This finding shows that ischemic but noninfarcted myocardium can exist in a state of hibernation without cell death. (medscape.com)
After 2 weeks in the low-flow state, positron emission tomography and dobutamine stress echocardiography were performed to document ischemic, viable (hibernating) myocardium in the left circumflex distribution. (duke.edu)
Whether this concept could be a therapeutic option in patients with ischemic cardiomyopathy was further investigated in a pre-clinical model of hibernating myocardium. (dpz.eu)
There might be many potential biomarkers for mild ischemic injury in myocardium, especially isoform 8 of titin and M-type of PGAM2 that are more specific in the cardiac tissue than in the others. (biomedcentral.com)
The modest prognostic benefit of an opened infarct-related artery may be realized even when recanalization is induced only 6 hours or later after the onset of symptoms, that is, when the salvaging of substantial amounts of jeopardized ischemic myocardium is no longer likely. (medscape.com)
The clinical situations where one can expect hibernating myocardium are:[citation needed] chronic stable angina unstable angina silent ischemia after AMI Stunned myocardium Myocardial scarring Wijns W, Vatner SF, Camici PG (July 1998). (wikipedia.org)
Stunned myocardium is myocardium that suffers transient reversible myocardial contractile dysfunction that is caused by acute ischemia during which the blood supply is almost completely restored by reperfusion, with no metabolic deterioration. (medscape.com)
The term hibernating myocardium is also used to indicate chronic myocardial contractile dysfunction due to ischemia, in which there is reduced coronary blood flow at rest and increased myocardial demand results in impaired contractility. (medscape.com)
Schematic representation of infarction (cell death), chronic ischemia with contractile dysfunction (hibernating myocardium), and transient ischemia (stunned myocardium) with restored blood flow with transient contractile dysfunction. (medscape.com)
Clinically, discerning the etiology of depressed myocardial contractile function is difficult, whether due to stunned myocardium, silent ischemia, or hibernating myocardium. (medscape.com)
Thus, reorganization of cytoskeletal proteins in patients with viable dysfunctional myocardium appears to reflect chronic and/or cyclical elevations in preload associated with episodes of spontaneous regional ischemia. (amsterdamumc.org)
We tested the hypothesis that these arose secondary to elevations in preload rather than ischemia.METHODS AND RESULTS: Expression of structural protein (desmin, desmoplakin, titin, cardiotin, alpha-smooth muscle actin, lamin-A/C, and lamin-B2) in viable dysfunctional myocardium was analyzed by immunohistochemistry. (amsterdamumc.org)
Hibernating myocardium: an incomplete adaptation to ischemia. (smw.ch)
Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. (smw.ch)
Furthermore, glycolysis is one of the important conversions during early ischemia in myocardium. (biomedcentral.com)
Partial ischemia at the periphery at the necrotic area may lead to "hibernating" myocardium, which may eventually recover. (fupress.net)
Coronary thrombolysis and mechanical revascularization have revolutionized the primary treatment of acute MI, largely because they allow salvage of the myocardium when implemented early after the onset of ischemia. (medscape.com)
Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. (biomedcentral.com)
Viable15
The regions of myocardium are still viable and can return to normal function. (wikipedia.org)
METHODS AND RESULTS: Expression of structural protein (desmin, desmoplakin, titin, cardiotin, alpha-smooth muscle actin, lamin-A/C, and lamin-B2) in viable dysfunctional myocardium was analyzed by immunohistochemistry. (amsterdamumc.org)
The histology of viable and hibernating myocardium in relation to imaging characteristics. (smw.ch)
Delay in revascularization is associated with increased mortality rate in patients with severe left ventricular dysfunction and viable myocardium on fluorine 18-fluorodeoxyglucose positron emission tomography imaging. (smw.ch)
There is no magical amount of viable ventricular myocardium that makes percutaneous coronary intervention (PCI) an effective addition to optimal medical therapy (OMT) in stable patients with coronary disease and poor ventricular function, suggests an analysis from a major trial. (medscape.com)
All the patients had shown viable but dysfunctional myocardium that could potentially be revascularized. (medscape.com)
That the extent of hibernating myocardium, which is viable but dysfunctional, didn't predict clinical outcomes or LV functional recovery "is disruptive of current practice and challenges a view that's been held for decades. (medscape.com)
It may require new, more granular definitions for viable and hibernating myocardium, Rao proposed. (medscape.com)
Extent of myocardial viability was defined 3 ways: volume of hibernating heart muscle, total volume of viable myocardium, and scar burden - all expressed as a percentage of total LV volume. (medscape.com)
Identification of viable and hibernating myocardium allows for a better selection of patients who need revascularisation. (escardio.org)
Consequently, the noninvasive determination of viable myocardium is becoming increasingly important. (escardio.org)
Among the techniques routinely used to detect the presence of viable myocardium, special mention should be made of dobutamine stress echocardiography (DSE), isotopic testing in the form of Thallium-201 redistribution scintigraphy and, more recently introduced, the myocardial contrast echocardiography (MCE) techniques and magnetic resonance. (escardio.org)
Although DSE and Thallium-201 with redistribution have been validated for the diagnosis of viable myocardium, they frequently yield conflicting results. (escardio.org)
When both DSE and Thallium-201 are performed in the same patient, discordant results are often obtained In fact, in comparative studies where both techniques have been used prior to revascularisation procedures, the sensitivity, specificity and predictive value for the detection of viable myocardium have been found to differ. (escardio.org)
BACKGROUND: In patients with coronary artery disease, dysfunctional hypoperfused myocardium at rest may represent either necrotic or viable hibernating myocardium. (unisa.it)
Perfusion9
Scholars@Duke publication: Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium. (duke.edu)
Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium. (duke.edu)
This study evaluated long-term changes in myocardial perfusion and contractile reserve after TMR in a model of hibernating myocardium. (duke.edu)
CONCLUSIONS: This study found improvements in myocardial perfusion and regional and global contractile reserve 6 months after TMR in a porcine model of hibernating myocardium. (duke.edu)
Som noget relativt nyt kan man ved ekg-synkroniseret, såkaldt gated, myokardiescintigrafi samtidigt bestemme venstre hjerteventrikels perfusion og pumpefunktion efter en enkelt i.v. injektion af et radiofarmakon. (ugeskriftet.dk)
Det er derfor klinisk relevant ikke alene at vurdere myokardiets perfusion, men også de funktionelle forandringer, som er en tidlig følge af iskæmi. (ugeskriftet.dk)
This hibernating myocardium appears to be amenable to therapeutic neovascularization because it can be reactivated by adequate perfusion. (dpz.eu)
In this model, both thymosin ß4 and MRTF-A were able to enhance angiogenesis and arteriogenesis as well as perfusion in the myocardium. (dpz.eu)
The accuracy of inotropic stimulation in identifying hypoperfused, reversibly dysfunctional myocardium has not been extensively investigated. (unisa.it)
If it is true, such markers would offer the opportunity for early diagnosis of IHD before permanent myocyte damage occurs, which will allow possible salvage of the myocardium by timely reperfusion. (biomedcentral.com)
Dose dobutamine2
Echocardiography: A wall motion abnormality at rest which improves during a low-dose dobutamine stress test is classified as "hibernating myocardium. (wikipedia.org)
Low-dose dobutamine infusion is able to demonstrate the contractile reserve of myocardium as it shows an improved contractility following infusion of this positive inotropic drug. (escardio.org)
Positron emission t2
And that may involve alternative imaging modalities, such as positron emission tomography, which can disclose metabolic activity in myocardium. (medscape.com)
Baseline positron emission tomography and dobutamine stress echocardiography were performed to document hibernating myocardium in the left circumflex coronary artery distribution. (elsevierpure.com)
Dobutamine stress echocardiography1
Dobutamine stress echocardiography after 2 weeks of low-flow demonstrated severe hypocontractility at rest in the left circumflex region of all animals, with a biphasic response to dobutamine consistent with hibernating myocardium. (duke.edu)
Outcomes2
Hibernating myocardium: diagnosis and patient outcomes. (nih.gov)
But in a secondary analysis, extent of such hibernating heart muscle was not a good predictor of clinical outcomes, which in the trial meant death from any cause or hospitalization for heart failure (HHF). (medscape.com)
Coronary3
In hibernating myocardium, contractile function can be partially or totally restored by improving coronary blood flow or by reducing oxygen demand of the myocardium. (medscape.com)
Rahimtoola suggested that hibernating myocardium is characterized by a state of persistently impaired myocardial and LV function at rest due to reduced coronary blood flow that can be partially or completely restored to normal by improving blood flow or by reducing oxygen demand (see the image below). (medscape.com)
The gradual occlusion of coronary arteries can result in reversible loss of cardiomyocyte function (hibernating myocardium). (dpz.eu)
Noninvasive1
Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. (smw.ch)
Defect2
The myocardium is scarred when the uptake of both markers is reduced (matched defect). (elsevierpure.com)
Second, the significance of QR and QS complexes in predicting hibernating myocardium was determined.Results-As a marker of matched PET defects, Q waves were specific (79%) but not sensitive (41%), with a 77% positive predictive accuracy and a poor (43%) negative predictive accuracy. (elsevierpure.com)
Alterations progressed with the transition to hibernating myocardium, in which desmin, cardiotin, and titin were globally reduced. (amsterdamumc.org)
Assessment1
Deformation assessment of tagged lines within the myocardium may overcome these limitations however requires acquisition of additional tagging sequences and post processing [ 3 ]. (biomedcentral.com)
Wall motion1
Den regionale systoliske pumpefunktion kan vurderes ud fra wall-motion (myokardievæggens bevægelser bedømt ud fra endokardiets bevægelser) og wall-thickening (fortykkelse af myokardievæggen i systolen, hvilket ses som en øgning af myokardiets intensitet). (ugeskriftet.dk)
Cardiac1
Cardiac magnetic resonance: The most frequently used MR contrast agents based on Gd-chelates accumulate in the extracellular space which is increased in scarred myocardium. (wikipedia.org)
Function2
In cardiology, hibernating myocardium is a state when some segments of the myocardium exhibit abnormalities of contractile function. (wikipedia.org)
He provided Core - Lab function for MRC sponsored study in Hibernating Myocardium. (imperial.ac.uk)
Left1
[18] The pace of recovery of left ventricual dysfunctionis similar to that of hibernating myocardium [19] . (wikidoc.org)
So the analysis "seems to call into question what the definitions of viability and hibernating myocardium really are. (medscape.com)
Regions1
BACKGROUND: Dysfunctional and normally perfused remote regions show equal myolysis and glycogen accumulation in pig hibernating myocardium. (amsterdamumc.org)