• A comparison of 13 guinea pig and human anti-tissue transglutaminase antibody ELISA kits. (bmj.com)
  • Unlike in celiac disease, anti-tissue transglutaminase antibody (tTG) and anti-endomysial antibody (EMA) are negative in patients with tropical sprue. (msdmanuals.com)
  • Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis. (wikipedia.org)
  • The associated autoantigen is an epidermal transglutaminase, transglutaminase 3 (TG3). (logicalimages.com)
  • A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. (medlineplus.gov)
  • Igg Antibody Laboratories manufactures the igg tissue transglutaminase antibodies (ttg igg antibodies) reagents distributed by Genprice. (science-bas.org)
  • This protocol uses two-step serologic testing of serum to determine the presence of antihuman recombinant tissue transglutaminase (TTG) and endomysial antibody (EMA). (phenxtoolkit.org)
  • The National Health and Nutrition Examination Survey (NHANES) uses red-top tubes to collect 0.5 ml serum for the antihuman recombinant tissue transglutaminase (TTG)/ endomysial antibody (EMA) bioassay. (phenxtoolkit.org)
  • Human IgG antibody Laboratories manufactures the refurbished sakura tissue tek cytospin reagents distributed by Genprice. (inyxinc.com)
  • Description: A Rabbit polyclonal antibody against Human Cytospin B (CYTSB). (inyxinc.com)
  • Tissue transglutaminase assay (IgA-TTG) and the IgA endomysial antibody assay (IgA EMA) estimates the prevalence of celiac disease in the United States population. (cdc.gov)
  • Substrate-bound IgA antibody is identified with a fluorescein-conjugated anti-human IgA (Fab2-specific) conjugate. (cdc.gov)
  • Multivariate logistic re- anti-endomysial antibody (EMA) and anti-EMA immunoglobulin (Ig)A and gression analysis was used to determine anti-tissue transglutaminase (anti-tTG) IgG. (who.int)
  • The Igg Tissue Transglutaminase Antibodies (Ttg Igg Antibodies) reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (science-bas.org)
  • In EMA-positive subjects, human tissue transglutaminase IgA antibodies and CD-associated human leukocyte antigen DQ2/DQ8 haplotypes were determined. (nih.gov)
  • In addition, CeD patients produce highly disease-specific antibodies against deamidated gluten peptides and the enzyme tissue transglutaminase 2 (TG2) ( 2 - 4 ). (frontiersin.org)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Very recently, human monoclonal antibodies were approved for use on patients with COVID-19. (frontiersin.org)
  • The human monoclonal antibodies used in this study are almost identical with these approved antibodies. (frontiersin.org)
  • In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
  • This ELISA method is for the semi-quantitative detection of IgA antibodies to tissue transglutaminase (endomysium) in human serum. (cdc.gov)
  • Keratinocyte transglutaminase enzymes serve to specifically catalyze the development of the cornified cell envelope, a defining characteristic of epidermal keratinocytes that have undergone the termination of differentiation. (wikipedia.org)
  • Since glutaraldehyde‐dependent cross‐linking of albumin molecules is not likely to occur in vivo, we considered the possibility that albumin may be polymerized by the action of transglutaminase enzymes present in plasma as activated factor XIII or released into plasma from tissues. (mssm.edu)
  • The use of isolated transglutaminase enzymes from microbiological sources in industrial food processing has allowed certain processes to be simplified, resulting in energy and cost savings. (theceliacscene.com)
  • Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z". The Journal of Biological Chemistry. (wikipedia.org)
  • Transglutaminase 2 (TG2), encoded by the TGM2 gene, is also known as tissue transglutaminase (tTG), transgluytaminase C (TGC), and protein-glutamine-gamma-glutamyltransferase. (rndsystems.com)
  • TGM2 has been implicated in a variety of human diseases including celiac disease, inclusion body myositis, atherosclerosis, and neurodegenerative diseases. (rndsystems.com)
  • Transglutaminase 2/TGM2 " has 8 results in Products. (rndsystems.com)
  • Extracellular matrix derived from irradiated astrocytes were found to be a major driver of this phenotype and astrocyte-derived transglutaminase 2 (TGM2) was identified as a promoter of glioma stemness and radioresistance. (figshare.com)
  • TGM2 levels increased after radiation in vivo and in recurrent human glioma, and TGM2 inhibitors abrogated glioma stemness and survival. (figshare.com)
  • Second, proteolytic analysis of a representative gamma-gliadin led to the identification of another multivalent 26-mer peptide that was also resistant to further gastric, pancreatic and intestinal brush border degradation, and was a good substrate of human transglutaminase 2 (TG2). (nih.gov)
  • The Jarjour lab has discovered that proinflammatory protein HMGB1 is a substrate of transglutaminase-2 and forms high-molecular-weight complexes with autoantigens. (osu.edu)
  • Vimentin is a strong arterial substrate for transglutaminases. (whispermovie.com)
  • There is a genetic predisposition to the disease, as it is associated with certain human leukocyte antigen (HLA) haplotypes, HLA class II DQ2. (logicalimages.com)
  • Several environmental, genetic, and immune factors create a "perfect storm" for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. (frontiersin.org)
  • CeD is triggered by gluten consumption in genetically susceptible individuals carrying certain major histocompatibility complex (MHC) class II human leukocyte antigen (HLA) variants ( 5 , 6 ). (frontiersin.org)
  • This mouse displays robust inflammatory myositis that recapitulate, in part, the human disease ( Aberrant Muscle Antigen ). (osu.edu)
  • Introduction: Coeliac disease is a lifelong immune-mediated enteropathy manifested as gluten intolerance in individuals carrying specific human leukocyte antigen (HLA) molecules. (lu.se)
  • Microwells are pre-coated with recombinant human tTG antigen. (cdc.gov)
  • The first study, which examined whether early exposure to gluten was protective against celiac sprue, involved 944 children who were positive for the human leukocyte antigen (HLA) haplotype DQ2 or DQ8 and had at least one first-degree relative with celiac sprue. (medscape.com)
  • Human leukocyte antigen (HLA)-DQ2 and -DQ8 haplotypes in celiac, celiac with type 1 diabetic, and celiac suspected pediatric cases. (cdc.gov)
  • Human Leucocyte Antigen Genotyping in Celiac Disease: Reasons for Inappropriate Use. (cdc.gov)
  • The specific cross linkages formed by keratinocyte transglutaminase are between n^ε-(γ-glutamyl)lysine residues which develop into isopeptide protein-protein linkages that adds to the stabilization of the cornified cell envelope. (wikipedia.org)
  • A study on the mutation of keratinocyte transglutaminase (TGK) came to conclude that those affected with ichthyosis lamellaris, present a substantial deficit in keratinocyte transglutaminase activity. (wikipedia.org)
  • Genomic structure of keratinocyte transglutaminase. (wikipedia.org)
  • Protein-glutamine gamma-glutamyltransferase K is a transglutaminase enzyme that in humans is encoded by the TGM1 gene. (wikipedia.org)
  • Ubiquitously expressed in humans, TG2 can act either as a transamidase by crosslinking two substrates through formation of an Ne(G-glutaminyl)lysine bond or as an intracellular G-protein. (unife.it)
  • The fluorescent probes were internalized and imaged in cellulo, and provide the first implicit experimental evidence that by comparison with their cell-impermeable analogues, it is specifically intracellular TG2, and presumably its G-protein activity, that contributes to transglutaminase-associated cancer progression. (unife.it)
  • For each protein, basic characteristics about its composition and length, its human relatives and relatedness to proteins in other species, and direct links to resources at NCBI are included. (cshlpress.com)
  • The entire text of the Guide is searchable, and tools are available for identifying human protein sequences using those from other species. (cshlpress.com)
  • Antioxidant enzyme expression, lipid peroxidation, and protein oxidation in human myometrium with parturition Reproductive Sciences. (nottingham.ac.uk)
  • Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2. (harvard.edu)
  • Whey protein and casein are good substrates for transglutaminase (TG). (yimingbiotechnology.com)
  • Most of the variants that cause the condition change single protein building blocks (amino acids) in transglutaminase 5. (medlineplus.gov)
  • A shortage of transglutaminase 5 function impairs protein cross-linking, which weakens the cornified cell envelope and allows the outermost cells of the epidermis to separate easily from the underlying skin and peel off. (medlineplus.gov)
  • This examination of protein expression changes determined potential biomarkers of exposure including transglutaminase 2, advillin, collagen type 1, perilipin- 2, and others. (cdc.gov)
  • The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. (medicaljournals.se)
  • It has been postulated that polymerized human serum albumin may play a role in the infection of hepatocytes by hepatitis B virus, because both the envelope of hepatitis B virus (HBsAg) and hepatocytes exhibit binding activity for human serum albumin after cross‐linking by glutaraldehyde. (mssm.edu)
  • Guinea pig liver transglutaminase covalently cross‐linked human serum albumin molecules into dimers, trimers and polymers up to hexamers as shown by polyacrylamide gel electrophoresis in sodium dodecyl sulfate. (mssm.edu)
  • HBsAg particles bound transglutaminase‐cross‐linked as well as glutaralde‐hyde‐cross‐linked human serum albumin as demonstrated by radioimmunoassay and immunoelectron microscopy. (mssm.edu)
  • The binding was blocked by preincubation of HBsAg with transglutaminase‐or glutaraldehyde‐cross‐linked human serum albumin, anti‐HBs or monoclonal anti‐pre‐S2, but not by polymerized bovine or rat serum albumin or by monomeric human serum albumin. (mssm.edu)
  • These data indicate that HBsAg particles contain specific binding sites for transglutaminase‐cross‐linked human serum albumin, but it remains to be determined whether the albumin polymers play a role in the attachment of hepatitis B virus to hepatocytes. (mssm.edu)
  • Description: A sandwich ELISA for quantitative measurement of Mouse Anti tissue transglutaminase IgG,IgG tTG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (science-bas.org)
  • Description: A sandwich ELISA for quantitative measurement of Human Anti tissue transglutaminase IgG,IgG tTG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (science-bas.org)
  • Iga Serum Laboratories manufactures the tissue transglutaminase iga ab serum reagents distributed by Genprice. (lentivectors.com)
  • Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. (wikipedia.org)
  • Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)
  • In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)
  • Thanks to established transgenesis procedures, gene transfer has become possible, and the expression of genes has given rise to the massive production of microbial transglutaminase. (theceliacscene.com)
  • In addition, the gene that encodes psoriasin is positioned within the epidermal differentiation complex (EDC) (10-12), a gene cluster that contains several genes of importance in the terminal differentiation of the human epidermis (10, 11). (medicaljournals.se)
  • In the epidermis, transglutaminase 5 is involved in the formation of a structure called the cornified cell envelope, which surrounds epidermal cells and helps the skin form a protective barrier between the body and its environment. (medlineplus.gov)
  • Methods: This dissertation should prove the reliability of the recently approved anti-IgA human transglutaminase ELISA for the diagnosis of coeliac disease. (uni-tuebingen.de)
  • Methods: We examine the impact of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 supplementation on the faecal metabolome in genetically predisposed children having tissue transglutaminase autoantibodies, i.e., coeliac disease autoimmunity. (lu.se)
  • The food industry's increased use of microbial transglutaminase in wheat processing and an increased incidence of celiac disease has lead to the hypothesis that microbial transglutaminase is a new environmental enhancer of celiac disease, further increasing the risk for gluten-sensitive populations. (theceliacscene.com)
  • HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease. (cdc.gov)
  • Transglutaminase-1 (TG1)-deficient autosomal-recessive congenital ichthyosis (ARCI) is a rare and severe genetic skin disease caused by mutations in TGM1. (uc3m.es)
  • In this study, we firstly explored the expression and the role of transglutaminase 2 (TG2) in MPM cell adaptation to hypoxia. (units.it)
  • Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. (whispermovie.com)
  • It belongs to the family of transglutaminases that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions. (rndsystems.com)
  • Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. (unife.it)
  • Additional links to NCBI resources are provided for human noncoding RNAs and repeated DNA elements and for proteins of interest from other species. (cshlpress.com)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or "" T cells. (tcd.ie)
  • Specifically, transglutaminase 5 forms strong bonds, called cross-links, between the structural proteins that make up the cornified cell envelope. (medlineplus.gov)
  • Measurement of vasoactive metabolites (hydroxyeicosatetraenoic and epoxyeicosatrienoic acids) in uterine tissues of normal and compromised human pregnancy Journal of Hypertension. (nottingham.ac.uk)
  • Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
  • We prepared sterically stabilized liposomes with encapsulated recombinant human TG1 (rhTG1) and equipped with a highly cationic lipopeptide vector to mediate cellular uptake. (uc3m.es)
  • It was concluded that those afflicted, display a decrease in activity of the enzyme, as a result of a lessened amount of transcription of the human TGK gene. (wikipedia.org)
  • Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with alpha-enolase devoid of plasminogen binding activity. (cnr.it)
  • This and other T GM5 gene variants reduce the activity of transglutaminase 5 or prevent cells from making any of this enzyme. (medlineplus.gov)
  • Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
  • In addition, extracellular, administered Tβ 4 promoted the cell migration of various types of cells including cardiomyocytes, human umbilical vein endothelial cells and conjunctival epithelial cells ( 4 - 6 ). (spandidos-publications.com)
  • Prophylaxis of primary human airway epithelial cells (hAEC) with different IFNα subtypes during SARS-CoV-2 infection uncovered distinct functional classes with high, intermediate, and low antiviral IFNs. (bvsalud.org)
  • disbiosis en pacientes con enfermedad celíaca y sensibilidad al gluten no celíaca. (bvsalud.org)
  • 3 Moreover, perfusion of human anterior eye segments with TGF-β2 in concentrations comparable to those measured in the AH of patients with POAG resulted in an increase of IOP and an increase of ECM in the outflow tissue. (arvojournals.org)
  • RÉSUMÉ La prévalence de la maladie coeliaque chez des patients atteints d'hypothyroïdie auto-immune n'a pas été étudiée auparavant en Jordanie, ni dans d'autres pays arabes. (who.int)
  • This study has significant implications for human disease. (osu.edu)
  • 1 2 In tissue culture experiments in trabecular meshwork (TM) cells, TGF-β2 augmented the synthesis of extracellular matrix (ECM) and its cross-linking by transglutaminases. (arvojournals.org)
  • Transglutaminase (TG) performs as a meat glue with strong binding force in the food processing industry. (yimingbiotechnology.com)
  • With Transglutaminase (TG), chicken meat can be transformed into chicken breast, roulade, meat ball and other uniform portions thanks to its strong binding force. (yimingbiotechnology.com)