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InfectionsTissueIncludePrimaryBlastomycosisGranulomaSarcoidosisDisease

Infections1

• The spleen most importantly protects against infections from polysaccharide-encapsulated bacteria including Streptococcus pneumoniae, Haemophilus influenzae type B, Neisseria meningitidis, Escherichia coli, Salmonella, Klebsiella, and group B Streptococci (SHiNE SKiS) 1 . (healthjade.net)

Tissue2

• The most accurate use of the term granuloma requires a pathologist to examine surgically removed and specially colored (stained) tissue under a microscope. (wikipedia.org)
• This tissue is composed of splenic nodules, which are similar to the lymphatic nodules in lymph nodes and are packed with lymphocytes (T lymphocyte cells and B lymphocyte cells). (healthjade.net)

Include1

• The major functions of the spleen include clearance of abnormal erythrocytes, removal of microorganisms and antigens as well as the synthesis of immunoglobulin G (IgG). (healthjade.net)

Primary1

• The spleen also acts as the primary reservoir for platelets and as a filter for red blood cells (RBCs), removing damaged or malformed red blood cells from the circulation. (healthjade.net)

Blastomycosis1

• Acute histoplasmosis may not need treatment or may need three months of treatment if symptomatic (itraconazole 200 mg twice daily for 3 months, as compared to 12 months with blastomycosis). (medscape.com)

Granuloma2

• The most accurate use of the term granuloma requires a pathologist to examine surgically removed and specially colored (stained) tissue under a microscope. (wikipedia.org)
• Necrosis in granulomas Granuloma without necrosis in a lymph node of a person with sarcoidosis Granuloma with central necrosis in a lung of a person with tuberculosis: Note the Langhans-type giant cells (with many nuclei arranged in a horseshoe-like pattern at the edge of the cell) around the periphery of the granuloma. (wikipedia.org)

Sarcoidosis1

• Histoplasmosis may mimic lung cancer and sarcoidosis. (medscape.com)

Disease1

• In a child whose spleen is palpable without underlying disease, the organ will be elastic, soft, porous, homogenous, nontender, and less than 2 cm inferior to the left costal margin. (medscape.com)