Protein StabilitySaltsAnionsEnzyme StabilityThermodynamicsPerchloratesDrug StabilityIonsModels, ChemicalProtein FoldingProtein DenaturationIodine CompoundsProteinsThiocyanatesSolutionsCircular DichroismStatic ElectricityModels, MolecularOsmolar ConcentrationElectrolytesProtein ConformationWaterTemperaturePhase TransitionHydrocarbonsKineticsRNA StabilitySolubilityMutationSulfatesMolecular Sequence DataAmino Acid SequenceHydrogen-Ion ConcentrationSodium ChlorideUbiquitinationProtein Structure, TertiaryProteasome Endopeptidase ComplexBiophysicsProteolysisProtein Structure, SecondaryProtein BindingUbiquitinGuanidinePotassium ChlorideProtein EngineeringAmino Acid SubstitutionMolecular StructureMutagenesis, Site-DirectedProtein UnfoldingCell LineUbiquitin-Protein LigasesPeptidesCalorimetry, Differential ScanningHot TemperatureHalf-LifeProtein Processing, Post-TranslationalUreaHEK293 CellsHydrogen BondingRNA, MessengerMuramidaseSolventsBase SequencePhosphorylationBinding SitesRecombinant ProteinsEscherichia coliTransition TemperatureMutation, MissenseStructure-Activity RelationshipCell Line, TumorMutant ProteinsAmino Acid MotifsNuclear ProteinsTranscription, GeneticDNA-Binding ProteinsHydrophobic and Hydrophilic InteractionsTranscription FactorsRecombinant Fusion ProteinsLeupeptinsSpectrometry, FluorescenceCrystallography, X-RayGene Expression RegulationBacterial ProteinsSignal TransductionComputer SimulationTumor Suppressor Protein p53Models, BiologicalProto-Oncogene Proteins c-mdm2HeLa CellsCOS CellsSequence AlignmentTransfectionSequence Homology, Amino AcidAmino AcidsPoint MutationProteasome InhibitorsLysineProtein Structure, QuaternarySumoylation