• The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
  • In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
  • With the exception of 1-pentyl- and 1-(2'-oxopropyl)-3,7-dimethyluric acids, all other analogues tested are effective inhibitors of tert-butylhydroperoxide-induced lipid peroxidation in human erythrocyte membranes. (iisc.ac.in)
  • This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
  • The 3T3 cells were exposed to the oxidant agent tert-butyl hydroperoxide (tBH) and evaluated for ROS generation, in the presence or not of the recombinant enzymes. (pimac.org)
  • Abstract �� OBJECTIVE To explore the protective effect of Radix Rhapontici water extract (RRWE) on the damage of vascular endothelial cells induced by tert-butyl hydroperoxide (TBHP) in vitro . (magtechjournal.com)
  • Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells:roles of NOX4 and mitochondrion[J]. Redox Biol, 2017, 11:524-534. (magtechjournal.com)
  • Based on its exceptionally low anodic oxidation potential (Epa) and high activity against the representative oxidative stressors tert-butyl hydroperoxide and peroxynitrite, 4,4′-dihydroxydiphenyltelluride is predicted to be a potent antioxidant. (elsevierpure.com)
  • The climbing index in GSO-treated Drosophila was significantly higher than that in the tert-butyl-hydroperoxide-treated flies. (sdbonline.org)
  • Tert-butyl-hydroperoxide and n-dodecane enhanced metabolic cooperation. (cdc.gov)
  • On the contrary, only RE was capable of preventing the deleterious effects - cytotoxicity, DNA damage and depletion of non protein sulphydrils (NPSH) pool - caused by treatment of cells with H2O2, tert-butylhydroperoxide (tB-OOH) or oxidized lipoproteins (Ox-LDL) via a mechanism which is likely to involve both direct scavenging of radical species and iron chelation. (uniroma5.it)
  • Aim of the present study was to investigate if the pre-coating of MWCNTs with pulmonary surfactant has an influence on potential adverse effects, upon both (i) human monocyte derived macrophages (MDM) monocultures, and (ii) a sophisticated in vitro model of the human epithelial airway barrier. (biomedcentral.com)
  • An over-production of these reactive species can occur in the human body, due to oxidative stress brought about by the imbalance of the body antioxidant defense system and free radical accumulation. (scirp.org)
  • PCA has been reported to induce apoptosis of human leukemia cells, as well as malignant HSG1 cells taken from human oral cavities, but PCA was found to have mixed effects on TPA-induced mouse skin tumours. (wikipedia.org)
  • METHODS The cellular model was established by treating human umbilical vein endothelial cells with TBHP, and randomly assigned to 4 groups:the control, TBHP, low and high-dose RRWE groups. (magtechjournal.com)
  • The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
  • Premature senescence of human ARPE-19 cells was induced by repeated treatments with 6 mM tert-butylhydroperoxide (tert-BHP). (nist.gov)
  • Antioxidants are important for human health because they stop free radicals from damaging cells in the body. (medicalnewstoday.com)
  • DNA damage responses in human induced pluripotent stem cells and embryonic stem cells. (setonhill.edu)
  • Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2[J]. Cell Physiol Biochem, 2017, 41(6):2255-2267. (magtechjournal.com)
  • The objectives of the current study were to demonstrate directly glycine-mediated protection of human intestinal epithelial cells and to determine the requirement for glycine uptake by the specific transporter GLYT1. (ncl.ac.uk)
  • Exogenous glycine protected human intestinal Caco-2 and HCT-8 cells against the oxidative agent tert-butylhydroperoxide and reduced the intracellular concentration of reactive oxygen species, when applied prior to but not concomitant with the oxidative challenge. (ncl.ac.uk)
  • ARPE-19 cells maintained in this medium could also phagocytose human photoreceptor outer segments (POS). (allergy-link.com)
  • Here, the antioxidant capacity in cell free-systems of preparations from various parts of pomegranate has been compared with their cytoprotective - bona fide antioxidant - activity in cultured human cells (U937 promonocytes and HUVEC endothelial cells) exposed to an array of oxidizing agents. (uniroma5.it)
  • Dong Y. et al "Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals" J Leukoc Biol 2020 Dec;108(6):1711-1725. (wellnessadvantage.com)
  • Kučerová Lucia, Školeková Svetlana, Matúšková Miroslava, Bohac Martin, Kozovská Zuzana: Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells. (sav.sk)
  • Ab-TrSOD, when compared to TrSOD, promoted a decrease in the formation of ROS of 19 and 14% at the concentrations of 1 and 6 μmol/L, respectively, indicating that this joplinks Recombinant Human Regulator of G-protein form was more effective in reducing oxidative stress compared to SOD without the cell penetrating peptide (CPP). (pimac.org)
  • Oxidative stress is implicated, either directly or indirectly, in the pathology of a range of human diseases. (elsevierpure.com)
  • Polyunsaturated fatty acid in the phospholipids of the human spermatozooa is highly susceptible to peroxidation. (ijbs.com)
  • Based on these results, the development and evaluation of rinds-only based derivatives for antiatherogenic preventive purposes in humans should be encouraged. (uniroma5.it)
  • Studies in humans have found that rooibos tea consumption increases the levels of antioxidants in the body, but that the effects are small and wear off quickly. (medicalnewstoday.com)
  • Pritchard DE, Ceryak S, Ha L, Fornsaglio JL, Hartman SK, O'Brien TJ, and Patierno SR. (2001) Mechanism of apoptosis and determination of cellular fate in chromium(VI)-exposed populations of telomerase-immortalized human fibroblasts Cell Growth Differ 12: 487-496. (setonhill.edu)
  • Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)
  • Because many genetic factors discovered using C. elegans are evolutionarily conserved, survival assays can provide insights into mechanisms underlying physiological processes in mammals, including humans. (molcells.org)
  • Protocatechuic acid is one of the main catechins metabolites found in humans after consumption of green tea infusions. (wikipedia.org)
  • However expression of the genes encoding GLYT1 and the glutathione synthesising enzymes, glutamate-cysteine ligase, both catalytic and modifier sub-units, and glutathione synthetase was not altered by glycine or tert-butylhydroperoxide, suggesting transcriptional regulation is not involved. (ncl.ac.uk)
  • Human spermatozoa possess these defense enzymes, which might be useful in the prediction of sperm fertilizing potentials [ 5 ]. (ijbs.com)
  • Kučerová Lucia, Feketeova Lucia, Matúšková Miroslava, Kozovská Zuzana, Janega Pavol, Babál Pavol, Poturnajová Martina: Local bystander effect induces dormancy in human medullary thyroid carcinoma model in vivo. (sav.sk)
  • This study demonstrated important differentiation markers, including pigmentation and Western blots of RPE65 protein, and showed human POS phagocytosis in ARPE-19 cultures using a simple differentiation protocol. (allergy-link.com)
  • ARPE-19 is a nontransformed human RPE cell line that displays many differentiated properties typical of RPE in vivo. (nist.gov)
  • Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19. (allergy-link.com)
  • The human RPE cell-line ARPE-19 is used widely as an alternative to primary RPE. (allergy-link.com)
  • Also to your human AD brain, the improved expression levels of cell cycle relevant proteins were also found in transgenic mouse models of AD. (fgfrinhibitors.com)
  • Reactive oxygen species (ROS) play an important role in the human reproduction. (ijbs.com)
  • Increasing concern has been expressed regarding the potential adverse health effects that may be associated with human exposure to inhaled multi-walled carbon nanotubes (MWCNTs). (biomedcentral.com)
  • Aberrant GLYAT expression is associated with human cancers, yet its role in cancer remains unknown. (sdbonline.org)
  • However, Free radical reactions occur in the human body and food systems. (scirp.org)
  • There may be tremendous practical value to understanding how to neutralize or reduce the damaging (and lethal) effects of radiation on the human body. (tfljournal.org)
  • Possible portals by which CNTs may enter the human body include the skin, the gastro-intestinal tract and injection (nanomedicine). (biomedcentral.com)
  • With their increasing number of applications, CNT emissions into the environment and human exposure may increase. (biomedcentral.com)
  • Although the application of this method is becoming increasingly popular, its experimental implementation has been broadly restricted to manipulations of a limited set of common alleles that are often commercially produced at great expense, with costs and technical challenges associated with the production of intersectional mouse lines hindering customized approaches to many researchers Joblinks Human ADAM10 cDNA . (gointerlabs.com)