• 1] "Construction and properties of Escherichia coli mutants defective in two genes encoding homologous membrane proteins with putative roles in anaerobic C4-dicarboxylic acid transport. (tcdb.org)
  • Many bioY genes are located at loci encoding biotin biosynthesis or are unlinked to either biotin synthesis or other biotin transport genes. (tcdb.org)
  • They included genes coding for proteins with domains homologous to calcium transporters, casein kinase II, UBC13, AMSH, Vps23p, and Vps27p of Saccharomyces cerevisiae. (duke.edu)
  • Analysis of the blue coral transcriptome revealed enrichment of genes involved in stress response, including heat-shock proteins and antioxidants, as well as genes participating in signal transduction and stimulus response. (nature.com)
  • LKB1 is homologous to the Par-4 polarity genes in C. elegans and D. melanogaster. (nih.gov)
  • In humans, the CRYAA gene encodes a 173 amino acid residue protein by single copy genes located on chromosome 21. (molvis.org)
  • The most relevant eleven candidate genes for layer-specific angle modification include those homologous to genes controlling leaf angle in rice and maize or genes associated with cell size/expansion, shape, and cell number. (biomedcentral.com)
  • Complexin (cx) I and II are homologous synaptic protein genes which are differentially expressed in mouse and human brain and differentially affected in schizophrenia. (ox.ac.uk)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • describe the identification of two homologous genes in the yeasts Saccharomyces cerevisiae and Pichia pastoris involved in targeting cytoplasmic proteins and organelles to the vacuole for degradation. (rupress.org)
  • The two genes are structurally and functionally homologous. (rupress.org)
  • Schekman identified three classes of genes that control different facets of the cell´s transport system, thereby providing new insights into the tightly regulated machinery that mediates vesicle transport in the cell. (bostonese.com)
  • It turned out that some of the genes Schekman had discovered in yeast coded for proteins corresponding to those Rothman identified in mammals, revealing an ancient evolutionary origin of the transport system. (bostonese.com)
  • Mutations in the CLCNKA and CLCNKB genes prevent the ClC-Ka and ClC-Kb channels from transporting chloride ions in the kidneys. (medlineplus.gov)
  • Additionally, human-mouse chimeras may determine whether proteins domains between types are homologous functionally. (unscburma.org)
  • Recent studies in yeast and animal cells suggest that these types of intracellular membrane fusion are mediated by two homologous but functionally distinct proteins, p97/Cdc48p and NSF. (wisc.edu)
  • Our results indicate that loss of Rab3-GEF results in the development of NMJs that are structurally and functionally indistinguishable from NMJs that lack the protein Rab3. (eneuro.org)
  • They are homologous with each other and, unexpectedly, with the glucose transporters of human hepatoma and rat brain cells. (ox.ac.uk)
  • The generalized transport reactions catalyzed by MFS porters are: Uniport: S (out) ⇌ S (in) Symport: S (out) + [H+ or Na+] (out) ⇌ S (in) + [H+ or Na+] (in) Antiport: S1 (out) + S2 (in) ⇌ S1 (in) + S2 (out) (S1 may be H+ or a solute) Though initially identified as sugar transporters, a function conserved from prokaryotes to mammals, the MFS family is notable for the great diversity of substrates transported by the superfamily. (wikipedia.org)
  • 2] "Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membrane transporters (DcuA and DcuB) distinct from the aerobic dicarboxylate transport system (Dct). (tcdb.org)
  • BioMNY proteins are considered to constitute tripartite biotin transporters in prokaryotes. (tcdb.org)
  • 2006 ) revealed the similarity of BioMN to homologous modules of prokaryotic transporters mediating uptake of metals, amino acids and vitamins. (tcdb.org)
  • Some transporters have a conserved transmembrane protein and two nucleotide binding proteins similar to those of ABC transporters. (tcdb.org)
  • However, unlike typical ABC transporters (E.I. Sun & M.H. Saier, unpublished results), they use small integral membrane proteins that are postulated to capture specific substrates. (tcdb.org)
  • Families 2.A.88 and 2.A.87 which are part of a superfamily, and 3.A.1.26, are homologous but function as secondary versus primary active transporters, respectively. (tcdb.org)
  • The era of proteins chimeras continues to be used as a technique to study many mechanistic, biochemical, and structural properties of ABC transporters.14-22 Chimeras generated with the exchange of homologous domains between mouse and individual P-gp may be used to investigate the structural versatility of the proteins and Ezetimibe (Zetia) probe for residues that are crucial for normal proteins function. (unscburma.org)
  • Using modeling, molecular dynamics, crystallography, functional assays, and site-directed spin labeling combined with double electron-electron resonance (DEER) spectroscopy, we present a detailed study of the transport dynamics of two bacterial oligopeptide transporters, PepTSo and PepTSt. (philipwfowler.me)
  • Our results identify several salt bridges that stabilize outward-facing conformations and we show that, for all the current structures of MFS transporters, the first two helices of each of the four inverted-topology repeat units form half of either the periplasmic or cytoplasmic gate and that these function cooperatively in a scissor-like motion to control access to the peptide binding site during transport. (philipwfowler.me)
  • Mouse P-gp (87% homologous to human P-gp) has been crystallized and several structures have been recently reported.7-9 However, while human and mouse P-gps are highly homologous, both subtle and profound functional differences between homologs have been reported. (unscburma.org)
  • Two highly homologous members of the ClC chloride channel family in both rat and human kidney. (medlineplus.gov)
  • The first structures were of the glycerol 3-phosphate/phosphate exchanger GlpT and the lactose-proton symporter LacY, which served to elucidate the overall structure of the protein family and provided initial models for understanding the MFS transport mechanism. (wikipedia.org)
  • The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-like structures harboring Arc mRNA. (lu.se)
  • For instance, analysis of proteins in the manner of displaying their structures. (projectguru.in)
  • In the meantime, the investigation results can help to annotate or refine the annotation of the proteins with known structures yet unknown or not fully understood functions. (biomedcentral.com)
  • Many biological processes are controlled by large multi-component protein assemblies, the size and complexity of which typically precludes the determination of their high-resolution structures. (lu.se)
  • Currently we are working with development of methods to determine structures of fibrillar proteins by a combination of structure modeling and X-ray fiber diffraction interference. (lu.se)
  • Previous work in this area has been on modeling the assembly structure of the type III secretion system and prediction of the high-resolution structures of homo-oligomeric proteins using limited experimental data from Nuclear Magnetic Resonance (NMR) in order to speed up the process of structure determination. (lu.se)
  • This macromolecular assembly comprises more than 20 conserved proteins that form a series of ring-like structures and a needle-shaped protrusion, which allows the transport of proteins into a host cell. (lu.se)
  • The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. (wikipedia.org)
  • 1, 4 Structurally, P-gp is typified by a four-domain architecture consisting of two cytoplasmic nucleotide-binding domains (NBDs) that bind and hydrolyze ATP and two transmembrane domains (TMDs) that recognize and transport substrates. (unscburma.org)
  • Structural homology studies confirm similar membrane transport proteins in gut epithelial cells and the gut microbiome of the host that may compete for drug substrates with the host itself for its absorbance. (biomedcentral.com)
  • Gut microbiome may competitively absorb the non-antibiotics such as phenobarbital as novel substrates due to the presence of structurally homologous transporting proteins as in enterocytes. (biomedcentral.com)
  • While one substrate of particular biological importance is often used to name the transporter or family, there may also be co-transported or leaked ions or molecules. (wikipedia.org)
  • These include water molecules or the coupling ions which energetically drive transport. (wikipedia.org)
  • Introduction For nearly 40 years, the ATP-Binding Cassette (ABC) transporter P-glycoprotein (P-gp, ABCB1, MDR1) has been extensively studied due to its ability to recognize and transport an array of structurally diverse molecules. (unscburma.org)
  • This manuscript reports data consistent with a new and unanticipated phenomenon: that Cre or its mRNA may be transmitted between tissues in the mouse and that the male reproductive tract (epididymis) appears to be the most common target of such transported molecules. (elifesciences.org)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous. (lu.se)
  • To enable the tracking of Arc molecules from individual neurons in vivo, we devised an adeno-associated virus (AAV) mediated approach to tag the N-terminal of the mouse Arc protein with a fluorescent reporter using CRISPR/Cas9 homologous independent targeted integration (HITI). (lu.se)
  • The hst loss-of-function phenotype suggests that this protein regulates the nucleocytoplasmic transport of molecules involved in several different morphogenetic pathways, as well as molecules generally required for root and shoot growth. (silverchair.com)
  • This work was done in primate parasites, and Kappe's project was to find homologous molecules in rodent malaria parasites. (the-scientist.com)
  • MAEBL is a chimera between two previously known molecules: AMA-1 (apical membrane antigen-1) and EBL (erythrocyte binding-like) protein. (the-scientist.com)
  • These molecules are transported around the cell in small packages called vesicles. (bostonese.com)
  • In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. (bvsalud.org)
  • We have determined the sequences of the arabinose-H+ and xylose-H+ membrane transport proteins of Escherichia coli. (ox.ac.uk)
  • In this article, the protein sequence of merA enzyme is studied with respect to its closely related sequences found in NCBI database, through Multiple Sequence Alignment (MSA) . (projectguru.in)
  • MSA refers to the alignment of three or more biological sequences, protein or nucleic acid of similar length. (projectguru.in)
  • It also determines the consensus sequence of the aligned sequences and reveals biological facts about proteins. (projectguru.in)
  • 1996 for mercury phytoremediation, with respect to its homologous protein sequences. (projectguru.in)
  • Computers became essential in molecular biology when protein sequences became available after Frederick Sanger determined the sequence of insulin in the early 1950s. (ind.in)
  • For example, there are methods to locate a gene within a sequence, to predict protein structure and/or function, and to cluster protein sequences into families of related sequences. (ind.in)
  • While the human (h) ETF has been studied in great detail, very little is known about the biochemical properties of the homologous protein in the model organism Saccharomyces cerevisiae (yETF). (elsevierpure.com)
  • The major facilitator superfamily (MFS) is a superfamily of membrane transport proteins that facilitate movement of small solutes across cell membranes in response to chemiosmotic gradients. (wikipedia.org)
  • Investigation of UCP3 reconstituted in planar bilayer membranes revealed that it transports protons solely when activated by fatty acids (FA). (aabioetica.org)
  • Biochemical assays revealed that the BioM, N, and Y proteins form stable complexes in membranes of the heterologous host. (tcdb.org)
  • Pore forming proteins are typically the proteins that form channels in membranes. (umass.edu)
  • When studying vesicle transport in mammalian cells in the 1980s and 1990s, Rothman discovered that a protein complex enables vesicles to dock and fuse with their target membranes. (bostonese.com)
  • In the fusion process, proteins on the vesicles and target membranes bind to each other like the two sides of a zipper. (bostonese.com)
  • Some CLC channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells. (medlineplus.gov)
  • Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. (joplink.net)
  • AD is pathologically characterized by the deposition of pathogenic Aβ peptides that are derived from larger integral membrane proteins, termed β-amyloid precursor proteins (APPs). (jneurosci.org)
  • Aβ is liberated from type I integral membrane proteins, termed β-amyloid precursor proteins (APPs), by the concerted action of β-secretase (BACE1) and γ-secretase (for review, see Selkoe, 2002 ). (jneurosci.org)
  • Moreover, the evolutionary relationship of useful proteins and enzymes in bioremediation processes are identifiable across different species. (projectguru.in)
  • The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. (unl.edu)
  • In S. cerevisiae , the Cvt9 gene is a required component for the uptake of the prAPI protein into vacuoles, while the P. pastoris gene Gsa9 was identified by its role in the turnover of peroxisomal enzymes. (rupress.org)
  • Kappe didn't find the homologs (those were identified later by another group), but he uncovered something else: a paralog of the Duffy protein that his group named MAEBL, for membrane antigen-1-erythrocyte binding-like protein. (the-scientist.com)
  • The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. (lu.se)
  • In summary, the data have implications both for understanding the effects of antipsychotic medication on synaptic organization, and for synaptic protein expression studies in patients treated with the drugs. (ox.ac.uk)
  • Purification of APP-AT protein complexes and identification of the constituents by mass spectrometry revealed several previously reported APP-interacting proteins as well as proteins involved in synaptic maintenance. (jneurosci.org)
  • However, the synaptic phenotype in the rab3-GEF mutant cannot be fully explained by defective transport and loss of GEF activity. (eneuro.org)
  • These proteins aggregate at presynaptic active zones (AZs) to form the cytomatrix at the active zone (CAZ), which controls the recruitment, docking, and priming of synaptic vesicles and enhances calcium channel accumulation ( Gundelfinger and Fejtova, 2012 ). (eneuro.org)
  • Future studies will include genetic screens for mutants defective in cytokinesis in order to identify other proteins, such as those involved in regulation of cytokinesis, which may escape detection in a purely biochemical approach. (wisc.edu)
  • In a genetic screen, he identified yeast cells with defective transport machinery, giving rise to a situation resembling a poorly planned public transport system. (bostonese.com)
  • Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein]. (nih.gov)
  • UCP3's properties, similar to its excessive homology to different mitochondrial carriers, particularly to UCP2, its quick lifetime and low specificity of UCP3 antibodies , have hindered progress in understanding its organic operate and transport mechanism over many years. (aabioetica.org)
  • 2009 identified 21 families of these substrate capture proteins, each with a different specificity predicted by genome context analyses. (tcdb.org)
  • Our work was the first revelation that a "noisy" nanopore sensor could not only discriminate among homologous proteins but could maintain this sensitivity and specificity in a serum sample. (umass.edu)
  • Most of the vacuole transport machinery identified to date is involved in both selective and nonselective pathways, so the new findings help illuminate the poorly understood mechanisms that confer specificity on vacuole targeting. (rupress.org)
  • Understanding the binding specificity of a DNA binding protein is helpful for the research of protein functions. (biomedcentral.com)
  • We are also interested in understanding how oligomerization specificity is encoded in protein sequence and structure, in particular in coiled-coils. (lu.se)
  • When evidence suggests that homologous membrane transport proteins of the ABC2 type couple transport to ATP hydrolysis using a homologue of the ABC-type ATPases, we list these proteins in the ABC superfamily. (tcdb.org)
  • periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. (unl.edu)
  • P-gp ATPase assays and photo-crosslinking with [125I]-Iodoarylazidoprazosin confirmed that transport and biochemical properties of P-gp chimeras were similar to those of wild-type P-gp, although differences in drug-binding were detected when human and mouse transmembrane domains were combined. (unscburma.org)
  • Here, we report the biochemical properties of yETF and Dld2 as well as the electron transfer reaction between the two proteins. (elsevierpure.com)
  • However, homologous proteins have been found in yeast (P38793) suggesting this protein may be involved in methionine biosynthesis, transport and/or utilisation [1]. (gzsys.org.cn)
  • Positional cloning demonstrated that HST is the Arabidopsis ortholog of the importin β-like nucleocytoplasmic transport receptors exportin 5 in mammals and MSN5 in yeast. (silverchair.com)
  • Consistent with a potential role in nucleocytoplasmic transport, we found that HST interacts with RAN1 in a yeast two-hybrid assay and that a HST-GUS fusion protein is located at the periphery of the nucleus. (silverchair.com)
  • The macromolecules transported by various karyopherins have been defined primarily by biochemical methods in yeast and mammals, and often have conserved functions in these two organisms. (silverchair.com)
  • Though there are three overlapping pathways by which cytoplasmic components are transported to the vacuole in yeast, the newly discovered gene products appear to be involved only in the selective Cvt and pexophagy pathways, not in nonselective macroautophagy. (rupress.org)
  • Randy Schekman was fascinated by how the cell organizes its transport system and in the 1970s decided to study its genetic basis by using yeast as a model system. (bostonese.com)
  • These nucleocytoplasmic transport receptors include proteins that regulate nuclear import (importins), proteins that regulate nuclear export (exportins),and proteins that import some proteins and export others. (silverchair.com)
  • Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). (eneuro.org)
  • ClC-Ka is one of several proteins that work together to regulate the movement of ions into and out of kidney cells. (medlineplus.gov)
  • Heterologous expression of the bioMNY operon and of the single bioY of the α-proteobacterium Rhodobacter capsulatus conferred biotin-transport activity on recombinant E. coli cells. (tcdb.org)
  • The HuProt microarray results showed that the signals of 343 proteins were higher in the recombinant CRYAA group than in the control group. (molvis.org)
  • OmpG specifically interacted with target proteins and with a high sensitivity. (umass.edu)
  • In addition, we found that OmpG could discriminate among eight target proteins, four avidin homologues and four antibody homologues. (umass.edu)
  • CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)
  • 2009 have a dedicated energizing module, but in 459 cases distributed among almost 100 gram-positive bacteria, different and unrelated substrate capture proteins share the same energy-coupling module. (tcdb.org)
  • Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA. (bvsalud.org)
  • Chylomicrons transport dietary TGs and cholesterol from within enterocytes through lymphatics into the circulation. (msdmanuals.com)
  • Patient-derived cells exhibited high-grade mosaic variegated aneuploidy, slowed-down proliferation, and instability of truncated p31comet mRNA and protein. (bvsalud.org)
  • Localized cx II mRNA signal was seen in the dentate gyrus molecular layer, suggestive of its transport into granule cell dendrites. (ox.ac.uk)
  • These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. (unl.edu)
  • After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)
  • The uptake of a sugar across the boundary membrane is a primary event in the nutrition of most cells, but the hydrophobic nature of the transport proteins involved makes them difficult to characterize. (ox.ac.uk)
  • The purpose of multiple sequence alignment is to characterize protein families. (projectguru.in)
  • Here, we characterize RRG-1, a response regulator protein from the filamentous fungus Neurospora crassa . (llu.edu)
  • Currently, we are using these cells to identify and to characterize the transport of several soluble and membrane secretory proteins to the plate. (wisc.edu)
  • Membrane uncoupling protein 3 (UCP3), a member of the mitochondrial uncoupling protein household, was found in 1997. (aabioetica.org)
  • In view of the absence of client dehydrogenases, for example, the acyl-CoA dehydrogenases involved in the β-oxidation of fatty acids, d-lactate dehydrogenase 2 (Dld2) appeared to be the only relevant enzyme that is serviced by yETF for electron transfer to the mitochondrial electron transport chain. (elsevierpure.com)
  • Truncated BID (tBID), a proapoptotic BCL2 family protein, induces BAK/BAX-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. (nih.gov)
  • Possibly, these two transmembrane proteins comprise the pathway for transmembrane transport. (tcdb.org)
  • Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. (lbl.gov)
  • Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. (lbl.gov)
  • Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. (lbl.gov)
  • Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. (lbl.gov)
  • The addition of an affinity tag allowed us to avoid the use of antibodies targeted toward the intracellular C-terminal tail of APP, a region to which a number of reported interacting proteins bind ( King and Turner, 2004 ). (jneurosci.org)
  • The fact that there are many such proteins and that they bind only in specific combinations ensures that cargo is delivered to a precise location. (bostonese.com)
  • This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
  • Injected intravenously into adult Xenopus females, the protein-DNA complex is rapidly transported through the bloodstream and, within the ovary, the vitellogenin ligand present in the protein binds to the receptors at the surface of the oocytes. (biologists.com)
  • A small high affinity ligand, biotin, was covalently attached to loop 6 of OmpG and used to capture biotin-binding proteins. (umass.edu)
  • One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
  • The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)
  • Search proteins in UniProtKB for this molecule. (rhea-db.org)
  • They have several roles ranging from molecule transport to triggering the death of a cell. (umass.edu)
  • All four proteins share similarities with the E. coli citrate transporter. (ox.ac.uk)
  • There is little apparent homology with the lactose-H+ (LacY) or melibiose-Na+ (MelB) transport proteins of E. coli. (ox.ac.uk)
  • This work focuses on two E. coli pore forming proteins that have vastly differing roles in nature. (umass.edu)
  • The MFS family was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drugs, metabolites, oligosaccharides, amino acids and oxyanions were all transported by MFS family members. (wikipedia.org)
  • BioMNY-mediated biotin uptake was severely impaired by replacement of the Walker A lysine residue of BioM, demonstrating dependency of high-affinity transport on a functional ATPase. (tcdb.org)
  • Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. (joplink.net)
  • Biochemical and morphological studies demonstrate that the selective uptake of peroxisomes into the vacuole for degradation requires Cvt9 or Gsa9, but nonselective macroautophagy induced by nitrogen starvation does not require either protein. (rupress.org)
  • This short learning module is about homologous proteins: Proteins of different species that fulfill the same function. (ru.nl)
  • By proximity ligation assay (PLA), we demonstrated that the mCherry-Arc fusion protein retains the Arc function by interacting with the transmembrane protein stargazin in postsynaptic spines. (lu.se)
  • A total of five proteins were selected for analysis based on their similarity to a known citrate exporter, but neither a citrate transport activity nor any other phenotypic function could be attributed to them. (rhea-db.org)
  • The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, O27901. (gzsys.org.cn)
  • To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
  • It has been proposed that one function of IRBP may be to transport retinoids between the retinal pigment epithelium and the photoreceptors. (residencypersonalstatementhelp.com)
  • In an attempt to understand the function of APP, in vitro studies have focused on the identification of interacting proteins. (jneurosci.org)
  • Here, we show that APP can coimmunoprecipitate NEEP21 from nontransgenic mouse brain and from mammalian cells stably coexpressing both proteins. (jneurosci.org)
  • https://doi.org/10.1128/JB.186.19.6595-6604.2004 Motility responses triggered by changes in the electron transport system are collectively known as energy taxis. (llu.edu)
  • Derived by automated computational analysis using gene prediction method: Protein Homology. (string-db.org)
  • The tyrosinase protein target was selected through homology modeling. (genominfo.org)
  • These proteins energetically drive transport utilizing the electrochemical gradient of the target substrate (uniporter), or act as a cotransporter where transport is coupled to the movement of a second substrate. (wikipedia.org)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • The structural diversity of sPLA 2 -BPs reveals sPLA 2 s as very promiscuous proteins, and we offer some structural explanations for this nature that makes these proteins evolutionarily highly advantageous. (ijbs.com)
  • Since many of these gene products are homologous to the proteins involved in vesicle transport, sterility caused by inactivation of ste12 may be due to a disordered vesicle transport system. (duke.edu)
  • Our goal is to use high-resolution structural modeling techniques guided by constraints taken from lower resolution experimental data to generate structural models of important biological protein assemblies for which high resolution structural determination is unfeasible. (lu.se)
  • The identified proteins were subjected to subsequent bioinformatics analysis using the DAVID database. (molvis.org)
  • Protein-DNA interactions are essential for many biological processes. (biomedcentral.com)
  • DNA binding proteins can be classified into double-stranded DNA binding proteins (DSBs) and single-stranded DNA binding proteins (SSBs), and they take part in different biological functions. (biomedcentral.com)
  • The two halves of the protein pack against each other in a clam-shell fashion, sealing via interactions at the ends of the transmembrane helices and extracellular loops. (wikipedia.org)
  • IRBP is an extracellular protein localized to the subretinal space. (residencypersonalstatementhelp.com)
  • The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)
  • The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helices (TMH), with two 6- (or 7- ) helix bundles formed by the N and C terminal homologous domains of the transporter which are connected by an extended cytoplasmic loop. (wikipedia.org)
  • Nuclear transport of protein TTC4 depends on the cell cycle. (nih.gov)
  • Functional annotation clustering showed that they belong to cell cycle, organelle or nuclear lumen, protein transport, and DNA binding and repair clusters. (molvis.org)
  • Genetic studies will help to verify the in vivo role of proteins, identified through biochemical means in cell plate biogenesis. (wisc.edu)
  • To investigate the APP in vivo interactome in an unbiased manner, we generated mice that harbor a mouse prion protein promoter-driven cDNA encoding human APP-695 fused to a C-terminal affinity tag. (jneurosci.org)
  • Thus, this study demonstrates that using proteomic methods on our transgenic model can uncover important in vivo APP-interacting proteins that will provide insights into the biology of APP. (jneurosci.org)
  • Thus, this study demonstrates that our transgenic model can uncover important in vivo APP-interacting proteins that will contribute to our understanding of APP processing in in vivo settings. (jneurosci.org)
  • We have previously reported the identification and characterization of an LKB1-specific adaptor protein, STRAD, which activates LKB1 and translocates it from nucleus to cytoplasm. (nih.gov)
  • May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. (joplink.net)
  • Calcium ions were known to be involved in this process and in the 1990s, Südhof searched for calcium sensitive proteins in nerve cells. (bostonese.com)
  • Three areas of physiological engagement of sPLA 2 -BPs have appeared most clearly: cellular transport and signalling, and regulation of the enzymatic activity of sPLA 2 s. (ijbs.com)
  • The newly developed oocyte shuttle protein contains a streptavidin moiety that tightly binds biotinylated DNA. (biologists.com)