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  • gene
  • Strategy used by Gantz and Bier (2015) to create homozygous lines of Drosophila melanogaster involving the introduction of a Cas9-, gRNA-expressing construct flanked by sequences homologous to the target gene leading to the conversion of heterozygotes to homozygotes. (igtrcn.org)
  • However the 2008 study that mapped the gene and identified it as a dominant trait noted in passing that homozygotes may have less mottling or a slightly lighter hair color. (wikipedia.org)
  • The central value he chose for the gene was the midpoint between the two opposing homozygotes at the one locus. (wikipedia.org)
  • variant
  • We describe six homozygotes for the G20210A variant, among which the first pair of siblings (cases n. 3 and 4) reported so far that displayed a strongly heterogeneous clinical outcome. (biomedcentral.com)
  • Finally, cases n. 4 and 6 identified as homozygotes for the FII G20210A variant being consanguineous of symptomatic subjects bearing the variant, did not experience any episode of venous nor arterial disease. (biomedcentral.com)
  • The clinical history of six homozygotes for the FII G20210A variant studied by our group, among which the first pair of siblings described so far, indicates that the clinical outcome of these subjects is strongly heterogeneous, and that both trigger and protective factors may be involved. (biomedcentral.com)
  • Laboratory revealed she was homozygote for FII G20210A, with a normal activity of ATIII, PC and PS, the absence of the Factor V Leiden (FVL) and methylenetetrahydrofolate reductase (MTHFR) C677T variant and the absence of antiphospholipid syndrome. (biomedcentral.com)
  • protein
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • Whereas l7Rn6 mRNA levels were indistinguishable from wild type, l7Rn6 4234SB homozygotes exhibited decreased expression of the truncated protein, suggesting protein instability. (genetics.org)
  • white
  • Homozygotes Bl/Bl are white with a faint bluish gray tinge, and blue in feathers with the form of large irregular shaped blobs. (wikipedia.org)
  • Although homozygotes I/I have always a solid white plumage color, heterozygous I/i+ chicks are generally black spotted, while the presence of black or partially black feathers on a whitish adult plumage is very common. (wikipedia.org)