• symptoms
  • Methods and Results In the Department of Veterans Affairs cooperative study of amiodarone in congestive heart failure, 674 patients with New York Heart Association class II through IV symptoms and ejection fractions of ≤40% were treated with amiodarone or placebo for a median of 45 months in a randomized, double-blind, placebo-controlled protocol. (ahajournals.org)
  • Patients had, on average, struggled with symptoms for 17 years. (nytimes.com)
  • After three doses of MDMA administered under a psychiatrist's guidance, the patients reported a 56 percent decrease of severity of symptoms on average, one study found . (nytimes.com)
  • METHODS: The 'Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image: (UMPIRE)' trial is a multicenter, prospective, randomized, placebo controlled trial, designed to evaluate the effect of udenafil on myocardial ischemia and symptoms in female patients with MVA. (biomedsearch.com)
  • Typically, elderly patients with depression do not report depressed mood, but instead present with less specific symptoms such as insomnia, anorexia, and fatigue. (wikipedia.org)
  • To meet criteria for a major depressive episode, a patient must have 5 of these 9 symptoms nearly every day for at least 2 weeks. (wikipedia.org)
  • CBT based on this model attempts to reverse patients' symptoms by altering their interpretation of their symptoms and/or the behaviours they engage in as a result. (wikipedia.org)
  • Under intense stress patients with BPD may exhibit transient dissociative or paranoid symptoms. (wikipedia.org)
  • discomfort
  • For instance, cancer patients will generally tolerate an immense amount of pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache, will not. (wikipedia.org)
  • fail
  • Under conditions of high stress, borderline patients may fail to appreciate the "whole" of the situation and interpret events in catastrophic and intensely personal ways. (wikipedia.org)
  • medication
  • Around 30 to 40 per cent of patients who begin TB medication experience severe side effects, including hyperacidity, jaundice, loss of vision, vertigo and numbness in the limbs. (hindustantimes.com)
  • Patients, especially those from economically disadvantaged families, do not eat a balanced diet while on medication. (hindustantimes.com)
  • At the Ameritox lab in Greensboro, N.C., samples are used to determine if patients are taking the proper medication. (nytimes.com)
  • Both patient and health-care provider affect compliance, and a positive physician-patient relationship is the most important factor in improving compliance, The cost of prescription medication also plays a major role. (wikipedia.org)
  • Efforts to improve compliance have been aimed at simplifying medication packaging, providing effective medication reminders, improving patient education, and limiting the number of medications prescribed simultaneously. (wikipedia.org)
  • not in citation given] perhaps because people do not feel immediately threatened or, in the case of symptomless conditions such as raised cholesterol levels (hypercholesterolaemia) and raised blood pressure (systemic hypertension), feel no obvious benefits at the time of taking the medicines As patients are asymptomatic, they may not see a need to take medication. (wikipedia.org)
  • Basic demographics data like address and phone number are also recorded into the system along with the schedule of the patient for coming into Operation ASHA's centers to take their medication. (wikipedia.org)
  • When the patients come to the center to take their medication, their fingerprint is scanned along with the fingerprint of the health worker present. (wikipedia.org)
  • She then goes to the patients house to give her the medication and scan her fingerprint alongside. (wikipedia.org)
  • For example, when a patient anticipates a side effect of a medication, he/she can suffer that effect even if the "medication" is actually an inert substance. (wikipedia.org)
  • Psychologic therapies are recommended for elderly patients with depression because of this group's vulnerability to adverse effects and high rates of medical problems and medication use. (wikipedia.org)
  • Only 10 to 40 percent of depressed elderly patients are given medication. (wikipedia.org)
  • clinical trials
  • If udenafil demonstrates cardioprotective effects, it may provide a novel therapeutic option to reduce myocardial ischemia and improve cardiac function in female MVA patients.Trial registration: Clinical Trials.gov: NCT01769482 (registered on 20 November 2012). (biomedsearch.com)
  • A 2013 review found that nearly 1 out of 20 patients receiving a placebo in clinical trials for depression dropped out due to adverse events, which were believed to have been caused by the nocebo effect. (wikipedia.org)
  • often
  • There is no current research as to how often this occurs in patient dropout cases. (wikipedia.org)
  • It is often beneficial to both the client and the patient to have a balance in which the clinician asks questions and the patient also volunteers certain information. (wikipedia.org)
  • The Patient Protection and Affordable Care Act, often shortened to the Affordable Care Act (ACA) or nicknamed Obamacare, is a United States federal statute enacted by the 111th United States Congress and signed into law by President Barack Obama on March 23, 2010. (wikipedia.org)
  • Concurrent medical problems and lower functional expectations of elderly patients often obscure the degree of impairment. (wikipedia.org)
  • Patients with BPD are often characterized by intense affects, stormy relationships, and impulsive behaviors. (wikipedia.org)
  • Due to their high reactivity to environmental stimuli, patients with BPD often experience dramatic and short-lived shifts in their mood, alternating between experiences of euphoria, depression, anxiety, and nervousness. (wikipedia.org)
  • Patients with BPD often experience intolerable feelings of emptiness that they attempt to fill with impulsive and self-damaging behaviors, such as substance abuse, risky sexual behavior, uncontrolled spending, or binge eating. (wikipedia.org)
  • data
  • This data suggests that OAG patients with DM may have more retinal capillary dropout associated with their disease compared to OAG patients without DM. (arvojournals.org)
  • As each protocol was changed data forms were also revised in an effort to increase enrollment by reducing any burden of paperwork for investigators and patients. (druglibrary.org)
  • In all, 1412 patients had complete data and constituted the study population. (wiley.com)
  • If a patient drops out of the study after the third week, then this value is "carried forward" and assumed to be his or her score for the 5 missing data points. (wikipedia.org)
  • Regulators see most of the trial data, but only from early on in a drug's life, and even then they don't give this data to doctors or patients, or even to other parts of government. (wikipedia.org)
  • describe
  • Pharmacometrics can be defined as that branch of science concerned with mathematical models of biology, pharmacology, disease, and physiology used to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects. (wikipedia.org)
  • To receive the corresponding point, an article should describe the number of withdrawals and dropouts, in each of the study groups, and the underlying reasons. (wikipedia.org)
  • eligible
  • Patients were considered eligible if they were aged between 15-70 yr, ASA physical status I-III, and were scheduled for lower limb surgery under spinal anesthesia. (clinicaltrials.gov)
  • The primary feasibility outcome is patient enrollment defined as the number of patients who enroll in the study divided by the number of patients who were eligible to enroll. (clinicaltrials.gov)
  • Any adult patient with active systemic cancer diagnosed with acute ischemic stroke at the main MSKCC campus or at any of MSKCC's New York City outpatient center WCMC, NYPH/CUMC within the prior four weeks would be eligible. (clinicaltrials.gov)
  • depression
  • Underuse or misuse of antidepressants and prescribing inadequate dosages are the most common mistakes physicians make when treating elderly patients for depression. (wikipedia.org)
  • Major depression is more common in medically ill patients who are older than 70 years and hospitalized or institutionalized. (wikipedia.org)
  • time
  • Clinicians experience losses in the form of time spent on patient intakes, missed appointments prior to termination, and other diagnostic work performed. (wikipedia.org)
  • After a defined time period, the patients in the test group are assessed for health improvements in comparison with the control group. (wikipedia.org)
  • therapy
  • The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection. (actgnetwork.org)
  • In addition, patients receiving radiation therapy were then allowed to use smoked marijuana. (druglibrary.org)
  • Cognitive behaviour therapy (CBT) can reduce tinnitus distress but is not available for most patients. (diva-portal.org)
  • Background Although trials of amiodarone therapy in patients with congestive heart failure have produced discordant results with regard to effects on survival, most studies have reported a significant rise in left ventricular ejection fraction during long-term therapy. (ahajournals.org)
  • Conclusions Although amiodarone therapy resulted in a substantial increase in left ventricular ejection fraction in patients with congestive heart failure, this was not associated with clinical benefit in the population as a whole. (ahajournals.org)
  • effects
  • Ideally, any patient with side effects should be referred to a doctor. (hindustantimes.com)
  • In addition, the study aims to compare the effects, good and/or bad, of enoxaparin with those of aspirin on patients with cancer and recent stroke. (clinicaltrials.gov)
  • Cyclically, long waiting lists have shown some increased dropout effects, further exacerbating the problem. (wikipedia.org)
  • Blinding should be appropriate to the study, and is ideally double blind, wherein neither the patient nor doctor is aware of whether they are in the control or test group, eliminating any such psychological effects from the study. (wikipedia.org)
  • When trials throw up results that companies don't like, they are perfectly entitled to hide them from doctors and patients, so we only ever see a distorted picture of any drug's true effects. (wikipedia.org)
  • It has been shown that, due to the nocebo effect, warning patients about side effects of drugs can contribute to the causation of such effects, whether the drug is real or not. (wikipedia.org)
  • make
  • Studies have found that almost all patients make a decision about whether to return or not after the intake interview. (wikipedia.org)
  • chronic
  • citation needed] This may affect patient health, and affect the wider society when it causes complications from chronic diseases, formation of resistant infections, or untreated psychiatric illness. (wikipedia.org)
  • negatively
  • For example, a recently published study of 800 pain patients treated at a Veterans Affairs facility in North Carolina found that one-quarter of them tested negatively in a urine-screen test for a drug they had been prescribed, while 20 percent of patients tested positively for an illicit drug or a narcotic painkiller that was not prescribed. (nytimes.com)
  • This can lead to lower self-esteem, confidence, and thus their effectiveness which will negatively impact their delivery of treatments to other patients. (wikipedia.org)
  • studies
  • In contrast to these favorable results with amiodarone, in the recently completed randomized, double-blind, placebo-controlled trial of amiodarone in patients with CHF conducted by the Department of Veterans Affairs Cooperative Studies Program, no improvement was observed in all-cause or sudden death mortality. (ahajournals.org)
  • The Multidisciplinary Association for Psychedelic Studies , a small nonprofit created in 1985 to advocate the legal medical use of MDMA, LSD, marijuana and other banned drugs, sponsored six Phase 2 studies treating a total of 130 PTSD patients with the stimulant. (nytimes.com)
  • Currently, few studies have researched CL patient dropouts. (reviewofoptometry.com)
  • In smoking cessation studies, for example, it is routine to consider all dropouts as failures. (wikipedia.org)
  • enrollment
  • Clinical Trial Portals can include patient recruitment management applications that track actual vs projected enrollment, site recruitment plans, IRB/EC submission/approval dates, recruitment material management, outreach tactics and ROI. (wikipedia.org)
  • Questionnaires
  • The agreements, however, proved to be of limited value, so pain specialists turned to diagnostic questionnaires that were supposedly able to predict whether a patient was likely to abuse a narcotic because of factors like a family history of substance abuse. (nytimes.com)
  • important
  • As doctors try to ensure their patients do not abuse prescription drugs, they are relying more and more on sophisticated urine-screening tests to learn which drugs patients are taking and - just as important - which ones they're not. (nytimes.com)
  • Among respondents in the Asia/Pacific region, inconvenience (10%) and fear of or history of ocular infections (17.5%) were also important factors contributing to patient dropouts. (reviewofoptometry.com)
  • One of the most important problems in analyzing a clinical trial is the occurrence of the dropout. (wikipedia.org)
  • It was found that eCompliance helps to draw patients to the center by incentivizing health workers to convince patients to come and by persuading patients that in-person visits are important. (wikipedia.org)
  • However, it is also important that none of those involved in a clinical trial, whether the researcher, the subject patient or any other involved parties, should allow their own prior expectations to affect reporting of results. (wikipedia.org)
  • lower
  • This study evaluated two parallel interventions delivered in regular care: ICBT for tinnitus distress (n=293) and a low-intensity version of ICBT (n=81) for patients with lower levels of tinnitus distress. (diva-portal.org)
  • For help-seeking patients with lower distress, a low-intensity version of ICBT can be used. (diva-portal.org)
  • found
  • For example, if an illicit drug is found, he will tell patients that the use of such a drug also means they are more likely to abuse the narcotic painkiller that he is prescribing them. (nytimes.com)
  • Doctors
  • Still, doctors say they now face tough choices about what to do with patients when tests show they are not taking prescribed drugs or are mixing them with unapproved drugs or illegal ones. (nytimes.com)
  • Urine tests are by no means the first technique that doctors have used to try to better monitor how patients are using prescription narcotics. (nytimes.com)
  • Medical cannabis, or medical marijuana, is cannabis and cannabinoids that are recommended by doctors for their patients. (wikipedia.org)
  • affecting the ability of both patients and doctors to report accurately on the clinical outcome. (wikipedia.org)
  • Bad Pharma: How Drug Companies Mislead Doctors and Harm Patients is a book by the British physician and academic Ben Goldacre about the pharmaceutical industry, its relationship with the medical profession, and the extent to which it controls academic research into its own products. (wikipedia.org)
  • risk
  • Of note is the trend toward a reduction in the combined end point of hospitalizations and cardiac deaths (relative risk, 0.82 [CI, 0.65 to 1. P =.08), which was significant in patients with nonischemic etiology (relative risk, 0.56 [CI, 0.36 to 0. P =.01) and absent in the ischemic group (relative risk, 0.95). (ahajournals.org)
  • However, the recognition of that side effect may be spooking investors given the risk of dehydration and patient dropouts. (fool.com)
  • severe
  • 2 In a randomized, controlled trial of amiodarone in patients with severe CHF, there was both a survival benefit and a reduction in the number of hospitalizations for heart failure. (ahajournals.org)
  • efficacy
  • DISCUSSION: The UMPIRE trial is the first randomized controlled trial to evaluate the efficacy of udenafil in female MVA patients. (biomedsearch.com)
  • Evidence is lacking for both efficacy and safety of cannabis and cannabinoids in treating patients with HIV/AIDS or for anorexia associated with AIDS. (wikipedia.org)
  • population
  • Based on the lowest estimated prevalence of pre-eclampsia of 3% and a test sensitivity of 93% and a test specificity of 97%, then to be 90% certain that the true specificity of the patient population is no less than 95%, a sample size of 4,800 participants is required. (clinicaltrials.gov)
  • However, by restricting the analysis to a selected patient population, it does not show the practical value of the new drug. (wikipedia.org)
  • trial
  • The purpose of this Phase I/II study is to determine if a clinical trial of different blood thinners in patients with cancer and stroke is possible. (clinicaltrials.gov)
  • A year ago, Puma kicked off a 600-patient phase 3 trial that pitted oral neratinib and Roche 's ( NASDAQOTH:RHHBY ) Xeloda head to head against GlaxoSmithKline 's Tykerb and Xeloda. (fool.com)
  • A phase 2 trial combing neratinib with paclitaxel showed that patients treated with that combination outperformed patients treated with Roche's infused Herceptin and generic paclitaxel. (fool.com)
  • Using Bayesian predictive probability to determine whether neratinib would outperform Herceptin in a 300-patient trial shows neratinib would have a 79% likelihood of besting Herceptin. (fool.com)
  • Also, the per-protocol restricts the comparison of the treatments to the ideal patients, that is, those who adhered perfectly to the clinical trial instructions as stipulated in the protocol. (wikipedia.org)
  • positive
  • But such talks may have only limited success, and some patients continue to test positive for illicit drugs, said Dr. Alford, who is a professor at Boston University. (nytimes.com)
  • In HER2 positive patients, 39% of those in the neratinib arm showed no remaining evidence of the tumor, versus 23% for Herceptin. (fool.com)
  • effectiveness
  • Anecdotal reports by a few patients who had used both marijuana cigarettes and THC, rated the effectiveness of the smoked marijuana as comparable to that of the oral THC used in this study. (druglibrary.org)
  • reasons
  • Anecdotal reports suggested that reasons for the low accrual included a general objection to smoking on the part of some patients, their oncologists, or their hospitals, and some reluctance to use a drug associated with street use. (druglibrary.org)
  • Dropout reasons. (reviewofoptometry.com)
  • better
  • For example, it may be used help the patient cope with their disability by better management of rest and activity within the boundaries of the energy constraints of the disorder, and does not actively attempt to improve the patient's physical or psychological capacity. (wikipedia.org)
  • suggests
  • The substantial reduction in the combined end point of cardiac death plus hospitalizations for heart failure in the nonischemic group suggests possible benefit in these patients. (ahajournals.org)
  • treatments
  • Goldacre writes in the introduction of Bad Pharma that he aims to defend the following: Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analysed using techniques which are flawed by design, in such a way that they exaggerate the benefits of treatments. (wikipedia.org)
  • physicians
  • Describing the situation as a "murderous disaster", he makes suggestions for action by patients' groups, physicians, academics and the industry itself. (wikipedia.org)