These cells line the gastric mucosa (mucous neck cells are found in the necks of the gastric pits). (wikipedia.org)
The gastric mucosa that lines the inner wall of the stomach has a set of microscopic features called gastric glands which, depending on the location within the stomach, secrete different substances into the lumen of the organ. (wikipedia.org)
A mucus layer of variable thickness covers the mucosa of different digestive tract parts that appear more remarkable within the large intestine. (biomedcentral.com)
The two main sources of mucins within the digestive tract are the glandular acini located within the deep face of the mucosa and goblet cells dispersed throughout the gut epithelium [ 12 ]. (biomedcentral.com)
Helicobacter pylori (HP) infection and the autoimmune inflammation of the gastric mucosa are recognized as the leading etiological factors of chronic atrophic gastritis, a disease associated with an increased risk of stomach cancer development. (encyclopedia.pub)
At the same time, autoimmune inflammation of the gastric mucosa, in addition to the formation of atrophy and an increase in the risk of stomach cancer, carries additional risks, both in relation to neoplasms (neuroendocrine tumors) and in relation to the deficiency of a number of micronutrients with the involvement of other organs and systems. (encyclopedia.pub)
TFFs are rapidly and coordinately secreted from mucus-secreting cells when the gastrointestinal mucosa suffers mechanical and/or chemical damage, and they respond to the mucosal injury ( 4 , 5 ). (spandidos-publications.com)
Secretion3
The openings of these glands into the stomach are called gastric pits which foveolar cells line in order to provide a protective alkaline secretion against the corrosive gastric acid. (wikipedia.org)
In addition, the ability of KT4 to reduce gastric acid secretion might also contribute to its ulcer-healing activity. (rsc.org)
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
Left gastri1
The lesser curvature of the human stomach is supplied by the right gastric artery inferiorly and the left gastric artery superiorly, which also supplies the cardiac region. (explained.today)
Goblet cells4
The mucus-secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells, another type of mucus-secreting cell. (wikipedia.org)
They were mainly localized in the acini of the esophageal glands and SPG, gastric surface epithelium, duct system of DPG, and intestinal goblet cells. (biomedcentral.com)
Mucin 2 (MUC2) is the major intestinal gel-forming mucin produced predominantly by goblet cells. (ox.ac.uk)
Goblet cells express anterior gradient 2 (AGR2), a protein disulfide isomerase that is crucial for proper processing of gel-forming mucins. (ox.ac.uk)
Mucosal lesions1
The prophylactic action of the tea seed-derived triterpene saponins against ethanol -induced gastric mucosal lesions, 6,7 and of BT extract against various ulcerogens 8,9 have been reported in rat models. (rsc.org)
Gastroesophageal junction1
Adenocarcinoma of the stomach can also be classified into proximal tumors (gastric cardia and gastroesophageal junction) and distal tumors (fundus, body and antrum of the stomach). (clinicalgate.com)
Acute gastric1
The cytoprotective action of the green tea- catechins against ethanol - or restraint plus water -immersion stress-induced acute gastric mucosal injury, and acetic acid-induced chronic gastric ulcers in rats has been reported. (rsc.org)
Stomach9
Foveolar cells or surface mucous cells are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid. (wikipedia.org)
256 Foveolar cells line the surface of the stomach, the gastric pits, and the top part of gastric glands: the neck. (wikipedia.org)
257 Surface mucous cells have large quantities of mucin granules in their apical (top) surface and project short microvilli into the lumen of the stomach. (wikipedia.org)
578 The mucus produced by these cells is extremely important, as it prevents the stomach from digesting itself. (wikipedia.org)
The stomach is involved in the gastric phase of digestion, following chewing . (explained.today)
The stomach secretes digestive enzyme s and gastric acid to aid in food digestion. (explained.today)
The stomach is surrounded by parasympathetic (stimulant) and sympathetic (inhibitor) plexuses (networks of blood vessel s and nerve s in the anterior gastric, posterior, superior and inferior, celiac and myenteric), which regulate both the secretory activity of the stomach and the motor (motion) activity of its muscles. (explained.today)
The fundus of the stomach, and also the upper portion of the greater curvature, is supplied by the short gastric arteries , which arise from the splenic artery. (explained.today)
Parietal cells2
and mucous neck cells, which are a part of the neck of gastric glands along parietal cells. (wikipedia.org)
577 Mucous neck cells are located within gastric glands, interspersed between parietal cells. (wikipedia.org)
Ulceration1
The gastro-toxicity of non-steroidal anti-inflammatory drugs (NSAIDs), often leading to gastric ulceration and delayed healing, remains a crucial problem, despite recent pharmaceutical advances. (rsc.org)
Adenocarcinoma2
Gastric adenocarcinoma makes up the majority of malignant gastric tumors, and will be referred to as gastric cancer in this chapter. (clinicalgate.com)
Proposed Correa pathway of pathologic events in gastric adenocarcinoma. (clinicalgate.com)
Gastrointestinal1
Cancer in the body and tail may cause splenic vein obstruction, resulting in splenomegaly, gastric and esophageal varices, and gastrointestinal hemorrhage. (msdmanuals.com)
MUC21
We demonstrate that DBZ elicits a homogeneous goblet cell conversion all along the mouse intestinal tract, associated with an overexpression of the gene Muc2 without ectopic expression of the gastric genes Muc5ac and Muc6 , and with the emergence of lysozyme-positive 'intermediate cells' in the colon. (biologists.com)
Tissues1
The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. (rsc.org)
Pylori2
5 It is believed that polyphenols or polyphenol derivatives from green tea may be useful either in prevention or treatment of H . pylori -associated gastric diseases. (rsc.org)
In well-differentiated, intestinal-type gastric cancer, histopathologic studies have indicated that chronic Helicobacter pylori infection progresses over decades through stages of chronic gastritis, atrophy, intestinal metaplasia, dysplasia, and cancer. (clinicalgate.com)
Atrophy2
The development of cancer has been attributed to alterations in DNA caused by chronic inflammation, recruitment and engraftment of bone marrow-derived cells, an imbalance between epithelial cell proliferation and apoptosis, and, in a milieu of atrophy and achlorhydria, gastric colonization by enteric bacteria with nitrate reductase activity, which facilitates the formation of carcinogenic nitrosamines. (clinicalgate.com)
Gastric chief cells produce pepsinogen, which is activated by the acid to form pepsin. (wikipedia.org)
The mucus allows the acid at pH above 4 to penetrate lining, but below pH 4 (i.e. when acid is more concentrated) the acid cannot penetrate the mucus. (wikipedia.org)
Disease3
Human AGR2 Deficiency Causes Mucus Barrier Dysfunction and Infantile Inflammatory Bowel Disease. (ox.ac.uk)
The Mendelian deficiency of AGR2, termed "Enteropathy caused by AGR2 deficiency, Goblet cell Loss, and ER Stress" (EAGLES), results in a mucus barrier defect, the inability to mitigate ER stress, and causes infantile-onset inflammatory bowel disease. (ox.ac.uk)
Most symptoms of gastric cancer reflect advanced disease. (medscape.com)
Patients2
however, some patients with incidental complaints are diagnosed with early gastric cancer. (medscape.com)
Early gastric cancer develops in 42% of patients with type III IM within five years of follow-up, suggesting that IM represents a precursor lesion for the intestinal form of gastric cancer. (clinicalgate.com)
Preparation1
As mucins are lost during routine histology preparation, they stain pale, but if preserved correctly the cells stain strongly with special techniques like PAS or toluidine blue, the last representing the anionic nature of foveolar cell secretions. (wikipedia.org)
Surface2
Below the mucin granules, surface mucous cells have a Golgi apparatus, the nucleus, and small amounts of rough endoplasmic reticulum. (wikipedia.org)
These are shorter than their surface counterpart and contain lesser quantities of mucin granules in their apical surface. (wikipedia.org)
All physical signs in gastric cancer are late events. (medscape.com)
The surgical approach in gastric cancer depends on the location, size, and locally invasive characteristics of the tumor. (medscape.com)
This type of gastric cancer is more closely linked to environmental and dietary risk factors, tends to be the predominant form in regions with a high incidence of gastric cancer, and is the form of cancer that is now declining worldwide. (clinicalgate.com)
Type I metaplasia does not raise the risk of gastric cancer. (clinicalgate.com)
Human1
List of human cell types derived from the germ layers "Mucous" is an adjective whereas "mucus" is a noun, i.e. mucous cells secrete mucus. (wikipedia.org)
Factors1
Mucins are essential for intestinal barrier function and serve as a scaffold for antimicrobial factors. (ox.ac.uk)
Play1
This layer is rich in mucosubstances or mucins that are known to play important roles in lubrication and protection of the underlying layers via limiting their exposure to toxins and pathogens [ 10 ]. (biomedcentral.com)
Effects1
To prevent these disastrous effects, mucus and bicarbonate ions (HCO3−) are secreted by the foveolar cells. (wikipedia.org)
Potential1
Gastric tumors are defined as benign or malignant based on their potential to metastasize. (clinicalgate.com)