• Distraction of these elements in central nervous system (CNS) have been demonstrated in many neurological disorders, which are vital in generating free radicals, causing oxidative stress, and contributing to neuronal maladies. (fluoridealert.org)
  • Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
  • This effect was correlated with reduced glucose intolerance, body weight gain, fat mass development, lower inflammation, oxidative stress, and macrophage infiltration marker mRNA expression in visceral adipose tissue. (diabetesjournals.org)
  • NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)
  • Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
  • The increased lipid peroxidation due to oxidative stress induction (increased TBARS and decreased \alpha-tocopherol concentration) found in neoplastic compared to normal mammary tissue of dogs with mammary cancer was similar in both groups of dogs fed with a different kind of diet, commercial or homemade. (tubitak.gov.tr)
  • The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)
  • The present study investigated the effects of insulin and/or metformin treatment on oxidative stress levels in the gastrocnemius muscle of diabetic rats. (hindawi.com)
  • Then, oxidative stress levels, glutathione antioxidant defense system, and antioxidant status were analyzed in the gastrocnemius muscle of hypoinsulinemic rats. (hindawi.com)
  • We do not known studies that verified the role of metformin associated with insulin compared to insulin therapy alone in oxidative stress control in gastrocnemius muscle of streptozotocin-diabetic rats. (hindawi.com)
  • We also evaluated total antioxidant capacity and lipid peroxidation in gastrocnemius muscle of diabetic rats treated with metformin and/or insulin. (hindawi.com)
  • The effect of the extract was studied on lipid peroxidation and antioxidant parameters in liver and gastrocnemius muscle of rats on attaining the rectal temperature (T(rec)) of 23 degrees C during C-H-R exposure and after recovery (T(rec)37 degrees C) from C-H-R-induced hypothermia. (nih.gov)
  • We hypothesized that MGST1 may also protect against nanomaterial -induced cytotoxicity through a specific effect on lipid peroxidation. (cdc.gov)
  • We evaluated the induction of cytotoxicity and oxidative stress by TiO2, CeO2, SiO2, and ZnO in the human MCF-7 cell line with or without overexpression of MGST1. (cdc.gov)
  • This condition can lead to lipid peroxidation in muscle cell membranes, which contributes to the development of insulin resistance [ 5 , 6 ]. (hindawi.com)
  • For years, moderate-intensity continuous training (MICT) has been the most popular exercise modality for improving body composition, cardiorespiratory fitness, insulin resistance, and lipid profile [ 2 , 5 ]. (hindawi.com)
  • mtROS also causes oxidation of lipids and proteins identified in bleomycininduced mouse models of pulmonary fibrosis and in sufferers with IPF (80, 81). (namptinhibitor.com)
  • ROS can react with proteins, nucleic acids, and can cause lipids cell and tissue damage and can be measured using selective or general indicators. (creativebiomart.net)
  • Alternatively, indirect methods for assessing oxidative stress have been applied and focus mainly on the oxidative damage ROS cause in biomolecules, such are lipids, proteins, and DNA. (molvis.org)
  • Functional analysis showed that cholesterol biosynthesis pathways and the cytochrome 450 family of proteins (specifically Cyp4A10 that is associated with oxidative stress and lipid peroxidation leading to hepatocyte injury) were increased in mice exposed to e-cigarette aerosol. (medscape.com)
  • Microsomal glutathione transferase 1 (MGST1) is an antioxidant enzyme located predominantly in the mitochondrial outer membrane and endoplasmic reticulum and has been shown to protect cells from lipid peroxidation induced by a variety of cytostatic drugs and pro-oxidant stimuli. (cdc.gov)
  • Vestena S, Cambraia J, Ribeiro C, Oliveira JA, Oliva MA (2011) Cadmium-induced oxidative stress and antioxidative enzyme response in water hyacinth and salvinia. (springer.com)
  • RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
  • Bilirubin may act as an antioxidant that suppresses lipid oxidation. (ajol.info)
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
  • Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
  • Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
  • Consider that altered oxidative stress/antioxidant status is related to T1D complications [ 22 , 23 ] and metformin action in the decrease of mitochondrial ROS. (hindawi.com)
  • Lipid peroxidation in neoplastic tissue of dogs with mammary cancer fe" by MARIA KARAYANNOPOULOU, ANNA FYTIANOU et al. (tubitak.gov.tr)
  • Pretreatment with T. terrestris resulted in the increased activities of SOD, CAT, GSHPx and prevention of depletion of tissue glutathione along with inhibition of lipid peroxidation. (scialert.net)
  • Numerous markers of oxidative activity are present in persons with asthma. (namptinhibitor.com)
  • Elevation in markers of oxidative stress, alterations in other monoamines were observed in injured rats, whereas vinpocetine treated rats showed significant recovery with improved alterations in cognitive and motor functions and also restored traumatic brain injury induced biochemical alterations. (researchsquare.com)
  • On 21st postnatal day, the concentration of fluoride, biometals, and oxidative stress markers were determined in discrete regions of CNS. (fluoridealert.org)
  • The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. (fluoridealert.org)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
  • A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
  • 0.0001)) after adjustment for lipid status parameters and traditional risk factors in this study population. (ajol.info)
  • In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
  • Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
  • Among adults with a history of chronic stress , 300 mg ashwagandha extract reduces cortisol and anxiety and improves resistance to additional stress. (marksdailyapple.com)
  • Zinc Reduces Copper Toxicity Induced Oxidative Stress By Promoting Antioxidant Defense in Freshly Grown Aquatic Duckweed Spirodela Polyrhiza L." Journal of Hazardous Materials, vol. 175, no. 1-3, 2010, pp. 1081-4. (unboundmedicine.com)
  • Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
  • Our hypothesis is that the inhibition of complex I can minimize damage oxidative in muscles of hypoinsulinemic rats. (hindawi.com)
  • Increased serum MDA concentration, as a biomarker of lipid peroxidation, low serum bilirubin and antioxidant capacity were observed in patients with angiographically defined CAD. (ajol.info)
  • Many tumor promoters manifest inhibitory effectson antioxidative defence mechanisms, thus increasing the level of oxidative stress in the tumor cell. (iiarjournals.org)
  • This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
  • Fatty structures in your body are susceptible to oxidative damage . (healthline.com)
  • In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
  • However, the excessive generation of ROS, such as super oxide anions (O 2 − ) and hydrogen peroxide (H 2 O 2 ) due to environmental stress results in significant oxidative damage to cell structures, such as DNA, the mitochondria and cell membranes ( 3 , 4 ). (spandidos-publications.com)
  • This is known as lipid peroxidation , a key driver of many serious diseases. (healthline.com)
  • This necessitates the investigation of past experimental approaches in their attempt to correlate oxidative stress and ocular diseases in humans in both the epithelial cells plus the capsule (LECs/capsule) and in the aqueous humor (AH). (molvis.org)
  • Lipid peroxidation is a well-demonstrated mechanism of cellular which injury in both plants and animals. (creativebiomart.net)
  • Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
  • By virtue of this stress-reducing effect, ashwagandha may help improve or mitigate other stress-related conditions, like insomnia, lack of libido/erection, and anxiety. (marksdailyapple.com)
  • In male infertility patients, ashwagandha improves semen quality and improves testosterone status by reducing the impact of oxidative stress. (marksdailyapple.com)
  • Giving ashwagandha to animals exposed to stress prevents the normal rise in lipid peroxidation. (marksdailyapple.com)
  • Since ashwagandha is traditionally used as an adaptogen, it is used for many conditions related to stress. (medlineplus.gov)
  • Taking ashwagandha by mouth seems to help reduce stress in some people. (medlineplus.gov)
  • The data point toward a role of lipid peroxidation in SiO2 nanoparticle -induced cell death. (cdc.gov)
  • Relationships between ROS, uncontrolled cell proliferation, activation of NF-κB and overexpression of p53 point to the significance of oxidative stress in cancer development. (iiarjournals.org)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)