• tumors
  • A high degree of MSI (MSI-high) is present as a distinct phenotype in ∼15% of colorectal cancers, and MSI-high tumors are believed to arise through a distinct precursor pathway ( 25 ). (aacrjournals.org)
  • Furthermore, basal-like tumors do not respond to conventional therapies and commonly present with the triple-negative phenotype (negative expression of estrogen receptor-α, progesterone receptor, and Her2/neu) ( 2 , 6 ). (aacrjournals.org)
  • disorder
  • Hereditary thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) is a rare disorder characterized by thrombocytopenia as a result of platelet consumption, microangiopathic hemolytic anemia, occlusion of the microvasculature with von Willebrand factor-platelet-thrombic and ischemic end organ damage. (clinicaltrials.gov)
  • Southeast Asian ovalocytosis is a blood disorder that is similar to, but distinct from hereditary elliptocytosis. (wikipedia.org)
  • common
  • Hereditary spherocytosis (HS) is the most common type of hereditary hemolytic anemia. (frontiersin.org)
  • Another common feature of the basal-like phenotype is activated β-catenin signaling as nuclear β-catenin is associated with the expression of basal-like markers and decreased patient survival ( 9, 10 ). (aacrjournals.org)
  • Unlike those with the Leach phenotype of common hereditary elliptocytosis (see above), there is a clinically significant reduction in both disease severity and prevalence of malaria in those with SAO. (wikipedia.org)
  • stem
  • When connected into a network, these concerted events link NO to the development of a stem cell-like phenotype, resulting in the upregulation of CD44 and STAT3 phosphorylation. (aacrjournals.org)
  • subsequent
  • Alloimmunization with the formation of antibodies acting as inhibitors of treatment are well known in other congenital coagulation factor deficiencies (e.g. hemophilia A), but so far no case of treated hereditary TTP with subsequent antibody formation has been reported. (clinicaltrials.gov)
  • cancers
  • concluded that despite undergoing increasing genetic alteration, most individual breast cancers rather surprisingly maintain their phenotype when they evolve from in situ to the metastatic state. (wikipedia.org)
  • biological
  • Many factors in this problem have been identified, but it is likely that also student understanding of the genetic concepts hereditary traits and phenotype is problematic and much narrower than in biological science. (uu.nl)
  • terms
  • In this study, the two major Dutch secondary school biology textbooks were analysed and use of the terms hereditary traits and phenotype was classified according to six categories in which the concepts were expected to differ from scientific use. (uu.nl)
  • known
  • Despite extensive research into red blood cell biochemistry and physiology, little is known about red cell deformability and vesiculation in hereditary hemolytic anemias, and the associated pathophysiological role is incompletely assessed. (frontiersin.org)
  • association
  • It predisposes for renal cell cancer, an association denominated hereditary leiomyomatosis and renal cell cancer, and it is also associated with increased risk of uterine leiomyosarcoma. (wikipedia.org)
  • expression
  • PTGS2 (COX-2) expression in colon cancer has been inversely associated with survival as well as tumoral microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). (aacrjournals.org)
  • blood
  • Integrating bio-analytical findings on abnormalities of red blood cells and their microvesicles will be critical for a better understanding of the pathophysiology of hereditary hemolytic anemias. (frontiersin.org)