Hair cells auditory. Medical search. Frequent questions

Sensory hair cells in the mammalian cochlea convert mechanical stimuli into electrical impulses that subserve audition. (elsevierpure.com)
Here we show that in utero gene transfer of Atoh1 produces functional supernumerary hair cells in the mouse cochlea. (elsevierpure.com)
Our results demonstrate that manipulation of cell fate by transcription factor misexpression produces functional sensory cells in the postnatal mammalian cochlea. (elsevierpure.com)
The mainstay of the human auditory system is the cochlea, a coiled duct measuring about 30 millimeters. (home-remedies-for-you.com)
The cochlea consists of nerve fibers and specialized cells designed to detect a plethora of sound frequencies and noise levels. (home-remedies-for-you.com)
Within the inner ear is the cochlea, a delicate structure with hair cells inside. (webmd.com)
Loud noise damages the hair cells in the cochlea. (webmd.com)
Loud noise can damage cells and membranes in the cochlea. (cdc.gov)
The average person is born with about 16,000 hair cells within their cochlea. (cdc.gov)
When the sound vibrations reach the cochlea, they push against specialized cells known as hair cells. (medel.com)
The auditory nerve connects the cochlea to the auditory centers of the brain. (medel.com)
When the hair cells of the cochlea are missing or damaged, this is known as sensorineural hearing loss. (medel.com)
Auditory brainstem response (ABR) audiometry typically uses a click stimulus that generates a response from the basilar region of the cochlea. (medscape.com)
The response is believed to originate from afferent activity of the CN VIII fibers (first-order neurons) as they leave the cochlea and enter the internal auditory canal. (medscape.com)
The vibrations entering the cochlea cause the fluid and hair cells to move, much like the movement of seaweed on the seabed when waves pass over it. (ndcs.org.uk)
Metal accumulation is regulated in part by the functionality and affinity of these metals for the different transport systems responsible for uptake across the blood-cochlea barrier and their subsequent uptake into the different cells within the inner ear. (cdc.gov)
The auditory brainstem response (ABR) test tells us how the inner ear, called the cochlea, and the brain pathways for hearing are working. (kyoto2.org)
In fact, a team of researchers has recently used new findings from research on development of the inner ear to induce a few new cells in the guinea pig cochlea to become hair cells again proving that hair cell regeneration will be possible. (hearingreview.com)
The good news is that, for the first time in history, there are teams of investigators worldwide exploring the possibility that hair cell regeneration can be induced in the mammal and human cochlea. (hearingreview.com)
With sensorineural hearing loss (SNHL), the damaged hair cells of the organ of Corti within the cochlea interfere with typical hearing and, as a result, cause impaired language development. (intechopen.com)
There are tiny, delicate hair cells in your inner ear (cochlea) that move when your ear receives sound waves. (sparrow.org)
The sound waves then travel through the cochlea (the snail shell looking structure in the image) and transmit sound to the persons brain via the auditory nerve. (hubpages.com)
Often this means the tiny hair cells in the cochlea are bent, broken, or sheared. (hubpages.com)
You can see the difference between normal hair cells in the cochlea and damaged hair cells here. (hubpages.com)
Mn accumulates in the inner ear (cochlea) following acute in vivo treatment and in vitro studies show that uM levels of Mn damage sensory hair cells and spiral ganglion neurons (SGN) in the inner ear. (cdc.gov)
Tiny sensory hair cells within the cochlea capture the vibrations and transform them into electrical signals. (betterhearing.org)
The fibers of the cochlear nerve originate from an aggregation of nerve cell bodies in the spiral ganglion, located in the modiolus of the cochlea. (medscape.com)
The vibrations are amplified via the auditory ossicles and sent to the cochlea in the inner ear. (lu.se)
The hair cells inside the fluid-filled cochlea react to sounds of different frequencies, 20-20 000 Hz. (lu.se)

One hallmark embodying the auditory temporal precision is phase-locking, a phenomenon that the timing of spikes fired by single auditory neurons is synchronized and therefore phase-locked to acoustic cycles ( Heil and Peterson, 2017 ). (jneurosci.org)
Hair cells that respond to high frequency stimuli send information to specific neurons, and the information remains segregated in the brain. (wikipedia.org)
Thus, information about sound frequency is preserved, rather than being lost as it would if all information from different hair cells converged on the same neuron or group of neurons. (wikipedia.org)
Loss of hair cells and their innervating neurons is the most frequent cause of hearing impairment. (elsevierpure.com)
The flow of information through the brain relies on the coordinated activity of thousands or millions of cells, and on ensembles of neurons that are active simultaneously. (amherst.edu)
Hearing loss correlated with cell death in hair cells, degeneration of spiral neurons and increased macrophage infiltration. (datadryad.org)

Interestingly, hair cell loss was not present in the frequency regions where elevated cochlear thresholds and central hyperactivity were measured, suggesting that subtle changes in hair cell or primary afferent neural function are sufficient for central hyperactivity to be triggered and maintained. (edu.au)
Damage to the inner ear or auditory neural system is generally permanent. (cdc.gov)
When the auditory nerve is damaged or missing, this is known as neural hearing loss. (medel.com)
Vision is known to impact auditory perception and neural mechanisms in vision and audition are tightly coupled, thus, in order to understand how we hear and how CIs affect auditory perception we must consider the integrative effects across these senses. (aro.org)
What are the basic 7 steps of the auditory system to convert sound to neural signals? (freezingblue.com)
But perhaps we can do better by ignoring the details and modeling the auditory system as a black box, via a deep neural network (DNN). (stanford.edu)
However, supporting Schwann and satellite cells, as in all cranial ganglia, are entirely of neural crest origin, apparently arising from the ganglion of the facial nerve (see the image below). (medscape.com)
In contrast, all the supporting and Schwann cells are derived from neural crest cells, possibly from the VIIth nerve ganglion to which the vestibulocochlear ganglion is initially attached. (medscape.com)
Sensorineural hearing loss is caused by lesions of either the inner ear (sensory) or the auditory (8th) nerve (neural). (msdmanuals.com)
Auditory brainstem response is a response to external stimulation that represents the neural electrophysiological activity of the auditory system at the brainstem level. (bvsalud.org)
The Brainstem Auditory Evoked Response (BAEP) is a complex response to externalstimulation that represents the neural electrophysiological activity of the auditory system at the level of the brainstem, mapping the synapses of the auditory pathways from the cochlear nerve, cochlear nucleus, superior olivary brainstem complex to the inferior colliculus-midbrain 1,2 . (bvsalud.org)

Auditory brainstem response (ABR) audiometry is a neurologic test of auditory brainstem function in response to auditory (click) stimuli. (medscape.com)
Unique among human sensory receptors, the ear's hair cells are not passive, but use an active process that results in a thousandfold amplification of auditory stimuli. (eurekalert.org)

The positive peaks of the waveforms reflect combined afferent (and likely efferent) activity from axonal pathways in the auditory brain stem. (medscape.com)
Progenitor cell therapy may also allow functional reorganization of the auditory pathways including primary auditory cortex (Heschl's gyrus). (intechopen.com)

Sensory hair-cells are required to reliably transmit auditory and vestibular information to the brain. (amherst.edu)
While the majority of hearing loss is due to damage of sensory hair cells, there is accumulating evidence that in cases of noise-induced hearing loss, the pathology may be due to damage of hair-cell synapses rather than hair cells. (amherst.edu)
Recently we examined how ensembles of sensory hair cells function in vivo using optical indicators in intact zebrafish. (amherst.edu)
Therefore synaptically silent hair cells may be an important reserve that acts to maintain sensory function. (amherst.edu)
For many years, auditory research has placed considerable emphasis on the regeneration of sensory hair cells. (news-medical.net)
Hair cells and supporting cells of inner ear and lateral line sensory organs evolved from a common cell type to accommodate diverse forms of mechanical input. (frontiersin.org)
We seek to highlight contemporary research into the function of sensory hair cells and supporting cells in diverse hair cell organs, with consideration of the major questions and impediments to full understanding of sensory processing in the inner ear. (frontiersin.org)
In preclinical and clinical studies, progenitor cell therapy (cord blood and mesenchymal stem cells) has shown promise in reversing the underlying pathology of SNHL, the loss of cochlear sensory hair cells. (intechopen.com)
The implant helps those who are deaf because of damage to sensory hair cells in the inner ear, by providing electronic stimulation of the auditory nerve. (talkingpointsmemo.com)
The sensory taste cells are specialised cells on the tongue, taste buds, which can distinguish between five tastes: sour, sweet, salty, umami and bitter. (lu.se)

Acoustic trauma caused by exposure to a very loud sound increases spontaneous activity in central auditory structures such as the inferior colliculus. (edu.au)
In this study we further investigated the relationship between cochlear compound action potential threshold loss, cochlear outer and inner hair cell loss, and central hyperactivity in inferior colliculus of guinea pigs. (edu.au)
The signal travels along the auditory pathway from the cochlear nuclear complex proximally to the inferior colliculus. (medscape.com)
What is the function of the inferior colliculus in the auditory systme? (freezingblue.com)

The peripheral segments of the cochlear and vestibular nerves join at the lateral part of the internal auditory canal (IAC) to form the vestibulocochlear nerve. (medscape.com)
The "mouth" of the internal auditory canal (IAC) is called the porus acusticus. (medscape.com)

And finally, route three gets us in the primary afferent auditory and/or vestibular nerve cells. (iflscience.com)

An OAE test uses a small, very sensitive microphone inserted into the ear canal to monitor the faint sounds produced by the outer hair cells in response to auditory stimulation. (kyoto2.org)

In this study, we combined patch-clamp recording and two-photon Ca 2+ imaging to examine Ca 2+ dynamics in hair cell ribbon synapses in the bullfrog amphibian papilla of both sexes. (jneurosci.org)
SIGNIFICANCE STATEMENT Hair cell synapses can transmit sound-driven signals precisely in the kHz range. (jneurosci.org)
This allowed us to reveal the Ca 2+ extrusion mechanisms that are required for phase-locking at auditory hair cell ribbon synapses. (jneurosci.org)
Recent advances feature the identification of proteins constituting the mechanosensing machinery of hair bundles, how electromechanical amplification arises from prestin, novel mechanisms of signal transmission across specialized synapses and how supporting cells contribute to the homeostasis , maturation and regeneration of hair cell epithelia. (frontiersin.org)

Hearing function was assessed using distortion product otoacoustic emissions (DPOAE), auditory brainstem responses (ABR) and the compound action potential (CAP). (cdc.gov)

gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
As an example, hair cells express different sets of ion channels that shape the frequency, gain and time course of receptor potentials to optimize sensitivity to sounds, head or body motions. (frontiersin.org)
the hair cell portion of hearing is were the acoustical pressure waves are turned into electrical potentials) the electrial potentials transfer on the auditory nerve (I know thier is alot more to it) the electrical potentials are transfered to the brain which actually interpets the sound. (mast-victims.org)
ECochG generally involves measurement of the stimulus-related cochlear potentials (as opposed to the resting potentials), and often includes measurement of the whole nerve or compound action potential (AP) of the auditory nerve. (audiologyonline.com)
Although available to the hearing scientist/clinician for over 50 years, ECochG's emergence as a clinical tool (as well as all other auditory evoked potentials) was rekindled in part by the discovery, application and popularity of the auditory brainstem response (ABR). (audiologyonline.com)
The technical capability of recording cochlear and auditory nerve potentials in humansled to a variety of clinical applications for ECochG. (audiologyonline.com)

Proper perception of sounds in the environment requires auditory signals to be encoded with extraordinary temporal precision up to tens of microseconds, but how it originates from the hearing organs in the periphery is poorly understood. (jneurosci.org)
As the waves peak, they cause tiny hair cells to bend, which converts the vibrations into electrical signals. (cdc.gov)
The auditory nerve carries the electrical signals from the inner ear to the brain. (cdc.gov)
The auditory nerve carries these signals to the brain where they are understood as sound. (ndcs.org.uk)
This movement triggers electrical signals along the nerve from your ear to your brain (auditory nerve). (sparrow.org)

However, previous studies of Ca 2+ handling in auditory hair cells have often been conducted in immature hair cells, with elevated extracellular Ca 2+ concentration, or through steady-state stimulation that may not be physiologically relevant. (jneurosci.org)

Moreover, the hair cells are capable of mechanoelectrical transduction and show basolateral conductances with age-appropriate specializations. (elsevierpure.com)

Hair cells convert the vibrations into electrical impulses that the auditory nerve sends to your brain, and your brain interprets as sound. (webmd.com)
The hair cells turn the vibrations into electrical nerve impulses. (medel.com)

Waves move the basilar membrane but not the tectorial membrane resulting in conformational changes in the stereocilia of hair cells. (powershow.com)
Ignoring details like the basilar membrane transmission line, and inner and outer hair cells, and all sorts of brain structures, can a DNN provide a good enough model? (stanford.edu)

First described by Jewett and Williston in 1971, ABR audiometry is the most common application of auditory evoked responses. (medscape.com)
Adding separate R and C responses (middle tracing) enhances the cochlear Summating Potential (SP) and auditory nerve Action Potential (AP). (audiologyonline.com)
Dusp1 gene knock-out caused premature progressive hearing loss, as confirmed by auditory evoked responses in Dusp1-/- mice. (datadryad.org)

I think this hum effect is a auditory nerve reaction, that stimulates the auditory cortex. (mast-victims.org)
Talk into the ear and follow the sound's path via the ear canal into the auditory cortex in the temporal lobes of the cerebral cortex. (lu.se)

These results tell us that auditory-nerve fibers carrying impulses from the ear to the brain can regrow, which is essential to the recovery of hearing, and that the central auditory system in the brain reorganizes itself to maintain its function while the nerve fibers are damaged. (kyoto2.org)
If the hairs inside your inner ear are bent or broken - this happens as you age or when you are regularly exposed to loud sounds - they can "leak" random electrical impulses to your brain, causing tinnitus. (sparrow.org)

Mammals have long cochleae, and are able to distinguish different sounds by mechanisms such as mechanical tuning, in which the stiffness and length of hair cells' stereocilia makes a given cell best suited to respond to a certain type of stimulus. (wikipedia.org)
These tiny hair cells are called stereocilia (types of receptors that can detect sound). (cdc.gov)
These hair-like structures are known as stereocilia, and Shin's new research shows a process they use to repair themselves. (news-medical.net)
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia. (nih.gov)

So far as microwaves being turned into acoustics, If you look into the auditory pathway -acoustics occur from external sound vibrations, entering the auditory pathway from the outer ear. (mast-victims.org)
This article discusses the anatomy of the auditory pathway (see the following images), as well as a few physiologic considerations and clinical applications. (medscape.com)
Illustration of the auditory reflex pathway. (medscape.com)

A study by Bramhall et al indicated that in persons with normal pure-tone auditory thresholds, those with a history of greater noise exposure tend to have smaller ABR wave I amplitudes at suprathreshold levels. (medscape.com)

13 Genetic testing can also identify mild deafness, later-onset childhood deafness, syndromic forms of deafness, risk factors for aminoglycoside-induced deafness, and auditory neuropathy that may not be detected by the current physiologic NBHS. (nature.com)
Is cochlear microphonic present in auditory neuropathy? (kyoto2.org)
Conclusion: The presence of the Cochlear Microphonic is a determining finding in the differential diagnosis of Auditory Neuropathy/Dyssynchrony. (kyoto2.org)
What can be done about auditory neuropathy? (kyoto2.org)
Its detection in surface recordings has been considered a distinctive sign of outer hair cell integrity in patients with auditory neuropathy. (kyoto2.org)
How is auditory neuropathy ABR diagnosed? (kyoto2.org)

Later waves may reflect postsynaptic activity in major brainstem auditory centers that concomitantly contribute to waveform peaks and troughs. (medscape.com)

There is evidence however, that the hair cells in our vestibular system can transduce sounds even higher than 20,000 Hz, but the dynamic range would be small. (hearinghealthmatters.org)

L-type Ca 2+ channels (LTCCs) drive the bulk of voltage-gated Ca 2+ entry in vertebrate inner ear hair cells (HCs) and are essential for mammalian auditory processing. (jneurosci.org)

Hair cell regeneration was not a major topic of research in hearing science until 1986-87. (hearingreview.com)
Hair cell regeneration occurring after hair cells were destroyed. (hearingreview.com)
We and others are working hard to understand the molecular chain of events responsible for hair cell regeneration in species where it occurs. (hearingreview.com)
We have also discovered one gene (and there will be others) that is responsible for turning off the production of hair cells during development and may be involved in preventing regeneration. (hearingreview.com)
From discovery of molecules that could induce regeneration in laboratory animals, it could be as little as another 10 years until we achieve hair cell regeneration in humans. (hearingreview.com)
Dr. Cocchiola is internationally published in the area of genetics of hearing loss and auditory hair cell regeneration. (healthyhearing.com)

Consistently, phase-locking of synaptic vesicle releases from hair cells was also significantly reduced by blocking PMCA, MCU, or SERCA, but not NCX. (jneurosci.org)
Here we examine Ca 2+ clearance from hair cell synaptic ribbons in a fully mature preparation at physiological concentration of external Ca 2+ and at physiological temperature. (jneurosci.org)

Although it is not yet known, it will be exciting to see if our data are generalizable to other hair-cell organs and model systems. (amherst.edu)
We invite primary papers, review papers or commentaries that provide insight into hair cell or supporting cell function and dysfunction - dynamic or homeostatic, and from a diversity of approaches and model organisms and hair cell organs. (frontiersin.org)

Then, the machine records the response made by the cochlea's outer hair cells. (kidshealth.org)
The amplitude differences between the groups could not be attributed to either sex or outer hair cell function variability. (medscape.com)
The cochlear microphonic is a receptor potential believed to be generated primarily by outer hair cells. (kyoto2.org)
They seem to have though it was the outer hair cells that were being directly stimulated to produce the effect. (mast-victims.org)
These hair cells (called inner and outer hair cells) help to transmit the sound waves through the cochlear to the auditory nerve. (hubpages.com)
Cochlear pathologies were assessed by measuring inner hair cell (IHC) and outer hair cell (OHC) losses. (cdc.gov)
Generated predominantly by the outer hair cells of the organ of Corti. (audiologyonline.com)
The longer central fibers, also called the primary auditory fibers, form the cochlear nerve, and the shorter, peripheral fibers extend to the bases of the inner and outer hair cells. (medscape.com)
The remainder cross the tunnel of Corti to innervate the outer hair cells. (medscape.com)

Cells with higher oscillating frequencies respond best to higher-frequency sounds, while those with lower frequencies respond best to lower frequency ones. (wikipedia.org)
Which cells resonate best with a given sound tells the brain what the frequency of the sound is. (wikipedia.org)
cells in the middle can detect mid-frequency sounds while those at the end of the coil detect low frequency sounds. (home-remedies-for-you.com)
However, the frequency ranges for which the auditory system can use ITDs and ILDs significantly overlap, and most natural sounds will have both high and low frequency components, so that the auditory system will in most cases have to combine information from both ITDs and ILDs to judge the location of a sound source. (wikipedia.org)
And like ultrasound, even if there are higher frequency harmonics (within our auditory bandwidth of hearing), they would be easily heard and not be infrasound. (hearinghealthmatters.org)

Our experiments have revealed the proapoptotic function of CDK2 in postmitotic cochlear cells and have identified promising therapeutics for preventing hearing loss. (nih.gov)
Any kind of damage to the auditory system can result in loss of hearing ability and sense of balance. (home-remedies-for-you.com)
With more of such exposure, you will lose more hair cells until permanent hearing loss happens. (webmd.com)
By the time you notice hearing loss, many hair cells have been destroyed and cannot be repaired. (cdc.gov)
Understanding and harnessing internal mechanisms by which hair cells counteract wear and tear will be crucial in identifying ways to prevent age-related hearing loss. (news-medical.net)
The ABR (Auditory Brainstem Response) test can be used to detect hearing loss. (kyoto2.org)
We will present a summary of the effect of hearing loss on auditory development, existing preclinical and clinical data on progenitor cell therapy, and its potential role in the (re)habilitation of non-genetic SNHL. (intechopen.com)
Auditory disturbances such as hearing loss and tinnitus (ringing in the ears) have been reported by people infected with SARS-CoV-2, the pathogen that causes the disease COVID-19. (iflscience.com)
MnCl2 in drinking water did not cause hearing impairment or hair cell pathologies by itself and it did not potentiate noise-induced hearing loss or hair cell pathologies. (cdc.gov)
Very low frequencies or infrasound below 20 Hz have many non-auditory side effects but as far as the literature is concerned, does not cause hearing loss. (hearinghealthmatters.org)
Conductive hearing loss occurs secondary to lesions in the external auditory canal, tympanic membrane (TM), or middle ear. (msdmanuals.com)

In particular, sound-evoked spikes in auditory afferent fibers in vivo are phase-locked to sound frequencies up to 5 kHz, but it is not clear how hair cells can handle intracellular Ca 2+ changes with such high speed and efficiency. (jneurosci.org)
Atonal homologue 1 (encoded by Atoh1, also known as Math1) is a basic helix-loop-helix transcription factor required for hair-cell development, and its misexpression in vitro and in vivo generates hair-cell-like cells. (elsevierpure.com)
Our research studies leverage the strengths of the zebrafish model system by using genetics and in vivo imaging to dissect the molecular and functional requirements underlying hair-cell synapse function and assembly. (amherst.edu)
The work on mammals now is at a point where we can induce a small amount of cell division in the inner ear in a dish (that is, in a culture), as well as in vivo (occurring within a living organism). (hearingreview.com)
The in vitro and in vivo experiments demonstrate superior cancer cell killing and tumor eradication effect of Fe@HRP-ABTS/GOx nanodot under near-infrared (NIR) laser irradiation. (bvsalud.org)

Hair cell mechanotransduction regulates spontaneous activity and spiral ganglion subtype specification in the auditory system. (logosbio.com)
The primary function of our auditory system is detection of sound. (home-remedies-for-you.com)
The auditory system is also responsible for the sense of balance and maintaining equilibrium. (home-remedies-for-you.com)
To be able to understand the implications of auditory damage, the knowledge of how the auditory system functions is imperative. (home-remedies-for-you.com)
Damage to the auditory system can result in a condition known as tinnitus. (home-remedies-for-you.com)
Notably, the visual system is tightly couples to the auditory system. (aro.org)
I think it's our auditory nervous system that is picking up the signal. (mast-victims.org)
What is the purpose of the auditory system? (freezingblue.com)
What is the function of the reticular formation in the auditory system? (freezingblue.com)
What is the function of the medial geniculate body in the auditory system? (freezingblue.com)
Our auditory system is wonderfully rich, and there are innumerable ways that it can go wrong. (stanford.edu)
There are many models that attempt to mimic the structure of the auditory system, with various levels of fidelity. (stanford.edu)

Approximately half of congenital SNHL is hereditary and is the result of genetic mutations causing improper development of cochlear hair cells. (intechopen.com)
Route one infects and kills cochlear hair cells which are instrumental in hearing. (iflscience.com)

Given that phase-locking can be achieved in auditory afferent fibers for frequencies up to ∼5 kHz ( Taberner and Liberman, 2005 ), exocytosis from hair cells must be tightly controlled with sufficient temporal precision required. (jneurosci.org)
Different cells have different delays for K+ leaving and thus the voltage oscillates at different frequencies. (wikipedia.org)
The delays can be as short as 0.7 ms or as long as 150 ms, whereas the Ca2+ entry always occurs within about 1 ms. Thus, by varying the length of delay for K+ to leave, cells' ion concentrations can oscillate at specific frequencies. (wikipedia.org)

With a combination of voltage-gated calcium channels and calcium sensitive K+ channels, the cells set up an oscillation in voltage and oscillate in response to a depolarizing stimulus. (wikipedia.org)

Both assays utilized MEC-2 cells, a chronic B cell leukemia cell line, pre-labeled with calcein AM as the target cells, and natural killer (NK) cells engineered to stably express Fc gamma receptor IIIa_ F158 as effector cells. (bvsalud.org)

It is high time people start paying enough care to have a healthy auditory function. (mid-day.com)
Although the ABR provides information regarding auditory function and hearing sensitivity, it is not a substitute for a formal hearing evaluation, and results should be used in conjunction with behavioral audiometry whenever possible. (medscape.com)
We encourage functional and molecular-genetic studies in the development, mature function, and aging of hair cell epithelia, as well as dysfunctions arising through genetic mutations or ototoxic drug treatment. (frontiersin.org)
The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells. (nih.gov)
She has also given a national presentation and locally published in the area of auditory function of individuals with autism spectrum disorders. (healthyhearing.com)
Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in neurodevelopment, and how MECP2 mutations cause postnatal neurodevelopmental disorders. (bcm.edu)
The proteins in the cell membrane function as pumps, receptors and transporters and regulate which substances find their way into and out of the cell. (lu.se)

Recognizing the importance of protein interactions for mediating SCA1 pathogenesis, and given that SCA1 shares clinical and pathological features with several other inherited ataxias, we proposed that understanding the interactions of Ataxin-1 as they relate to the interactions of proteins implicated in other ataxias might provide better insight about molecular mechanisms leading to Purkinje cell degeneration and ataxia. (bcm.edu)

These cells allow your brain to detect sounds. (cdc.gov)
Route two infects and kills vestibular hair cells, tiny hairs that detect changes in movement such as turning your head, speeding up, or slowing down. (iflscience.com)

Once damaged, your auditory nerve and cilia cannot be repaired. (kyoto2.org)

In addition to damaging hair cells, noise can also damage the auditory nerve that carries information about sounds to your brain. (cdc.gov)
Research Summary - In the Scott Lab, we are interested in the workings of the brain at the level of cells and circuits. (amherst.edu)

Does auditory nerve regenerate? (kyoto2.org)
We now know that all vertebrates, except mammals, can regenerate new hair cells in the inner ear after native hair cells are damaged or destroyed. (hearingreview.com)
I feel that, within 5-10 years, we could easily find out if it s possible to regenerate hair cells at robust levels sufficient to restore hearing in mammals. (hearingreview.com)

The ABR wave I response is the far-field representation of the compound auditory nerve action potential in the distal portion of cranial nerve (CN) VIII. (medscape.com)
The cochlear microphonic and the summating potential (SP) are generated by the hair cells of the organ of Corti, whereas the compound action potential (AP) of the auditory nerve represents the summed synchronized response of many individual nerve fibers. (kyoto2.org)

They are known as hair cells because the cells are covered in hair-like structures that serve as mechanical antennas for sound detection. (news-medical.net)

They extend radially from the spiral ganglion to the habenula perforata, a series of tiny holes beneath the inner hair cells. (medscape.com)

Prolonged exposure to loud noise causes the death of some of these cells. (webmd.com)
But loud, intense sound exposure can destroy some hair cells in your ear, causing permanent damage even if some healthy hair cells remain and you can hear well enough. (webmd.com)
Prolonged exposure to loud noise harms hair cells in a variety of ways, and one of those is by damaging the cores of the 'hairs' themselves. (news-medical.net)

Atoh1-based gene therapy to ameliorate auditory and vestibular dysfunction has been proposed. (elsevierpure.com)

Anatomy56

Organisms19

Diseases15

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology2

Phenomena and Processes33

Disciplines and Occupations3

Information Science1

Health Care1

Cochlea29

Neurons6

Neural11

Stimuli2

Pathways2

Sensory10

Inferior Colliculus4

Internal auditory canal2

Afferent auditory1

Response to auditory1

Synapses4

Brainstem responses1

Potentials6

Signals5

Stimulation1

Transduction1

Vibrations into electrical2

Basilar membrane2

Responses3

Cortex2

Impulses2

Stereocilia4

Pathway3

Thresholds1

Neuropathy6

Centers1

Vestibular system1

Mammalian1

Regeneration6

Synaptic2

Organs2

Outer hair9

Frequency5

Loss11

Vivo5

System12

Cochlear hair cells2

Frequencies3

Stimulus1

Receptor1

Function7

Clinical1

Detect2

Cannot be repaired1

Brain2

Regenerate3

Compound2

Detection1

Spiral1

Exposure3

Gene therapy1