Hypothermia induced. Medical search. Frequent questions

A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest. (ucsf.edu)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. (ucsf.edu)
Retrospective review of clinical, imaging, and electroencephalography data of 33 adult comatose survivors of cardiac arrest following therapeutic hypothermia was performed. (ajnr.org)

Intentional hypothermia is an induced state generally directed at neuroprotection after an at-risk situation (usually after cardiac arrest, see Therapeutic Hypothermia ). (medscape.com)
To study the systemic levels of matrix metalloproteinases (MMP) -7, -8 and -9 and their inhibitor TIMP-1 in cardiac arrest patients and the association with mild therapeutic hypothermia treatment on the serum concentration of these enzymes. (nih.gov)
The biomarker levels were compared between patients (N=51) and healthy controls (N=10) and between patients who did (N=30) and patients who did not (N=21) receive mild therapeutic hypothermia. (nih.gov)
Patients who received therapeutic hypothermia had lower MMP-9 levels compared to non-hypothermia treated patients, which generates hypothesis about attenuation of inflammatory response by hypothermia treatment. (nih.gov)
The study's lead investigator, Children's Hospital of Pittsburgh neurosurgeon P. David Adelson, MD, and fellow researchers determined that induced moderate hypothermia initiated after severe traumatic brain injury (TBI) is a safe therapeutic intervention for children. (scienceblog.com)
1 ⇓ ⇓ ⇓ - 5 The role of MR imaging is not standardized despite relatively good sensitivity and specificity documented in studies performed before routine therapeutic hypothermia. (ajnr.org)
6 , 7 However, brain imaging and malignant EEG patterns following therapeutic hypothermia have not been comprehensively described, to our knowledge. (ajnr.org)
When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)

Conductive and convective heat loss, or direct transfer of heat to another object or circulating air, respectively, are the most common causes of accidental hypothermia. (medscape.com)
Larger scale trials seem warranted to determine if acetaminophen administration is associated with an increased risk of accidental hypothermia, particularly in vulnerable populations such as frail elderly individuals. (kent.ac.uk)

Systemic hypothermia may also be accompanied by localized cold injury (see Emergent Management of Frostbite ). (medscape.com)
Systemic inflammation evoked by LPS also produced greater increases in proinflammatory cytokines, pentraxin 3, and inducible nitric oxide synthase transcription in prion-diseased mice than in control mice and induced microglial expression of IL-1β. (jneurosci.org)
The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases. (jneurosci.org)
However, current methods induce systemic hypothermia which requires significant time and has associated complications. (sbir.gov)

FGF21 is dispensable for hypothermia induced by fasting in mice. (nel.edu)
We examined whether FGF21 is essential for fasting-induced hypothermia using FGF21 knockout (KO) mice. (nel.edu)
d-MDMA (20 mg/kg) induced the same degree of damage whether mice were housed singly or in groups. (erowid.org)
Higher dosages in singly housed mice induced greater lethality, but not greater neurotoxicity. (erowid.org)
d-MDMA was also effective in inducing striatal damage in mice of the B6C3F1 strain. (erowid.org)
2007). Ginger and its bioactive component inhibit enterotoxigenic Escherichia coli heat-labile enterotoxin-induced diarrhea in mice. (healthline.com)
A groundbreaking study published in Nature Metabolism has unveiled a noninvasive and safe method to induce a torpor-like state in mice and rats. (scienceblog.com)

Many patients have recovered from severe hypothermia, so early recognition and prompt initiation of optimal treatment is paramount. (medscape.com)
BACKGROUND: Trauma-induced coagulopathy (TIC) is commonly seen among patients with severe injury. (tau.ac.il)
The trial, which is the only multi-center clinical trial involving children underway in the United States, was conducted to determine whether moderate hypothermia (32 degrees Celsius) begun in the early period after severe TBI and maintained for 48 hours is safe compared with normal body temperature (36.55 degrees Celsius). (scienceblog.com)
After severe TBI, 48 children less than 13 years of age admitted within six hours of injury were randomized by age to moderate hypothermia treatment in conjunction with standardized head injury management versus normal body temperature. (scienceblog.com)
In a dose response study, implants of 10, 100 and 200 mg of brand (C) drain material produced dose dependent clinical signs (severe vasodilatation, hypothermia, and ataxia) and clevations in serum alanine amino-transferase, blood urea nitrogen, and creatinine. (cdc.gov)

More recently, our group has shown that Catuama also produces a prominent reduction of the mechanical hypersensitivity induced by LPS in rats [ 4 ]. (hindawi.com)
2 h after a single dose of 3,4-methylenedioxymethamphetamine (20 mg/kg, s.c.), rats exhibited hyperthermia (38.7 degrees C) or hypothermia (35.8 degrees C) when maintained at 25 degrees C or 6 degrees C, respectively. (erowid.org)

Since AMPs are noted for both their stimulatory and hyperthermia-inducing properties, activity, as well as core temperature, was monitored in several experiments. (erowid.org)
d-MDMA caused hyperthermia, whereas d-FEN induced hypothermia. (erowid.org)
Non-drug-induced hyperthermia or hypothermia did not affect tryptophan hydroxylase activity. (erowid.org)

One such study, "L-NAME, a nitric oxide synthase inhibitor, and WIN 55212-2, a cannabinoid agonist, interact to evoke synergistic hypothermia," published in the February issue of the Journal of Pharmacology and Experimental Therapeutics , reveals how cannabinoids produce one of the drug's most robust actions, hypothermia, or decreased body temperature. (cannabisuk.com)
Preventing hypothermia did not affect its sleep-inducing actions suggesting that altered sleep is not secondary to decreased body temperature. (nature.com)

Hypothermia results in decreased depolarization of cardiac pacemaker cells, causing bradycardia. (medscape.com)
The American Heart Association recommends induced hypothermia for post cardiac arrest care. (miamicountyks.org)
Induced hypothermia provides the greatest chance of a positive recovery in patients with post cardiac arrest syndrome. (miamicountyks.org)
Hospital criteria for receiving induced hypothermia patients include having an intensive care unit, a cardiac catheterization lab, and induced hypothermia capabilities. (miamicountyks.org)
DESCRIPTION (provided by applicant): Hypothermia is a powerful neuroprotective treatment for ischemic injury and is indicated for use in cardiopulmonary bypass, cardiac arrest, and neonatal hypoxia. (sbir.gov)

Our findings suggest that FGF21 is not essential for the hypothermia that is associated with the early stages of fasting, although it might be involved in the adaptive response of body temperature to chronic starvation. (nel.edu)
Hypothermia describes a state in which the body's mechanism for temperature regulation is overwhelmed in the face of a cold stressor. (medscape.com)
[ 1 ] Primary hypothermia is due to environmental exposure, with no underlying medical condition causing disruption of temperature regulation. (medscape.com)
[ 2 ] Secondary hypothermia is low body temperature resulting from a medical illness lowering the temperature set-point. (medscape.com)
When the body's temperature is altered, as in hypothermia, normal body functions, such as blood pressure and circulation, are impaired. (cannabisuk.com)
Knowing that the molecule nitric oxide (NO) plays an important role in the regulation of body temperature, the Temple researchers set out to determine what role it might play in cannabinoid-induced hypothermia. (cannabisuk.com)
Induced Hypothermia is a medical treatment that lowers the body's temperature to protect the brain. (ucsf.edu)
Clinically, peritoneal injury caused by drying has been linked to post-operative pain, evaporative cooling resulting in a decrease in core temperature and increased risk of intra-operative hypothermia, as well as adhesion formation. (wikipedia.org)
The risk of a loss of body temperature and hypothermia increase with the duration of surgery, especially for surgery that lasts more than one hour. (wikipedia.org)
Surgical hypothermia, defined as a core temperature below 36.0 °C, is associated with increased risk of infectious and non-infections complications, longer post-operative ICU and overall hospital recovery, and more frequent requirement of transfusions. (wikipedia.org)
The goal temperature for induced hypothermia is 89.6 degrees Fahrenheit. (miamicountyks.org)
Hypothermia is a lowering of the core body temperature to less than or equal to 95 F (less than or equal to 35 C) (1). (cdc.gov)
Significant increases in activity were induced by d-MDMA, and these increases were not blocked by pretreatment with MK-801, despite the profound lowering of body temperature induced by this combination. (erowid.org)
Preadministration of N-tert-butyl-alpha-phenylnitrone prevented 3,4-methylenedioxymethamphetamine from raising the temperature above normal and attenuated the drug-induced decrease in tryptophan hydroxylase activity in hippocampus, striatum and frontal cortex. (erowid.org)
These results suggest that body temperature plays a prominent role in the 3,4-methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. (erowid.org)
Prolonged immersion in sub-body temperature water can induce fatal hypothermia. (farmanddairy.com)
5 The severity of hypothermia is also influenced by the environmental temperature, duration of anesthesia, and exposure of body cavities. (vin.com)
Auciliems 2 reported that combinations of low temperatures with strong winds induced a feeling of thermal discomfort and increased the risk of hypothermia (body temperature below 35°C). Thus, the heart rate also tends to become lower, breathing slows down, and the blood vessels constrict, resulting in increased blood pressure. (bvsalud.org)

Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress. (kent.ac.uk)
Few studies have examined the acute exercise-induced changes in cognitive performance in different thermal environments and the time course effects. (frontiersin.org)

See Treating Hypothermia: What You Need to Know , a Critical Images slideshow, to help recognize the signs of hypothermia as well as the best approach for hypothermic patients. (medscape.com)

Hemodilution was produced by mixing the blood with 40% Tris/saline solution, fibrinolysis by treating the blood with 160 ng/mL tPA, acidosis by adding 1.2 mg/mL lactic acid achieving pH 7.0 to 7.1, and hypothermia by running the assay at 31°C. Intact blood tested at 37°C served as control. (tau.ac.il)
Clotting initiation was reduced by hemodilution and further reduced by additive hypothermia. (tau.ac.il)
The propagation phase of blood clotting was reduced by hemodilution, further reduced by additive hypothermia, and maximally reduced if additionally combined with fibrinolysis. (tau.ac.il)
No effect of fibrinolysis on clot propagation was observed at 37°C. Maximum clot firmness was reduced by hemodilution, further reduced by additive fibrinolysis, and maximally reduced if additionally combined with hypothermia. (tau.ac.il)
CONCLUSION: The study revealed a differential effect of TIC constituents - hemodilution, hypothermia, fibrinolysis, and acidosis - on clot formation and platelet function. (tau.ac.il)
Induced hypertension, hypervolemia, and hemodilution (ie, "triple-H therapy") aimed to maintain adequate cerebral perfusion pressure in the setting of impaired cerebrovascular autoregulation. (medscape.com)

A cooling water blanket used to induce whole body cooling for 30 min after the end of resuscitation. (medsci.org)
A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)

Fibroblast growth factor 21 (FGF21) is a key metabolic regulator that is induced by peroxisome proliferator-activated receptor alpha (PPARalpha) activation in response to fasting. (nel.edu)
Elderly persons particularly are at risk for hypothermia because of medical and socioeconomic factors such as underlying diseases, social isolation, and physiologic changes (e.g., lack of appropriate vasoconstriction in response to cold environments, decreased basal metabolic rate, and impaired shivering mechanism). (cdc.gov)
Adult research has produced evidence that hypothermia may limit some of these deleterious metabolic responses. (scienceblog.com)

These trials aim to find the best way to use induced hypothermia to improve neurological outcomes. (ucsf.edu)

By inducing hypothermia in pediatric patients down to 32 degrees Celsius, doctors found that hypothermia tended to reduce mortality, lower the severity of intracranial hypertension during the cooling phase and has the potential to improve the functional outcome of young patients. (scienceblog.com)

Substances in marijuana bind to one of these receptors and set off a chemical process that leads to an effect, such as hypothermia. (cannabisuk.com)

Given this profound hypothermia, she is taken to an outside hospital emergency department (ED). En route to the hospital, the patient has right eye deviation concerning for seizure activity. (contemporarypediatrics.com)

In cats, Redondo and colleagues correlated intraoperative hypothermia with mortality. (vin.com)

Hypothermia treatment associated with attenuated elevation of MMP-9 (p=0.001) but not MMP-8 (p=0.02) or MMP-7 (p=0.69). (nih.gov)
Exposure to drain brand (A) induced significant elevation in total IgE (5748 ng/ml VS. 347 ng/ml for the sham control) by day 21. (cdc.gov)

Conclusions: Intravascular and surface cooling was equally effective during induction of mild hypothermia. (lu.se)

Researchers will conduct further studies to determine the effect of moderate hypothermia on functional outcome and intracranial hypertension. (scienceblog.com)

A deficiency of FGF21 affected neither fasting-induced hypothermia nor hypothalamic NPY induction. (nel.edu)
Chen expressed the potential impact of ultrasound-induced hypothermia and hypometabolism, stating, "UIH has the potential to address the long sought-after goal of achieving noninvasive and safe induction of the torpor-like state, which has been pursued by the scientific community at least since the 1960s. (scienceblog.com)

From 1979 through 1992, a total of 10,550 persons in the United States died from hypothermia, an average of 754 deaths per year (range: 557-1021 deaths) (2). (cdc.gov)
From October 1994 through February 1996, a total of 10 hypothermia-related deaths were reported by the chief medical examiner in Vermont. (cdc.gov)
This report summarizes the investigation of three of these deaths and describes risk factors commonly associated with hypothermia. (cdc.gov)
Editorial Note: From 1979 through 1992, approximately half of all hypothermia deaths in the United States occurred among persons aged greater than or equal to 65 years ( Figure 1 ). (cdc.gov)

No. Currently only patients who have a return of a circulation receive induced hypothermia. (miamicountyks.org)

This preliminary trial suggests that acetaminophen-induced hypothermia is exacerbated during cold stress. (kent.ac.uk)
Ethanol abuse, which is strongly associated with hypothermia, results in vasodilation and interferes with peripheral vasoconstriction, an important physiologic mechanism of defense against the cold. (cdc.gov)
A cold induced condition caused by the formation of ice crystals in exposed body parts. (toronto.ca)
A cold induced condition which results from over cooling of the body due to excessive loss of body heat. (toronto.ca)
Because you have less natural insulation, you can get hypothermia in cold weather. (medlineplus.gov)

On the other hand, a deficiency of FGF21 significantly attenuated chronic hypothermia and hypoactivity induced by a ketogenic diet (KD). (nel.edu)
A study from 1990 showed that ginger significantly inhibited serotonin-induced diarrhea. (healthline.com)

Hypothermia is classified as accidental or intentional, primary or secondary, and by the degree of hypothermia. (medscape.com)

Induced hypothermia slows the body's metabolism down. (miamicountyks.org)

Barring preventive interventions, hypothermia occurs in more than half of all surgical patients undergoing anesthesia. (wikipedia.org)
Unfortunately, induced hypothermia will not save all patients. (miamicountyks.org)
At this time, not all hospitals accept induced hypothermia patients. (miamicountyks.org)
Patients are transported to the closest facility that meets criteria for handling induced hypothermia patients. (miamicountyks.org)

Drug overdose was listed as the primary cause of death with hypothermia as a contributing cause. (cdc.gov)

Hypothermia affects virtually all organ systems. (medscape.com)

Amphetamines (AMPs) can cause long-term depletions in striatal dopamine (DA) and serotonin (5-HT), and these decrements are often accepted as prima facie evidence of AMP-induced damage to the dopaminergic and serotonergic projections to striatum. (erowid.org)

The stimulatory effects of d-MDMA appeared to have little impact on the neurotoxicity induced by d-MDMA or the protection conferred by MK-801. (erowid.org)
4 The negative impact of hypothermia is greatly underestimated and its occurrence often goes undetected because intra-operative temperatures are not often monitored. (vin.com)

Clues in favor of a specific IgE role in food protein-induced enterocolitis syndrome pathogenesis. (medscape.com)

Medically induced coma prevents the body from cutting off blood to parts of the brain, giving those parts a chance to heal. (newmars.com)
Blood withdrawal (6 mL/100 g body weight) for 60 min through the right jugular vein catheter-induced an HS. (medsci.org)

The authors have also evaluated the effects of extracts made from the plants present in the product Catuama, T. catigua, P. cupana , P. olacoides and Z. officinalis , and verified that T. catigua had the higher antinociceptive effect on the acetic acid-induced nociception [ 3 ]. (hindawi.com)
No effect of hypothermia on clot strength was observed in the absence of fibrinolysis. (tau.ac.il)
Since hypothermia may prevent the 3,4-methylenedioxymethamphetamine-induced decrease in tryptophan hydroxylase activity by reducing the formation of free radicals, the effect of a free radical scavenging agent, N-tert-butyl-alpha-phenylnitrone, was examined. (erowid.org)
N-tert-butyl-alpha-phenylnitrone (200 mg/kg, i.p.) alone caused hypothermia but had no direct effect on tryptophan hydroxylase activity. (erowid.org)

Experimental evidence demonstrated that TRPM2 served as an ultrasound-sensitive ion channel and played a crucial role in inducing the torpor-like state. (scienceblog.com)

Current studies have shown that the use of surgical humidification during open abdominal surgery (laparotomy) have warmer core body temperatures and reduced risk of operative hypothermia. (wikipedia.org)
Elderly persons, especially those with lower muscle and body mass are at greater risk of hypothermia. (wikipedia.org)

Astrogliosis, assessed by quantification of glial fibrillary acidic protein (GFAP), was the main indicator of d-MDMA-induced neural damage. (erowid.org)

Induced hypothermia can be accomplished using several methods. (scienceblog.com)

While generally associated with hypothermia, the J wave may be a normal variant and is seen occasionally in sepsis and myocardial ischemia. (medscape.com)

The smaller the animal the greater its body surface area:weight ratio and the more prone it is to hypothermia. (vin.com)

Anatomy1

Organisms2

Diseases16

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes12

Technology, Industry, Agriculture1

Information Science1

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Health Care8

Comatose survivors of cardiac arrest3

Therapeutic8

Accidental hypothermia2

Systemic4

Mice7

Severe5

Rats2

Hyperthermia3

Decreased body2

Cardiac5

Temperature18

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Hypothermic1

Hemodilution6

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Metabolic3

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