• Here, we report a case of ACC arising from minor salivary gland that metastasized to the colon 19 years after the primary tumor resection, with literature review of the clinical, histological, and molecular features of ACC. (hindawi.com)
  • Here, we report a case of ACC metastatic to the colon 19 years after resection of the primary tumor, to broaden the differential diagnosis of colorectal malignancies and to better understand the clinical, histological, and molecular features of ACC. (hindawi.com)
  • The primary tumor was 4 cm in size, with multiple positive margins and lingual nerve involvement. (hindawi.com)
  • Consistent with this observation, primary tumor explants cultured in a randomly organized collagen matrix realigned the collagen fibers, allowing individual tumor cells to migrate out along radially aligned fibers. (biomedcentral.com)
  • If a Wilms tumor is suspected or if the primary tumor is histologically confirmed, it should be staged by using CT or MRI. (medscape.com)
  • Maximum size of the primary tumor (largest single dimension), in centimeters, on preoperative imaging studies. (mdanderson.org)
  • Surgical excision of the primary tumor is the crux of treatment. (urotoday.com)
  • In a ease-cohort study of 78 patients with favorable histology Wilms' tumor, we compared tumor telomerase levels in patients with and without eventual recurrence. (northwestern.edu)
  • Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. (urotoday.com)
  • Since the discovery of platinum-based chemotherapy, testicular germ cell tumors are a highly curable disease. (urotoday.com)
  • Teratomas are a germ cell tumors composed of two or more tissues which originate from ectoderm, endoderm or mesoderm. (medscape.com)
  • Urothelial carcinomas account for more than 95% of urothelial tumors of the upper urinary tract. (medscape.com)
  • subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
  • Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
  • New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
  • The malignant tumours consisted of 18 adenoid cystic adenomas, 10 mucoepidermoid carcinomas, 5 acinic cell carcinomas, 5 carcinoma in pleomorphic adenoma as well as of 12 other malignancies belonging to 7 different tumour entities. (researchgate.net)
  • There was no significant correlation of ploidy status or SPF with the tumor grades of mucoepidermoid carcinomas. (researchgate.net)
  • Type II tumors are usually high-grade and include grade 3 endometrioid carcinomas and tumors with nonendometrioid histology (eg, serous, clear cell, mixed cell, undifferentiated, carcinosarcoma). (msdmanuals.com)
  • We investigated whether telomerase level predicts outcome for patients with the pediatric renal malignancy Wilms' tumor. (northwestern.edu)
  • Fifteen percent of patients with Wilms'' tumor (WT) experience relapse. (unifesp.br)
  • Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms'' tumor. (unifesp.br)
  • Wilms tumor , or nephroblastoma, is the most common solid renal mass and abdominal malignancy of childhood, with a prevalence of 1 case per 10,000 population. (medscape.com)
  • Most children with Wilms tumor will present with signs of a renal condition, including abdominal swelling or a suspicious mass. (medscape.com)
  • MRI diffusion studies have been shown to help differentiate Wilms tumor from neuroblastoma, with the apparent diffusion coefficient (ADC) being substantially higher for Wilms tumor. (medscape.com)
  • About 5% of renal masses that are initially thought to be Wilms tumor are subsequently diagnosed as another condition. (medscape.com)
  • Although modern imaging techniques such as color Doppler sonography, helical or multidetector-row CT, and MRI have substantially improved the potential to image Wilms tumors, definitive diagnosis is still based on histology. (medscape.com)
  • In a study of ultrasound and laboratory findings in Wilms tumor survivors with a solitary kidney, signs of kidney damage were seen in 22 of 53 patients (41.5%) on ultrasonography. (medscape.com)
  • Wilms tumor, also called nephroblastoma, is a malignant (cancerous) tumor originating in the cells of the kidney. (luriechildrens.org)
  • Approximately 400 children in the U.S. are diagnosed with a Wilms tumor each year. (luriechildrens.org)
  • The most common site for Wilms tumor to metastasize is the lungs. (luriechildrens.org)
  • In approximately 5% of children with Wilms tumor, both kidneys are involved. (luriechildrens.org)
  • Other tumors such as rhabdoid tumors of the kidney, clear cell sarcoma of the kidney and mesoblastic nephroma occur in the kidney but are not Wilms tumors and have different prognoses and treatment. (luriechildrens.org)
  • What Causes Wilms Tumor? (luriechildrens.org)
  • It is uncommon for Wilms tumor to run in families. (luriechildrens.org)
  • The acronym WAGR stands for the four diseases present in WAGR syndrome, including: Wilms tumor, aniridia (absence of the iris, the colored part of the eye), genitourinary malformations and intellectual disabilities. (luriechildrens.org)
  • How Is Wilms Tumor Diagnosed? (luriechildrens.org)
  • In 26 consecutive patients operated for Wilms' tumour samples from the tumour were genetically analyzed. (lu.se)
  • The observed cytogenetic heterogeneity illustrates the complexity of genetic changes involved in the genesis and progression of Wilms' tumour. (lu.se)
  • Bei 26 Patienten, die wegen eines Wilms-Tumors operiert wurden, wurden genetische Analysen durchgeführt. (lu.se)
  • article{aa64b742-ed00-4c00-97b7-a2db7a4e01ad, abstract = {{In 26 consecutive patients operated for Wilms' tumour samples from the tumour were genetically analyzed. (lu.se)
  • Gene therapies have been tested for other solid tumors for quite some time - for decades. (medscape.com)
  • They're often found at sites of inflammation, including in a variety of solid tumors. (mdanderson.org)
  • The malignant SGTs had higher SPF than the benign tumors but with no significant difference. (researchgate.net)
  • Methods: Flow cytometric analysis of DNA pliody and S-Phase Fraction (SPF) was done in 50 fresh tumor tissue sections of SGTs which diagnosed as 15 benign and 35 malignant tumors. (researchgate.net)
  • Results: 93.3% of the benign SGTs tumors were diploid, while only 34% of malignant tumors were diploid and 66% were aneuploid. (researchgate.net)
  • Dziegiel P, Podhorska-Okolow M, Zabel M. Melatonin: adjuvant therapy of malignant tumors. (unboundmedicine.com)
  • Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
  • The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
  • Tumour development, histology and grade of breast cancers: prognosis and progression. (who.int)
  • Histologically the tumor showed the mass to be a malignant epitheioid gastrointestinal stromal tumor with mitoses in 8 - 9 of 10 high-power fields ( Figure 1 ). (scirp.org)
  • As little is known about epithelial-stromal interactions in vivo, it is necessary to visualize the stroma surrounding normal epithelium and mammary tumors in intact tissues to better understand how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • Epithelial-stromal interactions in normal mammary glands, mammary tumors, and tumor explants in three-dimensional culture were studied with histology, electron microscopy, and nonlinear optical imaging methodologies. (biomedcentral.com)
  • Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM) to generate multiphoton excitation (MPE) of endogenous fluorophores and second harmonic generation (SHG) to image stromal collagen. (biomedcentral.com)
  • The presentation of these tumor-associated collagen signatures allowed us to identify pre-palpable tumors and see cells at the tumor-stromal boundary invading into the stroma along radially aligned collagen fibers. (biomedcentral.com)
  • Background: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors that may mimic ovarian tumor on presurgical testing. (scirp.org)
  • Case Report: We reported a case of 55-year-old post menopausal woman who presented to us as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Considering that only few patients with gastrointestinal stromal tumors have been reported in the obstetrical and gynecological literature, the awareness of such an entity by the obstetricians-gynecologists is necessary in order to facilitate coordinated approach with the general surgeons and oncologists for the optimal care of the patients. (scirp.org)
  • GISTs (Gastrointestinal stromal tumors) are most common mesenchymal neoplasms of gastrointestinal tract. (scirp.org)
  • Our case was also presented as ovarian mass which turned out to be malignant epithelioid gastrointestinal stromal tumor intraoperatively and by immunohistochemistry. (scirp.org)
  • Gastrointestinal stromal tumors (GISTs) account for less than 1% of GI tumors, but they are the most common mesenchymal neoplasms of the GI tract. (medscape.com)
  • Shown here is a gastric gastrointestinal stromal tumor (GIST). (medscape.com)
  • She says the demand is particularly high for tools to characterize the complex tumor microenvironment and interactions between tumor cells, immune cells and stromal cells. (mdanderson.org)
  • This innovative device utilizes advanced imaging technology and artificial intelligence to generate three-dimensional renderings of tissue samples with a granularity of 500um 3 , providing a comprehensive and spatially accurate view of tumors and surrounding tissues. (purplefoxyladies.com)
  • Ents and their tumor tissues differ broadly. (dna-pkinhibitor.com)
  • Such CD133+ TICs have also been isolated from three other HCC animal models and patient HCC tissues and were characterized by their NANOG-dependent self-renewal and tumor-initiating activities 6 , 7 , 8 . (nature.com)
  • As such, TACS should provide indications that a tumor is, or could become, invasive, and may serve as part of a strategy to help identify and characterize breast tumors in animal and human tissues. (biomedcentral.com)
  • The tumor can be very large and it may spread (metastasize) to other body tissues. (luriechildrens.org)
  • We have identified a candidate etiologic agent, dubbed raccoon polyomavirus, that was present in the tumor tissue of all affected animals but not in tissues from 20 unaffected animals. (cdc.gov)
  • Tumors associated with Balkan nephropathy are generally low-grade, multiple, and bilateral, in contrast to urothelial carcinoma of other etiologies. (medscape.com)
  • Urothelial carcinoma is associated with Lynch syndrome type II (hereditary nonpolyposis colorectal carcinoma), which is a syndrome characterized by an early onset of proximal colonic nonpolyposis tumors, numerous synchronous and metachronous colonic tumors, and extracolonic tumors. (medscape.com)
  • Urothelial carcinoma is the most common histology observed, accounting for greater than 95% of upper urinary tract urothelial tumors. (medscape.com)
  • Squamous cell carcinoma comprises 1-7% of upper tract urothelial tumors. (medscape.com)
  • Adenoid cystic carcinoma (ACC) is a tumor characterized by slow growth and late distant metastasis. (hindawi.com)
  • Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
  • Trichilemmal carcinoma (TC) is a rare cutaneous tumor thought to be derived from the follicular outer root sheath (ORS). (jcadonline.com)
  • the authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. (unifesp.br)
  • This case raises our awareness of such tumors as a differential diagnosis of colorectal cancer. (hindawi.com)
  • Immunohistochemically, the tumor demonstrated epithelial-myoepithelial dual lineage differentiation, which confirmed the diagnosis of metastatic ACC. (hindawi.com)
  • Diagnosis is based on histology and immunohistochemistry, while the role of imaging studies is not specific. (scirp.org)
  • She was taken for exploratory laparotomy with provisional diagnosis of malignant ovarian tumor. (scirp.org)
  • This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)
  • Most veterinary diagnostic laboratories receive large numbers of raccoon ( Procyon lotor ) carcasses for diagnosis, yet tumors of any type are rarely reported ( 15 - 17 ). (cdc.gov)
  • 3. Educational Value: Medical institutions can use this technology to enhance education and training in the fields of histology and pathology, ensuring the next generation of professionals is equipped with the latest tools and knowledge. (purplefoxyladies.com)
  • A classification system used by tumor or cancer registries to code the site and the histology of the cancer, usually from a pathology report. (cdc.gov)
  • Bland-Altman analysis showed that MDCT tended to overestimate tumor volume, and there was stronger agreement for tumor volume between CBCT and pathology than with MDCT, possibly because of the intra-arterial contrast injection. (johnshopkins.edu)
  • Conclusions: Tumor volume as measured using semiautomatic tumor segmentation software showed a strong correlation with the "real volume" measured on pathology. (johnshopkins.edu)
  • The diversity of histologic composition reflects the inter- and intra-tumor heterogeneity of lung adenocarcinomas (LUADs) macroscopically. (nih.gov)
  • Immune checkpoint inhibitors in lung tumors with rare histologies and other thoracic malignancies. (figshare.com)
  • 4 cm tumor size) or II non-small cell lung cancer [NSCLC]) and may provide the best possibility for a cure. (medscape.com)
  • He was tumor free until 9 years ago when multiple small nodules in the right lung were identified. (hindawi.com)
  • in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of patients with metastatic non-squamous non-small cell lung cancer (NSCLC) with no EGFR or ALK genomic tumor aberrations. (nih.gov)
  • Objective 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) detection of metastatic nodal disease is useful for guiding cervical cancer treatment but the impact of tumor histology is unknown. (bmj.com)
  • Metastatic tumors involving colon are rare, accounting for only 0.338% of all colorectal malignancies in a large multi-institutional study, when lymphoproliferative diseases, direct invasion, and mesenteric and peritoneal spreading are excluded [ 1 ]. (hindawi.com)
  • In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)
  • High-grade brain tumors, consistently located in the frontal lobes and olfactory tracts, were detected in 10 raccoons during March 2010-May 2012 in California and Oregon, suggesting an emerging, infectious origin. (cdc.gov)
  • Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
  • JCV, for example, induces brain tumors when intracerebrally inoculated in experimental animals ( 7 - 11 ). (cdc.gov)
  • In northern California and southern Oregon, we diagnosed 10 cases of olfactory tract/frontal lobe brain tumors in free-ranging raccoons during March 2010-May 2012. (cdc.gov)
  • Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. (oncolink.org)
  • Biology, clinical characteristics, and management of adrenocortical tumors in children. (oncolink.org)
  • Results of clinical studies were preceded by a description of experiments conducted on tumor cell lines and on laboratory animals. (unboundmedicine.com)
  • A meta-analysis of clinical studies in which melatonin was applied as an adjuvant drug in the therapy of various tumors pointed to some effects of its administration. (unboundmedicine.com)
  • Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
  • Provide a comprehensive tumor, plasma, and urine bank linked to a clinical database for further study of molecular markers in SCLC. (knowcancer.com)
  • Malignant proliferating trichilemmal tumor (MPTT) - Clinical features concerning for potential malignant transformation include a location off the scalp, recent and/or rapid growth, ulceration of the surface, and size greater than 5 cm. (logicalimages.com)
  • To further elucidate the phenotypic impact of chromosomal aberrations the correlation to histology and the clinical course will be important. (lu.se)
  • Urothelial tumors of the renal pelvis and ureters (upper urinary tract) are relatively rare. (medscape.com)
  • Tumors of the renal pelvis account for approximately 10% of all renal tumors and only 5% of all urothelial tumors of the urinary tract. (medscape.com)
  • Ureteral tumors occur about one half as often as tumors located in the renal pelvis. (medscape.com)
  • A CT scan of the abdomen confirms the renal origin of the tumor and determines the presence of bilateral tumors. (medscape.com)
  • The tumors may be large, and their size may make it difficult to identify its renal origin on sonograms. (medscape.com)
  • Therefore, CT and MRI may be useful for distinguishing between renal tumors and adrenal tumors. (medscape.com)
  • can provide an outline of the kidneys, the tumor and determine if there are problems in the renal or other major veins in the abdomen. (luriechildrens.org)
  • Tumor suppressor genes usually suppress the growth of tumors and control cell growth. (luriechildrens.org)
  • G to T transversion mutations in codon 249 of the p53 tumour-suppressor gene have been found in human liver tumour from geographic areas with high risk of aflatoxin exposure and in AFB 1 -induced liver toxicity [ 8 ]. (hindawi.com)
  • This is caused by loss or inactivation of a tumor suppressor gene called WT1 on chromosome #11. (luriechildrens.org)
  • This is also caused by loss or inactivation of a tumor suppressor gene called WT1 on chromosome #11. (luriechildrens.org)
  • The median hTERT mRNA level in tumors with recurrence was higher than that in tumors without recurrence (1.42 versus 0.97 units, P = 0.023, Wilcoxon). (northwestern.edu)
  • Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. (nature.com)
  • This entity was first identified and documented by Headington 9 in 1976, who described an epidermal-based tumor composed of atypical clear cells derived from adnexal keratinocytes. (jcadonline.com)
  • Histopathological inflammatory features of prostate tumors may be influenced by neighborhood. (harvard.edu)
  • Designed to elevate the art of tumor histopathological assessment, this groundbreaking device promises to reveal the spatial characteristics of tumors. (purplefoxyladies.com)
  • Histology was available for 2,132 patients, 397 (18.6%) of whom developed brain metastases (32 [8.1%] brain only, 38 [9.6%] brain as the first site of stage IV disease). (cancernetwork.com)
  • MRI can determine if there are metastases (spreading), if there are any tumor cells in the lymph nodes, and/or if any other organs are involved. (luriechildrens.org)
  • These tumors occasionally present a pelvic mass and lead to the misdiagnosis of gynecologic diseases. (scirp.org)
  • Conclusion: DNA aneuploidy may be a key indicator for tumors activity and malignancy in SGTs, while the SPF has a minor role in the evaluation of SGTs activity. (researchgate.net)
  • 1% of all Gastrointestinal (GI) tumors and its incidence is approximately 10 - 20 per million people per year. (scirp.org)
  • The incidence of adrenocortical tumors in children is extremely low (only 0.2% of pediatric cancers). (oncolink.org)
  • Internationally, however, the incidence of adrenocortical tumors appears to vary substantially. (oncolink.org)
  • In the non-Brazilian cases, relatives of children with adrenocortical tumors often, although not invariably, have a high incidence of nonadrenal cancers (Li-Fraumeni syndrome). (oncolink.org)
  • Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. (cdc.gov)
  • Insights into the oncological characteristics and tumor microenvironment (TME) of different histologic subtypes of LUAD at the single-cell level can help identify potential therapeutic vulnerabilities and combinational approaches to improve the survival of LUAD patients. (nih.gov)
  • 4. Research Advancements: Researchers and scientists can accelerate their studies by gaining deeper insight into the spatial characteristics of tumors, potentially leading to breakthroughs in cancer treatment. (purplefoxyladies.com)
  • The PathoCruz 3D is set to bring new understanding to professionals about tumor characteristics. (purplefoxyladies.com)
  • In: Schneider DT, Brecht IB, Olson TA: Rare Tumors in Children and Adolescents. (oncolink.org)
  • However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates. (cdc.gov)
  • Aim: The aim of this study is to investigate the DNA ploidy and S-Phase Fraction (SPF) of some Salivary Gland Tumors (SGTs) in Egyptian patients and to investigate the correlation between these two biological parameters and the presumptive behavior of these neoplasms. (researchgate.net)
  • Studies reliant on molecular detection of tumor-associated virus in isolation, however extensive, are inconclusive because association between PyVs and naturally occurring neoplasms varies and because PyV infections are highly prevalent, yet tumor formation is rare ( 3 , 4 , 12 - 14 ). (cdc.gov)
  • We used both laser-scanning multiphoton and second harmonic generation microscopy to determine the organization of specific collagen structures around ducts and tumors in intact, unfixed and unsectioned mammary glands. (biomedcentral.com)
  • One important step to elucidating these signaling interactions is to determine the organization of the collagenous stroma surrounding both normal mammary glands and tumors within intact tissue so as to better understand the cell-matrix interaction and how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
  • Fibroblastic and myofibroblastic tumors (FMTs) develop from the mesenchymal stem cells which differentiate into fibroblasts (the most common cell type in connective tissue) and/or the myocytes/myoblasts that differentiate into muscle cells. (wikipedia.org)
  • these tumors differ from lipofibromatosis-like neural tumors which have not been classified as fibroblastic and myofibroblastic tumors. (wikipedia.org)
  • Inflammatory myofibroblastic tumour (IMT) rarely presents in the skin as a slow-growing dermal tumour. (dermnetnz.org)
  • Besides, the tumor metabolic preferences vary across histologic subtypes and may correspondingly impinge on the metabolism and function of immune cells. (nih.gov)
  • Remarkably, tumor cells from solid LUADs upregulate energy and substance metabolic activities, particularly the folate-mediated one-carbon metabolism and the key gene MTHFD2, which could serve as a potential therapeutic target. (nih.gov)
  • The World Health Organization (2020) defined tumors as being FMTs based on their morphology and, more importantly, newly discovered abnormalities in the expression levels of key gene products made by these tumors' neoplastic cells. (wikipedia.org)
  • EWSR1-SMAD3-positive fibroblastic tumor was named based on the finding that its tumor cells express a EWSR1-SMAD3 fusion gene. (wikipedia.org)
  • The tumour is composed of an admixture of spindle-shaped and ovoid cells with a prominent inflammatory infiltrate (figures 2-3). (dermnetnz.org)
  • There may be some pleomorphism of the tumour cells and some mitotic figures (figure 3, arrow). (dermnetnz.org)
  • The tumour cells stain strongly with vimentin and variably with smooth muscle markers. (dermnetnz.org)
  • A malignant skin tumor composed of cells similar to those from the basal cell layer of the epidermis. (cdc.gov)
  • At higher magnification, the tumor cells showed minimal cytological atypia, scant cytoplasm, fine chromatin, small inconspicuous nucleoli, and rare mitotic figures (Figure 2 ). (hindawi.com)
  • The tumor cells were round to oval with fine chromatin, small inconspicuous nucleoli, indistinct cell borders, and light nongranular cytoplasm. (hindawi.com)
  • the abluminal myoepithelial cells of the tumor are positive for SMA and P63. (hindawi.com)
  • This treatment had demonstrated some efficacy when put inside the bladder, but largely due to the limited dwell time and the exposure of the interferon protein to the bladder tumor cells, it ultimately did not pan out as an effective treatment choice. (medscape.com)
  • They also provide insights into the interactions between tertiary lymphoid structures, cancer cells and other cells in the tumor microenvironment. (mdanderson.org)
  • Wang worked with colleagues from the University of Pennsylvania and Emory University to develop state-of-the-art computational tools that effectively integrate histology data to create an advanced spatial profile of tumor-infiltrating T cells, B cells and plasma cells both within and outside of tertiary lymphoid structures. (mdanderson.org)
  • Indicate whether tumor cells were present in blood vessels or lymphatic structures. (mdanderson.org)
  • Moreover, PTT shows positive staining for AE13, AE14, and CD34, whereas SCC tumor cells show negative staining for these markers. (logicalimages.com)
  • ERBB1 and ERBB2 inhibition can rapidly block tumor cell invasive properties. (aacrjournals.org)
  • Measure the maximum tumor size (single dimension) on imaging before and after neoadjuvant chemotherapy and calculate the percent decrease in size. (mdanderson.org)
  • the decision to treat the patient with concurrent chemoradiation rather than surgery, radiation, or chemotherapy individually should be made by a multidisciplinary tumor board (including a medical oncologist, radiation therapist, and thoracic surgeon). (medscape.com)
  • 1. Spatial Accuracy for Enhanced Diagnostics: By synchronizing maps of cancerous regions across adjacent slides from a tumor, the software provides a unique perspective on factors such as size, shape, invasion depth, volume, and other spatial metrics. (purplefoxyladies.com)
  • In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
  • Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)
  • These experiments temporally and molecularly separate two key stages in tumor cell entry into blood vessels: invasion and intravasation. (aacrjournals.org)
  • Only a small number of malignant proliferating trichilemmal tumor (MPTT) cases with documented invasion and metastasis have been reported. (logicalimages.com)
  • Moreover, we observed and defined three tumor-associated collagen signatures (TACS) that provide novel markers to locate and characterize tumors. (biomedcentral.com)
  • Colonic metastasis of such a tumor is rare, with few case reports available. (hindawi.com)
  • In most cases, there will be a solitary tumor in one kidney, but 5-13% of children have bilateral tumors and 10% have multifocal tumors in a single kidney. (medscape.com)
  • Capillarosclerosis, which is characterized by a thickening of the basement membrane, is the pathognomonic finding of analgesic abuse and is found in 15% of patients with upper urinary tract tumors. (medscape.com)
  • Affected patients frequently present with moderately to poorly differentiated tumors and advanced disease. (medscape.com)
  • 1,2 These tumors predominantly occur in elderly patients on sun-exposed areas, specifically on the head and neck, with the face being the most common location. (jcadonline.com)
  • The main emphasis is on supervised machine learning methods for classification and prediction of tumor gene expression profiles. (lu.se)
  • S-phase value is correlated with the behavior of the tumors [13, 14]. (researchgate.net)
  • These tumors commonly arise from the ovary although other extragonadal sites can be involved, especially in children. (medscape.com)
  • Histological observation confirmed the induction of tumour in Group II animals and complete regression of tumour in Group III animals. (hindawi.com)
  • The main differentiating histological feature in a TC is the evidence of trichilemmal keratinization, where the tumor exhibits an absence of granular layer between the stratum spinosum and stratum corneum. (jcadonline.com)
  • Photoacoustic (PA) imaging has shown tremendous promise for imaging tumor vasculature and its function at deeper penetration depths without the use of exogenous contrast agents. (mdpi.com)
  • In this study, we evaluated the capability of a Light-Emitting Diode (LED)-based PA and ultrasound (US) imaging system for monitoring heterogeneous microvasculature in tumors (up to 10 mm in depth) and quantitatively compared the PA images with gold standard histology images. (mdpi.com)
  • After imaging, the tumors were excised for pathologic volume measurement. (johnshopkins.edu)
  • The imaging-based tumor volume measurements were compared to the pathologic volumes using linear regression, with Pearson's test, and correlated using Bland-Altman analysis. (johnshopkins.edu)
  • Proliferating trichilemmal tumor (PTT), also known as proliferating pilar tumor / cyst, is an uncommon benign dermal neoplasm that arises from the outer root sheath of the hair follicle. (logicalimages.com)
  • Mortality rate of adrenocortical tumors in children under 15 years of age in Curitiba, Brazil. (oncolink.org)
  • Stereotactic body radiotherapy (SBRT) may be used in early-stage NSCLC tumors that are smaller than 5 cm and without lymph node involvement. (medscape.com)