• hypertension
  • Thiazide (/ˈθaɪəzaɪd/) is a type of molecule and a class of diuretics often used to treat hypertension (high blood pressure) and edema (such as that caused by heart failure, liver failure, or kidney failure). (wikipedia.org)
  • However, the recent 2011 UK National Institute for Health and Clinical Excellence (NICE) guideline on the management of primary hypertension in adults (CG127) recommend calcium channel blockers (CCBs) as first line agents in hypertension and advise that thiazide-like diuretics should only be used first line if CCBs are not suitable or if the patient has oedema or has a high risk of developing heart failure. (wikipedia.org)
  • obesity
  • According to guidelines from the World Health Organization (WHO), overweight in adults is defined by body mass index (BMI) of 25.0 to 29.9, and obesity is defined by a BMI of 30.0 or higher [ 7 ]. (hindawi.com)
  • mice
  • C57BL/6 male mice were divided in two groups according to their diet for 8 weeks: standard diet (ST) and high-fat diet (HF). (hindawi.com)
  • Its role in liver steatosis is well established, since mice with liver-specific deletion of PGC-1α exhibit lipid accumulation and high-fat diet reduces hepatic PGC-1α expression in mice. (springer.com)
  • C57black/6 mice were fed a high-fat diet containing 30% fat for 10 weeks. (springer.com)
  • Glucose elimination after an intravenous glucose challenge (1 g/kg) was significantly delayed after 1, 4, and 8 weeks on the high-fat diet compared with normal-diet-fed mice. (diabetesjournals.org)
  • In contrast, the early islet changes after feeding these mice a high-fat diet are less well studied. (diabetesjournals.org)
  • Finally, we also examined the expression of the functional full-length leptin receptor (ObRb) because β-cells express this receptor ( 15 ), and circulating leptin is increased in high-fat-fed mice ( 4 , 16 , 17 ). (diabetesjournals.org)
  • PPARG knockout mice fail to generate adipose tissue when fed a high-fat diet. (wikipedia.org)
  • diabetic
  • Diabetic nephropathy (DN), a leading cause of end-stage renal disease, is the most common diabetic microvascular complication with high mortality and morbidity [ 7 ]. (hindawi.com)
  • Produced in high levels during periods of stress, infection, etc possibly leading to diabetic ketoacidosis, a very serious condition. (wikipedia.org)
  • The following characteristics suggest the possibility of a diagnosis of MODY in hyperglycemic and diabetic patients: Mild to moderate hyperglycemia (typically 130-250 mg/dl, or 7-14 mmol/l) discovered before 30 years of age. (wikipedia.org)
  • impairs
  • Loader J, Montero D, Lorenzen C, Watts R, Meziat C et al (2015) Acute hyperglycemia impairs vascular function in healthy and cardiometabolic diseased subjects: systematic review and meta-analysis. (springer.com)
  • mitochondrial
  • Hyperglycemia leads to the overproduction of mitochondrial superoxide, which causes the accumulation of intracellular reactive oxygen species (ROS) that are responsible for the defective angiogenesis and inflammatory pathway activation [ 11 ]. (hindawi.com)
  • inflammation
  • High-fat diet induces liver inflammation by inhibiting PGC-1α expression and its suppressive effect in NFκB pathway. (springer.com)
  • kidney
  • Potential side effects include poor kidney function, electrolyte imbalances especially low blood potassium and less commonly low blood sodium, gout, high blood sugar, and feeling faint initially upon standing up. (wikipedia.org)
  • hepatic
  • We investigated the inhibitory effect of aqueous extracts from Solanum nigrum (AESN) on AGEs-induced RAGE signaling and activation of hepatic stellate cells (HSCs) and hyperglycemia induced by high-fat diet with ethanol. (mdpi.com)
  • Prolonged hyperglycemia in DM results in various secondary complications including nephropathy, hepatic damage, retinopathy, neuropathy, and cardiovascular disease [ 4 - 6 ]. (hindawi.com)
  • inflammatory
  • In this study, we investigated the role of PGC-1α in the inflammatory changes observed in steatohepatitis induced by high-fat diet. (springer.com)
  • Bioavailability
  • Bioavailability of pistachio polyphenols, xanthophylls, and tocopherols is very high - until you put them into a muffin (Mandalari. (blogspot.com)
  • Thus
  • The caloric value on both food labels and respective nutrient tables is thus off 25% too high. (blogspot.com)
  • aorta
  • The present study aimed to investigate the involvement of ACE and TGF- β in the aorta stiffness induced by high-fat diet. (hindawi.com)
  • nuclear translocation
  • However, the nuclear translocation of the homeobox transcription factor, pdx-1, and the plasma membrane translocation of GLUT2 were both impaired in high-fat-fed animals after 1 week. (diabetesjournals.org)
  • diseases
  • Changes in lifestyle such as increase in high-fat food consumption are an important cause for vascular diseases. (hindawi.com)
  • type
  • Recent evidences suggest that high fat diet, which is also characteristic of cafeteria type diet, as well as sedentary life style are two contributory factors for increased trends of obese people among the nations [ 5 ]. (hindawi.com)
  • Hyperchylomicronemia or hyperlipoproteinemia is a type of inherited hyperlipidemia in cats. (wikipedia.org)
  • Patients with glycogen-storage disease type 0 have normal-to-increased response to glucagon in the fed state, with hyperglycemia and lactic acidemia. (wikipedia.org)