• [ 8 , 9 ] A recent meta-analysis of 27 referral center studies showed that overall, the greater odds of CD for carriers of a single CARD15 mutant allele (simple heterozygotes, " MW " genotype) was 2.4, and for carriers of two mutant alleles (mutant homozygotes or compound heterozygotes, " MM " genotype) was 17.1. (medscape.com)
  • With the exception of the extremely rare mutations, only those individuals born to 2 gene carriers (heterozygotes or homozygotes) may develop thalassaemia major. (who.int)
  • On average, one fourth of their children are affected, half are heterozygotes, and one fourth are neither affected nor carriers (genotypically normal). (msdmanuals.com)
  • In certain populations, the percentage of heterozygotes (carriers) is high because of a founder effect (ie, the group started with few members, one of whom was a carrier) or because carriers have a selective advantage (eg, heterozygosity for sickle cell trait protects against malaria). (msdmanuals.com)
  • In keeping with the specific definition of analytic sensitivity above, analytic specificity is defined in this document as the proportion of individuals that are not C282Y homozygotes who are correctly identified as not being homozygous for C282Y. (cdc.gov)
  • ie, both heterozygotes and homozygotes for the abnormal gene are affected. (msdmanuals.com)
  • Heterozygotes are unaffected but carry the abnormal gene. (msdmanuals.com)
  • We call these types of organisms heterozygotes . (madsci.org)
  • A study of 400 individuals reported that an increase in plasma total homocysteine (tHcy) of 10.4% (CI: 0.01-0.21, p=0.03) for associated with rs4680 (A;A) homozygotes compared with rs4680 (G;G) subjects. (snpedia.com)
  • So the other requirement for this new species to emerge from the chromosomal rearrangement is that heterozygote brothers and sisters from the parent with the unusual chromosome must mate (inbreeding). (madsci.org)
  • All children of an affected parent and a parent who is not a carrier are unaffected heterozygotes. (msdmanuals.com)
  • On average, half the children of an affected parent and a heterozygote are affected, and half are heterozygotes. (msdmanuals.com)