Human interleukin 1. Medical search. Frequent questions

To examine the possible involvement of cytokines in reperfusion injury, we have studied production of IL-1 by human vascular cells, including smooth muscle and mononuclear phagocytes. (jci.org)
As both interleukin-1-alpha and interleukin-8 provoke proliferation of keratinocytes, it is not unreasonable to propose that these two cytokines play a profound role in the enhancement of keratinocyte proliferation as a result of He-Ne laser irraditiation. (eurekamag.com)
Three human leukemia cell lines (TALL-101, AML-193, and MV4-11) that require granulocyte/macrophage-colony stimulating factor (GM-CSF) for growth in a chemically defined medium were examined for their response to recombinant human (rh) cytokines. (aai.org)
Although neither rh macrophage (M)-CSF nor rhIL-1 alpha independently promoted proliferation of the three leukemia cell lines, these cytokines were able to either up- or down-regulate the GM-CSF-dependent growth of these cells. (aai.org)
Growing evidence suggests that proinflammatory cytokines (PICs), such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNFα), are induced in the spinal cord under various injury conditions and contribute to pain hypersensitivity. (jneurosci.org)
The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
Induction of hepatic cytokines (interleukin-1β, tumor necrosis factor-α, and interleukin-6), c-Jun N-terminal kinase, and nuclear factor-κB was blocked in TLR4-mutant mice. (aspetjournals.org)
IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. (rndsystems.com)
To inves- inflammatory cytokines and the timing of their production support tigate the interplay of proinflammatory and anti-inflammatory cyto- an immunologic response appropriate to the amount of Ag and kines in human granulomatous disease, we evaluated the ability of duration of exposure. (cdc.gov)

The Toll/interleukin-1 receptor (TIR) domain is conserved in the intracellular regions of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) as well as in several cytoplasmic adapter molecules. (tcd.ie)
IL-1α and IL-1β bind to the same receptors. (fujifilm.com)
Interleukin 1 (IL-1) is a name that designates two proteins, IL-1 alpha and IL-1 beta, which are the products of distinct genes, but which show approximately 25% amino acid sequence identity and which recognize the same cell surface receptors. (rndsystems.com)
Both forms of IL-1 bind to the same receptors, designated type I and type II. (rndsystems.com)
Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity. (uc.edu)

Mortality benefit of recombinant human interleukin-1 receptor antagonist (rhIL1RA) for sepsis varies by initial IL1RA plasma concentration. (upenn.edu)

Also, Interleukin-4 antagonizes the activity of interleukin-1 by inducing the expression and release of this protein. (prospecbio.com)
This protein binds to interleukin-12 (IL-12) with a low affinity, and is part of the IL-12 receptor complex. (wikipedia.org)
IL-6 and Mcl-1 protein levels were not only elevated in HPV 16/18 E6- and E7-transfected A549 cells but also in TL-1 cells. (tmu.edu.tw)
Northern blot analysis documented that two transcription factor genes chosen for further study, c-myc promoter-binding protein (MBP-1) and X-box binding protein 1 (XBP-1), were up-regulated in U266 cells about 3-fold relative to the cell cycle-dependent β-actin gene 12 h after IL-6 treatment. (elsevierpure.com)
Preadipocytes were incubated with IL-1β and cytokine and chemokine release measured at 24 h by protein arrays, while the expression of cytokine/chemokine genes was assessed by qPCR at 4 and 24 h. (buckingham.ac.uk)
LPS binds to the cell-surface receptor, Toll-like receptor 4 (TLR4), which initiates a signal transduction cascade, including recruitment of the Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP). (aspetjournals.org)
IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. (rndsystems.com)
My research is focused on investigating the function of the melanocortin 1 receptor (MC1R) , its agonists α-melanocyte stimulating hormone (α-MSH) and ACTH, and antagonists agouti signaling protein and human β-defensin 3 in regulating cutaneous pigmentation and the response to UV radiation. (uc.edu)
The drug substance anakinra is a recombinant protein (Interleukin-1 receptor antagonist) produced in E. coli bacteria containing an expression plasmid in which a synthetic gene coding for human IL-1Ra has been inserted.According to the Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use (EMEA 2006), proteins are exempted from environmental risk assessment because they are unlikely to result in significant risk to the environment. (janusinfo.se)
By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase. (lu.se)
By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-κB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. (lu.se)

It is commercially produced as anakinra, which is a human recombinant form of IL-1Ra. (dadamo.com)
27 kg/m 2 and were randomly assigned to receive 13 weeks of anakinra, a recombinant human IL-1Ra, or placebo, 67 completed treatment and were included in this double-blind 39-week follow-up study. (diabetesjournals.org)
IL-1 blockade with anakinra induces improvement of the PI/I ratio and markers of systemic inflammation lasting 39 weeks after treatment withdrawal. (diabetesjournals.org)
Scholars@Duke publication: Feasibility randomised multicentre, double-blind, double-dummy controlled trial of anakinra, an interleukin-1 receptor antagonist versus intramuscular methylprednisolone for acute gout attacks in patients with chronic kidney disease (ASGARD): protocol study. (duke.edu)
This paper describes the protocol for a feasibility randomised controlled trial (RCT) comparing anakinra, a novel interleukin-1 antagonist versus steroids in people with chronic kidney disease (ASGARD). (duke.edu)
METHODS AND ANALYSIS: ASGARD is a two-parallel group double-blind, double-dummy multicentre RCT comparing anakinra 100 mg, an interleukin-1 antagonist, subcutaneous for 5 days against intramuscular methylprednisolone 120 mg. (duke.edu)

abstract = "Human papillomavirus (HPV) 16/18 infection is reported to be associated with nonsmoking Taiwanese female lung cancer. (tmu.edu.tw)

Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. (nih.gov)

The results revealed (i) a significant increase in interleukin-1-alpha and interleukin-8 production and their respective mRNA expression in He-Ne laser treated groups as compared with nonirradiated controls, and (ii) under 1.5 joules/cm-2 irradiation, this stimulating effect of He-Ne laser treatment is concentration-dependent. (eurekamag.com)
Objective To observe the effects of oxymatrine on the expression of interleukin-6（IL-6）, interleukin- 1β（IL-1β）mRNA of human periodontal ligament cell（PDLC） stimulated by lipopolysaccharides（LPS）, and to discuss oxymatrine's inhibition mechanism on periodontal inflammation stimulated by LPS. (hxkqyxzz.net)
Then reverse transcription -polymerase chain reaction（RT -PCR） for checking the level of IL -6 and IL -1β mRNA. (hxkqyxzz.net)
Conclusion Oxymatrine can restrain the expression of IL-6 and IL-1β mRNA of human PDLC stimulated by LPS. (hxkqyxzz.net)
The effects of oxymatrine on expression of interleukin-6 and interleukin-1β mRNA of human periodontal ligament cell stimulated by lipopolysaccharides[J]. West China Journal of Stomatology, doi: 10.3969/j.issn.1000-1182.2010.06.022 . (hxkqyxzz.net)
Levels of IL-1β, IL-1Ra and IL-1R1 mRNA were significantly increased in atherosclerotic arteries compared with normal arteries. (go.jp)
Human cytotoxic lymphocyte maturation factor 40 kDa subunit mRNA, complete cds. (lu.se)

1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)
In this study, we aim to determine the serum level and to detect the expression of IL-33 in human tissues in patients with breast carcinoma, using Luminex-based measurements and immunohistochemistry, to further explore the role of IL-33 in anti-tumor immunity in BC. (frontiersin.org)
Both IL-6 and Mcl-1 expression were significantly associated with HPV 16/18 infection (P - 0.014 and P - 0.004, respectively). (tmu.edu.tw)
The involvement of HPV infection in lung tumorigenesis may be partly through a concomitant increased expression of autocrine and/or paracrine IL-6 and the downstream Mcl-1. (tmu.edu.tw)
Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
Results 25 μg·mL-1 LPS can significantly enhance the expression of both IL-6 and IL-1β mRNA's level, and oxymatrine could restrain above phenomena. (hxkqyxzz.net)
MATERIALS AND METHOD: The expression of hBD-2 by IL-1a in HMEEC (Human Middle Ear Epithelial Cell) was detected by RT-PCR. (ajou.ac.kr)
CONCLUSION: These results indicate there are two effective gene regions that regulate hBD-2 expression by IL-1a between 2.7kbp and 1.1kbp, and 500bp upstream of the translation starting point of hBD-2 in HMEEC-1. (ajou.ac.kr)
bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)

Examination of these early cellular changes showed that IL-1 did not produce similar induction of cellular proteins and the morphological changes associated with growth stimulation. (rupress.org)
IL-1 alpha and IL-1 beta are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. (rndsystems.com)

Previous studies have demonstrated that interleukin-1 (IL-1) stimulates fibroblast growth (Schmidt, J. A., S. B. Mizel, D. Cohn, and I. Green. (rupress.org)

Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes. (ucdenver.edu)
Interleukin (IL)-1 impairs insulin secretion and induces β-cell apoptosis. (diabetesjournals.org)
We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. (lu.se)

IL12RB1, is the name of its human gene. (wikipedia.org)
Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. (dadamo.com)
METHODS: To investigate effects of the IL-1 gene cluster polymorphisms on wasting and inflammation, we studied 189 ESRD patients (52+/- 12 years, 62% males) close to the start of renal replacement therapy. (dadamo.com)
CONCLUSION: The investigated IL-1 gene cluster polymorphisms were associated with nutritional status and inflammation in ESRD patients, but marked differences were found between the genders. (dadamo.com)
But, it is unclear about signal transduction pathway and gene regulatory region of human betadefensin-2 (hBD-2). (ajou.ac.kr)
인체 중이점막 상피세포주 (HMEEC)에서 인터루킨-1알파 (interleukin-1α)에 의하여 인체 베타 디펜신-2 (hBD-2)의 발현이 증가되는 것과 이 현상에 Src-dependent Raf MEK1/2 ERK 신호전달경로가 관여하는 것은 보고되어있으므로, 신호전달경로 하위의 전사인자나 그 결합부위가 있는 유전자 조절부위(gene regulatory region)를 조사하여 향후 상위 신호전달물질과의 연계를 연구하는데 발판을 마련하고자 하였다. (ajou.ac.kr)
재료 및 방법: Human papilloma virus type16의 oncogene인 E6/E7 gene을 포함하여 만든 정상 인체 중이점막 상피세포주(HMEEC-1)를 이용하였다. (ajou.ac.kr)
100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions of ~81% of human genes, as calculated following gene enrichment analysis. (mdpi.com)
Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
Interleukin gene polymorphisms in pneumoconiosis. (cdc.gov)

Either rh interleukin (IL)-3 or rhGM-CSF alone supported the long term growth of all three cell lines, and the two growth factors acted synergistically to stimulate the proliferation of the early T lymphoblastic leukemia (TALL-101) and of the monocytic leukemia (AML-193) cells. (aai.org)
In addition, the observation the G-CSF, M-CSF, and IL-1 alpha can, in some cases, arrest cell proliferation without inducing differentiation suggests that the programs of proliferative arrest and differentiation in leukemic cells can be dissociated. (aai.org)
Interleukin-6 (IL-6) is implicated in the in vivo proliferation of malignant plasma cells in multiple myeloma. (elsevierpure.com)
When genetically susceptible individuals are exposed to infection, stress or trauma, cutaneous dendritic cells are activated to produce tumor necrosis factor (TNF)-α and interleukin (IL)-23, which subsequently stimulate the proliferation and differentiation of proinflammatory T cells. (nature.com)
Release of interleukin-1 (IL1) was evaluated using the standard murine thymocyte proliferation assay. (cdc.gov)
CMIR)3 and, in the presence of persistent Ag, in the stricted, beryllium salt-specific T lymphocyte proliferation (1-3). (cdc.gov)

The work covers three main areas: identifying why current strategies for monitoring AAA are ineffective, analysis of different serum processing methodologies and commercially available immunoassays used to measure IL-1α, and linking IL-1α to different anatomical, morphological and patient-related AAA factors. (bham.ac.uk)
When tested at a wide range of concentrations (0.1-100 pM), natural IL-1 or recombinant IL-1 produced only a maximum of 5-10% of DNA synthesis elicited in response to PDGF or serum. (rupress.org)
The IL-1 Beta Human ELISA Assay (enzyme-linked immunoassay kit) is intended for the quantitative determination of human Interleukin 1 Beta (IL-1β) concentrations in cell culture supernates, serum, and plasma. (eaglebio.com)
In addition to elevated serum levels, IL-1 has been found in synovial fluids of patients with rheumatoid arthritis and in cerebrospinal fluid after neurological inflammation or insult. (eaglebio.com)
Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)
They monitored patients' response to serum interleukin-31, which is reported to be an effective marker of resolution or improvement of this sporadic symptom. (medscape.com)
In PRA testing, recipient serum is incubated with white blood cells pooled from a group of blood donors with human leukocyte antigen (HLA) types representative of the community. (medscape.com)

Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. (cusabio.com)

Interleukin-1 (IL-1), originally described as lymphocyte activating factor (LAF) for its effects on thymocytes, is a polypeptide cytokine with two molecular forms. (eaglebio.com)
Interleukin-12 beta chain precursor (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2). (lu.se)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)

IL-1 inhibits the function and induces apoptosis of β-cells ( 9 ) and has been implicated as a mediator of the β-cell destruction leading to type 1 diabetes ( 10 ). (diabetesjournals.org)

To evaluate the efficacy and safety of interleukin-1 receptor antagonist (IL-1Ra) in patients with rheumatoid arthritis (RA). (nih.gov)
Interleukin-1beta (IL-1beta) and its receptor antagonist (IL-1Ra) may play a pivotal role in the pathogenesis of wasting and inflammation. (dadamo.com)
The IL-1 receptor antagonist, IL-1Ra, is an agent which binds to the same receptor on the cell surface as IL-1, and thus prevents IL-1 from sending a signal to that cell. (dadamo.com)
IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. (rndsystems.com)
Interleukin (IL)-β plays a central role in inflammation and atherosclerosis, but levels of IL-1β, its natural antagonist, IL-1Ra, and their balance in human atherosclerotic lesions, are unknown. (go.jp)

The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis. (cdc.gov)

Fresh and endotoxin-stimulated explanted human atherosclerotic and normal arteries were analyzed for IL-1β, IL-1Ra and IL-1 receptor 1 (IL-1R1) using TaqMan PCR and enzyme-linked immunosorbent assay. (go.jp)
Endotoxin stimulation increased IL-1β levels more than IL-1Ra levels (ie, promoted a pro-inflammatory state). (go.jp)
Endotoxin concentrations of 1 to 10microg/ml enhanced macrophage bactericidal activity by 33 to 55%, while concentrations of endotoxin at 100microg/ml inhibited bactericidal activity. (cdc.gov)

The two distinct molecular forms of IL-1 are thought to be derived from two genes. (eaglebio.com)
It is thought that IL-1 genes are induced to respond to tissue damage or in infection. (eaglebio.com)
In addition, spinal IL-1β was also shown to induce the transcription of pronociceptive genes (e.g. (jneurosci.org)
Association between polymorphisms of interleukin-17A and interleukin-17F genes and silicosis susceptibility in Chinese Han people. (cdc.gov)

Effects of the Interactions between Dust Exposure and Genetic Polymorphisms in Nalp3, Caspase-1, and IL-1ß on the Risk of Silicosis: A Case-Control Study. (cdc.gov)

In vitro, long-term exposure to high glucose and the peptide hormone leptin secreted by adipose tissue induce β-cell apoptosis and production of the proinflammatory cytokine interleukin (IL)-1 in β-cells and pancreatic islets, respectively ( 7 , 8 ). (diabetesjournals.org)

Following incubation unbound samples are removed during a wash step, and then a detection antibody specific for IL-1βis added to the wells and binds to the combination of capture antibody-IL-1βin sample. (eaglebio.com)

The IL-1β precursor is cleaved by capsase 1 to produce the biologically active mature IL-1β. (fujifilm.com)
However, it has been reported that IL-1α, unlike IL-1β, shows significant activity in its precursor form. (fujifilm.com)
IL-1 beta develops biological activity when it is processed from a precursor to a mature one by caspase-1, whereas IL-1 alpha is reported to have a sufficient activity even in a precursor. (fujifilm.com)
Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. (rndsystems.com)
Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL-1 alpha remains in the cytosol of cells, although there is evidence for a membrane-bound form of the precursor form of IL-1 alpha. (rndsystems.com)
The IL-1 alpha precursor reportedly shows full biological activity in the EL-4 assay. (rndsystems.com)

Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA: Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile. (msdmanuals.com)

Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. (wikipedia.org)

Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. (springer.com)
Comparative study with the effect of stromal cell derived factor-1 on osteogenic differentiation of human healthy and inflammatory periodontal ligament stem cells [J]. West China Journal of Stomatology, 2019, 37(5): 469-475. (hxkqyxzz.net)
Human preadipocytes are highly sensitive to IL-1β, the cytokine stimulating a major inflammatory response in these cells similar to that in mature adipocytes. (buckingham.ac.uk)
Produced by a wide variety of cells, the interleukin-1 (IL-1) is known as cytokine with a wide range of biological activities in inflammatory response as well as the immune system, the nervous system, the endocrine system, hematopoeisis and other functions. (fujifilm.com)
IL-1 is known as a cytokine produced by various cells and having various biological activities such as inflammatory reaction in a wide range including the immune system, nervous system, endocrine system, and hematopoietic system. (fujifilm.com)
IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. (rndsystems.com)
IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. (rndsystems.com)
In response to classic stimuli produced by inflammatory agents, infections or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cells is seen. (rndsystems.com)
Activation of innate immunity changed the balance between IL-1β and IL-1Ra in atherosclerotic arteries towards a more pro-inflammatory state. (go.jp)
Purpose of review Blockade of interleukin (IL)-1 signaling is one of the oldest biologic therapies, yet the use of these agents is on the rise as the role of IL-1 activation is being recognized in a wide spectrum of inflammatory disorders. (medscape.com)
IL-1 blockade is an effective treatment for many inflammatory disorders where IL-1 levels have been reported to be elevated. (medscape.com)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)

Research progress on the relationship between triggering receptor expressed on myeloid cells 1 and 2 and malignant tumors [J]. West China Journal of Stomatology, 2017, 35(6): 648-653. (hxkqyxzz.net)

Synthesis and release of interleukin 1 by reoxygenated human mononuclear phagocytes. (jci.org)
Induction of DNA synthesis required continuous presence of IL-1 and did not exhibit synergism with plasma. (rupress.org)
When IL-1 was added to cells rendered competent by brief exposure to PDGF, 10-15% additional DNA synthesis occurred during the first 24 h. (rupress.org)
Extended incubation of PDGF-treated cells in the presence of IL-1 revealed that the stimulation by IL-1 occurred predominantly during the subsequent cycle of DNA replication, wherein DNA synthesis reached three- to fivefold higher than the untreated cultures. (rupress.org)

Although a period of hypoxia was necessary for subsequent IL-1 production during reoxygenation of either peripheral blood monocytes or cultured monocyte-derived macrophages, no IL-1 release occurred during the hypoxic exposure. (jci.org)
The potential pathophysiological effects of IL-1-containing supernatants from reoxygenated macrophages was shown by their induction of endothelial tissue factor and enhancement of endothelial adhesiveness for neutrophils, both of which could be blocked by anti-IL-1 antibody. (jci.org)
The effects on chemotaxis was evaluated by measuring the ability of the macrophages to recruit human neutrophils using a blind well chemotaxis chamber technique. (cdc.gov)

Functions of non-coding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells [J]. West China Journal of Stomatology, 2020, 38(3): 330-337. (hxkqyxzz.net)
Effects of salvianolic acid B on osteogenic differentiation of human periodontal ligament cells [J]. West China Journal of Stomatology, 2016, 34(5): 468-473. (hxkqyxzz.net)

15(1-4): 617-30, 1995. (bvsalud.org)

Increased levels of tumor necrosis factor, interferon-gamma, and interleukin 1 have been demonstrated. (medscape.com)

IL-12Rβ1 can also bind interleukin-23 (IL-23) as part of the IL-23 receptor complex. (wikipedia.org)

IL-1 released during reoxygenation was newly synthesized, and its production was triggered by the generation of oxygen free radicals, as it could be blocked by the addition of either allopurinol or free radical scavengers to cultures and could be stimulated in part by low concentrations of hydrogen peroxide or xanthine/xanthine oxidase. (jci.org)
Interleukin-1 alpha, soluble interleukin-2 receptor, and IgG concentrations in cystic fibrosis treated with prednisolone. (bmj.com)
IL-1 and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. (who.int)
Les taux sériques d'interleukine 1 et d'interleukine 6 étaient significativement plus élevés dans les groupes de l'étude, les groupes de première manifestation et de récidive ayant les concentrations les plus fortes. (who.int)
Les concentrations sériques d'interleukine 1, d'interleukine 6 et de TNF permettaient de sélectionner positivement (100 %) les groupes de première manifestation et de récidive alors que ces concentrations plus l'excrétion urinaire de 2-microglobuline urinaire sélectionnaient négativement (100 %) le groupe témoin. (who.int)

Human papillomavirus type 6 or type 16 has not been detected in patients with BXO, which strongly suggests that genital papillomaviruses do not have a strong association with BXO. (medscape.com)

IL-1 inhibitors that vary only in their degree of glycosylation have been described to bind to the IL-1 receptor. (eaglebio.com)
These inhibitors are structurally related to IL-1β and may be important in regulation of IL-1b action. (eaglebio.com)

Thyroid hormones stimulate basal and interleukin (IL)1 induced IL-6 production in human bone marrow stromal cells: a possible mediator of thyroid hormone-induced bone loss. (bvsalud.org)

This study demonstrated significant differences in the blood levels of IL-1 beta between people with epilepsy and healthy subjects. (cusabio.com)
The Human Interleukin 1 Beta (IL-1β) ELISA Assay Kit is for research use only and not to be used in diagnostic procedures. (eaglebio.com)
The Human Interleukin 1 Beta (IL-1β) ELISA Assay employs the quantitative sandwich enzyme immunoassay technique. (eaglebio.com)
IL-1 alpha and IL-1 beta bind to the same receptor and have almost the same biological activity. (fujifilm.com)
Detects human IL-1 beta /IL-1F2 in Western blots. (rndsystems.com)
Shows less than 5% cross-reactivity with recombinant mouse (rm) IL‑1 beta and rpIL‑1 beta and no cross-reactivity with rrIL‑1 beta, rmIL‑1 alpha, rhIL‑1ra, rmIL‑1ra, or rrIL‑1 alpha. (rndsystems.com)
Detection of IL‑1 beta /IL‑1F2 in Human PBMC by Flow Cytometry. (rndsystems.com)
Human PBMC stimulated with 250 ng/ml LPS overnight were stained with either (A) Mouse Anti-Human IL-1 beta /IL-1F2 Alexa Fluor® 594-conjugated Monoclonal Antibody (Catalog # IC201T) or (B) Mouse IgG1Isotype Control ( IC002T ) and Mouse Anti-Human CD14 APC-conjugated Monoclonal Antibody ( FAB3832A ). (rndsystems.com)
IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. (rndsystems.com)
While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. (rndsystems.com)
IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. (rndsystems.com)
The 17 kDa molecular weight mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67%-78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta. (rndsystems.com)
In direct ELISAs, no cross-reactivity with recombinant mouse IL-1 alpha, recombinant rat IL-1 alpha, recombinant cotton rat IL-1 alpha, recombinant human (rh) IL-1 beta or rhIL-18 is observed. (rndsystems.com)
At a concentration of 1% (vol/vol), DMSO blocked IL-8 release by approximately 90% in the presence of 1 microgram/ml LPS at a 24-h time point, but did not affect cell viability or reduce the production of tumor necrosis factor (TNF), interleukin 6, or interleukin-1 beta (IL-1 beta). (jci.org)
Furthermore, this effect was not LPS-specific, in that IL-8 production was reduced by DMSO to a similar extent upon stimulation of blood with phytohemagglutinin, aggregated immune complexes, TNF, or IL-1 beta. (jci.org)

This Thesis presents an analysis of the role of interleukin (IL)-1α (IL-1α) as a potential future surrogate biomarker for AAA. (bham.ac.uk)
It is the only research work to date to have looked into the role of IL-1α as a biomarker in AAA disease, correlating titres with different anatomical, morphological and patient-related factors. (bham.ac.uk)
At the other end of the spectrum, low levels of IL-1 have been found in malnutrition and advanced neoplasia suggesting perhaps a complex immunological and physiological regulatory role for this cytokine. (eaglebio.com)
It is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. (dadamo.com)
Thus, the data on the role of IL-33 in cancer progression was limited, and in particular, the function mediated by IL-33 in human BC is under-investigated. (frontiersin.org)
The role of extracellular signal regulated kinase 1/2 in mediating osteodifferentiation of human periodontal ligament cells induced by cyclic stretch [J]. West China Journal of Stomatology, 2017, 35(5): 520-526. (hxkqyxzz.net)
Nephrotic syndrome is neither a single gested that IL-1 has a significant role in the disease nor even a heterogeneous group of immunopathogenesis of proteinuria [ 7 ] and related diseases. (who.int)
Marie C, Verkerke HP, Theodorescu D, Petri WA: A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica. (msdmanuals.com)

Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome. (upenn.edu)

Because interleukin-1-alpha induces keratinocyte migration, this finding may partially explain the stimulatory effects on the motility of keratinocytes. (eurekamag.com)

Impairment in TNF, IL-1beta, and IL-17 production upon stimulation with mycobacterial antigens may contribute to the increased susceptibility to M. tuberculosis infection observed in HTLV-1 infected individuals. (cusabio.com)
IL-1 has multiple immunological functions including enhancement of IL-2 production by T cells and activation of B-cells (BAF) and thymocytes. (eaglebio.com)
In this report, we present evidence for the production of NO, as measured by the production of nitrite, in highly enriched human fetal astrocyte cultures stimulated with IL-1β. (elsevierpure.com)
human microglia, in turn, may control astrocyte NO production by providing IL-1β as an activating signal. (elsevierpure.com)
The effect of IL-1β on cytokine and chemokine production by human preadipocytes has been examined. (buckingham.ac.uk)
Although IL-1 production is generally considered to be a consequence of inflammation, recent evidence suggests that IL-1 is also temporarily upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. (rndsystems.com)
Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. (jci.org)
scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. (jci.org)

Exposure of cells to hypoxia (pO2 approximately 14 torr) followed by reoxygenation led to significant release of IL-1 only from the mononuclear phagocytes. (jci.org)
Hybridoma clones have been derived from hybridization of X63.Ag8.653 myeloma cells with spleen cells of Balb/c mice immunized with recombinant human IL-1, β. (advimmuno.com)
Human Achilles tendon-derived cells were preincubated with or without ciprofloxacin (50?µg/ml) and were then challenged with interleukin-1ß (IL-1ß, 1?ng/ml) for up to 48?h. (uea.ac.uk)
Secreting IL-6 levels and Mcl-1 expressions were examined by ELISA and Western blot, respectively, in HPV 16/18 E6- and E7-transfected A549 human lung cancer cells, as well as in the HPV16-infected TL-1 lung cancer cells established from lung cancer patients. (tmu.edu.tw)
Phosphatidylinositol-3-OH kinase pathway was the major pathway contributing to the up-regulation of Mcl-1 by IL-6 in HPV-infected lung cancer cells. (tmu.edu.tw)
Conclusions: The up-regulating effects of HPV 16/18 E6 and E7 to IL-6 and Mcl-1 expressions were observed in E6- and E7-transfected A549 cells and in HPV16-infected TL-1 cells, mainly through the phosphatidylinositol-3-OH kinase pathway. (tmu.edu.tw)
Protective effects of hydrogen-rich medium on lipopolysaccharides-induced injury in human periodontal ligament cells [J]. West China Journal of Stomatology, 2018, 36(2): 123-127. (hxkqyxzz.net)
A preliminary study on the autophagy level of human periodontal ligament cells regulated by nicotine [J]. West China Journal of Stomatology, 2017, 35(2): 198-202. (hxkqyxzz.net)
Human peripheral blood mononuclear cells treated with LPS and fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). (rndsystems.com)
Human peripheral blood mononuclear cells (PBMCs) treated with LPS for 24 hours were stained with Mouse Anti-Human IL-1a/IL-1F1 Membrane Form PE-conjugated Monoclonal Antibody (Catalog # FAB200P, filled histogram) or isotype control antibody (Catalog # IC002P , open histogram). (rndsystems.com)

pp65 mediates human cytomegalovirus immune evasion through downmodulation of IL-1beta. (cusabio.com)
IL-1 is one of the most important immune modifying interleukins. (dadamo.com)

Initially approved for the treatment of rheumatoid arthritis (RA), IL-1 blockade strategies have diversified in number and in the diseases for which they are used. (medscape.com)

These results suggest that the mode of IL-1 action on BALB/c3T3 was not through competence induction. (rupress.org)

Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)

Detection of IL‑1 alpha /IL‑1F1 in Human PBMCs by Flow Cytometry. (rndsystems.com)

In pediatric recipients of kidney transplants from deceased donors, the graft failure rate was 1.9% at 6 months and 2.8% at 1 year for transplants in 2018-2019, 6.4% at 3 years for transplants in 2016-2017, 15.2% at 5 years for transplants in 2014-2015, and 32.1% at 10 years for transplants in 2010-2011. (medscape.com)
The graft failure after living-donor pediatric transplantation was better at 0.8% at 6 months and 1.6% at 1 year for transplants in 2018-2019, 2.7% at 3 years for transplants in 2016-2017, 8.2% at 5 years for transplants in 2014-2015, and 21.7% at 10 years for transplants in 2010-2011. (medscape.com)
46(1): 21-28, January 2018. (upenn.edu)

These guidelines update previous CDC recommendations for the diagnosis, treatment, and prevention of tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) in the United States. (cdc.gov)
These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)

The relevance of IL-1 to hypoxia/reoxygenation in vivo was suggested by the presence of circulating nanogram amounts of this cytokine in the plasma of mice during the reoxygenation period following a hypoxia. (jci.org)
Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1β and KC/GRO. (springer.com)
Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes. (uc.edu)

Anatomy43

Organisms11

Diseases10

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Health Care2

Cytokines9

Receptors5

Recombinant human interleukin-1 receptor1

Protein11

Anakinra6

Abstract1

Tumor necro1

MRNA7

Expression11

Proteins2

Stimulates1

Secretion3

Gene10

Proliferation6

Serum7

IL121

Lymphocyte3

Induces apoptosis1

Antagonist5

Antigen1

Endotoxin3

Genes4

Polymorphisms1

Proinflammatory1

Binds1

Precursor6

Inflammasome1

Subunit1

Inflammatory12

Myeloid cells1

Synthesis4

Macrophages3

Differentiation2

19951

Interferon1

Receptor complex1

Concentrations5

Papillomavirus type1

Inhibitors2

Stimulate1

Beta15

Role8

Acute1

Keratinocytes1

Production8

Cells10

Immune2

Rheumatoid1

Induction1

Chronic1

Flow Cytometry1

20183

IMMUNODEFICIENCY2

Mice3