However polymorphism genetic. Medical search. Frequent questions

The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). (routledge.com)
Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. (routledge.com)
Single nucleotide polymorphisms (SNPs) in the Gγ-globin gene promoter in BCL11A regions and HBS1L-MYB intergenic polymorphism (HMIP) are thought to be associated with Hb F levels. (scirp.org)
We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
Single nucleotide polymorphisms (SNPs) denote the single nucleotide variations occurring at specific sites in the genome with substantial frequency within the population [ 1 , 9 , 10 ]. (medsci.org)
Four tagged single-nucleotide polymorphisms (SNPs) of HMGB1 were detected by a TaqMan-based real-time polymerase chain reaction (PCR) in patients. (jcancer.org)
Aim To examine whether intraocular pressure (IOP) reduction by latanoprost correlates with single nucleotide polymorphisms (SNPs) of the prostaglandin F2α (FP) receptor gene in patients with glaucoma and ocular hypertension (OH). (bmj.com)
These tests evaluate large numbers of individual variations (single nucleotide polymorphisms or SNPs) across a person's entire genome. (medlineplus.gov)
In ethnic groups with a smaller range of genetic variation due to the group's size and history, most members share many SNPs, and it may be difficult to distinguish people who have a relatively recent common ancestor, such as fourth cousins, from the group as a whole. (medlineplus.gov)
DISCUSSION AND CONCLUSIONS:The study suggests that several SNPs in the human genome that exist in Sri Lankan populations are significantly associated with anti-malarial antibodies, either with generation and/or maintenance of antibodies for longer periods, which can be due to either individual polymorphisms or most probably a combined effect of the markers. (ox.ac.uk)
Single nucleotide polymorphisms (SNPs) in TNF receptor superfamily (TNFRSF) 1A and 1B, and Fas ligand (FASLG) genes, have been associated with responsiveness to infliximab (IFX) in Crohn's disease. (regionh.dk)
Single nucleotide polymorphisms (SNPs) in various genes have been shown to associate with COPD, suggesting a role in disease pathogenesis. (lu.se)
This work aimed to gather information about different single nucleotide polymorphisms ( SNPs ) in genes that influence the host immune response during an infection by CHIKV. (bvsalud.org)

Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. (routledge.com)
So far, the studies which explore the relationship between the E2F1 polymorphisms and ovarian cancer susceptibility are rare. (hindawi.com)
Different genotypes of several genetic polymorphisms of certain genes, at least in part, might be accounted for susceptibility to COVID-19 infection. (degruyter.com)
However, the link between Nrf2 promoter polymorphisms and susceptibility to oxidative stress-related diseases such as vitiligo is unknown. (nih.gov)
This study evaluated the association of the Nrf2 and HO-1 genes polymorphisms with vitiligo susceptibility. (nih.gov)
The fact that genetic factors account for about 60% of the overall susceptibility to RA highlights the importance of research into genetic aberrations of this disease [ 3 , 6 - 8 ]. (medsci.org)
Furthermore, we found that HMGB1 rs1360485 polymorphisms seemed to be related to susceptibility to developing poorly differentiated cancer linked to tobacco consumption in EGFR mutant patients. (jcancer.org)
Recent studies suggest that ACE2 gene polymorphisms might be candidates for genetic susceptibility of SARS-CoV-2 infection. (researchsquare.com)
Results Our results suggest that, in the Thai population, polymorphisms in XRCC1 and OGG1 genes, particularly in combination, are associated with increased susceptibility to CCA, and that their role as modifiers of the effect of smoking and alcohol consumption influences the risk of CCA. (bmj.com)
Genetic susceptibility to the development of chronic obstructive pulmonary disease (COPD) might depend on variation in the activities of enzymes that detoxify cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GST). (ntu.edu.tw)
It was investigated whether polymorphisms in these genes had any association with susceptibility to COPD and COPD severity. (ntu.edu.tw)
During combined analysis of genetic polymorphisms for mEPHX, GSTM1 and GSTP1, it was found that there are strong indicators for susceptibility to COPD (genotype combination with at least one mutant mEPHX exon-3 allele (histidine 113), GSTM1 null and homozygous for the GSTP1 isoleucine 105 allele). (ntu.edu.tw)

The authors reported correlation between the frequency of the Del allele of the ACE Ins/Del polymorphism and prevalence and mortality rates of COVID-19 in 33 countries (25 European, three north-African and five Middle East countries). (degruyter.com)
A recent study suggested that the A allele of the 3′UTR biallelic polymorphism in the LBP-1c / CP2 / LSF gene was associated with reduced AD risk. (bmj.com)
They found that the A allele of a G/A polymorphism located in the 3′UTR was associated with sporadic AD in samples diagnosed predominantly by clinical, rather than pathological, criteria. (bmj.com)
1-3 It has an autosomal-dominant pattern linked to a point mutation (D178N) of the prion protein (PRNP) gene, which cosegregates with the methionine polymorphism at codon 129 of the mutated allele. (bmj.com)
The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)

T gene polymorphism. (bvsalud.org)

abstract = "Contemporary genetic programming (GP) systems for general program synthesis have been primarily concerned with evolving programs that can manipulate values from a standard set of primitive data types and simple indexed data structures. (ucl.ac.uk)
ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)

The main goal of the first project is to understand the role of natural and sexual selection in the evolution and maintenance of genetic variation at loci coding for melanin-based colour traits by combining disciplines of behavioural ecology, genetics and population genetics. (unil.ch)
Single nucleotide polymorphisms linked with resistance to SDH-inhibitors have been found in the SDHIs molecular targets genes in numerous fungal species using molecular genetics techniques. (tsijournals.com)

Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. (routledge.com)
This type of testing identifies genetic variations in mitochondrial DNA. (medlineplus.gov)
Rare variations are not classified as polymorphisms, and mutations by themselves do not constitute polymorphisms. (wikipedia.org)
This is the second example of a human enzyme isoelectrophoretic polymorphism revealed by research specifically aimed at detecting electrophoretically cryptic genetic variations. (torvergata.it)
Several factors, including host genetic variations and immune response against CHIKV, influence the outcomes of Chikungunya disease . (bvsalud.org)

Thus, we selected three widely-studied polymorphism loci (rs3213172, rs3213173, and rs3213176) to find a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
Using a population-based approach that analyzes multiple loci around the chromosome, we demonstrate that neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis . (cdc.gov)

Several groups have investigated the functional consequences of polymorphisms in key immunoregulatory moleculesincluding antigen presenting molecules, cytokines and chemokines and their receptors, adhesion and costimulatory molecules, toll-like receptors and intracellular signaling molecules that play a vital role in antigen recognition and the control of adaptive immune responses. (eurekaselect.com)
In each sequence of the following genes 'a 'functional polymorphism can occur. (psychiatriapolska.pl)
We also study the functional significance of genetic polymorphisms associated with hypertension. (massgeneral.org)
In collaboration with Christopher Holmes Newton-Cheh, MD, MPH, in the Division of Cardiology and Emmanuel Buys, PhD, in the Anesthesia Center for Critical Care Research, we are characterizing the functional significance of genetic polymorphisms associated with increased blood pressure. (massgeneral.org)
Ongoing studies are examining the functional significance of polymorphisms within other components of the ANP signaling pathway. (massgeneral.org)
Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)

To investigate whether genetic polymorphisms of glutathione S-transferases ( GSTM1 , GSTT1 , and GSTO2 ) in relation to the work place contribute to the development of cataract. (molvis.org)
This finding suggests that the polymorphisms of GSTM1 and GSTO2 and also work place may act additively for developing cataract. (molvis.org)
The genotypes of 184 patients with COPD and 212 control subjects were determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis of the mEPHX, GSTM1, GSTT1 and GSTP1 genes. (ntu.edu.tw)

Conclusions: Polymorphisms of TLR-2,3 genes and TLR4 Asp299Gly, NOD2/CARD15 prevailed in patients with the late UC onset that allows to suppose that bacterial flora plays one of the key roles in modification of immune response and UC development. (physiciansweekly.com)
Conclusions The statistically significantly worse mean baseline to post-concussion neuropsychological test scores in those with the APOEProm and TauSer polymorphisms suggests a possible genetic influence on post-concussion neurocognitive recovery. (bmj.com)
Conclusions In conclusion, our findings identify that certain ACE2 polymorphisms impact the severity of COVID-19 disease independently of other well-known risk factors. (researchsquare.com)

Sickle cell disease is an inherited genetic disorder, resulting from homozygous and compound heterozygote mutation in the β globin gene as a single base-pair point mutation (GAG to GTG) results in the substitution of glutamic acid (hydrophilic) to Valine (hydrophobic) in the 6th position of the β-chain of hemoglobin resulting in hemoglobin S formation [7]. (scirp.org)
In a population sample of 316 U.K. clinical isolates, silent single nucleotide polymorphisms (sSNPs) resolve an unambiguous phylogeny and provide a unifying framework for epidemiologic, population, and evolutionary analyses. (cdc.gov)
Genetic polymorphism is a term used somewhat differently by geneticists and molecular biologists to describe certain mutations in the genotype, such as single nucleotide polymorphisms that may not always correspond to a phenotype, but always corresponds to a branch in the genetic tree. (wikipedia.org)
We offer an alternative interpretation of the sequencing data of meiotic products, including the number and type of recombination events, to illustrate the potential for mistakes in single-nucleotide polymorphism calling. (psu.edu)

Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. (unibas.ch)
This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response. (unibas.ch)
Pharmacogenetic studies have been also performed in order to evaluate the role of host genetic variants in the prediction of recurrence risk and response to adjuvant treatment with FLs and OXA. (frontiersin.org)
Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka. (ox.ac.uk)
This paper discusses the association of 4 anti-malarial antibodies with selected host genetic markers. (ox.ac.uk)
Influence of host genetic polymorphisms involved in immune response and their role in the development of Chikungunya disease: a review. (bvsalud.org)

The kalemic systems in those breeds were characterized by a polymorphism of middle level due to the existence of the two phenotypes and of three genotypes. (academicjournals.org)
Objective Elucidate the core clinical and genetic characteristics and identify the phenotypic variation between different regions and genotypes of fatal familial insomnia (FFI). (bmj.com)
Present study was designed to explore the genetic diversity of plasmodium vivax genotypes based on Pvmsp-3α and Pvmsp - 3β genes using allelic specific nested PCR and RFLP assays markers from field isolates in district Mardan, Pakistan. (scielo.br)

Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β -thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. (scirp.org)
In sickle cell disease patients, Genetic polymorphisms in HBS1L-MYB (rs9376090 & rs4895441) affect the level of Hb F which could improve the prognosis of these patients. (scirp.org)
Scholars@Duke publication: Genetic polymorphisms associated with priapism in sickle cell disease. (duke.edu)
Priapism occurs in 30-45% of male patients with sickle cell disease (SCD), but the possible influence of genetic risk factors on the incidence of priapism is not well understood. (duke.edu)

We therefore studied the association of two polymorphisms - R353Q polymorphism at codon 353 involving the catalytic region and the 10 base pair (bp) insertion polymorphism involving the promoter region - with FVIIc levels in 176 healthy Tunisians. (who.int)
Nous avons donc étudié l'association de deux polymorphismes - R353Q au niveau du codon 353 intervenant sur la région catalytique et le polymorphisme d'insertion de 10 paires de bases (pb) impliquant la région du promoteur - avec les taux de FVIIc chez 176 Tunisiens en bonne santé. (who.int)

In addition, we determined polymorphisms in the promoter and all coding regions of FCN2 in 40 Gabonese. (nih.gov)
Assessment of Risk Factors APOE , APOE G-219T promoter (APOEProm), Tau exon 6 Ser53Pro (TauSer), and Tau exon 6 Hist47Tyr (TauHis) genetic polymorphisms. (bmj.com)

The results of this study will contribute in future studies about the genetic structure of parasite and vaccine development against the malaria. (scielo.br)

Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals. (cdc.gov)
This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione S-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. (cdc.gov)
Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption). (cdc.gov)

Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5'), or both (SEPP1 3'UTR). (cdc.gov)

The theoretical results are discussed in relation to population genomic data on inversion polymorphisms, with an emphasis on Drosophila melanogaster. (ed.ac.uk)

In this case-control study of 1136 Han Chinese vitiligo patients and 1200 controls, Nrf2 (rs35652124 and rs6721961) and HO-1 (rs2071746) genes were genotyped by PCR-restriction fragment length polymorphism analysis. (nih.gov)
After the addition of restriction enzyme (PsiI) in the ten samples, none of the samples showed fragmentation, which shows that there is a lack of rs622342 genetic polymorphism in the selected ten samples. (pharmdinfo.com)
Genetic diversity in nested PCR products was determined by Restriction Fragment Length Polymorphism (RFLP) utilizing Alu1 and PstI restriction enzymes for alpha and beta gene products digestion, respectively. (scielo.br)

Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. (routledge.com)
Our aim was to integrate our previously reported clinical-genetic prognostic score with new immunogenetic markers of 5-year disease-free survival (DFS) to evaluate the recurrence risk stratification before fluoropyrimidine (FL)-based adjuvant therapy. (frontiersin.org)
DNA polymorphisms are important markers in genetic analyses and are increasingly detected by using genome resequencing. (psu.edu)
Advances in knowledge about the genetic basis of the immune response during CHIKV infection are essential for expanding the understanding of disease pathophysiology, providing new genetic markers for prognosis , and identifying molecular targets for the development of new drug treatments . (bvsalud.org)

In a previous study Lambert et al 3 sequenced the transcription factor LBP-1c / CP2 / LSF gene, which lies within the chromosome 12 AD locus, in order to identify any genetic variants that may modify the risk of developing AD. (bmj.com)
Genetic variants in the vitamin D pathway affect vitamin D serum levels and, thus, atopy and asthma. (biomedcentral.com)
For analysis the genetic diversity of the sub allelic variants of Pvmsp3α and Pvmsp3β genes, Chi-Square test was performed by utilizing Minitab programming software 18. (scielo.br)
These genetic variants of SUMF1 may cause a deficient sulfation balance in the extracellular matrix of the lung tissue, thereby contributing to the development of COPD. (lu.se)

This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. (routledge.com)
Also, a significant association was detected between polymorphisms and disease severity. (scirp.org)
In patients with early UC onset polymorphisms of the JAK2 and IL-10 genes prevailed responsible for the cytokine cascade activation and cause the immune mechanism that might lead to a more aggressive course of the disease. (physiciansweekly.com)
The aim of the study was to evaluate the influence of ACE2 polymorphisms on COVID-19 disease risk and severity. (researchsquare.com)
Results In our study we confirmed that there is a statistically significant increased risk of a more severe disease course of SARS-CoV-2 infection associated with the need for hospitalization in the intensive care unit for patients with specific polymorphisms of the ACE2 gene. (researchsquare.com)
This disease is characterized by a chronic inflammation of lower airways that include complex pathophysiological mechanisms involving several pro-inflammatory cells and molecules, including different cytokine profiles that can change according to environmental and genetic factors [ 3 , 4 ]. (biomedcentral.com)

I read with great interest the study by Delanghe and his colleagues entitled "COVID-19 infections are also affected by human ACE1 D/I polymorphism" that was published in Clinical Chemistry and Laboratory Medicine [ 1 ]. (degruyter.com)
Objective: To investigate the associations of miRNA-related genetic polymorphisms, including miRNA-5189 rs562929801, miRNA-595 rs4909237, SLCO1A2 rs4149009 and MTHFR rs3737966, and clinical response to methotrexate in Chinese rheumatoid arthritis patients. (current-pharmaceutical-design.com)
The integration of IFNG -rs1861494 in our previous clinical genetic multiparametric score of DFS improved the patients' risk stratification (Log-rank P = 0.0026 in the pooled population). (frontiersin.org)
The prevalence of clinical symptoms and genetic profile were obtained, and then the phenotypic comparison between Asians versus non-Asians and 129Met/Met versus 129Met/Val were conducted. (bmj.com)
The relationships between the Arterial and venous thrombosis, which clinical presentation and FVII levels and the clinically manifest as stroke, myocardial in- associated molecular genetic defects lack farction or pulmonary embolism are a ma- apparent consistency [ 7,10 ]. (who.int)

In the present study, we tested the hypothesis that genetic variation in ABCG5 / ABCG8 influences the levels of serum plant sterol (sitosterol) and cholesterol precursor (lathosterol) in Japanese primary hypercholesterolaemic patients ( n =100). (portlandpress.com)
Certain patterns of genetic variation are often shared among people of particular backgrounds. (medlineplus.gov)
it is related to biodiversity, genetic variation, and adaptation. (wikipedia.org)
Polymorphism does not cover characteristics showing continuous variation (such as weight), though this has a heritable component. (wikipedia.org)
Polymorphism deals with forms in which the variation is discrete (discontinuous) or strongly bimodal or polymodal. (wikipedia.org)
The significance of geographical variation is that it may lead to allopatric speciation, whereas true polymorphism takes place in panmictic populations. (wikipedia.org)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)

Also, because most human populations have migrated many times throughout their history and mixed with nearby groups, ethnicity estimates based on genetic testing may differ from an individual's expectations. (medlineplus.gov)
On a larger scale, combined genetic ancestry test results from many people can be used by scientists to explore the history of populations as they arose, migrated, and mixed with other groups. (medlineplus.gov)
The genetic diversity in KLNP was low and exhibited a higher degree of genetic differentiation compared with major Indian populations. (nature.com)
Understanding the genetic variables that influence the dynamics of evolution of pathogen resistant populations is a critical step in ensuring the long-term usage of SDHI fungicides [ 3 ]. (tsijournals.com)

If data of Asian and European countries were used for analysis, it seems that we would observe no correlation between the ACE Ins/Del polymorphism and the prevalence of COVID-19 infection or the mortality due to COVID-19. (degruyter.com)

Neuronal nitric oxide synthase gene DNA polymorphism CA repeat Microsatellite Population study Japanese Human Heredity Short Communication Hum Hered 1997;47:58-59 Received. (karger.com)

However, this locus accounts for less than half the genetic variance. (bmj.com)
In goats belonging to the different breeds and sub breed, the genetic polymorphism at the determinant locus of blood potassium was revealed by flame spectrophotometer method. (academicjournals.org)

The FP receptor genetic polymorphism may influence the degree of IOP reduction by latanoprost in these patients. (bmj.com)

Recursion relations for mean pairwise coalescent times are used to obtain simple approximate expressions for diversity and divergence statistics for an inversion polymorphism at equilibrium under recombination and drift, and for the approach to equilibrium following the sweep of an inversion to a stable intermediate frequency. (ed.ac.uk)

In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. (wikipedia.org)
Polymorphism usually functions to retain a variety of forms in a population living in a varied environment. (wikipedia.org)
Balanced polymorphism refers to the maintenance of different phenotypes in population. (wikipedia.org)
Prion protein gene 129 Met was considered to be a risk factor for FFI in the non-Asian population, and 129 polymorphisms could modify survival duration. (bmj.com)
We therefore examined whether polymorphisms in DNA base-excision repair (BER) genes, XRCC1 G399A and OGG1 C326G, were associated with CCA risk and whether they modified the effect of smoking and alcohol drinking in the Thai population. (bmj.com)
Cholesteryl ester transfer protein (CETP) DNA polymorphisms Population study Italians Greeks Original Paper Hum. (karger.com)
The polymorphisms associated with warfarin sensitivity often differ by population and ethnic background. (medlineplus.gov)

Additionally, people who have more than one polymorphism in a gene or polymorphisms in multiple genes associated with warfarin sensitivity have a lower tolerance for the drug's effect or take even longer to clear the drug from their body. (medlineplus.gov)

Several CYP2C9 gene polymorphisms decrease the activity of the CYP2C9 enzyme and slow the body's metabolism of warfarin. (medlineplus.gov)

In this sample, there was antagonistic multiplicative interaction between MTRR G66A and MTHFR C677T polymorphisms in predicting breast cancer-specific mortality (p for interaction: 0.08). (louisville.edu)

A rare polymorphism in the gene encoding atrial natriuretic peptide (ANP) was found to be associated with decreased blood pressure. (massgeneral.org)

Genetic polymorphism in patients with early and late onset of ulcerative colitis. (physiciansweekly.com)

The aim of this study was to explore potential associations between genetic polymorphisms of HMGB1 and EGFR mutations in a cohort that included 280 patients with NSCLC, some of whom were smokers and others who never smoked. (jcancer.org)

The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer. (hindawi.com)
The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)

Objective To investigate associations of APOE and Tau gene polymorphisms with sports-related acute concussions and baseline to post-concussion neuropsychological test score changes. (bmj.com)

In this study we have typed for the 3′UTR polymorphism in a series of necropsy confirmed AD cases and age matched non-demented controls to see if we could confirm an association between this polymorphism and sporadic AD, and thus give further support for the role of this genetic variant as a risk factor in AD. (bmj.com)

Background: Emerging evidence indicates that microRNA (miRNA)-related genetic polymorphisms are strongly involved in the post-transcriptional regulation of the expression of pharmacokinetics and pharmacodynamics- related genes, therefore contributing to the genetic variability of drug response. (current-pharmaceutical-design.com)
We showed that the polymorphism was within the seed sequence of microRNA 425, making the mRNA encoding ANP relatively resistant to degradation and increasing the level of circulating ANP. (massgeneral.org)

For several years, scientists have recognised the mode of resistance at the molecular and genetic levels, as well as the existence of mutants resistant to complex II inhibitors like carboxin or flutolanil in several organisms. (tsijournals.com)

Polymorphisms in other genes, some of which have not been identified, have a smaller effect on warfarin metabolism. (medlineplus.gov)

The detection of prenatal structural anomalies should lead to further genetic evaluation so that many of these conditions can be identified before birth. (medscape.com)
Using these examples, we propose that the detection of DNA polymorphisms using resequencing data needs to account for nonallelic homologous sequences. (psu.edu)

Gene polymorphisms in key immunoregulatory molecules may contribute to the heterogeneity in outcome between individuals receiving the same immunotherapeutic treatment. (eurekaselect.com)
This review examines both genetic polymorphisms in these immunoregulatory molecules and their relationship to immunotherapeutic outcome, especially against carcinoma. (eurekaselect.com)

According to the theory of evolution, polymorphism results from evolutionary processes, as does any aspect of a species. (wikipedia.org)

The term polymorphism also refers to the occurrence of structurally and functionally more than two different types of individuals, called zooids, within the same organism. (wikipedia.org)

However, nonsignificant evidence was detected for the remaining three miRNA-related genetic polymorphisms in neither univariable analysis nor multivariable analysis. (current-pharmaceutical-design.com)
Polymorphisms in BER genes were analysed using a PCR with high-resolution melting analysis. (bmj.com)

The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer. (hindawi.com)
E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. (hindawi.com)
The present study is to explore whether E2F1 gene polymorphisms confer risk for ovarian cancer. (hindawi.com)
The Angiopoietin-2 (Ang2) gene encodes angiogenic factor, and the polymorphisms of Ang2 gene predict risk of various human diseases. (medsci.org)

Associations between seropositivity, antibody levels and genetic, non-genetic factors were determined. (ox.ac.uk)

Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. (routledge.com)

Further genetic heterogeneity of red cell phosphoglucomutase-1: a non electrophoretic polymorphism. (torvergata.it)

The polymorphisms of genes MAO-A and COMT have been described in relation to various expression or altered activity of these enzymes, their influence on cognitive functions, affective and anxiety disorders, learning disabilities, aggressive behaviour, eating disorders or gender differences. (psychiatriapolska.pl)

Additionally, we examined genes involved in nitric oxide biology (NOS2, NOS3, SLC4A1), as well as polymorphisms in the klotho (KL) gene, which has previously been associated with priapism. (duke.edu)

These preliminary findings provide no evidence for associations of the four APOE and Tau gene polymorphisms investigated with acute concussions, although the small sample size and lack of control for confounders are limitations. (bmj.com)

We concluded that G-197A polymorphism of IL-17A gene was significantly associated with the development of gastric cancer, especially intestinal-type cancer. (fujita-hu.ac.jp)

The main objective is to develop and validate the methodology to study the genetic polymorphism of Organic cation transporter (OCT1) rs622342. (pharmdinfo.com)
in this retrospective cohort study, LOX G473A polymorphism frequency was assessed in 148 women with breast cancer and 245 women without breast cancer. (bvsalud.org)

Anatomy2

Organisms3

Diseases19

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology2

Phenomena and Processes77

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups5

Health Care25

Geographicals19

SNPs13

Susceptibility12

Allele5

Gene polymorphism1

Abstract2

Genetics2

Variations5

Loci2

Functional6

GSTM13

Conclusions3

Single4

Host genetic6

Genotypes3

Sickle cell di4

Codon2

Promoter2

Malaria1

Glutathione3

GSTT11

Genomic1

Restriction3

Markers4

Variants4

Disease6

Clinical5

Variation7

Populations4

Correlation1

Microsatellite1

Locus2

Receptor1

Recombination1

Population7

Genes associated1

Enzyme1

MTHFR1

Associated with decreased1

Late onset1

Mutations1

Genotype2

Investigate1

Association1

MicroRNA2

Molecular1

Metabolism1

Detection2

Molecules2

Evolutionary1

Occurrence1

Analysis2

Risk4

Antibody1

Proteins1

Heterogeneity1

Enzymes1

Nitric1

Acute1

Significantly associated1

Study2