Chemicals and Drugs
Guanosine Diphosphate MannoseGuanosine Diphosphate SugarsGuanosine DiphosphateNucleoside Diphosphate SugarsPolyisoprenyl Phosphate MonosaccharidesMannoseGuanine Nucleotidesrho Guanine Nucleotide Dissociation Inhibitor betaGuanosine TriphosphateGuanine Nucleotide Dissociation InhibitorsGuanosine Diphosphate FucoseGuanosinerho-Specific Guanine Nucleotide Dissociation InhibitorsGuanosine 5'-O-(3-Thiotriphosphate)Polyisoprenyl PhosphatesAlkyl and Aryl TransferasesMannose-Binding LectinsAdenosine DiphosphateNucleoside-Diphosphate KinaseReceptor, IGF Type 2MannosephosphatesHemiterpenesDolichol Monophosphate MannoseGuanosine MonophosphateGuanosine Tetraphosphate
PyrophosphorylaseEnzymeUridineOligosaccharidesYeastReactionsMutantActivitySugarFoundNucleoside diphosphate sugarTriphosphateFucoseNucleotide sugarMannosyltransferaseDonor
Pyrophosphorylase2
  • One of the enzymes from the family of nucleootidyl-transferases, GDP-Mannose Pyrophosphorylase (GDP-MP) is an pervasive enzyme found in bacteria, fungi, plants, and animals. (wikipedia.org)
  • GDP-mannose pyrophosphorylase is a genetic determinant of ammonium sensitivity in Arabidopsis thaliana. (rhea-db.org)
Enzyme8
  • GDP-mannose is produced from GTP and mannose-6-phosphate by the enzyme mannose-1-phosphate guanylyltransferase. (wikipedia.org)
  • The enzyme produced from the ALG1 gene transfers a simple sugar called mannose to growing oligosaccharides at a particular step in the formation of the sugar chain. (medlineplus.gov)
  • The poorly functioning enzyme cannot add mannose to sugar chains efficiently, and the resulting oligosaccharides are often incomplete. (medlineplus.gov)
  • This last task was still in progress by the time of the project completion due to the initial unavailability of the specific d-mannose donors required by the enzyme. (europa.eu)
  • Moreover, because of the requirements and spin-offs of this project, new significant research objectives were identified and targeted, such as the structural characterisation and utilisation of the dolichol-phospho- beta -d-mannose synthase, which was a key enzyme for human and pathogenic glycosylation, and the elucidation of the d-mannose function in teicoplanin antibiotic action. (europa.eu)
  • PMM2-CDG is caused by deficiency of the PMM enzyme and results in a depletion of mannose-1-P and guanosine diphosphate mannose (GDP-mannose), which is essential for glycosylation. (sdsc.edu)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • Cell‐free multi‐enzyme synthesis and purification of uridine diphosphate galactose. (mpg.de)
Uridine1
  • 2. Maxwell, E.S. and de Robichon-Szulmajster, H. Purification of uridine diphosphate galactose-4-epimerase from yeast and the identification of protein-bound diphosphopyridine nucleotide. (qmul.ac.uk)
Oligosaccharides1
Yeast1
  • An improved method for the isolation of some nucleoside diphosphate sugar from yeast. (neglectedscience.com)
Reactions2
  • Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. (wikipedia.org)
  • Known as donor of activated mannose in all glycolytic reactions, GDP-mannose is essential in eukaryotes. (wikipedia.org)
Mutant1
  • Targeting AR with epalrestat decreases polyol levels and increases GDP-mannose in vivo in pmm2 mutant zebrafish. (sdsc.edu)
Activity1
  • The decrease in biochemical activity of guanosine 5'-diphosphate-D-mannose dehydratase (GMD) may be measured. (medscape.com)
Sugar1
  • In particular, we were interested in a new type of bacterial glycosyltransferase that allegedly attached the sugar d-mannose to teicoplanin. (europa.eu)
Found1
  • The DPMS was found to selectively employ guanosine diphosphate (GPD) mannose along with commercially available dolichylphospholipids to produce beta-d-mannosyldolichylphospholipids, currently being assessed as substrates for the teicoplanin mannosyltransferase. (europa.eu)
Nucleoside diphosphate sugar2
  • GDP-mannose is a nucleoside diphosphate sugar that is important in the production of fucosylated oligosaccharides. (ecmdb.ca)
  • A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. (nih.gov)
Triphosphate2
Fucose3
  • GDP-mannose is transformed to GDP-fucose via three enzymatic reactions carried out by two proteins, GDP-mannose 4,6-dehydratase (GMD) and a second enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase. (ecmdb.ca)
  • The epimerase converts the GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. (ecmdb.ca)
  • The GDP-Fuc de novo pathway, which requires the action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is conserved in the parasite genome, but the importance of fucose metabolism for the parasite is unknown. (johnshopkins.edu)
Nucleotide sugar1
  • Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. (wikipedia.org)
Mannosyltransferase1
  • A deficiency in guanosine diphosphate-mannose: GlcNAc(2)-PP-dolichol mannosyltransferase-1 (MT-1) causes CDG Ik (OMIM 608540), and only five patients, with severe multisystemic clinical presentations, have been described with this disease. (nih.gov)
Donor2
  • Known as donor of activated mannose in all glycolytic reactions, GDP-mannose is essential in eukaryotes. (wikipedia.org)
  • Also acts as mannose donor for glycolipid synthesis. (nih.gov)