AnatomyOrganismsDiseasesChemicals and DrugsPhenomena and ProcessesInformation Science
Hemolysin ProteinsHemolysisHemolysin FactorsStreptococcus bovisEnterococcusEnterococcus faecalisStreptococcusGram-Positive Bacterial InfectionsLanguage ArtsGram-Positive CocciStreptococcus pyogenesPharyngitisStreptococcal InfectionsPharynxStreptococcal VaccinesGases
PutativeAlpha-haemolysinBacillusHypothetical proteinMeSHMembraneSpecificitySecretionStaphylococcusNanoporesCytolysinTumorVirulenceInsecticidalSusceptibilityAmino AcidsPlasmodiumPlasmidInsect ControlChannel proteinsBiosynthesisPore sizeBiologicalVacuolesLysisInteractionsPoresGeneResiduesColiStrainsSimilarityPorinResistanceMolecularTargetsConformationalTypeProfilesNanopore
Putative1
  • The yeast metal resistance proteins, which are 850-900 amino acyl residues in length, also exhibit two or three putative TMSs. (tcdb.org)
Alpha-haemolysin2
  • Hha, along with the chromatin-associated protein H-NS, is involved in the regulation of expression of the toxin alpha-haemolysin in response to osmolarity and temperature. (wikipedia.org)
  • Serum antistaphylococcal alpha-haemolysin titres in cystic fibrosis. (bmj.com)
Bacillus3
  • The impacts of biotic and abiotic factors, and hybrids containing the Cry1Ab protein from Bacillus thuringiensis (Bt), were associated with fumonisin accumulation in the grain of maize across contrasting environments in Argentina and the Philippines between 2000 and 2002. (nih.gov)
  • BACKGROUND: Pyramided Bacillus thuringiensis (Bt) crops producing multiple Bt proteins with different modes of action are widely planted in the United States. (tamu.edu)
  • Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. (nih.gov)
Hypothetical protein1
  • Conserved hypothetical protein [Ensembl]. (ntu.edu.sg)
MeSH1
  • Hemolysin Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Membrane6
  • Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. (harvard.edu)
  • Each alpha-hemolysin monomer is water soluble and on the membrane surface these monomers self assemble in an ATP-independent process into the functional heptamer geometry. (immune-source.com)
  • The oligomerization that completes the formation of the heptamer provides the energy to punch through the membrane to form the highly stable alpha-Hemolysin channel. (immune-source.com)
  • Native Plasmodium hemolysin III in the digestive vacuole may contribute to lysis of the parasitophorous vacuole membrane derived from the host erythrocyte. (johnshopkins.edu)
  • The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein. (nih.gov)
  • This system would be broadly applicable for obtaining environmental measurements using membrane proteins as a highly sensitive sensor. (elsevierpure.com)
Specificity1
  • The yeast proteins appear to exhibit broad specificity transporting a wide range of di- and trivalent metal cations. (tcdb.org)
Secretion2
  • The Type VI Secretion System (T6SS) is a multiprotein device that has emerged as an important fitness and virulence factor for many Gram-negative bacteria through the injection of effector proteins into prokaryotic or eukaryotic cells via a contractile mechanism. (frontiersin.org)
  • The hemolysins TDH (thermostable direct hemolysin) and TRH (TDH-related hemolysin) as well as T3SS2 (type 3 secretion system 2) are considered to be major pathogenicity factors. (fu-berlin.de)
Staphylococcus3
  • Staphylococcus aureus-Derived a-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. (harvard.edu)
  • Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia. (harvard.edu)
  • Background The highly stable Alpha-Hemolysin protein channel The alpha-Hemolysin toxin is produced by the bacteria Staphylococcus aureus . (immune-source.com)
Nanopores2
  • These proteins can be used as an alternative to the nanopores in silicon. (scienceblogs.com)
  • To further explore the dynamics of polymer translocation through nanopores, we performed experimental studies of sodium polystyrene sulfonate translocation through α-hemolysin protein nanopores. (umass.edu)
Cytolysin1
  • Mutations in other exotoxins such as elastase, cytolysin/hemolysin, and/or extracellular metalloprotease did not affect the bleb formation or disruption. (ewha.ac.kr)
Tumor2
  • First, it can produce a molecule called hemolysin, which damages the tumor cells' essential membranes. (bostonmagazine.com)
  • We decellularized the metastatic lung sections, measured the micromechanics of the tumor ECM, and stained the sections for ECM proteins, proliferation, and cell death markers. (ibecbarcelona.eu)
Virulence4
  • YmoA modulates the expression of various virulence factors, such as Yop proteins and YadA adhesin, in response to temperature. (wikipedia.org)
  • Hemolysin/bacteriocin is a plasmid-encoded protein that generally is accepted as a virulence factor. (medscape.com)
  • This protein has been demonstrated to increase virulence in several animal models. (medscape.com)
  • Of note, the genes encoding these effectors and immunity proteins are widely distributed in Salmonella genomes, suggesting a relevant role in interbacterial competition and virulence. (frontiersin.org)
Insecticidal1
  • In an attempt to increase the insecticidal effect of the δ-endotoxin crystal protein CryIC on the relatively Cry-insensitive larvae of Spodoptera littoralis, a combination of CryIC and endochitinase was used. (agri.gov.il)
Susceptibility1
  • These results suggest that the pyramided strategy could be valuable for increasing the durability of Bt technology for managing H.zea, a pest with inherently low susceptibility against Cry proteins. (tamu.edu)
Amino Acids1
  • When MspA's residues are colored by charge (negatively charged amino acids are shown in red, positively charged in blue and neutral in gray) we can see that the native MspA protein might not let a negatively changed molecule like DNA pass through (see if you can see why). (scienceblogs.com)
Plasmodium3
  • We identified a panspecies Plasmodium hemolysin type III related to bacterial hemolysins. (johnshopkins.edu)
  • The identification of a hemolysin III homologue in Plasmodium suggests a potential role in host erythrocyte lysis. (johnshopkins.edu)
  • Here, we report the first characterization of Plasmodium falciparum hemolysin III, showing that the soluble recombinant P. falciparum hemolysin III is a pore-forming protein capable of lysing human erythrocytes in a dose-, time-, and temperature-dependent fashion. (johnshopkins.edu)
Plasmid2
  • This family consists of haemolysin expression modulating protein (Hha) from Escherichia coli and its enterobacterial homologues, such as YmoA from Yersinia enterocolitica, and RmoA encoded on the R100 plasmid. (wikipedia.org)
  • Aggregation substance is a plasmid-encoded surface protein that causes clumping or aggregation of enterococci. (medscape.com)
Insect Control1
  • Thus, a combination of the Cry protein and an endochitinase could result in effective insect control in transgenic systems in which the Cry protein is not expressed in a crystalline form. (agri.gov.il)
Channel proteins1
  • In this respect, and also with respect to topology, MIT family members resemble channel proteins. (tcdb.org)
Biosynthesis1
Pore size1
  • With this protein, the pore size is closer to the diameter of DNA. (scienceblogs.com)
Biological1
  • Here, we develop a biological nanopore sensor for single-molecule detection of proteins and PDIs using the pore-forming toxin YaxAB. (nature.com)
Vacuoles1
  • After merozoite egress from infected erythrocytes, remnant P. falciparum hemolysin III released from digestive vacuoles could potentially contribute to lysis of uninfected erythrocytes to contribute to severe life-threatening anemia. (johnshopkins.edu)
Lysis2
  • Hemolysin causes lysis of human erythrocytes, functions as a bacteriocin, and is active against other gram-positive cocci. (medscape.com)
  • Heterologous expression of recombinant P. falciparum hemolysin III in Xenopus oocytes demonstrated early hypotonic lysis similar to that of the pore-forming aquaporin control. (johnshopkins.edu)
Interactions4
  • In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. (nature.com)
  • Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)
  • Although protein-protein interactions (PPIs) are promising targets, drugging them is one of the key challenges in drug discovery 19 . (nature.com)
  • The introduction of chaotropic agents and its effects on protein-protein interactions have also been observed. (immune-source.com)
Pores1
  • Even though DNA can pass through nano pores of alpha-hemolysin, the shape of still presents certain challenges with respect to how DNA moves through the pore. (scienceblogs.com)
Gene4
  • These proteins act as modulators of bacterial gene expression. (wikipedia.org)
  • In addition, there is limited information regarding the repertoire of effector proteins encoded within T6SS SPI-6 and T6SS SPI-19 gene clusters in S . Dublin. (frontiersin.org)
  • Each antibacterial effector gene is located upstream of a gene encoding a hypothetic immunity protein, thus conforming an effector/immunity (E/I) module. (frontiersin.org)
  • [ 4 ] The emm gene encodes the M protein. (medscape.com)
Residues2
  • Highly conserved acidic residues found in the short periplasmic loop are not essential for CorA function or Mg 2+ selectivity but may be required for proper protein folding and stability. (tcdb.org)
  • The CorA proteins of E. coli and S. typhimurium are each 316 amino acyl residues in length. (tcdb.org)
Coli1
  • Finally, the E. coli can release a protein that stimulates the body's immune system. (bostonmagazine.com)
Strains1
  • We found 453 single nucleotide polymorphisms in protein-coding regions, which were used to assess the evolutionary relationships of these Y. pestis strains. (asm.org)
Similarity1
  • The HHA family of proteins display striking similarity to the oligomerisation domain of the H-NS proteins. (wikipedia.org)
Porin1
  • This has led scientists to experiment with other naturally occurring pore proteins such as Mycobacterium smegmatis porin A (MspA). (scienceblogs.com)
Resistance2
  • Helicoverpa zea is a major target pest of pyramided Bt crops and has evolved practical resistance to both Cry1 and Cry2 proteins in some regions of U.S. However, little information is available regarding redundant killing and the dominance of resistance for insects possessing multiple resistance on pyramided Bt crops. (tamu.edu)
  • The Cry1+Cry2-resistant H.zea displayed incompletely recessive to completely dominant resistance on pyramided Bt crops containing Cry1 and/or Cry2 proteins. (tamu.edu)
Molecular1
  • In molecular biology, the haemolysin expression modulating protein family is a family of proteins. (wikipedia.org)
Targets5
  • The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). (nature.com)
  • Aim of this study was to generate 3D models of protein drug targets in Erysipelothrix rhusiopathiae by homology modelling. (ijpsr.com)
  • Among 4153 proteins reported from Erysipelothrix rhusiopathiae , 396 proteins were identified as potential drug targets. (ijpsr.com)
  • The modelled proteins were subjected to protein-ligand docking analysis with standard antibiotics such as Ribostamycin, Cefalotin, Pefloxacin, Penicillamine, Artenimol, Cycloserine against their respective drug targets. (ijpsr.com)
  • The evidence indicates that trivalent, methylated, and relatively less ionizable arsenic metabolites may be capable of interacting with cellular targets such as proteins and even DNA [Kitchin 2001]. (cdc.gov)
Conformational1
  • Conclusion Nanopore-based approaches may eventually provide a direct analysis of the complex conformational "negotiations" that occur upon binding between proteins. (immune-source.com)
Type2
  • The notable contribution of the anginosus group to human in the N terminus of M proteins, driven by the adaptive infections suggests that this group of obligate pathogens immune response of the host, has led to a vast emm type di- deserves more attention in healthcare and research. (cdc.gov)
  • Site-mutation (RN4220-Δhld) and agrA deletion (RN4220-ΔagrA) mutants produced MVs (ΔhldMVs and ΔagrAMVs) with a greater number of bacterial proteins than those derived from wild-type RN4220 (wtMVs). (bvsalud.org)
Profiles2
  • This graph shows the total number of publications written about "Hemolysin Proteins" by people in Harvard Catalyst Profiles by year, and whether "Hemolysin Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Hemolysin Proteins" by people in Profiles. (harvard.edu)
Nanopore2
  • The long funnel-shaped structure and nanofluidic characteristics of the YaxAB nanopore enable the electro-osmotic trapping of diverse folded proteins and high-resolution monitoring of PDIs. (nature.com)
  • Many different molecules have been examined on the nanopore detector platform including biopolymers like ssDNA dsDNA ethylene glycol and a variety of sugars and proteins (see Background for more details). (immune-source.com)