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  • liver
  • Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. (wikipedia.org)
  • In humans for example, it is found in many forms depending on its origin within the body - it plays an integral role in metabolism within the liver and development within the skeleton. (wikipedia.org)
  • physiological
  • Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • However, their production is stimulated in human eosinophils by physiological agonists such as prostaglandin D2, leukotriene C4, and interleukin 5. (wikipedia.org)
  • pancreatic
  • An in vitro study showed that Acivicin at a concentration of 5 µM Acivicin inhibited by 78% the growth of human pancreatic carcinoma cells (MIA PaCa-2) after 72 hours in continuous culture. (wikipedia.org)
  • tissues
  • They are produced by human eosinophils (a class of white blood cells), mast cells, the L1236 Reed-Sternberg cell line derived from Hodgkin's Lymphoma, and certain other tissues tissue. (wikipedia.org)
  • Cells and tissues rich in 15-LOX-1 activity such as human eosinophils, umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells derived from Hodgkin's Disease tumors produce eoxins. (wikipedia.org)
  • arachidonic
  • For each subfamily, there is the potential to have at least 4 separate series of metabolites, two series derived from ω-6 PUFAs (arachidonic and dihomo-gamma-linolenic acids), one series derived from the ω-3 PUFA (eicosapentaenoic acid), and one series derived from the ω-9 PUFA (mead acid). (wikipedia.org)
  • mRNA
  • Studies with cultured human cells have found that there are a large number of ALOX5 mRNA splice variants due to Alternative splicing. (wikipedia.org)
  • vivo
  • A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. (biology-online.org)
  • LTC4
  • viz, LTC4, LTD4, and to a much lesser extent, LTE4) contributes to mediating various allergic and hypersensitivity reactions in humans as well as models of the reactions in other animals. (wikipedia.org)
  • pancreatic
  • An in vitro study showed that Acivicin at a concentration of 5 µM Acivicin inhibited by 78% the growth of human pancreatic carcinoma cells (MIA PaCa-2) after 72 hours in continuous culture. (wikipedia.org)
  • eosinophils
  • They are produced by human eosinophils (a class of white blood cells), mast cells, the L1236 Reed-Sternberg cell line derived from Hodgkin's Lymphoma, and certain other tissues tissue. (wikipedia.org)
  • Cells and tissues rich in 15-LOX-1 activity such as human eosinophils, umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells derived from Hodgkin's Disease tumors produce eoxins. (wikipedia.org)
  • liver
  • It did not inhibit CYP2A6 or the polymorphic CYP2D6 in human liver microsomes. (empowerpharmacy.com)
  • In humans for example, it is found in many forms depending on its origin within the body - it plays an integral role in metabolism within the liver and development within the skeleton. (wikipedia.org)
  • Biochim
  • Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L". Biochim. (wikipedia.org)
  • tissue
  • Animal model and human tissue (preclinical studies) implicate CysLTR1 antagonists as having protective/reparative effects in models of brain injury (trauma-, ischemia-, and cold-induced), multiple sclerosis, auto-immune encephalomyelitis, Alzheimer's disease, and Parkinson's disease. (wikipedia.org)
  • 1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A". FEBS Lett. (wikipedia.org)
  • Pregnancy
  • Ceftazidime falls under the pregnancy category B. According to the manufacturer, research studies in mice and rats showed no evidence of harm to the fetus, even at up to 40 times the human dose of ceftazidime. (wikipedia.org)
  • causes
  • Leptospiral infection in humans causes a range of symptoms, and some infected persons may have no symptoms at all. (wikipedia.org)