• Glutathione-related enzymes and the eye. (aaem.pl)
  • Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)
  • Therapy resulted in a significant increase of hepatic Glutathione levels both in patients with alcoholic and in those with non-alcoholic liver diseases as compared with placebo-treated patients. (relumins.com)
  • When compared to placebo-treated patients, therapy resulted in a significant rise in hepatic Glutathione levels in both alcoholic and non-alcoholic liver disease patients. (skinsolutionstore.in)
  • Glutathione peroxidase 1 is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (Ala) repeats in this sequence. (wikipedia.org)
  • Although the GPX1 Pro198Leu polymorphism, in general, did not significantly correlate with panic disorder risk, the study found a plausible association of the C allele of the GPX1 Pro198Leu polymorphism, found to be more frequent in the female cohort, with PD development. (wikipedia.org)
  • To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism, blood selenium levels and GPx activity in KD patients and healthy controls in Heilongjiang Province. (geneticsmr.com)
  • Glutathione peroxidase (GPx) activity decreased whereas catalase activity increased with RL in muscles from young and aged rats. (cdc.gov)
  • Experimental GPX1 deficiency amplifies certain aspects of aging, namely endothelial dysfunction, vascular remodeling, and invasion of leukocytes in cardiovascular tissue. (wikipedia.org)
  • 10.4194/1303-2712-v21_11_02 Viewed : 1352 - Downloaded : 812 In this study, full-length cDNA of glutathione peroxidases 1 (GPX1) of Onychostoma macrolepis was cloned by RACE, and expression of GPX1 and activity of GPX in O. macrolepis suffered from heat stress were analyzed. (trjfas.org)
  • A novel cDNA encoding glutathione peroxidase of tea plant (Camellia sinensis) was isolated by rapid amplification of cDNA ends (RACE) method and designated as CsGPX2 (GenBank Accession No. JQ247186). (springeropen.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutathione Peroxidase 1 (GPX1) in serum, plasma and other biological fluids. (jsce-ip.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutathione Peroxidase 1 (GPX1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
  • Description: A sandwich ELISA kit for detection of Glutathione Peroxidase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
  • sought to investigate connections between oxidative stress genes, including GPX1, and Panic Disorder, an anxiety disorder characterized by random and unexpected attacks of intense fear. (wikipedia.org)
  • Certain genetic variations in the GPX1 (Glutathione peroxidase) and EPHX1 (Epoxide hydrolase) genes are among the few that have been studied by researchers. (livemint.com)
  • Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)
  • Rathbun WB, Bovis MG. Activity of glutathione peroxidase and glutathione reductase in the human lens related to age. (aaem.pl)
  • In vitro studies showed H295R cells with knockdown of GPX1 had 50% less basal GPX activity and were less viable than wild-type when exposed to oxidative stress. (qmul.ac.uk)
  • By supplementing the diet of Vitamin E deficient rats with salicylic acid (1 g/kg diet), this study assessed effects of salicylic acid on cytosolic glutathione peroxidase activity in the colon. (elsevierpure.com)
  • Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. (geneticsmr.com)
  • However, the mutation frequency of exon 474 was higher in the KD group (7/36) than in controls (2/41), and GPx activity was lower in the mutation group (90.475 ± 23.757 U/L) than in the non-mutation group (93.947 ± 17.463 U/L). Further investigation is necessary to clarify a possible causality between GPx1 exon 474 mutation and KD. (geneticsmr.com)
  • 2011 ). On the other side, plants have developed some enzymatic systems including superoxide dismutases (SOD), catalases (CAT), ascorbate peroxidases (APX), peroxiredoxins and non-enzymatic mechanisms to protect against oxidative damage caused by these ROS (Agrawal et al. (springeropen.com)
  • Mechanistically, reduction of GPx1 expression by oleic acid inhibited FAK/NF-κB activation. (jejunu.ac.kr)
  • The GPx1 allele with five Ala repeats is significantly associated with breast cancer risk. (wikipedia.org)
  • Adrenals from Gpx1-/- mice showed no gross morphological changes and corticosterone levels were not significantly different from their wild-type counterparts (in contrast to the Nnt mutants). (qmul.ac.uk)
  • Glutathione level is significantly related to Vitamin E level, and supplementation with Vitamin E (100 IU/day) significantly increases Glutathione and lowers lipid per-oxidation and HbA1c concentrations in the erythrocytes of type 1 diabetic patients. (relumins.com)
  • Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo. (wikipedia.org)
  • In GPX1 (-/-) mice, oxidant formation is increased, endothelial NO synthase is deregulated, and adhesion of leukocytes to cultured endothelial cells is increased. (wikipedia.org)
  • Compared with the control group (24°C), the experimental fish were stressed for 0, 1, 3, 6, 12, 24, and 48 hours at the heated water (30°C). Liver had highest level and response speed in GPX1 expression among various tissues after heat stress, indicated that liver was the highest sensitive tissue to heat stress. (trjfas.org)
  • My data suggest that loss of PRDX3 alone is insufficient to cause adrenal failure and further that mutation in GPX1, either alone or in combination with PRDX3 mutation, may tip the redox balance to cause FGD. (qmul.ac.uk)
  • Kisić B, Mirić D, Žorić L, Ilić A, Dragojević I. Reduced glutathione level and GSH-dependent enzyme activities in corticonuclear blocks of lenses in patients with senile cataract. (aaem.pl)