• 90 mmHg in the preceding 12 hours, vasoactive therapy was required to maintain BP, and/or if acute kidney injury had been sustained. (medpagetoday.com)
  • New research suggests pregnancies conceived with assisted reproductive technology were associated with a more than doubling in risk for acute kidney injury. (hcplive.com)
  • An analysis comparing deliveries of children conceived with and without assisted reproductive therapy (ART), results of the analysis suggest conception with ART was independently associated with 1.7- and 2.5-fold increased risks for arrhythmia and acute kidney injury, respectively, after adjustment for baseline risk profile. (hcplive.com)
  • This Funding Opportunity Announcement (FOA) invites applications that propose basic, clinical, translational and outcomes research on acute kidney injury (AKI) in older persons. (nih.gov)
  • Among all age groups, older adults are the most vulnerable to develop acute kidney injury (AKI), defined as a precipitous decline in glomerular filtration rate (GFR). (nih.gov)
  • FILE - New York Giants running back Saquon Barkley (26) runs with the ball against the Indianapolis Colts during an NFL football game Jan. 1, 2023, in East Rutherford, N.J. The NFL has filed a grievance against the NFL Players Association, alleging that union leaders, including President JC Tretter, have advised running backs to "consider feigning or exaggerating injuries" to help increase their leverage in contract negotiations. (abc4.com)
  • After 12 years in the league, the left winger, 35, announced his retirement from the sport in a post to Instagram Aug. 30, having missed the entire 2022-2023 season due to the injury, according to multiple reports. (yahoo.com)
  • [ 12 ] This kinase has been clearly associated with myocardial protection in the setting of ischemic/reperfusion injury [ 13 ] as well as myocardial preconditioning. (medscape.com)
  • The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
  • This is called reperfusion injury. (justia.com)
  • Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
  • One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
  • The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
  • Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
  • Indications for surgical intervention in blunt traumatic injuries may be categorized according to the classification system previously described (see Presentation ). (medscape.com)
  • Tachycardia may indicate volume depletion, pain or stress, and higher heart rates have been found in patients that do not survive traumatic injuries. (nih.gov)
  • No published studies have evaluated the risks of cardiovascular (CV) events, stroke, congestive heart failure (CHF), interstitial lung disease (ILD), and severe acute liver injury (ALI) related to antiarrhythmics treatment in real-world clinical practice setting. (nih.gov)
  • Injuries "Severe" UPDATE 03/08/10: Lee County Coroner Alfred Elmore confirmed in a phone call today with DogsBite.org that Ethel Horton suffered severe injuries in the pit bull attack. (dogsbite.org)
  • Swedish hockey player Carl Hagelin's career in the NHL is coming to an end following a 'severe' eye injury . (yahoo.com)
  • Unfortunately my eye injury is too severe to keep playing the game I love,' he began in the post, referencing the injury he suffered in March 2022 when he took a hockey stick to his left eye. (yahoo.com)
  • The lad had suffered severe head injuries when his bike skidded at Koduvai,India on December 26. (medindia.net)
  • Operative intervention is rarely necessary in blunt thoracic injuries. (medscape.com)
  • In one report, only 8% of cases with blunt thoracic injuries required an operation. (medscape.com)
  • Rib fractures are the most common blunt thoracic injuries. (medscape.com)
  • These result from direct penetrating thoracic injury or injury to a peripheral venous structure with embolization to the heart. (doctorlib.info)
  • The reviewers also caution researchers against attempting to use findings from studies of people without spinal cord injuries to estimate the effectiveness and harms of interventions, such as exercise, in spinal cord-injured people because they may have unique physiologic differences. (spinalcordinjuryzone.com)
  • DUBLIN (AP) - Rugby will use mouthguard technology as part of its efforts to detect brain injuries suffered by players on the field. (fox5sandiego.com)
  • Wellington Senior Care (WSC) offers programs and services that cater to individuals that have sustained traumatic brain injuries. (biami.org)
  • WSC caters to residents who are challenged with ailments such as physical handicaps, alzheimer's, traumatic brain injuries and other factors that impair the individual's ability to live without assistance. (biami.org)
  • Open Heart Community Care Services, Inc. (OHCCS) mission is to provide quality senior home care, residential care, assisting living, and clinical adult day care for individuals that are mentally challenged, disabled or that have experienced traumatic brain injuries. (biami.org)
  • Please keep in mind that brain injuries can be as complex as the brain itself. (brainline.org)
  • Angina (chest pain caused by temporarily reduced blood flow to the heart muscle), shortness of breath with exertion, and heart attack can result from coronary artery disease. (medlineplus.gov)
  • Increased liver enzymes and acute hepatic injury. (nih.gov)
  • Lee et al reported a 1.4- and 1.7-fold increase in the incidence of splenic and hepatic injury, respectively, in those with rib fractures. (medscape.com)
  • Since these kinases have been shown to protect against myocardial injury, we hypothesized that GLP-1 could directly protect the heart against such injury via these prosurvival signaling pathways. (medscape.com)
  • We also noted that the relative risk of myocardial injury between groups, if replicated in a larger clinical effectiveness trial, may indicate significant benefits to continuing RAS inhibitors during the peri-operative period," Ackland's group wrote. (medpagetoday.com)
  • Study authors noted that hemodynamic instability is associated with peri-operative myocardial injury, which is known to be a frequent complication of noncardiac surgery. (medpagetoday.com)
  • Prior research has associated peri-operative myocardial injury with a greater risk of subsequent mortality even if caught early . (medpagetoday.com)
  • The primary endpoint, myocardial injury, was defined as plasma high-sensitivity troponin-T (hs-TnT) ≥ 15 ng/L within 48 hours after surgery, or a ≥5 ng/L increase when pre-operative hs-TnT ≥15 ng/L in blood samples collected immediately before the induction of anesthesia. (medpagetoday.com)
  • Myocardial Injury After Noncardiac Surgery. (bmj.com)
  • Most of the back injuries consisted of pulled muscles or strains, similar to shoulder complaints. (nfpt.com)
  • In this article, we examine the activities in which plantar flexion may occur, the muscles behind it, and what happens when injuries occur to these muscles. (medicalnewstoday.com)
  • Stronger muscles are also less prone to injury. (imperialvalleynews.com)
  • Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the body. (medindia.net)
  • Rarely, a tear in the membrane that separates two chambers of the heart (septal rupture) may occur. (msdmanuals.com)
  • Some babies are born with congenital heart defects, which are problems that occur with the baby's heart while the baby is developing in utero . (bila.ca)
  • Understanding the mechanics of such issues can help avoid potential problems as well as teach us the best manner of dealing with injuries, if and when they occur. (nfpt.com)
  • Why Do Injuries Occur? (nfpt.com)
  • Abnormal heart rhythms (arrhythmias) of various types can occur. (medlineplus.gov)
  • Blunt injury to the heart is a blow to the chest that bruises the heart muscle, tears (ruptures) the heart's walls, or damages a heart valve. (msdmanuals.com)
  • Chest injuries and disorders are problems that affect any of the organs or structures located in your chest. (nih.gov)
  • Chest injuries may happen from the force of car accidents, falls , or sports injuries . (nih.gov)
  • Because your chest holds so many important structures, certain chest injuries may be life-threatening. (nih.gov)
  • How are chest injuries and disorders diagnosed? (nih.gov)
  • Diagnosis of chest injuries or disorders depends on the type of symptoms you're having and whether you've had a chest injury. (nih.gov)
  • Treatments will depend on the type of chest injury or disorder you have. (nih.gov)
  • Chest X-ray s show lung injury, even in patients that only have gastrointestinal symptoms. (nih.gov)
  • The heart and its tributaries are encased in the chest cavity, composed of the manubrium, sternum, clavicle, rib cage, and vertebral bodies. (doctorlib.info)
  • The location of injury to the heart is associated with the location of injury on the chest wall. (doctorlib.info)
  • Heart disorders are. (msdmanuals.com)
  • Newswise - Americans who live with spinal cord injury do not appear to be at greater risk of developing carbohydrate and lipid disorders such as insulin resistance, diabetes, impaired glucose tolerance, and high or low blood cholesterol levels - risk factors for heart disease - than able-bodied persons, according to a new evidence review by HHS' Agency for Healthcare Research and Quality. (spinalcordinjuryzone.com)
  • In addition, the reviewers found no scientific support for establishing different standards for measuring carbohydrate and lipid disorders in spinal cord-injured persons versus the established ones for defining and treating these problems in people without such injuries. (spinalcordinjuryzone.com)
  • The report released today, Carbohydrate and Lipid Disorders and Relevant Considerations in Persons with Spinal Cord Injury is the newest analysis from AHRQ's Evidenced-based Practice Program. (spinalcordinjuryzone.com)
  • There continues to be tremendous confusion as the term blunt cardiac injury/cardiac contusion is applied to a wide spectrum of pathology. (doctorlib.info)
  • Blunt cardiac trauma has replaced the term "cardiac contusion" and describes injury ranging from insignificant bruises of the myocardium to cardiac rupture. (doctorlib.info)
  • On October 23, 2019, NHLBI convened an expert working group to identify research needs and opportunities toward understanding this new disease, which became known as e-cigarette, or vaping, product use-associated lung injury (EVALI). (nih.gov)
  • Specific weightlifting-related injuries over a 6-year period yielded very interesting data. (nfpt.com)
  • Heart Failure (HF) Heart failure is a disorder in which the heart is unable to keep up with the demands of the body, leading to reduced blood flow, back-up (congestion) of blood in the veins and lungs, and/or. (msdmanuals.com)
  • If your baby is born with a heart defect and there is any suggestion that it could have been diagnosed and/or treated in utero , an experienced obstetrical lawyer will be in a position to investigate the possibility of a malpractice claim. (bila.ca)
  • Only 2% of patients surviving the initial injury required reoperation for a residual defect. (doctorlib.info)
  • The Washington DC medical malpractice lawyers at Goldberg Finnegan are available for a free telephone consultation about Paxil Birth Injuries and Paxil heart defect cases. (goldbergfinnegan.com)
  • They are prone to injury because they sit just inside the front of the skull and near rough bony ridges. (brainline.org)
  • Spinal cord injury is usually caused by a sudden traumatic blow to the spine such as from accidents or violent events, including combat. (spinalcordinjuryzone.com)
  • Fractures of ribs 8-12 should raise the suggestion of associated abdominal injuries. (medscape.com)
  • However, many injuries worsen over hours or even longer. (msdmanuals.com)
  • Increasing temperatures and causing poor air quality that can affect the heart and worsen cardiovascular disease . (nih.gov)
  • The main artery from the heart (aorta) becomes thicker, stiffer, and less flexible. (medlineplus.gov)
  • Following the treatment for an occlusion of a coronary artery branch (an artery supplying the heart muscle), a damage to heart muscle occurs. (justia.com)
  • An earlier study on mice found that chronic, daily exposure to e-cigarette vapor can produce lasting increases in artery stiffness, which is a risk factor for heart attack and stroke. (nih.gov)
  • Heart rate may be altered by trauma in a couple of ways. (nih.gov)
  • This would include solutions-focused research on infectious diseases, injury and trauma, mental health impacts, asthma and other lung diseases, and health disparities. (nih.gov)
  • Penetrating trauma to the great vessels can lead to immediate exsanguination or pattern of injury similar to blunt trauma including pseudoaneurysm, partial transection with intimal flap, thrombosis, and propagation. (doctorlib.info)
  • 1 Penetrating cardiac trauma is a highly lethal injury, with relatively few victims surviving long enough to reach the hospital. (doctorlib.info)
  • Penetrating trauma is a common mechanism for cardiac injury, with the predominant etiology being from firearms and knives 4 ( Table 26-1 ). (doctorlib.info)
  • 4 Thus, the majority of injuries are to the myocardium, and are readily managed by the general/trauma or acute care surgeon. (doctorlib.info)
  • Injury (trauma) is the leading cause of death for all age groups under the age of 44. (medindia.net)
  • Golfers who carry their own bags have higher rates of shoulder and back injuries than do other golfers. (imperialvalleynews.com)
  • In one report, 50% of patients with blunt cardiac injury have rib fractures. (medscape.com)
  • Blunt cardiac injuries have been reported less frequently than penetrating injuries. (doctorlib.info)
  • We show for the first time that GLP-1 protects against myocardial infarction in the isolated and intact rat heart. (medscape.com)
  • People who have an abnormal heart rhythm (heartbeats that are too fast, too slow, or irregular) are admitted to the hospital so that the rhythm can be monitored continuously. (msdmanuals.com)
  • These can be structural (such as a problem with a valve or a blockage) or functional (such as problems with heart rhythm). (bila.ca)
  • Ambulatory blood pressure measurements (ABPMs) indicated a loss of circadian blood pressure rhythm (sympathetic control) but preserved heart rate rhythm (parasympathetic regulation) only in patients with complete tetraplegia. (nih.gov)
  • Measures included quantification of injury severity (New Injury Severity Score (NISS)), visceral fat area (dual-energy X-ray absorptiometry), arterial stiffness (heart rate-adjusted central augmentation index (cAIx) and pulse wave velocity (PWV)), fasting venous blood glucose, lipids and high-sensitivity C reactive protein (hs-CRP). (bmj.com)
  • CRTI, injury severity (↑NISS), age, socioeconomic status (SEC) and physical activity were independently associated with both MetS and cAIx. (bmj.com)
  • Conclusions CRTI is associated with an increased prevalence of MetS and arterial stiffness, which are also influenced by age, injury severity, physical activity and SEC. The longitudinal impact of CRTI on clinical cardiovascular events needs further examination. (bmj.com)
  • Increasing the frequency and severity of extreme weather events, in addition to causing injuries, deaths, illnesses, and effects on mental health from damage to property, loss of loved ones, displacement, and chronic stress. (nih.gov)
  • The valves inside the heart, which control the direction of blood flow, thicken and become stiffer. (medlineplus.gov)
  • Such a tear may not cause symptoms until some time after a blunt injury. (msdmanuals.com)
  • Heart failure: Monitor for signs and symptoms. (nih.gov)
  • Players who might not have shown symptoms can then be taken off the field and checked out as part of the Head Injury Assessment (HIA) process. (fox5sandiego.com)
  • RAS inhibitors were prescribed for hypertension in 97% of patients, and those with heart failure comprised fewer than 10% of the study population. (medpagetoday.com)
  • The review's authors, who are with the AHRQ-supported Minnesota Evidence-Based Practice Center in Minneapolis, caution clinicians on depending on the Body Mass Index to assess obesity - a key risk factor for developing diabetes and heart disease - in spinal cord-injured patients because it may underestimate their fat mass and is likely inaccurate. (spinalcordinjuryzone.com)
  • Initially most patients with mitral valve regurgitation have normal heart function. (beginnertriathlete.com)
  • But when the heart starts to function poorly, patients will start to become more short of breath with exertion. (beginnertriathlete.com)
  • To assess the impairment of supraspinal control over spinal sympathetic centres and the occurrence of autonomic dysreflexia in patients with spinal cord injury. (nih.gov)
  • Therefore, patients with spinal cord injury were examined clinically and by different techniques to assess the occurrence of autonomic dysreflexia and to relate disturbances of the sympathetic nervous system to episodes of autonomic dysreflexia. (nih.gov)
  • The urodynamic examination was more sensitive in indicating signs of autonomic dysreflexia in patients with spinal cord injury, whereas SSR allowed the assessment of the degree of disconnection of the sympathetic spinal centres from supraspinal control. (nih.gov)
  • In a series of 1,198 patients with penetrating cardiac injuries in South Africa, only 6% of patients reached the hospital with any signs of life. (doctorlib.info)
  • OHCCS serves individuals and their families with an open heart, changing one life at a time, by working diligently with the health community to sustain or improve an individual's quality of life. (biami.org)
  • 2 With improvements in organized emergency medical transport systems, up to 45% of those who sustain significant heart injury may reach the emergency department with signs of life. (doctorlib.info)
  • Overview of Abnormal Heart Rhythms Abnormal heart rhythms (arrhythmias) are sequences of heartbeats that are irregular, too fast, too slow, or conducted via an abnormal electrical pathway through the heart. (msdmanuals.com)
  • All of these observations have been made in intact, isolated hearts during a relatively short time-course (minutes) and appear to be independent of changes in collagen content [ 16 , 17 ], supporting an acute intracellular action of MMP-2. (hindawi.com)
  • In response to a surge of hospital admissions and deaths related to vaping last year, the National Heart, Lung, and Blood Institute (NHLBI) worked quickly to shed light on the epidemic and spur new research. (nih.gov)
  • Cardiac injury may account for 10% of deaths from gunshot wounds. (doctorlib.info)
  • According to statistical data, 0.8-1% of accidental deaths are caused by an electric injury, with approximately one quarter caused by natural lightning . (medscape.com)
  • A slight increase in the size of the heart, especially the left ventricle occurs in some people. (medlineplus.gov)
  • EPO usage for cytoprotection is undoubtedly advantageous, but it may need to be offset with an anti-inflammatory agent in some organs, like kidney and heart, where progression to chronic fibrosis after acute injury is often recorded. (medjournal.com)
  • The chronic endothelial injury hypothesis is one of two major mechanisms postulated to explain the underlying cause of atherosclerosis and coronary heart disease (CHD), the other being the lipid hypothesis. (wikipedia.org)
  • Several factors likely contribute to this rise in AKI incidence including more aggressive surgical and medical treatments, increasing numbers of chronic and comorbid illnesses, greater use of nephrotoxic medications and imaging agents, aging of the population, and longer exposure to chronic diseases and nephrotoxins, all of which may be associated with direct or vascular-related kidney injury. (nih.gov)
  • The nerve injury known as carpal tunnel syndrome, or median nerve entrapment at the wrist, presents with a tingling sensation/numbness, eventually leading to significant and often debilitating pain. (nfpt.com)
  • Neutrophil extracellular traps (NETs) assist pathogen clearance, while excessive NETs formation is associated with exacerbated inflammatory responses and tissue injury in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). (nature.com)
  • The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), solicit the submission of investigator-initiated research grant applications to support research investigating the Mechanisms of Alcohol Induced Tissue Injury in diverse groups and across the life span. (nih.gov)
  • People who have damage to a heart valve or a tear in the heart's wall usually require surgery. (msdmanuals.com)
  • The exact reason for cardiac arrest is unclear, but commotio cordis does not result from an underlying heart disorder or from physical damage to the heart muscle. (msdmanuals.com)
  • When dealing with the aftermath of any sports-related injury, distinguishing one involving potential nerve damage from the much more commonplace soft tissue tears can make a significant difference in how these issues get addressed, treated and resolved. (nfpt.com)
  • Will sustained exercise at or near maximum heart rate increase the risk of heart damage, or heart failure. (beginnertriathlete.com)
  • The acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is one of the most life-threatening forms of acute respiratory failure featured with diffuse alveolar damage secondary to pulmonary or systemic inflammation process [ 1 ]. (nature.com)
  • The FDA has not cited any complications involving the heart after CPAP use. (chaliklaw.com)
  • A tear in the wall of the heart (ventricular rupture) often causes fatal bleeding before people can be taken to a hospital. (msdmanuals.com)
  • The injury caused a rupture to his left choroid , which is the part of the eye located between the sclera, or whites of the eye, and the retina, the layer of cells lining the internal wall at the back of the eye, according to the American Academy of Ophthalmology. (yahoo.com)
  • At the time, Keelan noted that a no-fault compensation program for vaccine-related injuries would not only benefit people who suffer harm, it might also give those who are waffling about whether to get a vaccine the incentive they need to go ahead. (ctvnews.ca)
  • In a historic surgical achievement, U.S. medical professionals successfully transplanted a pig's heart into an end-stage cardiovascular disease patient. (medindia.net)
  • Because of an anterior location, the cardiac chambers at greatest risk for injury are the right and left ventricles. (doctorlib.info)
  • On December 8, 2005 the FDA advised the public that exposure to paroxetine (active ingredient in Paxil) in the first 3 months of pregnancy could increase the risk for congenital malformations, birth defects and particularly heart malformations and cardiac malformations. (goldbergfinnegan.com)
  • If you want to reduce the risk of golf injuries, consider taking lessons. (imperialvalleynews.com)
  • The smart technology, which measures the force of head impacts in real time, will send alerts to an independent matchday doctor to signal "a high level of acceleration which could lead to an injury," global governing body World Rugby said Monday. (fox5sandiego.com)
  • This rigid chassis, for the most part, provides adequate protection against small impacts/injuries. (doctorlib.info)
  • Resistance training, from the point of view of one's muscle tissue, practically invites injuries. (nfpt.com)
  • Non-suicidal self-injury (NSSI) involves deliberate harm to one's own body without the intention to die. (health.mil)
  • 4 More complicated intracardiac injuries involved the coronary arteries, valvular apparatus, and intracardiac fistulas (such as ventricular septal defects). (doctorlib.info)
  • Would you like to receive the Parents Guide to Birth Injury Lawsuits e-book? (bila.ca)
  • However, there is a limited understanding of the number of vaccine-injury related lawsuits in Canada. (ctvnews.ca)
  • 1 The actual incidence of cardiac injury is unknown because of the diverse causes and classifications. (doctorlib.info)
  • RAS inhibitors, namely angiotensin-converting-enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), are widely used drugs for high blood pressure (BP) and heart failure. (medpagetoday.com)
  • The person may then develop heart failure. (msdmanuals.com)
  • In addition, these machines did not appear to directly cause heart failure or heart attacks. (chaliklaw.com)
  • In the case of the heart, promotion of fibrosis may be advantageous where an infarct has destroyed a zone of cardiomyocytes, but if EPO stimulates progressive fibrosis in the heart, this may promote cardiac failure. (medjournal.com)
  • This acute inflammatory lung injury results in hypoxemia, pulmonary edema and other clinical manifestations [ 2 ]. (nature.com)
  • The long-term health outcomes of survivors of combat-related traumatic injury (CRTI) are unclear. (bmj.com)
  • Internet Medical Journal: Use of high-dose erythropoietin for repair after injury: A comparison of outcomes in heart and kidney. (medjournal.com)
  • This review compares the outcomes from use of EPO in the injured heart and kidney, two organs that are thought, traditionally, to have intrinsically-different repair mechanisms. (medjournal.com)
  • As fitness professionals, we accept the premise that most serious strength-training athletes and bodybuilders will experience injuries at some point in time. (nfpt.com)
  • Even for elite athletes/weightlifters, typical injuries arise predominantly from overuse. (nfpt.com)
  • In my nearly 30 years of practicing medicine, I have treated multiple athletes and weekend warriors with injuries. (active.com)
  • Overuse and overtraining injuries often fall into this category. (nfpt.com)
  • Many golfing-related injuries are a result of poor mechanics or overuse. (imperialvalleynews.com)
  • In the past, I would often describe traditional therapies for acute injuries, such as intermittent icing, wound compression and the use of anti-inflammatory agents. (active.com)
  • Then, the vessels begin to collect together into larger and larger veins, which return blood to the heart. (medlineplus.gov)
  • If a physician or coach cannot definitively pinpoint the specific injury site, nerve conduction tests can prove helpful. (nfpt.com)
  • Early diagnosis of fetal heart defects is important as it provides an opportunity to plan appropriate management of the baby at birth, including arranging for delivery at a tertiary care center with pediatric cardiac specialists immediately available. (bila.ca)
  • This is true, but, more importantly, acupuncture helps facilitate injury repair and wound healing by accessing energy pathways called meridians. (active.com)