Atropa belladonna is a medicinal plant and main commercial source of tropane alkaloids (TAs) including scopolamine and hyoscyamine, which are anticholine drugs widely used clinically. (bvsalud.org)
The term "tropane" is derived from just one genus in the family Solanaceae - Atropa (the belladonna genus), named after the Greek Fate, Atropos, who cut the thread of life. (allaboutheaven.org)
Hyoscyamine4
The tropane alkaloidsatropine, scopolamine, and hyoscyamine are highly anticholinergic compounds found in a number of plants. (medscape.com)
Tropane alkaloids (TA) including anisodamine, anisodine, hyoscyamine and scopolamine are a group of important anticholinergic drugs with rapidly increasing market demand, so it is significant to improve TA production by biotechnological approaches. (biomedcentral.com)
It is the levorotary isomer of atropine (third of the three major nightshade alkaloids) and thus sometimes known as levo-atropine. (curecrowd.com)
Datura2
Many cultures worldwide add plants with tropane alkaloids (particularly Datura species) to alcoholic beverages to increase intoxication. (medscape.com)
Broadly speaking, the genus Scopolia includes five species of inflorescent plants belonging to the Solanaceae family that are indigenous to Europe and Asia. (herbs2000.com)
The Solanaceae plants distributed in China belong to 105 species and 35 varietas of 24 genera. (bvsalud.org)
In this paper, the geographical distribution, chemical components, traditional therapeutic effect, and modern pharmacological activities of TAs-containing species in Solanaceae were analyzed for the first time. (bvsalud.org)
Based on these data, the genetic relationship of TAs-containing Solanaceae species was preliminarily discussed, which provided a scientific basis for the basic research on TAs-containing solanaceous species and was of great significance for the development of natural medicinal plant resources containing TAs. (bvsalud.org)
Toxicity2
Although most tropane alkaloids cause an anticholinergic syndrome, a case report indicates that the tropane alkaloid-containing medicinal herb Erycibe henri Prain ("Ting Kung Teng") contains a tropane alkaloid that may cause a cholinergic syndrome, as well as kidney, liver, and erythrocyte toxicity. (medscape.com)
Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. (medscape.com)
Plants4
Some medicinal plants of Solanaceae are rich in tropane alkaloids(TAs), which have significant pharmacological activities. (bvsalud.org)
Besides, the phylogeny of medicinal plants belonging to Solanaceae was visualized by network diagram. (bvsalud.org)
Fourteen genera of Solanaceae plants in China contain TAs and have medical records. (bvsalud.org)
Background: Since alkaloids are nitrogenous compounds, the availability of nitrogen [N] is expected to play an important role in the biosynthesis and accumulation of alkaloids in plants. (bvsalud.org)
Compounds1
[ 1 ] The alkaloids represent a very diverse group of medically significant compounds that include well-known drugs such as the opiates. (medscape.com)
Family1
[2] [3] A number of plant deliriants such as that of the Solanaceae family , particularly in the Americas have been used by some indigenous cultures to reach delirious and altered states for traditions or rituals, such as rites of passage, divination or communicating with the ancestors . (wikipedia.org)
Include1
A subgroup of the alkaloids is the alkaloid amines, which include three major pharmacologic groups: the hallucinogenic alkaloid amines, the stimulant alkaloid amines, and the tropane alkaloids (also called the belladonna alkaloids or bicyclic alkaloids). (medscape.com)
Important1
However, these alkaloids are all important in phyto-medicine with rapid increasing market demand. (biomedcentral.com)
Plant1
Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and pharmacologic activity. (medscape.com)
Chinese1
Chinese herbal medicines containing tropane alkaloids have been used to treat asthma, chronic bronchitis, pain, and flu symptoms. (medscape.com)
Drugs1
These pharmacological activities provide a reasonable explanation for the traditional therapeutic efficacy of tropane drugs. (bvsalud.org)
Anticholinergic3
Although most tropane alkaloids cause an anticholinergic syndrome, a case report indicates that the tropane alkaloid-containing medicinal herb Erycibe henri Prain ("Ting Kung Teng") contains a tropane alkaloid that may cause a cholinergic syndrome, as well as kidney, liver, and erythrocyte toxicity. (medscape.com)
[ 14 ] This is considered atypical for the tropane alkaloids, which are predominantly strongly anticholinergic. (medscape.com)
Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. (medscape.com)
Cultures2
In transgenic hairy root cultures, AgNPs application at a concentration of 100 mg/L resulted in the highest total tropane alkaloid production, which exhibited broad-spectrum antimicrobial activity. (bvsalud.org)
The study demonstrated the potential of nano-silver as an elicitor for promoting the production of target alkaloids in Hyoscyamus muticus hairy root cultures, which exhibit high biological activity. (bvsalud.org)
Chemical1
Alkaloids are plant metabolites that have a nitrogen-containing chemical ring structure, alkali-like chemical reactivity, and pharmacologic activity. (medscape.com)
Increase1
The hairy root culture technique can be used to increase secondary metabolites such as tropane alkaloids. (bvsalud.org)