ReactiveMalondialdehydeApoptosisIncrease in the lipid peroxidationFree radicalsThiobarbituricBiomarkers of oxidative stressEvidence that oxidative stressInflammation and oxidative stressMarkerGlutathione peroxidaseReduce oxidative stressTBARSGastrocnemius muscleSuggests that oxidativeCytotoxicityExposureInsulin resistanceProteinsEnzymeOxidationSuperoxide anionMammalian cellsActivity of catalaseAccumulationAntioxidantsMitochondrialTissueMarkersBlood lipidLiverInflammatoryParametersSuppressesMiceReducesInhibitionLevelsConcentrationAntioxidativeImbalanceStudy investigatedFattyProcessesHydrogen peroxideDiseasesMechanismSupplementationAshwagandhaCellularCell
Reactive14
- In addition, oxygen-derived reactive oxygen species including hydrogen peroxide and nitrogen free radicals, such as superoxide, hydroxyl radical and nitric oxide radical, undergo a complicated sequence of electron transfer reactions with other biomolecules, which lead to their modified physiological functions and diverse biological and pathophysiological consequences (e.g. oxidative stress). (nih.gov)
- Oxidative stress reflects an imbalance between reactive oxygen species (ROS) production and the biological systems ability to detoxify the reactive intermediates. (hindawi.com)
- Our results revealed that H2O2 increased the rate of apoptosis by stimulating various pro-apoptotic processes, such as the generation of intracellular reactive oxygen species (ROS), lipid peroxidation, DNA fragmentation and caspase-3 activation. (spandidos-publications.com)
- Oxidative stress can reflect a disturbance between the systemic production of reactive oxygen species (ROS) and antioxidant defenses against radicals. (creativebiomart.net)
- Lipid peroxides are unstable to form a complex series of compounds including reactive carbonyl compounds. (creativebiomart.net)
- It prevents damage to cellular components caused by reactive oxygen species such as peroxides, lipid peroxides, heavy metals and free radicals. (creativebiomart.net)
- were the first to demonstrate in obese mice and in humans with obesity that fat accumulation is positively associated with systemic oxidative stress, suggesting that the oxidative stress increase in people with obesity could be explained by reactive oxygen species (ROS) overproduction in adipose tissue [ 17 ]. (hindawi.com)
- Increased lipid peroxidation due to reactive oxygen species (ROS)-induced oxidative stress has been demonstrated in the neoplastic mammary tissue of dogs with malignant mammary tumors. (tubitak.gov.tr)
- The purpose of this preliminary study was to compare the extent of lipid peroxidation, as evidenced by thiobarbituric acid-reactive substances (TBARS) and \alpha-tocopherol concentration in the neoplastic mammary tissue, among dogs with mammary cancer fed with different kinds of diet (commercial or homemade). (tubitak.gov.tr)
- We therefore aimed to investigate peroxidation, measured as thiobarbituric the correlation between hypercholesterol- acid-reactive substance (TBARS). (who.int)
- In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
- Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. (iiarjournals.org)
- The most reliable evaluation of oxidative stress is via the direct quantification of the reactive oxygen species (ROS) components. (molvis.org)
- respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
Malondialdehyde6
- Malondialdehyde is an end product of lipid peroxidation while acrolein is a result of DNA peroxidation. (wikipedia.org)
- Aim: The aim of this study was to compare the tissue levels of antioxidant Super oxide dismutase (SOD) and lipid peroxidation marker Malondialdehyde (MDA) in established cases of OLP and healthy individuals. (medicopublication.com)
- Oxidative stress bilirubin malondialdehyde coronary artery disease antioxidant capacity homocysteine. (ajol.info)
- Malondialdehyde (MDA) is lipid peroxidation end product. (ajol.info)
- The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). (iiarjournals.org)
- Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress ( 2 - 6 ). (iiarjournals.org)
Apoptosis8
- In this study, we examined the cytoprotective effects of cyanidin-3-glucoside (C3G) isolated from mulberry fruit against pancreatic β-cell apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress. (spandidos-publications.com)
- The MIN6 pancreatic β-cells were used to investigate the cytoprotective effects of C3G on the oxidative stress-induced apoptosis of cells. (spandidos-publications.com)
- Taken together, our results suggest that C3G isolated from mulberry fruit has potential for use as a phytotherapeutic agent for the prevention of diabetes by preventing oxidative stress-induced β-cell apoptosis. (spandidos-publications.com)
- Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
- These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
- This study aimed to consider the oxidative damage induced by cadmium (Cd) and apoptosis and the role of N-acetylcysteine (NAC) in preserving hepatic cells against Cd toxicity. (springer.com)
- Cd exposure is strongly associated with oxidative stress, inflammation, antioxidant depletion, and liver cells apoptosis. (springer.com)
- Objective In addition to oxidative stress, inflammation and apoptosis have an important role in the pathogenesis of cisplatin-induced kidney damage. (thieme-connect.com)
Increase in the lipid peroxidation1
- superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and tissue antioxidant, reduced glutathione (GSH) along with a concomitant increase in the lipid peroxidation product malonaldehyde (MDA). (scialert.net)
Free radicals2
- Distraction of these elements in central nervous system (CNS) have been demonstrated in many neurological disorders, which are vital in generating free radicals, causing oxidative stress, and contributing to neuronal maladies. (fluoridealert.org)
- Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
Thiobarbituric1
- Cell viability was examined by MTT assay and lipid peroxidation was assayed by thiobarbituric acid (TBA) reaction. (spandidos-publications.com)
Biomarkers of oxidative stress1
- Using isoprostanes as biomarkers of oxidative stress: some rarely considered issues. (degruyter.com)
Evidence that oxidative stress1
- There is substantial evidence that oxidative stress participates in carcinogenesis ( 1 - 4 ). (iiarjournals.org)
Inflammation and oxidative stress3
- Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
- Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
- CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
Marker2
- This effect was correlated with reduced glucose intolerance, body weight gain, fat mass development, lower inflammation, oxidative stress, and macrophage infiltration marker mRNA expression in visceral adipose tissue. (diabetesjournals.org)
- NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)
Glutathione peroxidase4
- Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
- Among antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase were decreased and lipid peroxidation was increased with regional alterations. (fluoridealert.org)
- Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)
- To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)
Reduce oxidative stress1
- Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
TBARS2
- The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased \alpha-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade. (tubitak.gov.tr)
- The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
Gastrocnemius muscle5
- The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. (hindawi.com)
- Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats. (hindawi.com)
- We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
- We also evaluated total antioxidant capacity and lipid peroxidation in gastrocnemius muscle of diabetic rats treated with metformin and/or insulin. (hindawi.com)
- The effect of the extract was studied on lipid peroxidation and antioxidant parameters in liver and gastrocnemius muscle of rats on attaining the rectal temperature (T(rec)) of 23 degrees C during C-H-R exposure and after recovery (T(rec)37 degrees C) from C-H-R-induced hypothermia. (nih.gov)
Suggests that oxidative2
- Conclusion: The current study suggests that oxidative damage is one of the major causes for the pathogenesis of OLP. (medicopublication.com)
- This suggests that oxidative stress responses to HIIT and MICT are tissue-specific. (hindawi.com)
Cytotoxicity2
- We hypothesized that MGST1 may also protect against nanomaterial -induced cytotoxicity through a specific effect on lipid peroxidation. (cdc.gov)
- We evaluated the induction of cytotoxicity and oxidative stress by TiO2, CeO2, SiO2, and ZnO in the human MCF-7 cell line with or without overexpression of MGST1. (cdc.gov)
Exposure5
- Effect of maternal exposure of fluoride on biometals and oxidative stress parameters in developing CNS of rat. (fluoridealert.org)
- Studies have also shown correlations between VNA exposure and lipid peroxidation and oxidative stress (insulin-resistance and inflammation), chronic diseases (diabetes), and neurodegenerative diseases, such as Alzheimer's. (cdc.gov)
- Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
- Previous mouse studies suggest that electronic cigarette exposure plus a Western diet triggers oxidative stress leading to increased lipid peroxidation and hepatic steatosis, according to Dr. Theodore Friedman of Charles R. Drew University of Medicine & Science in Los Angeles. (medscape.com)
- In liver samples, they observed that e-cigarette exposure led to hepatic lipid accumulation and oxidative stress, as well as a significant increase in hepatic expression of p53, a known inducer of insulin resistance and NAFLD. (medscape.com)
Insulin resistance2
- This condition can lead to lipid peroxidation in muscle cell membranes, which contributes to the development of insulin resistance [ 5 , 6 ]. (hindawi.com)
- For years, moderate-intensity continuous training (MICT) has been the most popular exercise modality for improving body composition, cardiorespiratory fitness, insulin resistance, and lipid profile [ 2 , 5 ]. (hindawi.com)
Proteins4
- mtROS also causes oxidation of lipids and proteins identified in bleomycininduced mouse models of pulmonary fibrosis and in sufferers with IPF (80, 81). (namptinhibitor.com)
- ROS can react with proteins, nucleic acids, and can cause lipids cell and tissue damage and can be measured using selective or general indicators. (creativebiomart.net)
- Alternatively, indirect methods for assessing oxidative stress have been applied and focus mainly on the oxidative damage ROS cause in biomolecules, such are lipids, proteins, and DNA. (molvis.org)
- Functional analysis showed that cholesterol biosynthesis pathways and the cytochrome 450 family of proteins (specifically Cyp4A10 that is associated with oxidative stress and lipid peroxidation leading to hepatocyte injury) were increased in mice exposed to e-cigarette aerosol. (medscape.com)
Enzyme3
- Microsomal glutathione transferase 1 (MGST1) is an antioxidant enzyme located predominantly in the mitochondrial outer membrane and endoplasmic reticulum and has been shown to protect cells from lipid peroxidation induced by a variety of cytostatic drugs and pro-oxidant stimuli. (cdc.gov)
- Vestena S, Cambraia J, Ribeiro C, Oliveira JA, Oliva MA (2011) Cadmium-induced oxidative stress and antioxidative enzyme response in water hyacinth and salvinia. (springer.com)
- RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Oxidation1
- Bilirubin may act as an antioxidant that suppresses lipid oxidation. (ajol.info)
Superoxide anion2
- The induction of oxidative stress is shown by increased levels of lipid peroxidation, total peroxide, superoxide anion and lipoxygenase activity. (unboundmedicine.com)
- Change in oxidative stress biomarkers levels: lipid peroxidation index, nitric oxide metabolites, hydrogen peroxide (H2O2), superoxide anion radical (O2-), and glutation (GSH), catalasis(CAT) and superoxid dismutasis(SOD). (who.int)
Mammalian cells1
- The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Activity of catalase2
- D+I+M reduced the oxidative stress levels and the activity of catalase and superoxide dismutase in skeletal muscle when compared to D+I rats. (hindawi.com)
- The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
Accumulation2
- Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
- Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
Antioxidants4
- Recent studies have demonstrated that antioxidants present in natural products protect cells by reducing H 2 O 2 -induced oxidative stress in vitro and in vivo ( 5 - 7 ). (spandidos-publications.com)
- NAC can protect liver tissue against Cd by elevating antioxidants capacity, mitigating oxidative stress and inflammation, as well as down-regulating of apoptotic genes. (springer.com)
- The consumption of SSD therefore caused lipid peroxidation and reduction in activity of the antioxidants present in the tissues studied. (ajol.info)
- Research found that the antioxidants in spirulina may be particularly effective at reducing lipid peroxidation. (healthline.com)
Mitochondrial1
- Consider that altered oxidative stress/antioxidant status is related to T1D complications [ 22 , 23 ] and metformin action in the decrease of mitochondrial ROS. (hindawi.com)
Tissue2
- Lipid peroxidation in neoplastic tissue of dogs with mammary cancer fe" by MARIA KARAYANNOPOULOU, ANNA FYTIANOU et al. (tubitak.gov.tr)
- Pretreatment with T. terrestris resulted in the increased activities of SOD, CAT, GSHPx and prevention of depletion of tissue glutathione along with inhibition of lipid peroxidation. (scialert.net)
Markers4
- Numerous markers of oxidative activity are present in persons with asthma. (namptinhibitor.com)
- Elevation in markers of oxidative stress, alterations in other monoamines were observed in injured rats, whereas vinpocetine treated rats showed significant recovery with improved alterations in cognitive and motor functions and also restored traumatic brain injury induced biochemical alterations. (researchsquare.com)
- On 21st postnatal day, the concentration of fluoride, biometals, and oxidative stress markers were determined in discrete regions of CNS. (fluoridealert.org)
- The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. (fluoridealert.org)
Blood lipid2
- This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
- A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
Liver1
- This study was designed to find out if the oral administration of SSD is capable of generating oxidative stress in erythrocytes, liver and kidney using albino rats as experimental models. (ajol.info)
Inflammatory3
- Studies have indicated that CO may cause brain lipid peroxidation and leukocyte-mediated inflammatory changes in the brain, a process that may be inhibited by hyperbaric oxygen therapy. (medscape.com)
- An active nature product of Asian herb medicine, curcumin, shows many protective effects, including against inflammatory and oxidative stress conditions. (thieme-connect.com)
- Phycocyanin can help fight oxidative stress by blocking the production of molecules that promote inflammation and providing impressive antioxidant and anti-inflammatory effects. (healthline.com)
Parameters1
- 0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. (ajol.info)
Suppresses1
- Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)
Mice2
- In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
- Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
Reduces3
- Among adults with a history of chronic stress , 300 mg ashwagandha extract reduces cortisol and anxiety and improves resistance to additional stress. (marksdailyapple.com)
- Zinc Reduces Copper Toxicity Induced Oxidative Stress By Promoting Antioxidant Defense in Freshly Grown Aquatic Duckweed Spirodela Polyrhiza L." Journal of Hazardous Materials, vol. 175, no. 1-3, 2010, pp. 1081-4. (unboundmedicine.com)
- Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
Inhibition1
- Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. (hindawi.com)
Levels2
- IAE decreased enhanced lipid peroxidation levels in plasma and erythrocyte membrane and cholesterol levels in brain and plasma. (niscair.res.in)
- ing high levels of oxidative stress [1]. (who.int)
Concentration1
- Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. (ajol.info)
Antioxidative1
- Many tumor promoters manifest inhibitory effectson antioxidative defence mechanisms, thus increasing the level of oxidative stress in the tumor cell. (iiarjournals.org)
Imbalance1
- Many studies have suggested that increased oxidative stress, an imbalance in the antioxidant defense system may be involved in pathogenesis of Lichen planus. (medicopublication.com)
Study investigated1
- This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
Fatty1
- Fatty structures in your body are susceptible to oxidative damage . (healthline.com)
Processes1
- In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
Hydrogen peroxide1
- However, the excessive generation of ROS, such as super oxide anions (O 2 − ) and hydrogen peroxide (H 2 O 2 ) due to environmental stress results in significant oxidative damage to cell structures, such as DNA, the mitochondria and cell membranes ( 3 , 4 ). (spandidos-publications.com)
Diseases2
- This is known as lipid peroxidation , a key driver of many serious diseases. (healthline.com)
- This necessitates the investigation of past experimental approaches in their attempt to correlate oxidative stress and ocular diseases in humans in both the epithelial cells plus the capsule (LECs/capsule) and in the aqueous humor (AH). (molvis.org)
Mechanism2
- Lipid peroxidation is a well-demonstrated mechanism of cellular which injury in both plants and animals. (creativebiomart.net)
- Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
Supplementation1
- In fact, one small study showed that spirulina supplementation was able to reduce exercise-induced lipid peroxidation, inflammation, and muscle damage in 17 rugby players. (healthline.com)
Ashwagandha5
- By virtue of this stress-reducing effect, ashwagandha may help improve or mitigate other stress-related conditions, like insomnia, lack of libido/erection, and anxiety. (marksdailyapple.com)
- In male infertility patients, ashwagandha improves semen quality and improves testosterone status by reducing the impact of oxidative stress. (marksdailyapple.com)
- Giving ashwagandha to animals exposed to stress prevents the normal rise in lipid peroxidation. (marksdailyapple.com)
- Since ashwagandha is traditionally used as an adaptogen, it is used for many conditions related to stress. (medlineplus.gov)
- Taking ashwagandha by mouth seems to help reduce stress in some people. (medlineplus.gov)
Cellular2
- We believe that there is promise in the potential of modifying the course of PSP by mitigating the oxidative stress and cellular degeneration that is caused by pathogenic LPO. (globenewswire.com)
- This platform is designed to combat the oxidative stress and cellular degeneration that arises from lipid peroxidation (LPO). (globenewswire.com)
Cell3
- The data point toward a role of lipid peroxidation in SiO2 nanoparticle -induced cell death. (cdc.gov)
- Relationships between ROS, uncontrolled cell proliferation, activation of NF-κB and overexpression of p53 point to the significance of oxidative stress in cancer development. (iiarjournals.org)
- Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)