MyocardialCardiacLEFT VENTRICLEIschemiaIschemicHibernatingAtrial myocardiumContractilityRight ventricleViableReperfusionPeripheral nervesAcuteSkeletal muscleDysfunctionCoronary arteriesVenousInfarctEpicardiumEndocardiumRegenerationMiceCongenitalTissueExtracellularPathophysiologyHumanReceptorMuscleAdultFunctionalDiseaseCalciumFunctionPatientsProtein
Myocardial12
- The clinical situations where one can expect hibernating myocardium are:[citation needed] chronic stable angina unstable angina silent ischemia after AMI Stunned myocardium Myocardial scarring Wijns W, Vatner SF, Camici PG (July 1998). (wikipedia.org)
- Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
- The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
- Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
- Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
- Neurogenic stunned myocardium (NSM) is a triad of transient left ventricular dysfunction, electrocardiogram changes, and elevation in cardiac enzymes, often mimicking a myocardial infarction. (nih.gov)
- The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. (mcw.edu)
- Among the techniques routinely used to detect the presence of viable myocardium, special mention should be made of dobutamine stress echocardiography (DSE), isotopic testing in the form of Thallium-201 redistribution scintigraphy and, more recently introduced, the myocardial contrast echocardiography (MCE) techniques and magnetic resonance. (escardio.org)
- More recently it has been also used for the evaluation of myocardial strain or simplified for the assessment of regional deformations of the myocardium such as thickening, shortening or lengthening. (radiopaedia.org)
- To determine whether accumulation of very long-chain ceramides occurs in human failing myocardium, we analyzed myocardial tissue and serum from patients with severe heart failure (HF) undergoing placement of left ventricular assist devices and controls. (jci.org)
- Objectives The aim of this study was to investigate the clinical significance of native T1 values in remote myocardium in survivors of acute ST-segment elevation myocardial infarction (STEMI). (dundee.ac.uk)
- Intravenous calcium is primarily used to protect the myocardium from the deleterious effects of hyperkalemia (ie, arrhythmias) by antagonizing the potassium actions on the myocardial cell membrane. (medscape.com)
Cardiac16
- Cardiac magnetic resonance: The most frequently used MR contrast agents based on Gd-chelates accumulate in the extracellular space which is increased in scarred myocardium. (wikipedia.org)
- The myocardium defines the middle layer of the cardiac wall between the endocardium and the pericardium and forms the muscular part of the heart . (radiopaedia.org)
- The myocardium represents the middle layer of the cardiac wall. (radiopaedia.org)
- The vascular territories of the left ventricular myocardium are divided into 17 segments and illustrated by the cardiac segmentation model of the American Heart Association (AHA) 6,7 . (radiopaedia.org)
- Venous drainage of the myocardium is provided via the cardiac veins and the coronary sinus as well as the Thebesian veins 8 . (radiopaedia.org)
- Cardiac lymphatic flow passes from the endocardium through the myocardium to the epicardium where small lymphatic vessels drain into larger collecting vessels. (radiopaedia.org)
- The myocardium is innervated by the cardiac conduction system . (radiopaedia.org)
- The myocardium can be depicted and evaluated with ultrasound e.g. echocardiography, cardiac CT and cardiac MRI . (radiopaedia.org)
- Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
- In conclusion, cardiac ceramides accumulate in the failing myocardium, and increased levels are detectable in circulation. (jci.org)
- The myocardium consists of cardiac muscle , a type of muscle unlike any other muscle in the body. (wise-geek.com)
- The middle layer of the cardiac wall is referred to as the myocardium. (wise-geek.com)
- Using single-cell qRT-PCR and clonal analyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium all sharing stem cell antigen-1 (Sca1), based on side population (SP) phenotype, PECAM-1 (CD31) and platelet-derived growth factor receptor-α (PDGFRα) expression. (ox.ac.uk)
- To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. (duke.edu)
- The calcium transients associated with contraction in human working myocardium were recorded by use of the bioluminescent protein, aequorin, a substance that emits light when it combines with calcium ion (Ca ++ ). Small amounts of aequorin were microinjected into superficial cells of human atrial and ventricular muscle obtained from tissue routinely excised and discarded at the time of cardiac surgery. (elsevierpure.com)
- In this paper, we present a deep convolutional neural network model named Multi-Modal Cardiac Network (MMC-Net) for segmenting three cardiac structures namely right ventricle (RV), left ventricle (LV), and left ventricular myocardium (LVM) from multi-modal CMRI's. (techrxiv.org)
LEFT VENTRICLE2
- The ventricular myocardium is thicker than the atrial myocardium, in particular, the myocardium of the left ventricle . (radiopaedia.org)
- Thus, at least two p75 NTR ligands are elevated in the left ventricle after ischemia-reperfusion where they may stimulate p75 NTR -dependent denervation of peri-infarct myocardium. (elsevierpure.com)
Ischemia5
- Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
- To study the regional function of nonischemic myocardium after the onset of regional ischemia, graded circumflex coronary arterial stenosis was induced in 18 open-chest anesthetized dogs. (johnshopkins.edu)
- We conclude the following: (1) During transmural ischemia percent systolic thickening is markedly impaired in nonischemic myocardium immediately adjacent to the ischemic region, and is impaired to a lesser degree in regions located relatively far from the ischemic border. (johnshopkins.edu)
- 2) During subendocardial ischemia function ceases in the ischemic region and functional impairment of nonischemic myocardium is restricted to immediately adjacent regions. (johnshopkins.edu)
- 4) Mechanical tethering of nonischemic myocardium adjacent to ischemic regions, secondary to changes in left ventricular shape during contraction, may contribute to the impairment of systolic thickening in adjacent regions during transmural ischemia. (johnshopkins.edu)
Ischemic9
- This finding shows that ischemic but noninfarcted myocardium can exist in a state of hibernation without cell death. (medscape.com)
- Thallium-201 with redistribution is a classical isotopic test used to detect viable myocardium in patients with ischemic heart disease and depressed ventricular function. (escardio.org)
- Our preliminary data suggest that length-dependent changes in Ca2+ sensitivity are eliminated in myocardium from patients who have non-ischemic heart failure but preserved in organ donors and patients who have ischemic heart failure. (uky.edu)
- Aim 1: Test the hypothesis that length-dependent changes in Ca2+ sensitivity are reduced in myocardium from patients who have non-ischemic heart failure. (uky.edu)
- Aim 2: Test the hypothesis that the OFF state of the thick filament is destabilized in myocardium from patients who have non-ischemic heart failure. (uky.edu)
- Additional studies explore whether targeting OFF/ON transitions can improve lengthdependent activation in vitro in myocardium from patients with non-ischemic heart failure. (uky.edu)
- At the same time restoring the patency of the coronary vessels and providing the ischemic myocardium with blood can cause additional tissue damage. (eurekaselect.com)
- A key element of ischemic and reperfusion injury and major determinant of the evolution of damage in the injured myocardium is the inflammatory response. (eurekaselect.com)
- Although the mechanisms of ischemic preconditioning and APC are thought to be similar, it is not known whether the beneficial effects of APC are also reduced in the aged myocardium. (asahq.org)
Hibernating4
- In cardiology, hibernating myocardium is a state when some segments of the myocardium exhibit abnormalities of contractile function. (wikipedia.org)
- Echocardiography: A wall motion abnormality at rest which improves during a low-dose dobutamine stress test is classified as "hibernating myocardium. (wikipedia.org)
- In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
- Identification of viable and hibernating myocardium allows for a better selection of patients who need revascularisation. (escardio.org)
Atrial myocardium1
- These groups of internodal tissue are best referred to as internodal atrial myocardium, not tracts, as they do not appear to be histologically discrete specialized tracts. (medscape.com)
Contractility1
- Low-dose dobutamine infusion is able to demonstrate the contractile reserve of myocardium as it shows an improved contractility following infusion of this positive inotropic drug. (escardio.org)
Right ventricle1
- A myocardium that is part of a right ventricle of a heart. (virtualflybrain.org)
Viable5
- The regions of myocardium are still viable and can return to normal function. (wikipedia.org)
- Consequently, the noninvasive determination of viable myocardium is becoming increasingly important. (escardio.org)
- Although DSE and Thallium-201 with redistribution have been validated for the diagnosis of viable myocardium, they frequently yield conflicting results. (escardio.org)
- When both DSE and Thallium-201 are performed in the same patient, discordant results are often obtained In fact, in comparative studies where both techniques have been used prior to revascularisation procedures, the sensitivity, specificity and predictive value for the detection of viable myocardium have been found to differ. (escardio.org)
- Regions of sympathetic hyperinnervation and denervation appear in the viable myocardium beyond the infarcted area. (elsevierpure.com)
Reperfusion1
- Here we show, using large animal models of reperfused MI, that intramyocardial hemorrhage - the most damaging form of reperfusion injury (evident in nearly 40% of reperfused ST-elevation MI patients) - drives delayed infarct healing and is centrally responsible for continuous fatty degeneration of the infarcted myocardium contributing to adverse remodeling of the heart. (nature.com)
Peripheral nerves2
- In most cases, PDD is accompanied by nonsuppurative encephalomyelitis, and inflammation has also been noted in the peripheral nerves ( 5 ), myocardium ( 1 , 6 , 7 ), and adrenal glands ( 7 ). (cdc.gov)
- Acute necrotizing foci stippled with karyorrhexis and fibrin exudates and small plasmacytic infiltrates were found in myocardium, peripheral nerves and perineural tissues, liver, spleen, and lungs. (cdc.gov)
Acute1
- One of the most common, and perhaps the most damaging forms of tissue injury in the setting of revascularized acute MI is intramyocardial hemorrhage-a condition leading to bleeding within the heart muscle (myocardium). (nature.com)
Skeletal muscle2
- While skeletal muscle fibers are arranged into regular, non-branching bundles, the muscle fibers of the myocardium branch at irregular angles, and connect to other muscle cells at junctions called intercalated discs. (wise-geek.com)
- The purpose of this article is to observe the microstructure changes of the myocardium and skeletal muscle of experimental mice before and after infection by using an electron microscope. (actamedicamediterranea.com)
Dysfunction1
- Deletion of Txnip in the myocardium results in mitochondrial dysfunction with decreased expression of transcripts encoding mitochondrial metabolism. (jci.org)
Coronary arteries3
- The arterial supply of the myocardium is provided by the coronary arteries . (radiopaedia.org)
- BACKGROUND: In the medical literature, several cases of Tako-tsubo cardiomyopathy (TTC) with coronary artery disease (CAD) have been reported, and in clinical practice, several typical TTC cases show relevant stenoses of the coronary arteries spatially unrelated to the dysfunctional myocardium. (who.int)
- 50%) coronary stenosis not supplying the dysfunctional myocardium, whereas 407 patients (90.4%) had irrelevant stenosis or angiographically normal coronary arteries. (who.int)
Venous1
- HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)
Infarct1
- Sympathetic hyperinnervation was found in the distal peri-infarct myocardium in both genotypes 3days after MI, and hyperinnervation was increased in the p75 NTR -/- mice. (elsevierpure.com)
Epicardium1
- The outer layer of the heart wall is the epicardium, the middle layer is the myocardium, and the inner layer is the endocardium . (daviddarling.info)
Endocardium1
- The inner border merges with the subendocardial tissue layer, which contains collagen, elastic fibers small blood vessels and nerves as well as the Purkinje fibers and connects the extracellular matrix of the myocardium to the endocardium 4 . (radiopaedia.org)
Regeneration1
- 1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Mice1
- The results of the study showed that after treatment with low-dose Vibrio vulnificus, the experimental group mice developed obvious lesions in the myocardium. (actamedicamediterranea.com)
Congenital1
- Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. (mcw.edu)
Tissue1
- The walls of the heart are largely made from myocardium, which is a special kind of muscle tissue. (daviddarling.info)
Extracellular2
- The myocardium consists of cardiomyocytes grouped in strands also known as myofibres and the surrounding extracellular matrix with endomysial and perimysial components. (radiopaedia.org)
- Used in LGE assessment, gadolinium is an extracellular chelating agent that permeates the interstitial space of both normal and abnormal myocardium . (medscape.com)
Pathophysiology1
- Background The pathophysiology and prognostic significance of remote myocardium in the natural history of STEMI is uncertain. (dundee.ac.uk)
Human6
- Whether K201 exerts beneficial effects in human failing myocardium is unknown. (gla.ac.uk)
- The direct measurement of the spin-grid-relaxation times of phosphorus metabolites in the human myocardium]. (ox.ac.uk)
- Aim 3: Target OFF/ON transitions to manipulate the Ca2+ sensitivity of human myocardium. (uky.edu)
- The configuration and time course of the aequorin signal in human myocardium and its responses to inotropic interventions are similar to those recorded in lower mammalian species. (elsevierpure.com)
- abstract = "The calcium transients associated with contraction in human working myocardium were recorded by use of the bioluminescent protein, aequorin, a substance that emits light when it combines with calcium ion (Ca++). (elsevierpure.com)
- We prove the higher sensitivity of BA over CA to explain transcriptomic changes in the aging myocardium and report novel molecular insights into human LV biological aging. (i3a.es)
Receptor1
- Khabibrakhmanov I.I. The effect of α1 -adrenergic receptor subtypes blockade on the rat myocardium inotropy / I.I. Khabibrakhmanov, N.I. Ziyatdinova, T.L. Zefirov // Journal of Pharmacy Research. (kpfu.ru)
Muscle3
- In most imaging techniques the myocardium displays a muscle-like appearance. (radiopaedia.org)
- The myocardium is the muscle layer of the heart, responsible for the heart's pumping action, which supplies the entire body with blood. (wise-geek.com)
- The body's immune response can also damage the heart muscle (called the myocardium) in the process of fighting the infection. (medlineplus.gov)
Adult1
- PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium. (ox.ac.uk)
Functional1
- Scholars@Duke publication: Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. (duke.edu)
Disease1
- Coronavirus Disease 2019 and the Myocardium. (bvsalud.org)
Calcium1
- Protecting the myocardium from hyperkalemia is managed with intravenous (IV) calcium. (medscape.com)
Function1
- The contractions of the myocardium are responsible for pumping oxygenated blood throughout the body, providing the body with the oxygen and other nutrients it needs to function properly. (wise-geek.com)
Patients1
- Lipidomic analysis revealed increased total and very long-chain ceramides in myocardium and serum of patients with advanced HF. (jci.org)
Protein1
- Thioredoxin-interacting protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxins, but little is known about its roles in the myocardium. (jci.org)