AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHumanitiesInformation ScienceNamed GroupsHealth Care
Liver RegenerationHepatectomyRegenerationLiverHepatocytesNerve RegenerationLiver NeoplasmsLiver DiseasesLiver TransplantationLiver CirrhosisHepatocyte Growth FactorLiver Function TestsBone Regeneration2-AcetylaminofluoreneTime FactorsRats, Inbred F344Carbon TetrachlorideCell ProliferationProliferating Cell Nuclear AntigenFatty LiverCarcinoma, HepatocellularDrug-Induced Liver InjuryRats, WistarOrgan SizeLiver Failure, AcuteLiver Neoplasms, ExperimentalPortal VeinHyptisMicrosomes, LiverRNA, MessengerLiver CirculationSTAT3 Transcription FactorAlanine TransaminaseCarbon Tetrachloride PoisoningRats, Sprague-DawleyMice, Inbred C57BLGene Expression RegulationDiethylnitrosamineModels, AnimalCell DivisionLiving DonorsMitochondria, LiverRats, Inbred StrainsDNAMice, KnockoutMitotic IndexStem CellsGuided Tissue RegenerationBilirubinPyrrolizidine AlkaloidsSignal Transductionalpha-FetoproteinsKupffer CellsImmunohistochemistryBile DuctsInterleukin-6Liver Cirrhosis, ExperimentalCells, CulturedAspartate AminotransferasesThioacetamideDisease Models, AnimalHepatic InsufficiencyLiver ExtractsCytochrome ReductasesCell DifferentiationBromodeoxyuridineGalactosamineCell CycleHepatic Stellate CellsMice, TransgenicLiver FailureHepatic VeinsGene ExpressionBile Ducts, IntrahepaticDimethylnitrosaminePlanariansPortal SystemDrug-Induced Liver Injury, ChronicReverse Transcriptase Polymerase Chain ReactionMythologyTreatment OutcomeAlbuminsApoptosisProto-Oncogene Proteins c-metBile Duct NeoplasmsBlotting, WesternHepatic ArteryLithiasisAxonsBlotting, NorthernGrowth SubstancesCell TransplantationSalamandridaeKineticsAmbystoma mexicanumBiogenic PolyaminesExtremitiesUp-RegulationNerve CrushNecrosis
TransplantationHepatocytesResectionMiceCell proliferationTissueRatsImpairs liver regenerationRight hepatectomyHepatic regenerationProliferationCytokinesRole in stimuPathwaysDonorPlateletAbstractNormal liverUnderlying liver fibrosisMechanismsRegenerateHumansPlateletsRecurrenceHepatocellularClinicalGenesMethodsCirrhosisLigationCellsFibrosisInflammationMortalityVascularSurgicalComplicationLobesExpressionSurvivalBileOncologicalPhysiologicalGeneHepatocyteProgressionComplicationsInduceToxinsStem cellPreoperativePivotalStimulateRemnant liver volumeInadequateAdultPartial liverPortal veinChronic liverPerson's liverRegenerative effects
Transplantation30
Hepatocytes14
Resection20
  • We developed support System for hepatectomy considering regeneration of the liver after resection. (elsevierpure.com)
  • Inducing rapid liver hypertrophy using Associating Liver Partition and Portal vein ligation for a Staged hepatectomy (ALPPS) has been proposed for resection of borderline resectable liver tumors. (jove.com)
  • For some indications, like colorectal liver metastases, the amount of liver tissue left behind after liver resection has become the main limiting factor of resectability of large or multiple liver tumors. (jove.com)
  • Inducing liver growth of the prospective remnant prior to resection has become more established in liver surgery, either in the form of portal vein embolization by interventional radiologists or in the form of portal vein ligation several weeks prior to resection. (jove.com)
  • Recently, it was shown that liver regeneration is more extensive and rapid, when the parenchymal transection is added to portal vein ligation in a first stage and then, after only one week of waiting, resection performed in a second stage (Associating Liver Partition and Portal vein ligation for Staged hepatectomy = ALPPS). (jove.com)
  • 2 This post-hepatectomy liver failure is the most devastating complication after liver resection. (jove.com)
  • Therefore clinicians have tried to induce liver regeneration prior to resection of the liver by manipulating the flow of the portal vein. (jove.com)
  • The time necessary for the liver to grow is weeks to months even though the liver can regenerate at a much faster rate after resection. (jove.com)
  • 7 A novel procedure inducing liver regeneration at a similar pace as after partial hepactectomy was developed by a group of surgeons who discovered that adding a transection between the occluded and the non-occluded part of the liver induces liver hypertrophy at the same growth rate as after liver resection, but prior to resection. (jove.com)
  • 9 The procedure initiates rapid hypertrophy of 80% within a week in the future liver remnant, which allows the resection of extensive, primarily unresectable, liver tumors within a week. (jove.com)
  • The first successful resection of a liver tumor was performed in 1887 in Germany by Langenbuch, the same surgeon who performed the first successful cholecystectomy 5 years earlier. (medscape.com)
  • Liver resection is currently considered to be essential part of the curative treatment of primary and secondary liver malignancies. (nih.gov)
  • After three days of pre-therapy, all animals were submitted to 70% hepatectomy by resection of median and left lateral hepatic lobes which were weighed for posterior calculation of liver regeneration by Kwon's formula. (bvsalud.org)
  • hepatectomy by resection of median and left lateral hepatic lobes which were weighed for posterior calculation of liver regeneration by Kwon´s formula. (bvsalud.org)
  • Liver resection is considered the only curative treatment option for several neoplastic entities of the liver. (tellvienna.com)
  • Indeed, the potential of the liver to regenerate after resection is unique and orchestrated by a combination of highly redundant effector molecules, as blockage of a single molecule only delays but does not stop the process. (tellvienna.com)
  • ii) to identify patients with highly aggressive disease, that will not benefit from liver resection due to rapid recurrence of the tumor. (tellvienna.com)
  • Characterization of regulatory mechanisms and thereby identification of novel therapeutic targets to support the regenerative capacity after liver resection as well as to improve our understanding of the pathophysiological processes involved in liver regeneration. (tellvienna.com)
  • Experimental research of liver regeneration have utilized animal models, in which loss of hepatic tissue is induced by exposure to a toxin which include CCl4, or by surgical resection. (achrinhibitor.com)
  • As human being life expectancy offers improved greatly, more and more seniors individuals with liver disease need partial hepatic resection. (bioinbrief.com)
Mice16
  • Here, we explored the role of Gal1 in liver regeneration using 70% partial hepatectomy (PHx) of C57BL/6 wild type and Gal1-knockout (Gal1-KO, Lgals1-/- ) mice. (oncotarget.com)
  • We demonstrated that Gal1 transcript and protein expression was induced in the liver tissue of wild type mice upon PHx. (oncotarget.com)
  • Thrombin-dependent intrahepatic fibrin(ogen) deposition was recently reported after partial hepatectomy (PHx) in mice, but the role of fibrin(ogen) deposits in liver regeneration has not been investigated. (ashpublications.org)
  • Intrahepatic fibrin(ogen) deposition was abolished in mice with liver-specific tissue factor deficiency, pinpointing the trigger of coagulation after PHx. (ashpublications.org)
  • Removal of two-thirds of the liver in mice causes the remaining liver tissue to regrow to its original size and restore function within 7-10 days . (medicalnewstoday.com)
  • Conditional Met KO mice were generated using Cre‑loxP methodology and characterization of these mice indicated that the HGF‑Met signaling pathway is essential in regeneration, protection, and homeostasis in various tissue types and cells. (spandidos-publications.com)
  • Following partial hepatectomy (PH), recovery of residual liver weight was initially retarded in the mutant mice by down-regulation of hepatocyte proliferation, but occurred comparably between the mutant and control mice at 72 h after PH. (elsevierpure.com)
  • At this time point, the mutant mice showed lowered blood glucose levels with enhanced accumulation of glycogen in the liver. (elsevierpure.com)
  • TIMP-1 knockout mice also displayed greater degree of liver fibrosis after chronic CCl 4 injection when compared with wild-type mice. (biomedcentral.com)
  • Finally, up-regulation of TIMP-1 in the liver and serum after chronic CCl 4 treatment was markedly diminished in hepatocyte-specific signal transducer and activator of transcription 3 (STAT3) knockout mice. (biomedcentral.com)
  • To determine the relevance of NK cells to the TCDD-mediated suppression of liver regeneration, mice were treated with an α-asialo-GM-1 antibody to deplete NK cells prior to TCDD administration and PH. (boisestate.edu)
  • Depletion of NK cells did not restore hepatocyte proliferation in TCDD-treated mice, indicating that NK cells are not required for the attenuation of liver regeneration by TCDD. (boisestate.edu)
  • Studies of liver regeneration capacity were first demonstrated by partial hepatectomy (PH) in rats and mice (Zhao et al. (ebrary.net)
  • Bottom line Decreased survival proportion and impaired LR in aged KO mice is most likely due to reduced liver organ cell proliferation and elevated liver organ cell apoptosis. (bioinbrief.com)
  • Strategies and Components Pets as well as the incomplete hepatectomy model Within this experimental research, wTC57BL/6J and mutant mice were purchased from Shanghai Lab Pet Co. Ltd. The defined previously (28). (bioinbrief.com)
  • Mice survival percentage and liver coefficient Three mice underwent PH at each time point. (bioinbrief.com)
Cell proliferation5
Tissue11
Rats6
  • In rats, hepatic ketogenic capacity increases rapidly during postnatal development ( 4 ) or fasting ( 5 ) when the mRNA, protein, and activity of HMGCS2 increase in liver ( 6 - 8 ). (aacrjournals.org)
  • Administration of dibutyryl-cyclic AMP to adult rats increases mRNA, protein levels, and enzymatic activity of HMGCS2 in the liver ( 6, 9 ). (aacrjournals.org)
  • OBJECTIVE: To analyze, during two different moments of liver regeneration, the effect of the immunosuppressant Tacrolimus on the 70% hepatectomy model-induced liver regeneration in adult rats. (bvsalud.org)
  • hepatectomy model-induced liver regeneration in adult rats. (bvsalud.org)
  • According to the group of study, rats received 0.1mg/Kg/day of tacrolimus or the same volume of saline solution, by gavage, daily, starting three days before hepatectomy until the end of observation (animal death´s day). (bvsalud.org)
  • AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. (edu.mx)
Impairs liver regeneration1
  • Its manifestation can be elevated within 4-6 Rabbit polyclonal to AKT2 hours after PH, whereas decreased expression impairs liver regeneration with increased liver damage. (bioinbrief.com)
Right hepatectomy5
  • To predict the regenerative rate of liver in patients with HCCs after right hepatectomy using texture analysis on preoperative CT combined with clinical features. (hindawi.com)
  • 88 patients with 90 HCCs who underwent right hepatectomy were retrospectively included. (hindawi.com)
  • The use of texture analysis on preoperative CT combined with clinical features can be helpful in predicting the liver regeneration rate in patients with HCCs after right hepatectomy. (hindawi.com)
  • To our knowledge, few studies have investigated the relationship between the results of CT texture analysis and rate of liver regeneration after right hepatectomy in patients with HCCs. (hindawi.com)
  • Donor hepatectomy, even right hepatectomy, can be safely performed with accurate preoperative volumetry and careful decision-making concerning graft-type selection. (elsevierpure.com)
Hepatic regeneration1
  • In the past decades, essential insights in mechanisms of hepatic regeneration have been unraveled and several mediators of these mechanisms have been explored in detail. (tellvienna.com)
Proliferation9
  • Direct thrombin activation of platelets through protease-activated receptor-4 did not contribute to hepatocyte proliferation after PHx, indicating that thrombin contributes to liver regeneration primarily by driving intrahepatic fibrin(ogen) deposition. (ashpublications.org)
  • After the regeneration process has completed, TGF-β puts an end to the proliferation by inducing apoptosis. (wikipedia.org)
  • From the data of the present study we conclude that the cell cycle genes CDC42 and cyclin D1 could be involved in the mechanism of proliferation of the oval cell in the liver regeneration process. (uni-goettingen.de)
  • Bei Schädigung des Lebergewebes können sie durch ihre Fähigkeit zur Proliferation eine Regeneration der Leber herbeiführenUnter bestimmten Umständen wie z.B. Hepatokarzinogenese oder einer durch Drogen, Viren oder Toxine induzierten chronischen Leberschädigung, wenn die proliferative Fähigkeit der Hepatozyten beeinträchtigt ist, kommt es zur Rekrutierung fakultativer hepatischer Stammzellen den so genannten Ovalzellen die in der Lage sind Hepatozyten und Gallengangszellen zu generieren. (uni-goettingen.de)
  • Es kann daher angenommen werden, dass die Ovalzellen ein zweites Kompartiment sind, dass an der Regeneration der Leber beteiligt ist, wenn diese massiv geschädigt und die Proliferation der Hepatozyten suprimiert ist.Um die Rattenleberregeneration durch Ovalzellen zu untersuchen wurde das Protokoll der 70% igen partiellen Hepatektomie (PH) und einer zusätzlichen Behandlung mit 2-Acetoamidofluoren (2-AAF) verwendet. (uni-goettingen.de)
  • Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
  • Unidirectional regeneration in the basal chordate Ciona intestinalis involves the proliferation of adult stem cells residing in the branchial sac vasculature and the migration of progenitor cells to the site of distal injury. (biomedcentral.com)
  • A previous report indicates that exposure to TCDD suppresses hepatocyte proliferation in a mouse model of liver regeneration induced by 70% partial hepatectomy (PH). (boisestate.edu)
  • Hepatocyte proliferation in the remnant liver was measured based on the incorporation of a thymidine analog, bromodeoxyuridine. (boisestate.edu)
Cytokines3
Role in stimu1
Pathways2
Donor9
  • For the same reason, if a person needs a liver transplant , a living donor only needs to donate part of this organ. (medicalnewstoday.com)
  • The remaining portions of the liver then regrow in both the donor and the recipient. (medicalnewstoday.com)
  • [ 4 ] and the fact that a child needs only a small allograft, so an adult donor would not need to undergo major hepatectomy. (medscape.com)
  • However, the enthusiasm fell sharply after a donor death in 2001, which changed the climate for living donation. (medscape.com)
  • We investigated donor liver regeneration by the types of resected segments as well as recipients to assess that appropriate regeneration was occurring. (elsevierpure.com)
  • In the right lobe donor group, the remnant liver volume was 45.4%, and it rapidly increased to 68.9% at 1 month and 89.8% at 6 months. (elsevierpure.com)
  • At 6 months, the regeneration ratios were almost the same in all donor groups. (elsevierpure.com)
  • Livers of the right lobe donor group regenerated fastest in the donor groups, and the recipient liver regenerated faster than the donor liver. (elsevierpure.com)
  • Although the donor livers did not reach their initial volume, the donors showed normal liver function at 1 year. (elsevierpure.com)
Platelet3
Abstract2
  • abstract = "Liver architecture remodeling following partial hepatectomy (PHx) involves the formation of a complex network of liver sinusoids through which the blood flows. (biu.ac.il)
  • Mohammad, Ghulam Abstract: Probiotics are defined as live microbial food ingredients that produce several beneficial ef-fects to human health. (tu-dortmund.de)
Normal liver4
Underlying liver fibrosis1
  • Dr. Scott Friedman has assembled a world-class team of 18 individuals including students, postdoctoral fellows, technicians and physicians who are together exploring the fundamental mechanisms underlying liver fibrosis or scarring. (mssm.edu)
Mechanisms5
  • However, the exact mechanisms whereby platelets accumulate and promote liver regeneration remain uncertain. (ashpublications.org)
  • This model may elucidate mechanisms involved in rapid hypertrophy and allows testing of drugs that promote or block the acceleration of regeneration. (jove.com)
  • Animal models have been developed to explore both the physiological and molecular mechanisms of accelerated liver regeneration in ALPPS. (jove.com)
  • Recent clinical and experimental studies have indicated that cellular and molecular mechanisms associated with liver regeneration after partial hepatectomy may have a proliferative effect on occult micrometastases and circulating tumor cells and are thus responsible for recurrent disease. (nih.gov)
  • as novel contributors in the mechanisms of liver regeneration after partial hepatectomy[13]. (insulin-receptor.info)
Regenerate8
  • The liver is the only visceral organ with the capacity to regenerate. (wikipedia.org)
  • The liver can regenerate after partial surgical removal or chemical injury. (wikipedia.org)
  • As little as 51% of the original liver mass is required for the organ to regenerate back to full size. (wikipedia.org)
  • There are two types of damage from which the liver is able to regenerate, one being a partial hepatectomy and the other being damage to the liver by toxins or infection. (wikipedia.org)
  • The liver is the only visceral organ that can regenerate. (medicalnewstoday.com)
  • The liver has the unique capability to regenerate by itself after an injury. (uni-goettingen.de)
  • Hormone Regeneration - there are secretagogues , which increase the endocrine glands' ability to secrete more hormone, and there are substances that truly regenerate hormones which have degraded (by emitting electrons) into potentially carcinogenic "transient hormone" metabolites. (greenmedinfo.com)
  • In hepatobiliary surgery, this is of major clinical relevance as patient outcome correlates with the potential of the remnant liver to regenerate. (tellvienna.com)
Humans1
Platelets3
Recurrence1
  • Although limited, there is growing clinical evidence that I/R injury and liver quality are associated with the risk of post-sur-gical cancer recurrence. (123dok.net)
Hepatocellular1
  • Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. (medscape.com)
Clinical4
  • Recent clinical data support an aggressive surgical approach to both primary and metastatic liver tumors. (jove.com)
  • In partnership with key pharmaceutical companies, Dr. Friedman and his group monitor the development and testing of potential antifibrotic compounds in cultured cells, in animal models of hepatic fibrosis, and ultimately in clinical trials of patients with chronic liver disease. (mssm.edu)
  • In particular, a growing clinical trials unit has been assembled to rapidly translate basic science discoveries into new treatments for those with liver disease. (mssm.edu)
  • Identification of clinical and experimental markers of liver regeneration which reflect the prognosis of regenerative capability and therefore the postoperative outcome after liver surgery, to ultimately tailor surgical strategy to each individual patient and thereby avoid potentially fatal complications. (tellvienna.com)
Genes10
  • Transcripts of several known regulators of inflammation, cell cycle and cell signaling, including some known PHx-induced genes, were aberrantly expressed (mainly down-regulated) in Gal1-KO compared to control livers at 2, 6 and 24 hours post-PHx. (oncotarget.com)
  • Transient steatosis, which is imperative for liver regeneration following PHx, was significantly delayed and decreased in the Gal1-KO compared to the control liver and was accompanied by a significantly decreased expression in the mutant liver of several genes encoding lipid metabolism regulators. (oncotarget.com)
  • FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth. (nih.gov)
  • During this portion, hundreds of genes are activated and prepare the liver for regeneration. (wikipedia.org)
  • Comparative analysis of the transcriptomes from the 3 different conditions identifies 45 differentially expressed genes during oval cell regeneration, 27 up-regulated and 18 down-regulated. (uni-goettingen.de)
  • Temporal regulation of these genes in the context of the oval cell regeneration was studied by Real Time PCR. (uni-goettingen.de)
  • Kinetically down-regulated genes involved in the lipid metabolism are: hydroxyacid oxidase 3, fatty acid CoA ligase long chain 2, and steroyl CoA desaturase 1.The regulation of protein expression of the cell cycle genes CDC42 and cyclin D1 was studied by Western Blot technique, in the oval cell liver regeneration. (uni-goettingen.de)
  • All four DPP4-like genes were overexpressed in liver tumours and their joint high expression was associated with poor survival in HCC. (preprints.org)
  • We identified 1149 differentially expressed genes, which were separated into two major modules by weighted gene correlation network analysis, one consisting of mostly upregulated genes correlated with regeneration and the other consisting of only downregulated genes associated with metabolism and homeostatic processes. (biomedcentral.com)
  • The chaperone system genes hsp70 , dnaJb4 , and bag3 are significantly upregulated in the branchial sac vasculature following distal injury, defining a stress response that is essential for regeneration. (biomedcentral.com)
Methods2
  • A unique program, under the direction of Dr. Scott Friedman, the Division Director of Liver Diseases and world authority on liver fibrosis, has been established to facilitate the development of novel diagnostic methods and treatments of liver fibrosis. (mssm.edu)
  • In addition, Dr. Friedman and his colleagues are developing new methods for diagnosing fibrosis without the need to perform a liver biopsy, a relatively invasive procedure. (mssm.edu)
Cirrhosis7
  • Various injuries and diseases - such as cirrhosis and hepatitis - can cause liver problems. (medicalnewstoday.com)
  • In contrast, cirrhosis, which is a more severe type of liver disease, can significantly shorten life expectancy. (medicalnewstoday.com)
  • Hepatic fibrosis, or scarring of the liver, is increasingly recognized as a final common pathway for all forms of chronic liver that culminate in cirrhosis. (mssm.edu)
  • Previous findings showed that splenomegaly is usually secondary to PH with associated liver cirrhosis. (insulin-receptor.info)
  • Ahmer Irfan Epidemiology In the past 50 years there has been a marked increase in the incidence and mortality of liver cirrhosis. (ebrary.net)
  • Whereas in the past, HCC generally presented at an advanced stage with right-upper-quadrant pain, weight loss, and signs of decompensated liver disease, it is now increasingly recognized at a much earlier stage as a consequence of the routine screening of patients with known cirrhosis, using cross-sectional imaging studies and serum alpha-fetoprotein (AFP) measurements. (medscape.com)
  • There is also a growing problem with cirrhosis, which develops in the setting of nonalcoholic fatty liver disease (NAFLD), or nonalcoholic steatohepatitis (NASH). (medscape.com)
Ligation1
Cells11
  • In addition, the remnant liver volume can not only directly reflect the amount of the normal hepatic cells, but provide the chance to further evaluate the hepatic function [ 10 , 11 ]. (hindawi.com)
  • The liver or bone marrow stores iron released from hemoglobin, which makes the next generation of blood cells. (medicalnewstoday.com)
  • The liver stores iron from hemoglobin in the form of ferritin, ready to make new red blood cells. (medicalnewstoday.com)
  • Cells involved in immune activity, Kupffer cells, are found in high numbers in the liver. (medicalnewstoday.com)
  • These cells destroy disease-causing viruses, bacteria, or other microorganisms that might enter the liver through the gut. (medicalnewstoday.com)
  • The liver converts heme, a substance in red blood cells, to a greenish compound called biliverdin and then a yellowish-red compound called bilirubin. (medicalnewstoday.com)
  • The liver also affects several other bodily functions, including the breakdown of red blood cells, protein synthesis in the blood plasma, and the removal of iodine from the thyroid hormones. (medicalnewstoday.com)
  • HGF is produced and secreted by adjacent stromal and mesenchymal cells, it contributes to the development of epithelial organs in a paracrine fashion, exerts regenerative effects on epithelia in the liver, kidney, lung, and other tissues, and promotes the regression of fibrosis in numerous organs ( 7 , 8 ). (spandidos-publications.com)
  • However, after the Ciona body is bisected, regeneration occurs in the proximal but not in the distal fragments, even if the latter include a part of the branchial sac with stem cells. (biomedcentral.com)
  • Based on reports that liver regeneration is negatively regulated by interferon (IFN)-γ produced by activated natural killer (NK) cells, along with the well-established immunotoxic effects of TCDD in other model systems, we hypothesized that TCDD treatment attenuates liver regeneration by enhancing NK cell activation and IFN-γ production in the regenerating liver. (boisestate.edu)
  • RNA isolation and reverse transcriptasequantitative polymerase chain reaction Total RNA was isolated from liver cells by Trizol reagent (Dingguo, China). (bioinbrief.com)
Fibrosis7
  • Scott L. Friedman, MD , is the Director of the Fibrosis Research Center, the Irene and Dr. Arthur M. Fishberg Professor of Medicine, Dean for Therapeutic Discovery and the Chief of the Division of Liver Diseases. (mssm.edu)
  • All chronic liver diseases can cause fibrosis, or scarring. (mssm.edu)
  • Currently over 4 million people in the US have HCV, and many will develop severe fibrosis and liver failure over the next two decades. (mssm.edu)
  • Mount Sinai is at the forefront of Liver Fibrosis research. (mssm.edu)
  • Two DPP9 intronic SNPs that have been associated with lung fibrosis and COVID-19 were not associated with liver fibrosis or cancer. (preprints.org)
  • TIMP-1 plays an important role in protecting against acute and chronic liver injury and subsequently inhibiting liver fibrosis induced by CCl 4 . (biomedcentral.com)
  • Chronic liver fibrosis induced by viral hepatitis, alcohol abuse, and nonalcoholic steatohepatitis is a major cause of morbidity and mortality worldwide [ 1 ]. (biomedcentral.com)
Inflammation2
Mortality2
  • Objective Sufferers over 60 years have got higher morbidity and mortality after main liver organ resections. (bioinbrief.com)
  • It has been reported that individuals over 60 years of age possess higher mortality and morbidity after major liver hepatectomy (25). (bioinbrief.com)
Vascular4
  • The present study examines the involvement of vascular endothelial growth factor (VEGF) and angiopoietin-1 (ang-1) during liver regeneration. (biu.ac.il)
  • Thus, liver surgeons have the option to apply vascular inflow control procedures and sometimes total vascular exclusion to reduce intraoperative bleeding. (123dok.net)
  • A complete understanding of the surgical and interventional approach to the liver requires a comprehensive understanding of its anatomy and vascular supply. (medscape.com)
  • The vascular anatomy of the liver defines its functional segments. (medscape.com)
Surgical5
  • BACKGROUND: Liver regeneration is the result of physiological responses that occur after loss of parenchyma, as a consequence of drug abuse-toxic, infection, trauma or surgical procedure. (bvsalud.org)
  • the liver, I/R injury is at the source of poor outcomes after surgical procedures such as hepatectomy and liver trans-plantation [7]. (123dok.net)
  • Lowering intraoperative blood loss during hepatectomy is a crucial factor determining the success of liver resec-tion, as surgical bleeding and transfusion are associated with poor outcomes in both the short- and long term [9- 11]. (123dok.net)
  • Despite substantial improvements in surgical techniques and peri-operative care, post-operative failure of liver regeneration and concomitant liver dysfunction remain an important concern after partial hepatectomy. (tellvienna.com)
  • Philipp is a surgical resident with a specific interest in liver pathophysiology. (tellvienna.com)
Complication1
  • In particular, postoperative liver failure represents a frequently fatal postoperative complication with very limited therapeutic options. (tellvienna.com)
Lobes3
Expression4
  • Gene or protein expression, in liver samples collected at time intervals from 2 to 168 hours post-operation, was tested by either RT-PCR or by immunoblotting and immunohistochemistry, respectively. (oncotarget.com)
  • This appeared to result from reduced expression of PGK-1 and PEPCK since 3-PG, PEP and malate were accumulated to greater extents in the regenerated liver. (elsevierpure.com)
  • Hepatic expression of TIMP-1 mRNA and protein was up-regulated both in acute and chronic liver injury induced by carbon tetrachloride (CCl 4 ). (biomedcentral.com)
  • The hepatic expression of MMP10 in animal models of acute liver injury was tested in order to investigate the role of MMP-10 in liver repair and regeneration. (fupress.net)
Survival1
  • The development of modern agents specifically targeting these processes may improve disease-free and overall survival rates after oncological hepatectomy. (nih.gov)
Bile5
  • Bile acids are important liver products, and their levels are tightly regulated. (nih.gov)
  • Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR. (nih.gov)
  • We propose that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver. (nih.gov)
  • Bile is essential for vitamin K absorption and forms in the liver. (medicalnewstoday.com)
  • The liver must produce enough bile to make clotting factors. (medicalnewstoday.com)
Oncological1
  • This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
Physiological1
Gene3
  • HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)
  • Zakirova E. Use of the active 3D matrix in combination with gene and cell therapy to stimulate skin regeneration (P260) / M Zhuravleva E Garanina A Salmakova A P Kiassov A A Rizvanov // ESGCT XXV Anniversary Congress in Collaboration with the German Society for Gene Therapy October 17-20, 2017 Berlin, Germany. (kpfu.ru)
  • siRNA-mediated gene knockdown showed that hsp70 and dnaJb4, but not bag3, are required for progenitor cell targeting and distal regeneration. (biomedcentral.com)
Hepatocyte3
  • This delay was accompanied by a decreased Akt phosphorylation, and accumulation of the hepatocyte nuclear p21 protein in the Gal1-KO versus control livers at 24 and 48 hours following PHx. (oncotarget.com)
  • These processes occur outside of the hepatocyte and prime the liver for regeneration. (wikipedia.org)
  • This communication can occur because of β-catenin and Notch-1 move to the nucleus of the hepatocyte approximately 15-30 minutes after the hepatectomy. (wikipedia.org)
Progression1
Complications2
  • Scarring in the liver is very dangerous and can lead to further complications and liver disease. (wikipedia.org)
  • Complications increase when the initial cause of the damage to the liver is still present. (wikipedia.org)
Induce1
  • The major drawback of such strategies is that they can induce I/R injury to the residual liver parenchyma [4, 12]. (123dok.net)
Toxins5
  • Factors that increase the probability liver diseases are developed include but are not limited to obesity, type 2 diabetes, tattoos or body piercings, the injection of drugs using shared needles, exposure to other people's blood and body fluids, unprotected sex, and exposure to chemicals and toxins. (wikipedia.org)
  • The liver is a vital organ that regulates waste products in the blood, eliminates toxins, and stores excess energy in the form of glycogen. (medicalnewstoday.com)
  • In some cases, liver dialysis can support a failing liver by removing toxins from the blood. (medicalnewstoday.com)
  • The liver uses an enzyme-based processing and transport system to eliminate toxins and their intermediates. (mdprescriptives.com)
  • For example, Milk Thistle (Silybum marianum) and N-Acetyl Cysteine (NAC) are two superior neutralizers of many liver toxins passing through Phase I & II processing. (mdprescriptives.com)
Stem cell1
  • This study demonstrates the importance of a stress response for stem cell activation and regeneration in a basal chordate, which may have implications for understanding the limited regenerative activities in other animals, including vertebrates. (biomedcentral.com)
Preoperative1
  • The future remnant liver was semiautomatically segmented, and the volume of future remnant liver on preoperative CT (LV pre ) and the volume of remnant liver on following-up CT (LV fu ) were measured. (hindawi.com)
Pivotal1
  • Thus, accurate estimation of remnant liver volume and evaluation of remnant liver regenerative ability after surgery are of pivotal importance in avoiding postoperative liver insufficiency and even liver failure. (hindawi.com)
Stimulate2
  • Despite the outright heretical nature of things which stimulate healing and regeneration vis-à-vis the conventional medical system which frowns upon, or is incredulous towards, spontaneous remission in favor of symptom suppression and disease management, over the course of the past few years of trolling MEDLINE we have collected a series of remarkable studies on the topic. (greenmedinfo.com)
  • Liver Regeneration - Glycyrrhizin , a compound found within licorice, and which we recently featured as a powerful anti-SARS virus agent , has also been found to stimulate the regeneration of liver mass and function in the animal model of hepatectomy. (greenmedinfo.com)
Remnant liver volume1
  • This may be explained by the fact that the remnant liver volume is inadequate after hepatectomy and cannot meet the body's normal metabolic needs and may directly lead to liver dysfunction, liver failure, and even death [ 7 - 9 ]. (hindawi.com)
Inadequate1
  • As experience with liver resections increased dramatically while the supply of cadaveric liver grafts became increasingly inadequate to meet the needs for liver transplants, the concept of resecting a healthy person's liver to use for support of another person's life was raised. (medscape.com)
Adult1
  • 4, 5] The liver is the largest internal organ, representing 2-3% of the total body weight in an adult. (medscape.com)
Partial liver2
  • With a better understanding of hepatic anatomy and the segmental structure of the liver, surgeons started performing partial liver resections. (medscape.com)
  • 0.05) in animals that received a partial liver transplant after 10 h of cold ischemia compared with that in the animals that received a partial liver transplant after 30 min of cold ischemia. (geneticsmr.com)
Portal vein1
Chronic liver4
  • Chronic liver disease means that symptoms appear more gradually, often over months or years. (medicalnewstoday.com)
  • Chronic liver disease often responds well to treatment or lifestyle changes, especially in the early stages when people have minimal symptoms. (medicalnewstoday.com)
  • The remodeling of the extracellular matrix, accompanies the liver regeneration and when the reparative reaction goes awry in the setting of chronic liver injury, could be involved in the carcinogenic process (1,2). (fupress.net)
  • The incidence of HCC is highest in Asia and Africa, where the endemic high prevalence of hepatitis B and hepatitis C strongly predisposes to the development of chronic liver disease and subsequent development of HCC. (medscape.com)
Person's liver1
Regenerative effects1