• based on its antigenic and genetic characteristics, it is included in the Japanese encephalitis virus (JEV) serocomplex of the genus Flavivirus , family Flaviviridae ( 10 ) . (cdc.gov)
  • Because of the close antigenic relationships among many viruses in this genus, Flavivirus infections are difficult to differentiate by most serologic techniques, especially in persons or animals having a second or sequential Flavivirus infection ( 12 - 14 ). (cdc.gov)
  • In the case of dengue, enhancement of virus replication by heterologous flavivirus antibodies and T-cell activation are thought to occur in some patients during a second or sequential dengue infection, resulting in hemorrhagic fever or shock ( 15 , 16 ). (cdc.gov)
  • In contrast, animal data indicate that prior infection with a heterologous Flavivirus reduces the severity of subsequent challenge with WNV. (cdc.gov)
  • Results of experimental studies with rodents, monkeys, and pigs ( 17 - 21 ) suggest that heterologous Flavivirus antibodies protect against or modify subsequent infection with WNV. (cdc.gov)
  • The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. (patentsencyclopedia.com)
  • This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family. (patentsencyclopedia.com)
  • 1. Chimerical peptides, characterized by having a primary structure comprising at least one segment inhibitor of the activation of the NS3pro protease from a virus of the Flaviviridae family and a cell penetrating segment and these peptides are able to inhibit or attenuate the infection by the virus. (patentsencyclopedia.com)
  • 10. Chimerical peptides according to the claim 1, where the mentioned virus from the Flaviviridae family is a Hepacivirus and specifically HCV. (patentsencyclopedia.com)
  • This phenomenon could be important in vaccine development against WNV infection and in determining the ultimate geographic distribution and public health importance of WNV if it is introduced into areas of Central and South America where other flaviviruses, such as Dengue virus (DENV), Y ellow fever virus (YFV), SLEV, and Ilhéus virus (ILHV), are endemic. (cdc.gov)
  • To determine more precisely the degree of cross-protection among members of the JEV serocomplex and the possibility that this phenomenon could be used to protect against severe WNV infection, a series of experiments was carried out with three heterologous flaviruses and a recently described model ( 22 ) of WNV encephalitis. (cdc.gov)
  • No specific treatment is available for WNV encephalitis, and no licensed vaccine is available for its prevention. (cdc.gov)
  • In the case of dengue, enhancement of virus replication by heterologous flavivirus antibodies and T-cell activation are thought to occur in some patients during a second or sequential dengue infection, resulting in hemorrhagic fever or shock [ 15 , 16 ] . (medscape.com)
  • This phenomenon could be important in vaccine development against WNV infection and in determining the ultimate geographic distribution and public health importance of WNV if it is introduced into areas of Central and South America where other flaviviruses, such as Dengue virus (DENV), Y ellow fever virus (YFV), SLEV, and Ilhéus virus (ILHV), are endemic. (medscape.com)
  • In the case of dengue, W North America in summer of 1999, during an outbreak enhancement of virus replication by heterologous flavivirus involving humans, equines, and birds in the New York City antibodies and T-cell activation are thought to occur in some metropolitan area (1). (cdc.gov)
  • Persistence of the virus and its spread to patients during a second or sequential dengue infection, result- other states on the eastern seaboard during 2000 and 2001 sug- ing in hemorrhagic fever or shock (15,16). (cdc.gov)
  • Results of experimental studies with rodents, monkeys, and infections in humans are asymptomatic or unrecognized, some pigs (17-21) suggest that heterologous Flavivirus antibodies patients have an acute dengue-like illness, and a small percent- protect against or modify subsequent infection with WNV. (cdc.gov)
  • Flaviviruses are a large group of positive strand RNA viruses transmitted by arthropods that include many human pathogens such as West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus, dengue virus, and tick-borne encephalitis virus. (mdpi.com)
  • based on its antigenic and genetic characteristics, it is included in the Japanese encephalitis virus (JEV) serocomplex of the genus Flavivirus , family Flaviviridae [ 10 ] . (medscape.com)
  • To determine more precisely the degree of cross-protection encephalitis virus (JEV) serocomplex of the genus Flavivirus , among members of the JEV serocomplex and the possibility family Flaviviridae (10). (cdc.gov)