• B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
  • the remaining 10% are T-cell, mantle cell, Burkitt, or indolent B-cell lymphomas. (medscape.com)
  • Non-Hodgkin lymphoma is the 2nd most common cancer in HIV-infected patients Неходжкінські лімфоми AIDS-defining cancers in patients infected with HIV are Kaposi sarcoma Lymphoma, Burkitt (or equivalent term) Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of central nervous system прочитати більше , and some AIDS patients present with lymphoma. (msdmanuals.com)
  • Ultimately, however, anaplastic large cell lymphoma (ALCL) was diagnosed. (cancernetwork.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • In 1988, ALCL was added as a distinct entity to the revised Kiel classification, and in 1994, it was included in the Revised European-American Lymphoma (REAL) classification. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • Histologically, ALCL is characterized by sheets of large pleomorphic cells with abundant cytoplasm, horseshoe- or wreath-shaped nuclei, and multiple prominent nucleoli. (medscape.com)
  • GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)
  • Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
  • ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)
  • In order to assess whether additional granzymes might be important in promoting cell death in ALK+ ALCL, we examined whether other human granzymes were expressed in ALK+ ALCL cell lines using reverse-transcriptase PCR and western blotting. (biomedcentral.com)
  • Expression of several GzB shRNAs in multiple ALK+ ALCL cell lines resulted in a significant decrease in GzB levels and activity. (biomedcentral.com)
  • While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
  • Furthermore, we found that GzB is the only granzyme that is expressed at significant levels in ALK+ ALCL cell lines. (biomedcentral.com)
  • Our findings are the first to demonstrate that GzB expression sensitizes ALK+ ALCL cell lines to drug-induced apoptosis. (biomedcentral.com)
  • It was beginning approved in 2011 for Hodgkin's lymphoma patients in delinquency of autologous go stall relocate or two premature multi-agent chemotherapy regimens and patients with systemic anaplastic large-cell lymphoma (ALCL). (piwip.com)
  • The Non-Hodgkin's lymphomas (NHL) comprise a diverse collection of lymphoreticular neoplasms, usually but not necessarily arising in nodal tissue. (oncolink.org)
  • Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)
  • These neoplasms usually originate in lymph nodes or lymphatic tissue in other sites (extranodal lymphoma), and can be localized or widespread at the time of diagnosis. (mhmedical.com)
  • The term non-Hodgkin lymphoma (NHL) encompasses a heterogeneous mix of lymphomas, which are either of a B- or T-cell phenotype and that meet the diagnostic criteria for one of the subtypes detailed in the 2008 World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues. (medscape.com)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
  • This new paradigm has led to the current risk-adapted, response-based approach to the treatment of Hodgkin lymphoma (see Treatment). (medscape.com)
  • Immune checkpoint inhibitors have also been approved for treatment of Hodgkin lymphoma [ 24 ]. (biomedcentral.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • Primary NHL of bone (primary bone lymphoma) is a rare condition, accounting for less than 1-2% of adult NHL and less than 7-10% primary bone tumors. (medscape.com)
  • MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
  • Incidence of primary large bowel lymphomas comprises only 0.2-0.6% of large bowel malignant tumors ( 3 ). (frontiersin.org)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • They play a major role in defending the host from both tumors and virally infected cells. (newworldencyclopedia.org)
  • PCNSL occurs at an incidence of 0.47 per 100,000 person-years, accounting for 4%-6% of extranodal lymphomas and 4% of newly diagnosed CNS tumors. (medscape.com)
  • Although the cells of origin are lymphocytes, PCNSL should be considered a brain tumor, because the therapeutic challenges resemble those of other brain tumors. (medscape.com)
  • Загальні відомості про лімфоми Lymphomas are a heterogeneous group of tumors arising in the reticuloendothelial and lymphatic systems. (msdmanuals.com)
  • Brentuximab vedotin (trade name: Adcetris, marketed by Seattle Genetics and Millennium/Takeda) [11] was approved for relapsed HL and relapsed systemic anaplastic large-cell lymphoma (sALCL)) by the FDA on August 19, 2011 and received conditional marketing authorization from the European Medicines Agency in October 2012. (wikipedia.org)
  • Veelken HWood GSSklar J Molecular staging of cutaneous T-cell lymphoma: evidence for systemic involvement in early disease. (jamanetwork.com)
  • 2. Clinical epidemiology - using data from the Swedish Lymphoma Registry to provide clinically useful real world data on treatment and prognosis, in many cases in collaboration with Nordic colleagues. (lu.se)
  • Dr. Pinnix's ultimate aspiration is to advance the clinical outcomes of patients afflicted with Hodgkin's and Non-Hodgkin's lymphoma via the minimization of normal tissue toxicity related to radiotherapy. (mdanderson.org)
  • The FDA expanded the warnings for brentuximab vedotin (Adcetris) in Hodgkin's lymphoma to merge untreated mount III/IV complaint, to be adapted to in mosaic with doxorubicin, vinblastine, and dacarbazine (AVD), drugmaker Seattle Genetics heralded. (piwip.com)
  • Today's advise sanction puts an change for the more safely a improved in the initial treatment regimens of go Hodgkin's lymphoma that were indicated into clinical responsibility more than 40 years ago," articulate Richard Pazdur, MD, first of the FDA's Oncology Center of Eminence and thing overseer of the workings's Intermediation of Hematology and Oncology Commodities, in a allegation. (piwip.com)
  • The viewpoint III experimental randomized 1,334 true Hodgkin's lymphoma patients with stage-manage III or IV ailment to either brentuximab vedotin with the summing-up of AVD or doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). (piwip.com)
  • nodular lymphocyte predominant and classic Hodgkin's lymphoma. (wikidoc.org)
  • According to the Ann Arbor Staging System with Cotswolds modifications, there are 4 stages of Hodgkin's Lymphoma based on clinical features gathered from history and physical examination, and findings on positron emission tomography / computed tomography (PET/ CT ) scan of the chest , abdomen , and pelvis . (wikidoc.org)
  • Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell Non-Hodgkin's Lymphoma (B-NHL). (wikidoc.org)
  • Martí-Carvajal AJ, Cardona AF, Lawrence A. Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma. (medscape.com)
  • Vitamin D insufficiency and prognosis in non-Hodgkin's lymphoma. (medscape.com)
  • Lymphoma commonly is categorized broadly as Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL, all other types of lymphoma). (newworldencyclopedia.org)
  • In the nineteenth and twentieth centuries, the affliction was called simply Hodgkin's Disease, as it was discovered by Thomas Hodgkin in 1832. (newworldencyclopedia.org)
  • Hodgkin's lymphoma accounts for less than one percent of all cases of cancer in the United States. (newworldencyclopedia.org)
  • Pan LXDiss TCPeng HZNorton AJIsaacson PG Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? (jamanetwork.com)
  • In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) frequently express CD19, CD20 and CD22 on the cell surfaces. (biomedcentral.com)
  • Several antibody-drug conjugates (ADC) have been approved for clinical use (gemtuzumab ozogamicin in acute myeloid leukemia and brentuximab vedotin in Hodgkin lymphoma as well as CD30+ anaplastic large cell lymphoma). (biomedcentral.com)
  • The European Commission approved Inotuzumab ozogamicin [14] as a monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) on June 30, 2017 under the trade name Besponsa® (Pfizer/Wyeth), [15] followed on August 17, 2017 by the FDA. (wikipedia.org)
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
  • Although most lymphomas arise without an evident cause, human T-cell leukemia/lymphoma virus I (HTLV-1), Epstein-Barr virus, hepatitis C virus , and human herpes virus-8 infections, as well as infections with the bacteria Helicobacter pylori and, perhaps, Chlamydophila psittaci , either are established as causal (e.g. (mhmedical.com)
  • Загальні відомості про лейкоз Leukemia is a malignant condition involving the excess production of immature or abnormal leukocytes, which eventually suppresses the production of normal blood cells and results in symptoms. (msdmanuals.com)
  • 9] The radiologic differential diagnosis includes benign entities (reactive conditions, osteomyelitis) and malignant entities (Hodgkin lymphoma, sarcoma, neuroblastoma, metastatic disease). (medscape.com)
  • Lymphoid proliferations are traditionally thought to be either benign conditions (reactive hyperplasia and lymphadenitis) or malignant lymphomas. (medscape.com)
  • Distinction between atypical lymphoid proliferations rich in Reed-Sternberg-like cells (reactive immunoblasts) and classic Hodgkin lymphomas. (medscape.com)
  • CD30 positivity may also be observed in large cell transformation in MF, Hodgkin lymphoma, and other reactive disorders. (aad.org)
  • absence/loss of pan B-cell and pan T-cell antigens), reactive cell population of other lineage, aberrant antigen expression, gene rearrangement studies, lineage infidelity, dual clones, and composite lymphomas. (aad.org)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • Laboratory tests showed leukocytosis (20.79 × 10 9 /L), moderate anemia (69 g/L), increased percent of neutrophils (91.6%), increased C-reactive protein (CRP) (80.90 mg/L), procalcitonin (PCT) (5.87 ng/ml) and erythrocyte sedimentation rate (ESR) (106.0 mm/h) level, and mild hypoalbuminemia (31.0 g/L). Stool routine revealed Leukocyte ++++/HP, pus cell ++++/HP, stool blood was positive. (frontiersin.org)
  • Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed-Sternberg cells set in a background of reactive lymphocytes , eosinophils , and plasma cells with varying degrees of collagen fibrosis / sclerosis . (wikidoc.org)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • However, if clinical, morphologic and molecular findings are not sufficient for diagnosis of a benign condition versus lymphoma, the descriptive term AtLP can be used. (medscape.com)
  • Her clinical and research interests lie in improving the outcomes of patients with lymphoma. (mdanderson.org)
  • Immunotherapeutic agents including antibodies and chimeric antigen receptor T cells are widely studied in clinical trials. (biomedcentral.com)
  • The new regimen overhaulings on the standard of guardianship while outing for the complete winsome away of bleomycin, "an minister that can well-spring unpredictable and again fatal lung toxicity," foreshadowed Joseph M. Connors, MD, clinical big cheese at the Center for Lymphoid Cancer at BC Cancer in Vancouver, British Columbia, in Seattle Genetics' video receiver release. (piwip.com)
  • Computed tomography-based tumor volume in non-Hodgkin lymphoma: clinical correlation and comparison with magnetic resonance imaging. (medscape.com)
  • [ 4 ] Clinical outcomes differ by histologic subtype with 5-year overall survival rates ranging from 30% in DLBCL to 79% in marginal zone lymphoma. (medscape.com)
  • Since the clinical and neuroimaging presentation of PCNSL can be varied and the differential diagnostic possibilities are therefore large, no patient should be treated for PCNSL without definitive cytologic proof of diagnosis, either by vitrectomy, CSF sampling, or brain biopsy. (medscape.com)
  • Chhanabhai MAdomat SAGascoyne RDHorsman DE Clinical utility of heteroduplex analysis of TCR gamma gene rearrangements in the diagnosis of T-cell lymphoproliferative disorders. (jamanetwork.com)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • Among the changes to CTCL classification were the addition of primary cutaneous acral CD8 + T-cell lymphoma as a new provisional entity. (medscape.com)
  • Primary cutaneous gamma/delta T-cell lymphoma with simultaneous JAK2 and TP63 rearrangements: a new double-hit? (elsevierpure.com)
  • Primary non-Hodgkin lymphoma (NHL) of bone can be a difficult to diagnosis without a high level of suspicion. (medscape.com)
  • Anemia and/or elevated lactate dehydrogenase (LDH), alkaline phosphatase (ALP), erythrocyte sedimentation rates (ESRs), platelet counts, and calcium levels have been reported with primary non-Hodgkin lymphoma (NHL) of bone. (medscape.com)
  • Grossly the lesions of primary non-Hodgkin lymphoma (NHL) of bone are usually yellow-tan and fleshy in appearance. (medscape.com)
  • According to the World Health Organization (WHO), CD30+ LPD include primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions. (aad.org)
  • Extranodal NK/T cell lymphoma is a rare non-Hodgkin lymphoma mainly involving the upper aerodigestive tract, even rarer is primary extranasal disease involving the intestine. (frontiersin.org)
  • We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations. (frontiersin.org)
  • Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
  • Primary CNS lymphoma in children and adolescents: a descriptive analysis from the international primary CNS lymphoma collaborative group (IPCG). (medscape.com)
  • The DLBCL type of primary central nervous system lymphoma (PCNSL) is composed of immunoblasts or centroblasts that have a predilection for blood vessels and thus demonstrate a typical angiocentric growth pattern. (medscape.com)
  • Utility of microdissection and polymerase chain reaction for the detection of immunoglobulin gene rearrangement and translocation in primary intraocular lymphoma. (jamanetwork.com)
  • It is a unique neoplasm in which the malignant cell, the Reed-Sternberg cell (RSC), represents only a small proportion of cells constituting the bulk of the tumor. (medscape.com)
  • PCNSL is now known to be a form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type. (medscape.com)
  • A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
  • INO has been approved for treatment of relapsed /refractory B cell precursor ALL. (biomedcentral.com)
  • Rare cases of precursor B-LL involving orbital mass and plasmablastic lymphoma involving paranasal sinuses were studied. (ijmpo.org)
  • This type is most often associated with Epstein-Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma. (wikidoc.org)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • The diagnosis and differential diagnosis of 'small' B cell lymphomas. (llu.edu)
  • It cannot be overemphasized that the presence of CD30+ cells does not equate with neoplasia, in the same way that clonality does not confer the diagnosis of cancer. (aad.org)
  • The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
  • Fine-needle aspirate is sufficient for lymphoma diagnosis but rarely adequate for subtyping, thus excisional or incisional biopsy is considered mandatory[5]. (oncolink.org)
  • Bottaro MBerti EBiondi AMigone NCrosti L Heteroduplex analysis of T-cell receptor gamma gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. (jamanetwork.com)
  • A bone marrow smear was performed, in which 'cerebriform' cells were identified, confirming the diagnosis of Sézary syndrome. (bvsalud.org)
  • For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
  • Extranodal NK/T cell lymphoma nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma (NHL). (frontiersin.org)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • REAL/WHO- [6] - classification includes leukemias and lymphomas, with 3 categories based on lineage and morphology (Hodgkin, B cell, and T/NK cell). (oncolink.org)
  • Scientific classification of the types of lymphoma is more detailed. (newworldencyclopedia.org)
  • The WHO Classification , published by the World Health Organization in 2001, is the latest classification of lymphoma (Sarkin 2001). (newworldencyclopedia.org)
  • This classification attempts to classify lymphomas by cell type (i.e. the normal cell type that most closely resembles the tumor). (newworldencyclopedia.org)
  • Classification systems have considered the likely lymphoid progenitor that corresponds to the phenotype (immunotype) and genotype of the malignant cells in the transformed clone. (mhmedical.com)
  • Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
  • [1] Unlike chemotherapy , ADCs are intended to target and kill tumor cells while sparing healthy cells. (wikipedia.org)
  • An anticancer drug is coupled to an antibody that targets a specific tumor antigen (or protein ) that, ideally, is only found in or on tumor cells. (wikipedia.org)
  • The various types have little similarity to each other, and are categorized by the World Health Organization according to cell origin (B cell, T cell/NK cell). (oncolink.org)
  • The antibody is useful for studying the phenomenon of cell death by apoptosis as a pathogenic mechanism of numerous pathologies: nerve damage, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, AIDS and malignancies. (samatashkhis.com)
  • Most of these malignancies are of B-cell origin. (oncolink.org)
  • Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study. (medscape.com)
  • Lymphomas are a heterogeneous group of malignancies that originate from neoplastic transformation of lymphocytes that have undergone mutations that confer growth and survival advantages compared to their normal cellular counterparts. (mhmedical.com)
  • Sixty percent of cases express 1 or more T-cell antigens (CD3 + , CD43, or CD45RO). (medscape.com)
  • CD20, CD22, and CD30 are also targeted antigens of CAR T cells in ALL and lymphoma trials [ 26 ]. (biomedcentral.com)
  • Antibodies attach themselves to the antigens on the surface of cancerous cells. (wikipedia.org)
  • Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the spleen, the liver, and the gastrointestinal tract. (msdmanuals.com)
  • Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
  • Lymphoma is any of a diverse group of cancers that originate in lymphocytes of the lymphatic system , a secondary (but open) circulatory system in vertebrates . (newworldencyclopedia.org)
  • It is those cancers that originate in the lymphatic system that are referred to as lymphomas. (newworldencyclopedia.org)
  • But cancers can also originate outside the lymphatic system and then make their way into lymphoid tissues and glands. (newworldencyclopedia.org)
  • Non-Hodgkin lymphoma is not one disease but rather a category of lymphocyte cancers with a number of subgroups largely divided into aggressive and indolent types. (msdmanuals.com)
  • Because the lymphatic system is part of the body's immune system , patients with weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma. (newworldencyclopedia.org)
  • HTLV-1) or have very strong associations with lymphoma incidence (hepatitis C virus) , suggesting their role in causation. (mhmedical.com)
  • Several occupational and industrial exposures are suspected of being related to lymphoma incidence, for example, organochlorines, phenoxyacid herbicides, and others, but these associations have not been established with scientific certainty. (mhmedical.com)
  • Formally known as Hodgkin disease, Hodgkin lymphoma (HL) is a highly curable malignancy. (medscape.com)
  • See also the Medscape Reference topic Hodgkin Disease . (medscape.com)
  • The nature of disease (indolent vs. aggressive) is correlated to the stage of lymphocytic differentiation of the malignant cells. (oncolink.org)
  • Hodgkin disease (C81. (who.int)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • Ironically, the lymphatic system is fundamentally important for combating cancer cells-as well as foreign bodies, such as viruses and bacteria , and combating heart disease and arthritis as well. (newworldencyclopedia.org)
  • The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
  • Granzyme B (GzB) is a serine protease found in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biomedcentral.com)
  • It is an invasive lymphoma derived from NK cells or cytotoxic T cells, which is related to Epstein-Barr virus infection. (frontiersin.org)
  • Corticosteroids have a cytotoxic effect on lymphoma cells and can induce a radiographic response in up to half of patients, which limits the sensitivity of diagnostic tools like biopsy or lumbar puncture. (medscape.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • These fi ndings suggest that in human lymphoid tissues, blood cells, and lymphomas the lymphoid system plays a role in MCPyV infection and ( 17 - 20 ). (cdc.gov)
  • Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • Germinal-center B-cells undergo clonal expansion and activate the process of somatic hypermutation that introduces mutations at a high rate into rearranged immunoglobulin variable genes. (medscape.com)
  • In EBV-positive Hodgkin lymphoma, EBV-encoding genes play a role in preventing apoptosis. (medscape.com)
  • green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells. (newworldencyclopedia.org)
  • Langerak AWScczepanski Tvan der Burg MWolvers-Tettero ILvan Dongen JJ Heteroduplex PCR analysis of rearranged T-cell receptor genes for clonality assessment in suspect T-cell proliferations. (jamanetwork.com)
  • In the author's opinion, when confronted with a challenging lymphoproliferative lesion, the pathologist should marshall all resources available to interpret it as precisely as possible and therefore place it into one of the two categories: unequivocally benign condition or malignant lymphomas. (medscape.com)
  • I'll wager that most readers of DWI&I have experienced receiving a biopsy report, obtained from an inflammatory lesion, stating "scattered CD30+ cells were observed," accompanied by a comment that "clinicopathologic correlation is necessary to rule out the possibility of a lymphoproliferative disorder. (aad.org)
  • Another interest lies in the identification of improved treatment strategies that incorporate radiation in the management of aggressive and refractory lymphomas. (mdanderson.org)
  • Multiple ongoing trials are evaluating its role in the relapsed /refractory B cell NHL. (biomedcentral.com)
  • The cure rate for children and adolescents with Hodgkin lymphoma has steadily improved over the years, particularly with the introduction of combined radiation and multiagent chemotherapy. (medscape.com)
  • At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)
  • The proliferation of names reflects initial uncertainty about the cell of origin. (medscape.com)
  • Hodgkin lymphoma (HL) is a malignancy of the germinal-center B cells that affects the reticuloendothelial and lymphatic systems. (medscape.com)
  • Germinal-center B-cells with unfavorable mutations are functionally crippled and undergo programmed cell death (apoptosis). (medscape.com)
  • This may be secondary to a germinal center origin or attributable to increased apoptosis via induction of bax and/or enhanced T-cell interaction, resulting in improved autologous tumor response. (aacrjournals.org)
  • The constitutive translocation of NF-κB to the nucleus of Hodgkin lymphoma RSCs is essential for the malignant transformation of the RSCs. (medscape.com)
  • In the author's opinion, the use of this descriptive term AtLP may obviate the need to force some lymphoid proliferations (equivocal lesions or mimickers of lymphomas) into either the benign or malignant categories. (medscape.com)
  • HL-RSC carry clonal immunoglobulin gene rearrangements, which establishes their clonality and their B cell origin. (medscape.com)
  • In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)
  • AtLP is a descriptive term used when it is not possible for the pathologist to differentiate between the benign and the malignant nature of a given lymphoid infiltrate. (medscape.com)
  • They have some likelihood for subsequent transformation into lymphomas, and therefore AtLP occupy a middle ground between benign and malignant lymphoid proliferations. (medscape.com)
  • Scheller UMuche JMSterry WLukowsky A Detection of clonal T cells in cutaneous T-cell lymphoma by polymerase chain reaction: comparison of mutation detection enhancement-polyacrylamide gel electrophoresis, temperature gradient gel electrophoresis and fragment analysis of sequencing gels. (jamanetwork.com)
  • Tok JSzaboles MJSilvers DNZhong JMatsushima AY Detection of a clonal T-cell receptor gamma chain gene rearrangements by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE) in archival specimens from patients with early cutaneous T-cell lymphoma: correlation of histologic findings with PCR/DGGE. (jamanetwork.com)