• Psychological distress, such as anxiety and depressive symptoms, are prevalent among individuals with PD. (biomedcentral.com)
  • Playing Go was linked with improved working memory, as measured by the Trail Making Test-A. Those who played Mahjong reported improved executive functioning and a temporary decrease in depressive symptoms. (medscape.com)
  • The current authors' hypothesis was that generic well-being, HRQoL and morbidity can be improved with this intervention. (ersjournals.com)
  • This study evaluates the effect of a combined physical exercise and psychosocial intervention on cardiorespiratory fitness, muscle strength, body composition, psychosocial function and health-related quality of life (HrQoL). (biomedcentral.com)
  • Potential physical and psychosocial mediators in the intervention effect on HrQoL were examined using the product-of-coefficient test. (biomedcentral.com)
  • Intervention effects on HrQoL were not significantly mediated by physical fitness and psychological function. (biomedcentral.com)
  • Intervention applicability was satisfactory with an average session attendance of 67% and 22% dropout (mainly due to disease recurrence). (biomedcentral.com)
  • Yet, both the intervention and the control group showed improvements in bone mineral density and HrQoL over time. (biomedcentral.com)
  • Eligible patients will be approached before ICU discharge and randomised to the intervention (attending a shared care follow-up clinic 1 month after hospital discharge) or standard care. (biomedcentral.com)
  • If these benefits are confirmed, this exercise intervention could be systematically proposed to patients during the course of treatment by trastuzumab in addition to standard oncological care. (biomedcentral.com)
  • Interventions without long-term condition populations, psychological intervention and/or patient-assessed quality of life were excluded. (biomedcentral.com)
  • Many cancer patients require therapeutic intervention to correct the underlying anaemia. (nature.com)
  • however, it is unclear whether the app-based intervention can effectively improve UI symptoms during and after pregnancy. (jmir.org)
  • This study aimed to evaluate the effectiveness of the Urinary Incontinence for Women (UIW) app-based intervention for UI symptom improvement among pregnant women in China. (jmir.org)
  • The app-based UI self-management intervention (UIW) effectively improved UI symptom severity, quality of life, self-efficacy with PFMT, and knowledge of UI during the late pregnancy and early postnatal periods. (jmir.org)
  • As instructions can hear articulate art and ambiguity of records, it chairs house into route Polarization, intervention and the patients of brain, care and m. (flash-controller.de)
  • Compared with patients with other rheumatic and pulmonary diseases, patients with systemic sclerosis often require significantly more health care resources, including physician and staff time, to monitor and manage multiple organ system disorders. (rheumatologyadvisor.com)
  • These findings provide evidence that increasing haemoglobin levels by epoetin alfa administration can significantly improve cancer patients' quality of life. (nature.com)
  • Additionally, the study will provide information on long-term adherence, changes in motor symptoms, cognitive functions and patient-reported outcomes after the rehabilitation program. (frontiersin.org)
  • The purpose of this chapter is to describe some of the common meanings of pain in patients with DPNP, as currently reported in the literature, how these meanings interact with other common factors in pain experience, including specific negative emotions or moods (depression, anxiety, anger), or the psychosocial context surrounding pain, and to describe available evidence on the effectiveness of cognitive behavioral therapy (CBT) for patients with DPNP. (researchgate.net)
  • Clinical Implications: Pain in patients with DPNP involves a range of threatening pain sensations, including sensations with burning, shooting, tingling, or cramping qualities, and additional more cognitive meanings linked to persistent pain, including a sense that pain disrupts daily life in an intrusive way. (researchgate.net)
  • Playing chess or other board games slows cognitive decline and improves quality of life in older patients, results of a new systematic review suggest. (medscape.com)
  • For patients who are elderly and suffer from social isolation and mild cognitive issues, I would definitely recommend board games," study investigator Frederico Emanuele Pozzi, MD, a neurology resident at Fondazione IRCCS San Gerardo dei Tintori in Monza, Italy, told Medscape Medical News . (medscape.com)
  • He's enrolling patients aged 60 and over with subjective cognitive decline or MCI and separating participants into a control group, a group that plays chess, another that plays Go, and another that plays both Go and chess. (medscape.com)
  • Baseline PROs for physical and cognitive functioning were comparable in COLOR patients compared to the EORTC reference values. (bvsalud.org)
  • Translations must undergo a rigorous methodology under the guidance of FACIT.org which includes multiple translators, QA steps and cognitive interviews with patients. (facit.org)
  • Functional and cognitive impairment, social environment, frailty and adverse health outcomes in older patients with head and neck cancer, a systematic review. (jamanetwork.com)
  • Methods A systematic search of records up to March 2020 was performed on PubMed, CINAHL, Medline (Ovid), Cochrane and Embase to retrieve clinical trials that evaluated the efficacy of OPEP devices in patients with COPD. (bmj.com)
  • METHODS: Ten patients who were in a palliative stage of cancer treatment completed co-creation processes. (bvsalud.org)
  • METHODS/DESIGN: The DIPLOMA-2 trial is an international randomized controlled, patient-blinded, non-inferiority trial performed in 14 high-volume pancreatic centers in Europe with a minimum annual volume of 30 MIPD and 30 OPD. (bvsalud.org)
  • Further quantitative, qualitative or mixed methods research is needed to more fully understand common experiences of pain in patients with DPNP, and the common meanings ascribed to these experiences. (researchgate.net)
  • In this study we aimed to assess the feasibility and first year results of COLOR.Material and Methods: All patients diagnosed with lung cancer referred to the Radiotherapy department were eligible to participate in the ongoing prospective COLOR study. (bvsalud.org)
  • Materials And Methods: A cross-sectional descriptive study was conducted on HIV/AIDS patients on ART attending Bombo Hospital in Tanga from July to October 2019. (bvsalud.org)
  • Virtual reality (VR) has emerged as a promising treatment approach in rehabilitation for patients with multiple sclerosis (MS) due to its potential to increase patient motivation and rehabilitation adherence. (frontiersin.org)
  • One of the key features for rehabilitation adherence is patient satisfaction with the VR rehabilitation (VRR) program, and information on user satisfaction and not only effectiveness is required to systematically include VRR in routine clinical practice. (frontiersin.org)
  • Secondarily, discomfort with VRR will be evaluated, and therapy adherence and changes in a variety of domains typically affected by MS will be compared between patients receiving VRR and patients receiving CR. (frontiersin.org)
  • The study is aimed at determining the levels of medication adherence and health related quality of life (HRQOL) among HIV patients receiving care at Umuebule Cottage Hospital, Etche, Rivers State.Method: This cross-sectional study recruited 430 adult clients who have been on ART for at least one year using a convenient sampling method. (bvsalud.org)
  • Medication adherence levels were observed to be good (67.7%), poor (32.3%) respectively, while HRQOL of respondents were found to be poor (56.9%) and good (43.1%).Conclusion:A significant proportion of the respondents adhere to their medication whereas most of them had poor HRQOL. (bvsalud.org)
  • Medication adherence is an essential part of patient care, especially among patients with HIV, as it greatly determines the effectiveness of treatment. (bvsalud.org)
  • Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 6 January 2022. (breathinglabs.com)
  • Psychological distress is prevalent among people with Parkinson's disease (PD) and aggravates their motor symptoms, thereby leading to increased disability, high healthcare costs, and poor health-related quality of life (HRQoL). (biomedcentral.com)
  • Results will contribute to the value of yoga as a therapeutic option for managing psychological distress in PD patients. (biomedcentral.com)
  • Multiple outcomes including psychological, physiological, and spiritual and HRQoL will also be measured to elucidate the potential mechanisms of yoga. (biomedcentral.com)
  • PD-affected individuals with psychological distress are found to be poor in social communication and prone to adopt a sedentary lifestyle, which compromises their daily role functions and self-care capacity, leading to early retirement and low HRQoL [ 10 ]. (biomedcentral.com)
  • The quantitative studies will enroll 600 patients: 200 attending out-patient clinics (physical symptom assessement), 200 attending inpatient wards (psychological distress assessment) and 200 patients followed by multidisciplinary teams (patient experience with care assessment). (biomedcentral.com)
  • Conclusion The use of OPEP devices can have a positive impact in COPD, but confidence in effect sizes is low and there is a need for further, higher quality studies to examine their long-term efficacy in COPD as well as to identify specific patient phenotypes that are more likely to respond. (bmj.com)
  • Does the use of oscillating positive expiratory pressure (OPEP) devices impact health-related quality of life and symptoms, exacerbations, lung function parameters and exercise capacity, compared with usual care or alternative sputum clearance techniques in people with chronic obstructive pulmonary disease (COPD)? (bmj.com)
  • The aim of the present study was to establish the efficacy in terms of morbidity and health-related quality of life (HRQoL) of a group asthma education-exercise programme to children with low (below 10th percentile value) quality-of-life scores. (ersjournals.com)
  • Well-being can be measured as generic health-related quality of life (HRQoL). (ersjournals.com)
  • We describe a multi-centre randomized controlled trial to test whether these patients can be followed up by their general practitioner (GP) without altering quality of life, cost effectiveness and/or the incidence of serious clinical events. (biomedcentral.com)
  • We hypothesize that postoperative follow-up of colon cancer patients (according to national guidelines) by GPs will not have any impact on patients' quality of life. (biomedcentral.com)
  • However, nonmotor symptoms, such as anxiety and depression, reportedly have a great impact on health-related quality of life (HRQoL) and are thus gaining increasing attention [ 2 ]. (biomedcentral.com)
  • Method Surrogate outcome measures used were weight change, lean body mass (LBM), muscle strength, appetite, health-related quality of life (HRQOL) and serum albumin. (bmj.com)
  • We report on the safety and tolerability of all patients who received at least 1 dose of abatacept over 5 years, and the efficacy and health-related quality of life (HRQOL) of patients who had received ~10 mg/kg abatacept over 5 years in this continuing open-label extension of a Phase IIb study. (jrheum.org)
  • Persistent symptoms after COVID-19: qualitative study of 114 "long Covid" patients and draft quality principles for services. (breathinglabs.com)
  • Implementation of an effective management strategy is required to reduce symptoms, preserve lung function, quality of life, and exercise capacity, and prevent exacerbations. (inspiro-bg.com)
  • Many patients who survive the intensive care unit (ICU) experience long-term complications such as peripheral neuropathy and nephropathy which represent a major source of morbidity and affect quality of life adversely. (biomedcentral.com)
  • Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. (nature.com)
  • Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer patients receiving non-platinum-based chemotherapy. (nature.com)
  • Alexander M, Kewalramani R, Agodoa I, Globe D. Association of anemia correction with health related quality of life in patients not on dialysis. (facit.org)
  • The assessment of the patient perception of his/her health condition has been labelled differently, but the terms "Quality of Life" introduced in the 1980s, and the following "Health-related Quality of life", were for long the most frequently used. (biomedcentral.com)
  • A meta-analysis published in 2002, including 1342 patients, demonstrated that intensive follow-up in CRC was associated with an absolute reduction in 5-year all-cause mortality of 10% [ 8 ]. (biomedcentral.com)
  • Mortality among patients with systemic sclerosis is increased by approximately 3 to 5 times. (rheumatologyadvisor.com)
  • Physical activity status is increasingly recognized as a reliable predictor of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). (openrespiratorymedicinejournal.com)
  • Even in the early clinical stages, COPD carries a significant burden, with breathlessness frequently leading to a reduction in exercise capacity and changes that correlate with long-term patient outcomes and mortality. (inspiro-bg.com)
  • Acute hospital mortality for patients admitted to intensive care units (ICUs) has decreased substantially in the past two decades [ 1 ]. (biomedcentral.com)
  • In a study in Europe, half of children with asthma had persistent symptoms 4 that may lower their well-being. (ersjournals.com)
  • Background: While substantial progress has been made in the development of disease-modifying medications for multiple sclerosis (MS), a high percentage of treated patients still show progression and persistent inflammatory activity. (inims.de)
  • We searched PubMed using the search terms "post-COVID-19 syndrome", "long COVID" and "trial" or "treatment", from inception to Feb 20, 2022, with no limits on language, and found no randomised clinical trial data addressing interventions or treatments in people with ongoing symptoms following COVID-19. (breathinglabs.com)
  • Further randomised controlled trials of interventions targeting both symptoms and underlying pathology are required to create a portfolio of evidence-based management options adaptable to the specific needs of individual patients. (breathinglabs.com)
  • At each clinic visit, patients will be assessed independently by both an intensivist and a diabetologist who will provide screening and targeted interventions. (biomedcentral.com)
  • Because the long-term effect of a single episode of critical illness on health is substantial, and the costs associated with care of survivors, particularly those with pre-existing chronic illnesses, are considerable, there is an urgent need for interventions that modify these outcomes in patients with chronic illnesses. (biomedcentral.com)
  • This program has been specifically designed for MS patients by a multidisciplinary team of specialists, based on an effective conventional rehabilitation (CR) program. (frontiersin.org)
  • The disease is associated with a high economic burden for society, and Spain is the European country with the highest total annual cost per patient ( 3 , 4 ). (frontiersin.org)
  • Introduction In the past 20 years, the increasing burden of heart disease in an ageing population has resulted in cardiac surgery (CS) being offered to more frail and older patients with multiple comorbidities. (bmj.com)
  • Given the heavy personal burden that DPNP imposes on patients and the considerable challenge of managing the condition pharmacologically, clinical use of non-pharmacological therapies such as CBT for painful diabetic neuropathy might be warranted in individual patients. (researchgate.net)
  • Conclusion: This study revealed that the majority of patients carry significant concerns about becoming a burden on their family and are afraid of becoming dependent on others because of DPNP. (researchgate.net)
  • The symptom burden and the extent of impairment directly correlate to the degree of inflammation and/or fibrosis. (rheumatologyadvisor.com)
  • This review focuses on the current scientific evidence and expert opinion on the management of moderate COPD: the symptoms arising from moderate airflow obstruction and the burden these symptoms impose, how physical activity can improve disease outcomes, the benefits of dual bronchodilation in COPD, and the limited evidence for the benefits of inhaled corticosteroids in this disease. (inspiro-bg.com)
  • 1 COPD carries a significant burden for patients and health-care systems alike, 2-4 and rates are reported to be increasing. (inspiro-bg.com)
  • The management of PD primarily focuses on the pharmacological replacement of dopamine to control motor symptoms. (biomedcentral.com)
  • Some 25 % of all adult ICU patients have diabetes, and it is plausible that ICU survivors with co-existing diabetes are at heightened risk of sequelae from their critical illness. (biomedcentral.com)
  • Improvement of generic HRQoL can be sought through better self-management of asthma. (ersjournals.com)
  • The Edmonton symptom assessment scale, the Distress Thermometer, and a tool adapted from existing patient reported experience with cancer care questionnaires, will be used in quantitative studies. (biomedcentral.com)
  • Despite convincing evidence that routine patient reported outcomes and experience measurements (PRMs) with rapid feed-back to oncologists can improve symptom control, patient well-being and cost effectiveness, PRMs are not commonly used in cancer care, due to barriers at various level. (biomedcentral.com)
  • CONCLUSIONS: During co-creation, patients move through four phases in which experiences of contingency and ultimate life goals can be made explicit through art making and can be expressed in the work of art, supporting integration of experiences of contingency into one's life narrative. (bvsalud.org)
  • No significant changes in PROs were observed 3 months after inclusion, except for a slight increase in pain scores in the SBRT group (n = 97).Conclusions: The TwiCs-design appears feasible in lung cancer patients with fair participation rates (although negatively impacted by the COVID-19 pandemic). (bvsalud.org)
  • The use of nutritional ERPs may enhance short-term and long-term recovery and mitigate frailty progression while improving patient-reported outcomes. (bmj.com)
  • BACKGROUND: Minimally invasive pancreatoduodenectomy (MIPD) aims to reduce the negative impact of surgery as compared to open pancreatoduodenectomy (OPD) and is increasingly becoming part of clinical practice for selected patients worldwide. (bvsalud.org)
  • All patients who completed the 1-year, DB period of this study (clinical trial registration number: NCT00254293) 3 , 4 were eligible to enter the open-label LTE period. (jrheum.org)
  • Listening to "patient voices" in terms of symptoms, emotional status and experiences with care, is crucial for patient empowerment in clinical practice. (biomedcentral.com)
  • The purpose of this qualitative study was to elucidate the effects of DPNP on daily life and individual feelings regarding living with DPNP from the perspective of Turkish patients. (researchgate.net)
  • A web-survey on health care providers (HCPs), qualitative studies on patients and HCPs (semi-structured interviews and focus groups) as well as longitudinal and cross-sectional quantitative studies will be carried out. (biomedcentral.com)
  • To date, no study has evaluated the benefits of physical activity on the side effects of treatment in patients with HER2 positive breast cancer. (biomedcentral.com)
  • Although physical exercise is recommended to reduce the side effects of adjuvant treatments in breast cancer patients, no randomized study has been conducted to assess the benefits of a physical training program in patients with HER2 overexpressing breast cancer. (biomedcentral.com)
  • From the limited data available, MBIs may benefit some MS patients in terms of QOL, mental health, and some physical health measures. (biomedcentral.com)
  • The objective of the present study was to establish the efficacy, in terms of morbidity and HRQoL, of this group asthma education-exercise programme, offered to children who remained unhappy despite regular asthma care offered in a paediatric practice. (ersjournals.com)
  • While skin fibrosis and gastrointestinal dysfunction are primary symptoms in the majority of patients, interstitial lung disease (ILD) is both common and the most serious complication, normally developing early in the disease course. (rheumatologyadvisor.com)
  • To our knowledge, the 'COhort for Lung cancer Outcome Reporting and trial inclusion' (COLOR) is the first TwiCs in lung cancer patients. (bvsalud.org)
  • Patients will attend twice weekly rehabilitation sessions on site during 4 weeks, and they will continue with rehabilitation at home for five additional months. (frontiersin.org)
  • The results from this study will help to gather valuable knowledge on the use of rehabilitation with a new VR tool in MS patients. (frontiersin.org)
  • As LTC may be treated but not reversed, long-term care for patients and specialised rehabilitation training for staff is required to deal with the permanent and/or disabling nature of conditions [ 1 , 2 ]. (biomedcentral.com)
  • Chronic obstructive pulmonary disease and dementia are prevalent but under-diagnosed LTC as symptoms may often be mistakenly attributed to an anticipated gradual age-related decline in functioning. (biomedcentral.com)
  • Yellen SB, Cella DF, Webster K, Blendowski C, and Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. (facit.org)
  • The PATIENT VOICES initiative is aimed at achieving a stepwise integration of ePRMs assessment into routine cancer care. (biomedcentral.com)
  • RESULTS: Patients used 4-8 sessions (median 5 sessions) with a duration of 90-240 min each (median duration 120 min). (bvsalud.org)
  • This collated results from 916 patients with HIV/AIDS, end-stage renal failure, chronic obstructive pulmonary disease (COPD) and geriatric cachexia. (bmj.com)
  • Patient symptoms and experience following COVID-19: results from a UK-wide survey. (breathinglabs.com)
  • First-year results of PROs at baseline and 3 months after inclusion were evaluated separately for stereotactic body radiotherapy (SBRT) and conventional radiotherapy patients.Results: Of the 338 eligible patients between July 2020 and July 2021, 169 (50%) participated. (bvsalud.org)
  • A programme that includes both education and exercise has been shown to have favourable effects on HRQoL in adults 6 . (ersjournals.com)
  • Background: 'Trials-within-Cohorts' (TwiCs), previously known as 'cohort multiple randomized controlled trials' is a pragmatic trial design, supporting an efficient and representative recruitment of patients for (future) trials. (bvsalud.org)
  • At inclusion, written informed consent was requested for use of patient data, participation in patient-reported outcomes (PROs), and willingness to participate in (future) trials. (bvsalud.org)
  • Previous research has demonstrated large numbers of people experience long-term illness and disability due to COVID-19, with breathlessness being a common symptom. (breathinglabs.com)
  • As the proportion of those aged 65 years or older in Europe is projected to increase from 15% in 2000 to 23.5% in 2030, a major and increasing challenge is faced by public health to not only target LTC symptoms, but also the associated increased rates of disability and reductions in both healthy and overall life expectancy [ 5 , 6 ]. (biomedcentral.com)
  • The primary outcome of this study will be the recruitment and retention at 6 months of all eligible patients. (biomedcentral.com)
  • Cachexia is common in patients with advanced chronic disease with an estimated 25% of patients with chronic obstructive pulmonary disease (COPD) and 25-50% of patients with end-stage renal failure (ESRF) suffering from this syndrome. (bmj.com)
  • We emphasize the importance of maximizing bronchodilation in COPD with inhaled dual-bronchodilator treatment, enhancing patient-related outcomes, and enabling the withdrawal of inhaled corticosteroids in COPD in well-defined patient groups. (inspiro-bg.com)
  • BACKGROUND: Co-creation, characterized by artists and patients creating a joint work of art, may support patients with the integration of disruptive life events into their life story, such as living with cancer. (bvsalud.org)
  • Should the surgeon or the general practitioner (GP) follow up patients after surgery for colon cancer? (biomedcentral.com)
  • All patients who undergo surgery for colon cancer are followed up according to the guidelines of the Norwegian Gastrointestinal Cancer Group (NGICG). (biomedcentral.com)
  • Patients undergoing surgery for colon cancer with histological grade Dukes's Stage A, B or C and below 75 years of age are eligible for inclusion. (biomedcentral.com)
  • however, research has focused heavily on patients with cancer, and its effectiveness in other diseases remains unclear. (bmj.com)
  • The aetiology of fatigue in cancer patients is multifactorial and may include adverse effects of treatment, underlying disease, metabolic and physiological abnormalities, and other variables ( Groopman, 1998 ). (nature.com)
  • In several studies reported between 1990 and 2001, recombinant human erythropoietin (r-HuEPO, epoetin alfa) increased haemoglobin (Hb) levels and subsequently ameliorated anaemia in cancer patients. (nature.com)
  • It was developed in the mid-1990's to meet a growing demand for more precise evaluation of fatigue associated with anemia in cancer patients. (facit.org)
  • Berndt E, Kallich J, McDermott A, Xu X, Lee H, Glaspy J. Reductions in anaemia and fatigue are associated with improvements in productivity in cancer patients receiving chemotherapy. (facit.org)
  • Patients with head and neck cancer: are they frailer than patients with other solid malignancies? (jamanetwork.com)
  • Enhanced recovery protocols (ERPs), such as prehabilitation, have been associated with a reduction in complications after CS in vulnerable patients. (bmj.com)
  • 4 About half of patients with SSc with Raynaud's phenomenon may develop serious complications such as digital ulcers, pits, or gangrene, which require aggressive treatment to maintain tissue integrity. (rheumatologyadvisor.com)
  • Introduction: Diabetic peripheral neuropathy (DPN) affects almost 30% to 50% of patients with diabetes, 40% to 60% of whom suffer from diabetic peripheral neuropathic pain (DPNP). (researchgate.net)
  • Few studies have focused on individual experiences of DPNP in patients with diabetes. (researchgate.net)
  • Similar pathophysiological processes occur frequently in ambulant patients with diabetes mellitus who have never been critically ill. (biomedcentral.com)
  • Given that information on patient satisfaction with VRR is scarce, the primary objective of this study is to assess long-term patient satisfaction with a novel VRR program. (frontiersin.org)
  • The study is intended to provide a better understanding of long-term patient satisfaction with a VRR program specifically designed for MS patients. (frontiersin.org)
  • Data gathered from the PROTein to Enhance outComes of (pre)frail paTients undergoing Cardiac Surgery Study will be published in peer-reviewed journals and presented at national and international conferences. (bmj.com)
  • This Phase IIb study demonstrated the safety and efficacy of abatacept plus methotrexate (MTX) over 1 year of double-blind (DB) treatment in patients with RA and an inadequate response to MTX 3 , 4 , and confirmed ~10 mg/kg to be the most effective dose. (jrheum.org)
  • After explaining the purpose of study and obtaining consent,patients who met the eligibility criteria were recruited on each clinic day for a period of 12 weeks, until the sample size was reached. (bvsalud.org)
  • Data were collected using available data obtained from the patients' files, hospital record books and interviews of study participants by using semi-structured questionnaires. (bvsalud.org)
  • A total of 288 patients with an indication for elective pancreatoduodenectomy for pre-malignant and malignant disease, eligible for both open and minimally invasive approach, are randomly allocated for MIPD or OPD in a 2:1 ratio. (bvsalud.org)
  • The most frequent symptoms and signs observed at disease onset originate from the optic nerve, the brainstem or cerebellum, the spinal cord, and the cerebral hemispheres ( 5 ). (frontiersin.org)
  • Motor manifestations (such as spasticity, gait, and balance impairments), optic neuritis, and sensory symptoms appear early in the disease course ( 6 ), and usually lead to progressive limitation of daily life activities. (frontiersin.org)
  • At the time of diagnosis, about two thirds of patients had undergone resection, but 30-50% of them relapsed and died of the disease [ 4 ]. (biomedcentral.com)
  • and HRQoL measured by the Parkinson's Disease Questionnaire-8. (biomedcentral.com)
  • 2 Estimates show that more than half of patients with systemic sclerosis die as a direct result of their disease, most frequently caused by pulmonary fibrosis due to ILD, followed by pulmonary hypertension, and scleroderma renal crisis (SRC). (rheumatologyadvisor.com)
  • Patients with RP are known to develop connective tissue disease, which is preceded by the presence of abnormal capillaroscopy. (rheumatologyadvisor.com)
  • One-hundred and fifty CS patients will be randomised to receive either a leucine-rich protein supplement or a placebo with no supplemented protein. (bmj.com)
  • Patients were randomized to abatacept 10 or 2 mg/kg or placebo, plus MTX. (jrheum.org)
  • We describe safety analyses for all patients who received at least 1 dose of abatacept and efficacy analyses for the original ~10 mg/kg abatacept-treated group, over 5 years. (jrheum.org)
  • Background: Persons with multiple sclerosis (pwMS) might be particularly well suited to benefit from digital health applications because they are, on average, younger and less severely disabled than patients with many other chronic diseases. (inims.de)
  • A multi-disciplinary stakeholder team including researchers, clinicians, health informatics professionals, health system administrators and patients will be involved in the development of potentially effective implementation strategies in the post development phase. (biomedcentral.com)
  • In 2006 the U.S. Food and Drug Administration proposed to use the term PROs (Patient Reported Outcomes), later extended into PROMs (Patient Reported Outcomes Measures), to indicate " any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by a clinician or anyone else" [ 2 ]. (biomedcentral.com)
  • An average of 10 patients visits the facility on clinic days. (bvsalud.org)
  • DISCUSSION: The DIPLOMA-2 trial aims to establish the safety of MIPD as the new standard of care for this selected patient population undergoing pancreatoduodenectomy in high-volume centers, ultimately aiming for superior patient recovery. (bvsalud.org)
  • Listening to "patient voices" in terms of symptoms, function, emotional status, satisfaction and experiences with treatment and care received, is essential for the empowerment of both patients and their caregivers to become more involved in the care process. (biomedcentral.com)
  • Most studies on follow-up of CRC patients have been performed in a hospital outpatient setting. (biomedcentral.com)
  • Outcomes varied across studies, there were a lot of dropouts, and some were not randomized, meaning reverse causality can't be ruled out. (medscape.com)
  • Subsequent Phase III studies verified the efficacy and safety of abatacept both in patients with an inadequate response to MTX 5 and in patients with an inadequate response to anti-TNF agents 6 . (jrheum.org)