uk)

Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability. (nih.gov)
The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing. (ncl.ac.uk)

BACKGROUND: Hypoxia may contribute to the pathogenesis of various diseases of the vascular wall. (ox.ac.uk)

HIF-1 binds to hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. (bio-techne.com)

Cobaltous ions or iron chelators mimic hypoxia, indicating that the stimuli may interact through effects on a ferroprotein oxygen sensor. (ncl.ac.uk)

Thus, the levels of microenvironmental pO 2 affect the expression of predictive biomarkers HIF-1 alpha, CK20, and Ki67 in the development of CRC tissues. (hindawi.com)
Thus, hypoxia may affect the expression of Ki67. (hindawi.com)
We propose a mechanism whereby chronic hypoxia enhances HIF-2α stability, which causes increased arginase expression and dysregulates normal vascular NO homeostasis. (cam.ac.uk)
The expression of HIF-1α is significantly elevated in aortic aneurysms compared with nonaneurysmal arteries. (ox.ac.uk)
Results For advanced OSCC with necrotic changes, there was substantial agreement in primary tumor (kappa value 0.54) and almost perfect agreement in metastatic LN (kappa value 0.86) between HIF-1α and PD-L1 expression. (ntu.edu.tw)
After multivariate analysis, metastatic LN necrosis and positive PD-L1 expression were found to be significant independent adverse factors. (ntu.edu.tw)
Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1. (uchicago.edu)
On the other hand, the presence of nuclear FOXP1 expression was significantly linked with ER-alpha reactivity. (ox.ac.uk)
Hypoxia-inducible expression of tumor-associated carbonic anhydrases. (ox.ac.uk)
Acute hypoxia also increased rabbit alveolar macrophage IL-8 expression. (ox.ac.uk)

Anatomy21

Organisms14

Diseases11

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes57

Disciplines and Occupations2

Information Science3

Health Care1

Hypoxic19

Proteins2

Activity of hypoxia-induci1

1alpha11

Regulation14

Gene16

Response to hypoxia7

Transcription factor7

Protein9

Transcriptional2

Degradation2

Hydroxylation3

Activation by hypoxia1

Inhibitor1

HIFs1

Cells17

Exposure to hypoxia1

Hydroxylase1

Dependent1

Carcinoma1

Monocyte-derived macrophages1

Pathway6

Physiological1

Degraded by the proteasome1

Pulmonary1

Angiogenesis4

Antibodies3

Glucose1

Vascular endoth4

Induction1

20172

Angiogenic15

Regulator1

VEGF3

Mediates1

Interleukin1

MRNA1

Mice1

Cellular2

Pathogenesis1

Binds1

Mimic1

Expression10