AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
ChoreaHuntington DiseaseBasal GangliaBasal Ganglia DiseasesGangliaRetinal Ganglion CellsGlobus PallidusBasal Ganglia HemorrhageGanglia, SpinalRheumatic FeverPutamenCaudate NucleusCorpus StriatumGanglia, SympatheticGanglia, AutonomicTrigeminal GanglionTrinucleotide Repeat ExpansionBrainBasal Ganglia Cerebrovascular DiseaseTrinucleotide RepeatsMagnetic Resonance ImagingNerve Tissue ProteinsGanglia, ParasympatheticChorea GravidarumNeuronsGanglia, SensoryDystoniaChromosomes, Human, Pair 4NeuroacanthocytosisParkinson DiseaseSubthalamic NucleusAutoimmune Diseases of the Nervous SystemMovement DisordersNeural PathwaysAnti-Dyskinesia AgentsStellate GanglionNeostriatumTetrabenazineSubstantia NigraThalamusDyskinesia, Drug-InducedSpiral GanglionLevodopaAge of OnsetNodose GanglionDisease Models, AnimalDyskinesiasQuinolinic Acid
InvoluntaryMovementsHuntington's ChoreaDopamineAthetosisResting tremorTicsDisordersType of choreaBilateralPutamenSubstantiaCollections of nerve cellsNeuronsCause choreaOnsetSymptomsHereditaryLesionsNerve cellsOccurCharacteristicCortexCognitiveNucleiNeuronalFidgetyDegenerationChoreoathetosisBrainBallismParkinson's DiseasePsychiatricSydenhamLupusGeorge HuntingtonDiseaseAmantadineDisorderNeurologyGene
Involuntary15
  • Chorea is a continuous, random-appearing sequence of one or more discrete involuntary movements or movement fragments. (wikipedia.org)
  • Children with chorea appear fidgety and will often try to disguise the random movements by voluntarily turning the involuntary, abnormal movement into a seemingly more normal, purposeful motion. (wikipedia.org)
  • Chorea is a movement disorder that causes involuntary, irregular, unpredictable muscle movements. (clevelandclinic.org)
  • Involuntary movements present as tremors in Parkinson's disease and as chorea in Huntington's disease. (medicalnewstoday.com)
  • Chorea " is the term for involuntary, irregular, dance-like movements. (medicalnewstoday.com)
  • Huntington's disease can cause involuntary movements such as chorea. (medicalnewstoday.com)
  • This leads to an excessive amount of involuntary movement, known as chorea. (physio-pedia.com)
  • Chorea (sudden involuntary, uncoordinated jerky movements, e.g. (fpnotebook.com)
  • Chorea results in involuntary movements like jerking and writhing, typically beginning in the person's fingers, feet, face, or torso. (bestmindbodyhealth.com)
  • Chorea is characterized by repetitive, brief, irregular, somewhat rapid involuntary movements that start in one part of the body and move abruptly, unpredictably, and often continuously to another part. (msdmanuals.com)
  • Hemiballismus is a type of chorea, usually involving violent, involuntary flinging of one arm and/or one leg. (msdmanuals.com)
  • The basal ganglia help initiate and smooth out muscle movements, suppress involuntary movements, and coordinate changes in posture. (msdmanuals.com)
  • Huntington Disease Huntington disease is a hereditary disease that begins with occasional involuntary jerking or spasms, then progresses to more pronounced involuntary movements (chorea and athetosis), mental. (msdmanuals.com)
  • As of 2008, some progress was made when the U.S. Food and Drug Administration approved the drug tetrabenazine to treat involuntary writhing movements of H.D..D. (chorea), making it the very first Huntington's disease drug approved for use in the U.S. (mkexpress.net)
  • Intensive propulsion, involuntary muscle movements (limbs and face), muscle weakness of left upper and lower limbs, and "walk dance" in 38-year-old man with tick-borne encephalitis and chorea, Poland. (cdc.gov)
Movements11
  • Many hyperkinetic movements are the result of improper regulation of the basal ganglia-thalamocortical circuitry. (wikipedia.org)
  • Although chorea consists of discrete movements, many are often strung together in time, thus making it difficult to identify each movement's start and end point. (wikipedia.org)
  • Unlike dystonic movements, chorea-associated movements are often more rapid, random and unpredictable. (wikipedia.org)
  • At least two other movements related to chorea are seen in neurological diseases. (clevelandclinic.org)
  • Jerky movements (chorea). (osteopathyebooks.com)
  • This symptom is primarily caused by the disease's attacks on the brain, parts of the basal ganglia known as the caudate nucleus and putamen-a collection of nerve cells located at the base of the cerebrum that helps to smooth out and coordinate movements. (bestmindbodyhealth.com)
  • Uncontrolled movements (chorea), clumsiness, errors in judgement, emotional swings, and difficulty eating and swallowing are some of the symptoms. (yale.edu)
  • Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline, and psychiatric symptoms , caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. (symptoma.com)
  • Movements are wider and more intense than chorea. (msdmanuals.com)
  • Chorea and athetosis can occur together, usually causing writhing, dancelike movements. (msdmanuals.com)
  • Chorea and athetosis result from overactivity in the basal ganglia, the part of the brain that helps initiate and smooth out and coordinate intended (voluntary) movements initiated by nerve impulses from the brain. (msdmanuals.com)
Huntington's Chorea3
  • Huntington's disease, or also known as Huntington's Chorea, is an incurable hereditary brain disorder, which causes nerve cells to become damaged, resulting in various parts of the brain deteriorating. (nmmra.org)
  • The disease now bares Huntington's name because of a paper he wrote called On Chorea which was later published and the disorder he talked about became known as Huntington's Chorea. (nmmra.org)
  • Huntington's sickness (HD), additionally referred to as Huntington's chorea, is a rare, degenerative neurological disease with a robust hereditary thing. (eierkhjix.gq)
Dopamine3
  • Brain regions affected by HD have decreased GABA and acetylcholine but increased dopamine levels which helps explain why neuroleptics, which are dopamine receptor antagonists and tetrabenazine which depletes dopamine are used to treat chorea in people with HD but have no effect on overall survival. (edubirdie.com)
  • In most forms of chorea, an excess of dopamine , the main neurotransmitter used in the basal ganglia, prevents the basal ganglia from functioning normally. (msdmanuals.com)
  • Drugs and disorders that increase dopamine levels or increase the sensitivity of nerve cells to dopamine tend to worsen chorea and athetosis. (msdmanuals.com)
Athetosis5
  • Athetosis can occur in the resting state, as well as in conjunction with chorea and dystonia. (wikipedia.org)
  • The symptoms involve the central nervous system which will have an effect on movement (chorea and athetosis), cognitive disturbance, and mood. (edubirdie.com)
  • Chorea and athetosis are usually symptoms of another disorder, although chorea may develop on its own in older people or in pregnant women. (msdmanuals.com)
  • For chorea and athetosis, treating the cause may help, as may antipsychotic drugs. (msdmanuals.com)
  • Chorea and athetosis, which may occur together as choreoathetosis, are not disorders. (msdmanuals.com)
Resting tremor1
Tics3
  • Evidence shows that the basal ganglia circuitry underlies chronic tics. (medscape.com)
  • Movement learning" and "habit learning" occur in the basal ganglia, and because tics are learned, "you can learn to modify them," said Dr Mink. (medscape.com)
  • Although many open-label studies have assessed tetrabenazine , a drug approved to treat chorea associated with Huntington's disease , there are no well-controlled trials with this drug for tics, said Dr Mink. (medscape.com)
Disorders6
Type of chorea1
Bilateral3
  • CT scans showed high-intensity lesions in bilateral basal ganglia ( figure 1A ). (bmj.com)
  • B) MRI showed increased signal intensity on T1-weighted images in the bilateral basal ganglia. (bmj.com)
  • Moreover, rTMS with a LFP on the bilateral supplementary motor areas is effective in treating chorea in Huntington's disease (2). (bvsalud.org)
Putamen1
  • In Huntington`s Disease, mutated protein aggregates within the neuronal cells of the caudate and putamen of the basal ganglia causing neuronal cell death. (edubirdie.com)
Substantia1
Collections of nerve cells2
Neurons1
  • Huntington disease (HD) is an incurable, adult-onset, autosomal dominant inherited disorder associated with cell loss within a specific subset of neurons in the basal ganglia and cortex. (medscape.com)
Cause chorea1
Onset3
  • Basal ganglia lesions on MRI remained 4 weeks after the onset. (bmj.com)
  • A diagnosis can be received by a diagnostic genetic test before symptoms begin to check for the defective gene for Huntington protein (typically only done if a patient's parent has had Huntington's), or it may be prompted by the onset of symptoms. (bestmindbodyhealth.com)
  • Huntington disease, an autosomal dominant disorder, is a progressive, neurodegenerative disease characterized by insidious onset of incoordination, personality changes, and psychiatric symptoms leading to severe dementia and immobility. (symptoma.com)
Symptoms3
  • Moreover, additional anti-chorea medications may be needed in patients whose symptoms cannot be controlled by regulating blood glucose levels. (bmj.com)
  • Humans have two copies of the Huntington gene, however those who have a mutation to at least one of these copies have a greater chance of experiencing the HD symptoms [6] . (physio-pedia.com)
  • One of the most common, and likely most noticeable symptoms, is chorea. (bestmindbodyhealth.com)
Hereditary1
  • HD is named after George Huntington, the physician who described it as hereditary chorea in 1872. (medscape.com)
Lesions1
Nerve cells1
  • Huntington disease (HD) is an incurable, inherited disorder that occurs from gene mutation and results in the progressive degeneration of nerve cells in the brain [2] .The basal ganglia is the primary location of degeneration, specifically the striatum located within it. (physio-pedia.com)
Occur3
  • Chorea can occur in people of all ages. (clevelandclinic.org)
  • Acute to subacute ballism/chorea can also occur in patients with Huntington's disease, cerebrovascular disease, hepatic encephalopathy, Wilson's disease, systemic lupus erythematosus, poisoning (manganese and organic mercury) and several drugs (levodopa, antidepressant, phenytoin and cocaine). (bmj.com)
  • HD has been found to occur from the mutation of the Huntington gene. (physio-pedia.com)
Characteristic1
  • CT hyperintensity and increased signal intensity on T1WI MRI in basal ganglia are characteristic findings observed in 79% and 95% of patients with DS, respectively. (bmj.com)
Cortex3
Cognitive1
Nuclei1
Neuronal1
  • Polyglutamine expansion =} Huntington accumulates in nucleus and cytoplasm =} cytoplasmic Huntington aggregates in axonal terminals, neuronal loss and gliosis. (neuroradiologycases.com)
Fidgety1
  • The disorder can make you look like you're dancing (the word chorea comes from the Greek word for "dance") or look restless or fidgety. (clevelandclinic.org)
Degeneration2
  • As the disease progresses, so does the degeneration of this area of the brain, thus explaining why chorea becomes more and more intense over time. (bestmindbodyhealth.com)
  • We hypothesize that degeneration of subcortical regions, including the basal ganglia, is associated with damage of white matter tracts linking these affected regions. (frontiersin.org)
Choreoathetosis1
  • When combined with chorea, as in cerebral palsy, the term "choreoathetosis" is frequently used. (wikipedia.org)
Brain2
Ballism2
  • DS is an uncommon condition presenting in patients with poor diabetic control and characterised by acute to subacute ballism/chorea. (bmj.com)
  • Radiological abnormalities disappeared following improved blood glucose control in approximately 120 days on MRI and 24 days on CT, which considerably surpassed the time required for improvement in ballism/chorea. (bmj.com)
Parkinson's Disease1
Psychiatric1
  • After neurologic and psychiatric consultations, chorea in the course of TBE was diagnosed. (cdc.gov)
Sydenham4
Lupus1
George Huntington1
  • Huntington's disease was recognized by George Huntington in 1872. (nmmra.org)
Disease7
  • Chorea is also the prominent movement featured in Huntington's disease. (wikipedia.org)
  • Chorea itself isn't life-threatening, but it could be a sign of a neurological disease such as Huntington's disease . (clevelandclinic.org)
  • Chorea is the most common symptom of Huntington's disease. (clevelandclinic.org)
  • Among them, similar radiological findings on basal ganglia can be observed in patients with Wilson's disease, hepatic encephalopathy and poisoning (manganese and organic mercury). (bmj.com)
  • Huntington`s disease model (Gambazzi et al. (yale.edu)
  • Huntington`s Disease (HD) is an autosomal dominant neurodegenerative disease affecting 4-to-7 per 100,000 individuals. (edubirdie.com)
  • The purpose of these mice was to be able to study and understand repeat expansion which leads to Huntington`s Disease. (edubirdie.com)
Amantadine1
  • Regrettably, there is currently no cure for this condition, but there are treatment and medication options for symptom management, such as prescription medications like haloperidol, tetrabenazine, amantadine, and Austedo which specifically helps with chorea. (bestmindbodyhealth.com)
Disorder3
Neurology2
  • Moreover, a review from Neurology mentioned that CBD might have reduced chorea among patients with HD. (parkinsonsinfoclub.com)
  • We meet at one of her two workplaces, the Huntington unit, Neurology Clinic at Skåne University Hospital in Lund, high up in the main hospital building. (lu.se)
Gene2
  • TRACK-HD is a prospective observational study that reported 12-month longitudinal changes in 116 pre-manifest individuals carrying the mutant Huntington gene (preHD), 114 patients with early HD, and 115 age- and sex-matched controls. (medscape.com)
  • The Huntington gene contains a repetition of the CAG trinucleotide protein that everyone is born with and is typically repeated anywhere between 10-35 times. (physio-pedia.com)