Polymorphism, GeneticPolymorphism, Single NucleotideProtein ConformationModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesMolecular Sequence DataPolymorphism, Single-Stranded ConformationalHaplotypesCase-Control StudiesAmino Acid SequenceGenotypeProtein BindingPolymerase Chain ReactionBinding SitesProtein Structure, TertiaryProtein Structure, SecondaryBase SequenceCrystallography, X-RayCircular DichroismMolecular ConformationMutationGenetic VariationGenetic Association StudiesThermodynamicsLinkage DisequilibriumKineticsAsian Continental Ancestry GroupSpectrometry, FluorescenceAmino Acid SubstitutionSequence Analysis, DNAProtein FoldingMagnetic Resonance SpectroscopyMolecular Dynamics SimulationNucleic Acid ConformationDNAPhenotypeLigandsGenetic MarkersHomozygoteNuclear Magnetic Resonance, BiomolecularProtein DenaturationRisk FactorsStructure-Activity RelationshipHydrogen-Ion ConcentrationModels, ChemicalDNA PrimersTemperatureComputer SimulationEscherichia coliPromoter Regions, GeneticEuropean Continental Ancestry GroupMethylenetetrahydrofolate Reductase (NADPH2)Hydrogen BondingChinaAmplified Fragment Length Polymorphism AnalysisDNA Mutational AnalysisRecombinant ProteinsHeterozygoteMutagenesis, Site-DirectedProtein Structure, QuaternaryExonsProteinsPhylogenySpecies SpecificityPoint MutationTryptophanBacterial ProteinsChromosome MappingDimerizationAllosteric RegulationSolutionsPeptidesCatalytic DomainGlutathione TransferaseCattleSequence AlignmentMicrosatellite RepeatsOdds RatioFluorescence Resonance Energy TransferGenetic LinkageGenome-Wide Association StudyCatalysisEpitopesSpectrophotometry, UltravioletPeptide FragmentsModels, GeneticMutation, MissenseGenetics, PopulationAdenosine TriphosphatePeptidyl-Dipeptidase AIntronsModels, BiologicalSequence Homology, Amino AcidCysteineCatechol O-MethyltransferaseTime FactorsHydrolysisProtein Multimerization