• liver
  • Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. (wikipedia.org)
  • In humans for example, it is found in many forms depending on its origin within the body - it plays an integral role in metabolism within the liver and development within the skeleton. (wikipedia.org)
  • variants
  • Studies with cultured human cells have found that there are a large number of ALOX5 mRNA splice variants due to Alternative splicing. (wikipedia.org)
  • physiological
  • Up-regulation of ALOX5 may occur during the maturation of leukocytes and in human neutrophils treated with granulocyte macrophage colony-stimulating factor and then stimulated with physiological agents. (wikipedia.org)
  • However, their production is stimulated in human eosinophils by physiological agonists such as prostaglandin D2, leukotriene C4, and interleukin 5. (wikipedia.org)
  • pancreatic
  • An in vitro study showed that Acivicin at a concentration of 5 µM Acivicin inhibited by 78% the growth of human pancreatic carcinoma cells (MIA PaCa-2) after 72 hours in continuous culture. (wikipedia.org)
  • activity
  • b-Gamma-glutamyltransferase activity in human vulnerable carotid plaques. (biomedsearch.com)
  • Cells and tissues rich in 15-LOX-1 activity such as human eosinophils, umbilical cord-derived mast cells, nasal polyps from allergic subjects, airway epitheleal cells, and L1236 Reed-Sternberg cells derived from Hodgkin's Disease tumors produce eoxins. (wikipedia.org)
  • occur
  • Unlike P . malariae , which multiplies every 3 days in the blood and never results in severe infections, P . knowlesi multiplies daily, and high parasitemia with death in humans can occur ( 4 ). (cdc.gov)
  • arachidonic
  • For each subfamily, there is the potential to have at least 4 separate series of metabolites, two series derived from ω-6 PUFAs (arachidonic and dihomo-gamma-linolenic acids), one series derived from the ω-3 PUFA (eicosapentaenoic acid), and one series derived from the ω-9 PUFA (mead acid). (wikipedia.org)
  • type
  • Vaccines for animals exist for certain type of Leptospira which may decrease the risk of spread to humans. (wikipedia.org)