However cells rotenone. Medical search. Frequent questions

It biodegrades rapidly in soil, with 90% degraded after 1-3 months at 20 °C (68 °F) and three times faster at 30 °C (86 °F). Rotenone works by interfering with the electron transport chain within complex I in mitochondria, which places it in IRAC MoA class 21 (by itself in 21B). (wikipedia.org)
This protein is found in a cellular compartment called the mitochondria, which is responsible for supplying energy to the rest of the cell and therefore plays an important role in metabolic processes. (elifesciences.org)
found that when this variant form of ATP5G1 was introduced into the cells of mice, their mitochondria was better at coping with stress conditions, such as low oxygen, low temperature and poisoning. (elifesciences.org)
Following chronic exposure to rotenone, fatty acid synthesis is altered in the mitochondria, resulting in fatty changes in the liver and kidney. (merckvetmanual.com)
The chemical compound rotenone damages mitochondria by producing ROS, and Andreason found that lithium was able to reverse this production and reverse the adverse effects of oxidative stress. (bipolarnews.org)
Editor's Note: The ability of lithium to protect mitochondria (the energy storehouse of a cell) adds to an increasingly long list of lithium's neurotropic and neuroprotective benefits. (bipolarnews.org)
Lithium increases cell survival factors BDNF and Bcl-2, increases markers of neuronal integrity such as N-Acetylaspartic acid (NAA), increases the volume of the hippocampus and cortex, and now helps protect mitochondria from oxidative stress. (bipolarnews.org)
Biochemical and genetic mechanisms of oxidative stress (OS) developing in rat heart mitochondria were studied in a rotenone model of Parkinson's disease (PD), and the effect of Capicor (combination of meldonium dihydrate and gamma-butyrobetain dihydrate) on these mechanisms was evaluated. (ukrbiochemjournal.org)

Retinal ganglion cells (RGCs) undergo apoptosis after injury. (figshare.com)
Here, we used JIP1 gene knockout (KO) mice to investigate the importance of JIP1-JNK signaling in the apoptosis of RGCs in a rotenone-induced injury model. (figshare.com)
Together, our results demonstrate that the JIP1-mediated activation of JNK contributes to the apoptosis of RGCs in a rotenone-induced injury model in vitro and in vivo, suggesting that JIP1 may be a potential therapeutic target for RGC degeneration. (figshare.com)
Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. (logosbio.com)
Rotenone's toxicity in humans, animals, and fish is via inhibition of mitochondrial respiratory chain complex I, with cell death by apoptosis due to excess generation of free radicals. (merckvetmanual.com)
Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
We demonstrated that treatment of human blood lymphocytes with rotenone resulted in decreased mitochondrial membrane potential, inhibition of mitochondrial respiratory complex I, induction of apoptosis and selective oxidation of mitochondrial phospholipid, cardiolipin (CL). (cdc.gov)
The cell apoptosis was determined by flow cytometry analysis. (jcimjournal.com)
MPP + can cause severe damage to mitochondrial morphology and the function in SH-SY5Y cells, and echinacoside selectively reverse mitochondrial function and cell apoptosis, yet there is no effect on mitochondrial morphology. (jcimjournal.com)

Proteasomal inhibition induced significantly increased alpha-synuclein aggregation in cells expressing mutant alpha-synuclein. (unboundmedicine.com)

Rotenone is used as a pesticide, insecticide, and as a nonselective piscicide (fish killer). (wikipedia.org)
Theanine: Theanine protects brain cells against damage from exposure to the pesticide rotenone, commonly linked with PD (Cho, et al 2008). (appetitesforlife.com)
Oxidized cardiolipins as a biomarker of mitochondrial dysfunction triggered by pesticide , rotenone. (cdc.gov)
Exposure to a commonly used pesticide , rotenone, has been associated with the development of Parkinson's disease. (cdc.gov)

The oral LD 50 of rotenone is approximately 60-135 mg/kg in rats and 350 mg/kg in mice. (merckvetmanual.com)
In rabbits, the LD 50 for rotenone following IV, oral, and dermal routes are 0.35-0.65, 1.5, and 100-200 mg/kg, respectively.A no observed adverse effect level (NOAEL) of 0.4 mg/kg/d has been determined in rats and dogs. (merckvetmanual.com)
In rats and dogs, experimental inhalation of rotenone dust produced onset of signs earlier than after oral ingestion. (merckvetmanual.com)
Adult male Lewis rats (6 months old) were exposed to rotenone daily (3 mg/kg, I.P.) and sacrificed 1, 5 and 10-14 days thereafter. (cdc.gov)
Selective protective effects of echinacoside on nigral dopaminergic neurons in rats exposed to rotenone. (jcimjournal.com)

A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grown in a spheroid. (nature.com)
Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons. (uibk.ac.at)
Rotenone induces cell death of cholinergic neurons in an organotypic co-culture brain slice model. (uibk.ac.at)
Epigallocatechin-3-gallate (EGCG): Clinical studies suggest that EGCG has neuroprotective qualities and can significantly suppress toxicity of dopamine neurons through antioxidation, anti-inflammation, iron-chelation, cell death regulation and modulation of signaling pathways (Zhou et al, 2019). (appetitesforlife.com)
From the cover: Manganese and rotenone-induced oxidative stress signatures differ in iPSC-derived human dopamine neurons. (purdue.edu)
In particular, chemicals such as the insecticide Rotenone have been shown to increase the death of dopaminergic (DA) neurons by increasing levels of reactive oxygen species (ROS). (ucf.edu)

Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
We conclude that CL oxygenation products may represent a new biomarker of rotenone-induced mitochondrial dysfunction associated with Parkinson disease. (cdc.gov)
Correction of rat liver mitochondrial dysfunction under rotenone intoxication when treated with fixed combination meldonium with gamma-butyro-betaine. (ukrbiochemjournal.org)

2010). Rotenone enhances the antifungal properties of staurosporine . (up.pt)
Rotenone enhances antifungal activity of novel pyrazoles against Candida spp. (fiocruz.br)

Rotenone decays through metabolites and its final product is reduced to water and carbon dioxide. (wikipedia.org)
Selective toxicity of rotenone to insects and fish in comparison to mammalian species is due to greater absorption from the GI tract and formation of large quantities of highly toxic metabolites. (merckvetmanual.com)

Homocysteine enhances transmigration of rat monocytes through a brain capillary endothelial cell monolayer via ICAM-1. (uibk.ac.at)
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. (uni-regensburg.de)

In the UK, rotenone insecticides (sold under the trade name Derris) were banned for sale in 2009. (wikipedia.org)
Most insecticides derived from plants (eg, rotenone from Derris and pyrethrins from Chrysanthemum or Pyrethrum ) have traditionally been considered safe for use on animals. (merckvetmanual.com)

His lab utilizes a combined approach of molecular genetics, pharmacology, biochemistry, cell and developmental biology to understand the role of gene-environment interactions between metal exposure and neurodevelopmental and neurodegenerative diseases including Parkinson's Disease, Alzheimer's Disease and Huntington's Disease. (purdue.edu)

RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)

Stem Cells International 2021:6658271. (logosbio.com)
Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
2017). Systemic delivery of bone marrow mesenchymal stem cells for in situ intervertebral disc regeneration . (up.pt)
Stem Cells Translational Medicine, 6 (3), 1029 - 1039. (up.pt)
Stem Cells, 29 (11), 1738 - 1751. (up.pt)
The lab employs a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal cultures and mouse models. (purdue.edu)
Here, we found that prostate and breast cancer stem cells secreted vesicles of endosomal origin, called exosomes showed strong connection between autophagy and exosomes released from CSCs. (oncotarget.com)

These are a type of free radicals that can damage cells in two ways: nitrosylation of proteins (adding nitric oxide to a thiol molecule), and oxidation, which results in more lasting effects on synaptic structures. (bipolarnews.org)

Gene expression analysis and qPCR studies suggested that treating cells with C10 supports fatty acid metabolism, through increasing ACADVL and CPT1 expression, whilst downregulating genes involved in glucose metabolism (PDK3, PDK4). (nih.gov)
Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)

Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients. (uibk.ac.at)
Here, we used rat rotenone-infusion Parkinson disease model to assess possible accumulation of peroxidized phospholipids. (cdc.gov)

Thus, we employed Rotenone as a mitochondrial complex I inhibitor. (fiocruz.br)

This higher toxicity in fish and insects is because the lipophilic rotenone is easily taken up through the gills or trachea, but not as easily through the skin or the gastrointestinal tract. (wikipedia.org)
Rotenone has the potential for reproductive toxicity and teratogenicity. (merckvetmanual.com)

Rotenone dust is used for insects, lice, and ticks on animals. (merckvetmanual.com)
In insects, rotenone is both a contact and a systemic insecticide. (merckvetmanual.com)

Our results suggest that an increase in the rate of sodium chloride transport by MDCK cells stimulates formation by an inhibition of reesterification of free arachidonic acid. (uni-regensburg.de)
We therefore examined the roles of oxidative stress and proteasomal inhibition on protein aggregates induction in naïve and neuronally differentiated neuroblastoma SH-SY5Y cells. (unboundmedicine.com)
Naïve and transfected cells were exposed to oxidative stress induced by rotenone, SIN-I, FeCl(2,) and to proteasomal inhibition by lactacystin. (unboundmedicine.com)
Lev N, Melamed E, Offen D. Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage. (unboundmedicine.com)
2017). Synthetic microparticles conjugated with VEGF 165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition . (up.pt)

The development of new primary human cell culture technologies such as 3D culture, microfluidics and microfabrication in combination with human induced pluripotent stem cell (iPSC) derived models promise to generate more relevant human physiological systems for drug testing 11 . (nature.com)

His work on RNA binding proteins and SRSF1 has been continuously funded by the NIH and has recently expanded to the study of the role played by multiple RNA binding proteins on cellular gene transcription and T cell development and functions. (fau.edu)
2011). The T cell receptor triggering apparatus is composed of monovalent or monomeric proteins . (up.pt)
We detected tetraspanin proteins (CD9, CD63, CD81), Alix and tumor susceptibility gene-101 (TSG101) of exosomal markers from rotenone treated CSCs. (oncotarget.com)
We have also detected the induction of autophagy genes, Atg7 and conversion of autophagy marker (LC3-I to LC3-II), and tetraspanin proteins (CD9, CD63, CD81) in rotenone treated CSCs by western blotting. (oncotarget.com)

Typically, rotenone-containing plants in the legume family, Fabaceae, are crushed and introduced into a body of water, and as rotenone interferes with cellular respiration, the affected fish rise to the surface in an attempt to gulp air, where they are more easily caught. (wikipedia.org)
However, since not all cells from subjects with LS appeared to respond to C10, prior cellular testing in vitro could be employed as a means for selecting individuals for subsequent clinical studies involving C10 preparations. (nih.gov)
Despite the fact that there was no significant fall in total cellular ATP on stimulation of ion transport, we found a high and transient rise of lactate production of the cells on stimulation of the ion transport indicating an alteration of the ADP/ATP ratio. (uni-regensburg.de)
Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
To enhance the mechanical strength and cell adhesion of alginate hydrogel, making it satisfy the requirements of an ideal tissue engineering scaffold, the grafting of Arg-Gly-Asp (RGD) polypeptide sequence onto the alginate molecular chain was conducted by oxidation of sodium periodate and subsequent reduction amination of 2-methylpyridine borane complex (2-PBC) to synthesize alginate dialdehyde grafted RGD derivatives (ADA-RGD) with good cellular affinity. (bvsalud.org)

Through cell survival-based cDNA expression screens in neural progenitor cells, we identify a genetic variant of AGS Atp5g1 that confers cell resilience to metabolic stress. (elifesciences.org)

Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
Regulatory T cells (Treg) control mitochondrial function and cytokine production by CD4 + effector T cells (Teff) in prediabetes and type 2 diabetes by supporting T helper (Th)17 or Th1 cytokine production, respectively. (diabetesjournals.org)

In 1902 Kazuo Nagai, Japanese chemical engineer of the Government-General of Taiwan, isolated a pure crystalline compound from Derris elliptica which he called rotenone, after the Taiwanese name of the plant 蘆藤 (Min Nan Chinese: lôo-tîn) translated into Japanese rōten (ローテン). (wikipedia.org)
Rotenone is produced by extraction from the roots and stems of several tropical and subtropical plant species, especially those belonging to the genera Lonchocarpus and Derris. (wikipedia.org)
Rotenone is present in a number of plants ( Derris , Lonchocarpus , Tephrosia , and Mundulea ). (merckvetmanual.com)

They include nicotine extracted from tobacco (usually applied as nicotine sulphate), pyrethrum extracted from daisylike plants, and rotenone from several tropical shrubs. (encyclopedia.com)

2011). Systemic delivery of bone marrow-derived mesenchymal stromal cells diminishes neuropathology in a mouse model of Krabbe's disease . (up.pt)

Pyrazoles had a reduced cytotoxicity effect on in vivo cell culture than ketoconazole. (fiocruz.br)

This research focuses on testing an electrochemical sensor that uses cyclic voltammetry to quantitatively determine concentrations of H2O2 released from a cell culture. (ucf.edu)

Diagnosis of rotenone poisoning is based on detection of rotenone residue in blood, liver, urine, feces, and vomitus. (merckvetmanual.com)

Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein. (unboundmedicine.com)
Inclusion body formation and cell death of differentiated neuroblastoma cells overexpressing alpha-synuclein can serve as a valuable model for elucidating the molecular components that cause neurodegeneration in PD as well as evaluating pharmacological interventions. (unboundmedicine.com)

Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)
The drug accumulation of a human multidrug resistance 1 (mdr1) gene-transfected mouse lymphoma cell line and a multidrug resistance protein (MRP)-expressing human breast cancer cell line MDA-MB-231 was compared in the presence of sixteen flavonoids and five isoflavonoids. (iiarjournals.org)
The expression of the 170-kDa P-glycoprotein (P-gp) (MDR1) and 190-kDa multidrug resistance protein (MRP) in both cell lines was confirmed by immunocytochemistry. (iiarjournals.org)
In a checkerboard microplate method in vitro, furthermore, the most effective multidrug resistance (MDR) resistance modifiers, amorphigenin, formononetin, rotenone and chrysin, were assayed for their antiproliferative effects in combination with epirubicin. (iiarjournals.org)

In this study, we have for the first time incorporated cells from the most devastating brain cancer (glioblastoma) from primary brain tumor tissue from our patients into the BS. (nature.com)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)

We also found that JIP1 was located in the neurites of primary RGCs, but accumulated in soma in response to rotenone treatment. (figshare.com)
Neither treatment altered the number of normal neuronal cells in the model. (nature.com)
Moreover, treatment with C10 also decreased oxidative stress in complex I deficient (rotenone treated) cells. (nih.gov)
There is no specific antidote for rotenone poisoning, so treatment is supportive. (merckvetmanual.com)
Acute manganese treatment restores defective autophagic cargo loading in Huntington's disease cell lines. (purdue.edu)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Recently, cancer stem cell (CSC) research has shown promising results aiming towards cancer diagnostics and treatment. (oncotarget.com)

The effects of macrophage NLRP3 inflammasome activation on the function of hepatic stellate cells (HSCs) were explored by treating primary HSCs with preconditioned media from BMDMs culture. (bvsalud.org)

Fig. 3: Increased SCD activity is required for cancer cells to adapt to exogenous lipid limitation. (nature.com)
Rotenone intoxication increased the intensity of lipid peroxidation, protein oxidative modification, and H 2 O 2 production. (ukrbiochemjournal.org)

To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
By embryonic day 15.5, kidneys of nephron progenitor cell-specific VHL knockout mice begin to exhibit reduced maturation of nephron progenitors. (lww.com)

The differential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer drugs temozolomide (TMZ) and doxorubicin (DOX) were investigated. (nature.com)
Untreated gBS tumors increased in size over a 4-week culture period, however, there was no increase in the number of normal neuronal cells. (nature.com)

In the present work, we found that 5-ALA, a natural precursor of heme, can hinder cell glycolysis, which is the main path of energy production for most cancer cells. (mdpi.com)
2007). The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum . (up.pt)

The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)

MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in these cells. (uni-regensburg.de)
A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
We conclude that Treg control CD4 + T cell cytokine profiles through mechanisms determined, at least in part, by host metabolic status. (diabetesjournals.org)

Rotenone emulsions are used for eliminating unwanted fish in the management of bodies of water. (merckvetmanual.com)

Furthermore, FZHY was observed to block the activation of the NLRP3 inflammasome pathway, which can lead to excessive inflammatory cytokine release in supernatants and cell lysates in response to LPS and ATP. (bvsalud.org)

Small-scale sampling with rotenone is used by fish researchers studying the biodiversity of marine fishes to collect cryptic, or hidden, fishes, which represent an important component of shoreline fish communities, since it has only minor and transient environmental side effects. (wikipedia.org)

Lithium also increases the length of telomeres, which cap the ends of chromosome and protect them from damage during the DNA replication that occurs each time a cell divides. (bipolarnews.org)

The rhodamine 123 accumulation of the P-glycoprotein (P-gp)-expressing cells increased up to 46.4, while 2′,7′-bis(2-carboxyethyl)-5(6)-carboxy-fluorescein acetoxymethyl ester (BCECF-AM) accumulation of the MRP-expressing cells increased up to 1.6, in fluorescence activity ratio (FAR). (iiarjournals.org)

The results of the in vitro cytocompatibility showed that ALG/0.5PVA/0.3%CNCs and ADA-RGD/PVA/0.3%CNCs composite hydrogels showed better proliferative activity in comparison with other composite hydrogels, while ALG/PVA/0.3%CNCs and ADA-RGD/PVA/0.3%CNCs composite hydrogels displayed obvious proliferation effects, indicating that PVA, CNCs, and ADA-RGD with good biocompatibility were conducive to cell proliferation and differentiation for the IPN composite hydrogels. (bvsalud.org)

Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. (abcam.com)

Nephron progenitors, the self-renewing cells that give rise to nephrons, are particularly metabolically active, relying primarily on glycolysis for energy generation early in development. (lww.com)

Journal of Cell Biology, 186 (1), 11 - 26. (up.pt)

Overall, we are trying to determine if the electrochemical sensor can selectively and quantitatively measure H2O2 released from cells. (ucf.edu)

New data show that inflammatory profiles produced by CD4 + T cells define human prediabetes as a unique inflammatory state. (diabetesjournals.org)

2018) Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells. (fau.edu)
Exosomes may serve as vesicles to communicate with neoplastic cells (autocrine and paracrine manner) and normal cells (paracrine and endocrine manner) and thereby suppress immune systems and regulate neoplastic growth, and metastasis. (oncotarget.com)

But, it is unclear how their cells are able to endure this metabolic stress. (elifesciences.org)
These findings provide the first evidence of a protein variant that is responsible for protecting cells during the metabolic stress conditions caused by hibernation. (elifesciences.org)

Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line. (purdue.edu)

NRF2-transfected (+, including 3xFlag-tag) and HEK-293T whole cell extracts. (abcam.com)

Electron microscopy of rotenone treated CSCs showed the mitochondrial damage of CSCs as confirmed by the release of exosomes from CSCs. (oncotarget.com)

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