• The Registry of Toxic Effects of Chemical Substances published by NIOSH indicates that 174 substances have been found to cause kidney tumors in animals or humans. (cdc.gov)
  • Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. (duke.edu)
  • Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
  • JCV, for example, induces brain tumors when intracerebrally inoculated in experimental animals ( 7 - 11 ). (cdc.gov)
  • Impact of microibiota on development of tumors in human. (exp-oncology.com.ua)
  • Based on these preliminary results, we set two main objectives: (i) validate the oncogenic role of miR-221 in HCC, and (ii) validate the oncogenic role of miR-483 in Wilms' tumors and other human neoplasms. (unife.it)
  • Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
  • Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)
  • 2011. NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). . (oregonstate.edu)
  • This is a systematic review of studies in the PubMed database to April 2013, which fit the eligibility criterion of "Inflammatory Breast Neoplasms" (MeSH Terms), filtered by Languages (English OR Portuguese OR Spanish). (bvsalud.org)
  • inflammatory breast neoplasms, medical oncology. (bvsalud.org)
  • What has been researched about inflammatory breast neoplasms? (bvsalud.org)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • To date, much is known about the molecular subtypes of these malignant neoplasms and the mechanisms of drug resistance. (exp-oncology.com.ua)
  • Sufficient evidence for the carcinogenicity of acrolein in experimental animals was demonstrated in two rodent species: acrolein increased the incidence of malignant neoplasms in mice and increased the incidence of the combination of benign and malignant neoplasms in rats. (who.int)
  • Despite this, it is preferable to use host specific viruses and promoter sequences for a better translation between mice and humans. (helsinki.fi)
  • Administration of FGF2 neutralizing antibody to mice bearing experimental liver metastases phenocopied neutrophil depletion by reducing liver metastatic colony growth, vascular density, and branching. (ox.ac.uk)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • Approximately 15 percent of kidney neoplasms are in the renal pelvis and appear to be caused by the same carcinogens as bladder cancer, while the remaining 85 percent are in the parenchyma and have an apparently different etiology. (cdc.gov)
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of a fine-needle aspiration (FNA) biopsy specimen. (medscape.com)
  • the induction of benign neoplasms may in some circumstances (see Section 9) contribute to the judgement that the exposure is carcinogenic. (who.int)
  • A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of fine-needle aspiration (FNA) biopsy. (medscape.com)
  • We focus specifically upon mechanistic questions relating to human viral infection, tumour growth and metastasis and T cell activation. (ox.ac.uk)
  • T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms. (cdc.gov)
  • Gene Polymorphism of Xenobiotic Biotransformation Enzymes in Patients with Classical Ph-Negative Myeloproliferative Neoplasms. (cdc.gov)
  • JAK2 rs10974944 is associated with both V617F-positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker. (cdc.gov)
  • Study of CALR, MPL, and c-kit Gene Mutations in Thai Patients with JAK2 V617F Negative Myeloproliferative Neoplasms. (cdc.gov)
  • The differences of hemogram, myelogram, and driver gene mutations in classic myeloproliferative neoplasms. (cdc.gov)
  • Development of a Real-Time qPCR Assay for Detection of Common MPL Mutations in Myeloproliferative Neoplasms (MPNS). (cdc.gov)
  • Vascular Endothelial Dysfunction in Myeloproliferative Neoplasms and Gene Mutations. (cdc.gov)
  • Analysis of DNA Methylation Gene Mutations and Clinical Features in Patients with Myeloproliferative Neoplasm]. (cdc.gov)
  • The clinical relevance of broad mutational screening of myeloproliferative neoplasms at diagnosis. (cdc.gov)
  • The relevancy of findings of kidney cancers in experimental animals to humans is questionable. (cdc.gov)
  • The American Cancer Society estimates that infectious pathogens are associated with up to 20% of all human cancers worldwide. (cdc.gov)
  • In the 1990s Botstein, having moved to Stanford University School of Medicine, collaborated with Patrick O. Brown of Stanford in exploiting DNA microarrays to study genome-wide gene expression patterns in yeast and in human cancers. (nih.gov)
  • The Int7G24A allele was evident in 32% of patients with preinvasive neoplasms and 48% of patients with invasive breast cancers compared with 26% controls ( P = 0.00008). (aacrjournals.org)
  • We tested possible down-modulating effects of these monoclonal antibodies on SKBR-3 mammary tumor cells, which express high levels of wild-type human neu protein. (prinsesmaximacentrum.nl)
  • TERT RNA-transfected human DC stimulated TERT-specific CTL in vitro that lysed human tumor cells, including Epstein Barr virus (EBV)-transformed B cells as well as autologous tumor targets from patients with renal and prostate cancer. (nova.edu)
  • The terms 'neoplasm' and 'tumour' are used interchangeably. (who.int)
  • It is our hope that other genes coding for mouse and human tumour rejection antigens will soon be identified, so that it will become clear whether the activational mechanism is the rule or the exception. (ox.ac.uk)
  • In oncolytic therapies, transgenes can be used to prime the host system against neoplasms which has been shown to generate long term anti-tumour immunity. (helsinki.fi)
  • Human Ad's replicate poorly in mouse tumour cell lines, yet some promoters, which are included in the viral constructs to drive the transcription of beneficial transgenes, are able to function. (helsinki.fi)
  • The Monographs represent the first step in carcinogenic risk assessment, which involves examination of all relevant information in order to assess the strength of the available evidence that certain exposures could alter the incidence of cancer in humans. (who.int)
  • Critical windows of exposure for children's health: cancer in human epidemiological studies and neoplasms in experimental animal models. (cdc.gov)
  • Some epidemiological and experimental studies indicate that different agents may act at different stages in the carcinogenic process, and several different mechanisms may be involved. (who.int)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • We found that human colorectal cancer liver metastases and murine gastrointestinal experimental liver metastases are infiltrated by neutrophils. (ox.ac.uk)
  • Here, neutrophils promoted the growth of hepatic metastases, given that depletion of neutrophils in already established, experimental, murine liver metastases led to diminished metastatic growth. (ox.ac.uk)
  • After thoroughly reviewing the available scientific literature, the Working Group classified acrolein as probably carcinogenic to humans (Group 2A) on the basis of sufficient evidence of carcinogenicity in experimental animals and strong mechanistic evidence. (who.int)
  • Crotonaldehyde and arecoline were classified as possibly carcinogenic to humans (Group 2B) on the basis of strong mechanistic evidence. (who.int)
  • Acrolein was classified as probably carcinogenic to humans (Group 2A) on the basis of sufficient evidence of carcinogenicity in experimental animals and strong mechanistic evidence. (who.int)
  • Cesare Maltoni's contributions to understanding, identifying, and characterizing widely used commercial chemicals in experimental animals are among the most important methods developed in the history of toxicology and serve to protect working men and women, the general population, and our environment from hazardous substances. (nih.gov)
  • Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. (curehunter.com)
  • are less accessible for biological humans and experimental animals. (who.int)
  • Chemical analogues and compounds with biological or physical characteristics similar to those of suspected carcinogens may also be considered, even in the absence of data on a possible carcinogenic effect in humans or experimental animals. (who.int)
  • PyV-induced tumorigenesis in laboratory animals, by simian virus 40 (SV40) or by multiple human PyVs, such as JC virus (JCV), is used extensively as a cell transformation model. (cdc.gov)
  • There was limited evidence of carcinogenicity in experimental animals. (who.int)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • Maltoni developed experimental methods that have reached the "platinum standard" for protection of public health. (nih.gov)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
  • Studies reliant on molecular detection of tumor-associated virus in isolation, however extensive, are inconclusive because association between PyVs and naturally occurring neoplasms varies and because PyV infections are highly prevalent, yet tumor formation is rare ( 3 , 4 , 12 - 14 ). (cdc.gov)
  • These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. (nih.gov)
  • Our studies on the erythrocyte focus on a molecular understanding of how specific proteins that cause human disease. (yale.edu)
  • DES and BPA treatment approximated human exposure. (nih.gov)
  • Harmful effects of non-experimental exposure to ionizing or non-ionizing radiation in VERTEBRATES. (bvsalud.org)
  • Topics are selected on the basis of two main criteria: (a) there is evidence of human exposure, and (b) there is some evidence or suspicion of carcinogenicity. (who.int)
  • Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for titanium tetrachloride. (cdc.gov)
  • An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
  • Human papillomavirus in cervical cancer and oropharyngeal cancer: one case - two diseases. (exp-oncology.com.ua)
  • We have obtained monoclonal antibodies to the human neu protein by immunizing a Balb/c mouse with a Balb/c cell line expressing the human neu gene by transfection. (prinsesmaximacentrum.nl)
  • The Monographs programme has since been expanded to include consideration of exposures to complex mixtures of chemicals (which occur, for example, in some occupations and as a result of human habits) and of exposures to other agents, such as radiation and viruses. (who.int)
  • The objective of the programme is to prepare, with the help of international working groups of experts, and to publish in the form of monographs, critical reviews and evaluations of evidence on the carcinogenicity of a wide range of human exposures. (who.int)
  • The IARC Monographs are recognized as an authoritative source of information on the carcinogenicity of a wide range of human exposures. (who.int)
  • There was inadequate evidence in humans regarding the carcinogenicity of acrolein. (who.int)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
  • The strong evidence was primarily from studies in human primary cells and studies in experimental systems, supported by studies on DNA adducts in humans. (who.int)
  • This strong evidence was from studies in human primary cells and in various experimental systems. (who.int)
  • The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
  • Among oncogenic viruses are those in the Polyomaviridae family, whose members infect an array of vertebrate species, including birds, humans, nonhuman primates, bovids, rodents, and sea lions ( 1 , 2 ). (cdc.gov)
  • Amplification and overexpression of the neu gene have been found in several human adenocarcinomas. (prinsesmaximacentrum.nl)
  • We also used NIH3T3 cells transfected with either a normal or a mutated human neu gene, encoding a protein with a valine to glutamic acid substitution in the transmembrane domain. (prinsesmaximacentrum.nl)
  • However, natural disease studies of human infection and experimental disease studies suggest that a potential outcome of some polyomavirus (PyV) infections is tumor formation ( 4 - 6 ). (cdc.gov)
  • Applications of mechanistic modelling to clinical and experimental immunology: an emerging technology to accelerate immunotherapeutic discovery and development. (ox.ac.uk)
  • From this perspective, we will present a non-technical discussion of a small number of recent and historical applications of mathematical, statistical and computational modelling to clinical and experimental immunology. (ox.ac.uk)
  • These exemplar applications highlight the potential of this approach to impact upon human immunology informed by ever-expanding experimental, clinical and 'omics' data. (ox.ac.uk)
  • We outline ongoing challenges facing the integration of mechanistic modelling with experimental and clinical immunology, and suggest how these may be overcome. (ox.ac.uk)
  • The application of in-silico modelling is beginning to emerge as a key methodology to advance our understanding of mechanisms of disease pathophysiology and related drug action, and in the design of experimental medicine and clinical studies. (ox.ac.uk)
  • In fact, as many miRNAs are aberrantly expressed in human neoplasms, proper post-transcriptional regulation of oncogenes or tumor suppressors expression may be prevented. (unife.it)
  • At present, several miRNAs aberrantly expressed in human cancer have not yet been thoroughly investigated and understanding their role in human cancer is thus still at the beginning. (unife.it)
  • In the experimental part of this thesis, we compared the efficacies of two viral promoters, AdE3 and AdCVM, in transcribing mOX40Land mCD40L in vitro. (helsinki.fi)
  • MTS and burst assay were conducted to confirm if viral infection, killing and replication occurs in human and murine cell lines. (helsinki.fi)
  • Both AdE3 and AdCMV were able to infect and kill human cell lines and cell viability decreased in correlation to the number of viral particles used. (helsinki.fi)
  • In burst assay, viral replication was observed for both AdE3 and AdCMV in the human MDA-MB-436 cell line. (helsinki.fi)
  • The human glioblastoma cell line LI showed morphological features typical of its neuroectodermal origin. (torvergata.it)
  • The criteria established in 1971 to evaluate carcinogenic risk to humans were adopted by the working groups whose deliberations resulted in the first 16 volumes of the IARC Monographs series . (who.int)
  • International journal of clinical and experimental medicine 0 8 (9): 17006-17014. (cdc.gov)
  • experimental data consist of measurements of the heterozygous (green circles) and homozygous (blue triangles) CF in progenitor cells. (aspetjournals.org)
  • In contrast, the antibodies induced 50-65% down-modulation in NIH3T3 cells expressing the mutated human neu protein and could inhibit these cells to form colonies in soft agar. (prinsesmaximacentrum.nl)
  • A Hürthle cell neoplasm is defined generally as an encapsulated thyroid lesion comprising at least 75% Hürthle cells. (medscape.com)