GeneGpx4Gpx3Antioxidant enzymesSuperoxide dismutaseEnzymesHepatic Glutathione levelsPolymorphismPhospholipidGSSGCatalaseHydrogenAntioxidantsProteinDeficiencyCDNALipid peroxidationSerumGenesReactive OxygenOrganic hydroperoxidesActivityH2O2AscorbateReductionSignificantlyMiceProtects cellsTissuesSupplementationBoosterMutationLevelsSequenceLevel
Gene15
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
- Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. (wikipedia.org)
- This gene encodes a member of the glutathione peroxidase family. (wikipedia.org)
- This gene encodes a member of the glutathione peroxidase family, consisting of eight known glutathione peroxidases (GPx1-8) in humans. (wikipedia.org)
- Mammalian Gpx1 (this gene), Gpx2, Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. (wikipedia.org)
- Ergen and colleagues analyzed gene expression of oxidative stress genes, specifically GPX1, in colorectal tumors in comparison to healthy colorectal tissues. (wikipedia.org)
- The aim of the study is to analyse correlations between age-related cataract (ARC), serum selenium levels and glutathione peroxidase gene 1 and 4 (GPX-1 and GPX-4). (aaem.pl)
- Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice. (aaem.pl)
- However in a male patient a homozygous mutation in another antioxidant gene, glutathione peroxidase 1 (GPX1), was identified. (qmul.ac.uk)
- Association of Pro198Leu polymorphism in glutathione peroxidase one (GPX1) gene with peripheral neuropathy in type 2 diabetic patients. (cdc.gov)
- Gpx1 and Gpx2 gene transcripts were not elevated in association with increased activity of the soluble glutathione peroxidase activity. (elsevierpure.com)
- Four and 24 new mutation loci in the promoter and the exon region, respectively, of the GPx1 gene were found in the subjects, in contrast with the previously reported loci. (geneticsmr.com)
- The glutathione peroxidase gene has positive function to damage induced by ROS. (springeropen.com)
- To understand the mechanism of tolerance to deferent stresses in tea plant, a new glutathione peroxidase gene of tea plant was cloned and its expression pattern was analyzed under abiotic and biotic stresses. (springeropen.com)
- The protein encoded by this gene is an omega class glutathione S-transferase (GST). (cancerindex.org)
Gpx42
- In addition, Se and Se + VE significantly enhanced the glutathione peroxidase (GPx) activity and the expression of GPx1 and GPx4 in breast muscle tissues. (springeropen.com)
- The selenoproteins GPx1 and GPx4 (glutathione peroxidases) and TrxR (thioredoxin reductases) are important intracellular antioxidants in the brain and the neurons. (seleniumfacts.com)
Gpx32
- Studies show that Selenomethionone supplemented medium exhibited markedly elevated Glutathione peroxidase activity and linear increases in abundance of GPx1 and GPx3 proteins. (relumins.com)
- Selenomethionone, 200mcg: -Studies reveal that Selenomethionone supplemented medium has significantly increased Glutathione peroxidase activity and linear increases in GPx1 and GPx3 protein abundance. (skinsolutionstore.in)
Antioxidant enzymes4
- Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. (wikipedia.org)
- Such a resistance might be achieved by enhanced expression of many antioxidant enzymes, such as for example glutathione peroxidase-1 (Gpx-1) (12, 20). (mingsheng88.org)
- Catalase and glutathione peroxidase ( GPx1 ), the subject of this trait, are other antioxidant enzymes . (fitnessgenes.com)
- Glutathione peroxidases are key antioxidant enzymes, catalysing the decomposition of potentially toxic lipid peroxides. (elsevierpure.com)
Superoxide dismutase6
- In cells , antioxidants such as glutathione , mycothiol or bacillithiol , and enzyme systems like superoxide dismutase , can prevent damage from oxidative stress . (wikipedia.org)
- Superoxide dismutase and glutathione peroxidase are enzymatic antioxidants whereas, lipid-soluble vitamins (E and A), pro-vitamin A (beta-carotene) and water-soluble vitamin C are non-enzymatic antioxidants. (springeropen.com)
- Polymorphisms in the manganese superoxide dismutase ( MnSOD ) and glutathione peroxidase ( GPX-1 ) genes have been proposed as low penetrance alleles, and have not been clearly associated with breast cancer. (biomedcentral.com)
- Scutellarin의 항산화 효능을 확인하기 위하여 water-soluble tetrazolium salt (WST-1) assay를 이용한 세포독성 측정, 2′,7′-dichlorofluorescin diacetate (DCFDA) assay를 통한 세포 내 활성산소종 정량분석 그리고 quantitative realtime polymerase chain reaction (qRT-PCR)을 통해 superoxide dismutase 1 ( SOD1 ), catalase ( CAT ) 및 glutathione peroxidase 1 ( GPx1 ) mRNA의 발현 조절 양상을 측정하였다. (e-ajbc.org)
- To confirm the anti-oxidant effects of scutellarin, water-soluble tetrazolium salt (WST-1) was used to determine the cytotoxicity, 2′,7′-dichlorofluorescin diacetate (DCFDA) was used to quantitatively analyze intracellular reactive oxygen species (ROS), and quantitative real-time polymerase chain reaction (qRT-PCR) was used to determine the regulation of superoxide dismutase 1 ( SOD1 ), catalase ( CAT ) and glutathione peroxidase 1 ( GPx1 ) mRNA expression. (e-ajbc.org)
- BCO2, superoxide dismutase-2 (SOD2), glutathione peroxidase-1 (GPX1), reduced and oxidized glutathione (GSH/GSSG) ratio, and carbonylated proteins. (bvsalud.org)
Enzymes2
- Glutathione-related enzymes and the eye. (aaem.pl)
- Glutathione S-transferases (GSTs), a superfamily of multifunctional enzymes, play an important role in the onset and progression of renal cell carcinoma (RCC). (cancerindex.org)
Hepatic Glutathione levels2
- Therapy resulted in a significant increase of hepatic Glutathione levels both in patients with alcoholic and in those with non-alcoholic liver diseases as compared with placebo-treated patients. (relumins.com)
- When compared to placebo-treated patients, therapy resulted in a significant rise in hepatic Glutathione levels in both alcoholic and non-alcoholic liver disease patients. (skinsolutionstore.in)
Polymorphism3
- Glutathione peroxidase 1 is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (Ala) repeats in this sequence. (wikipedia.org)
- Although the GPX1 Pro198Leu polymorphism, in general, did not significantly correlate with panic disorder risk, the study found a plausible association of the C allele of the GPX1 Pro198Leu polymorphism, found to be more frequent in the female cohort, with PD development. (wikipedia.org)
- To further clarify the correlation between GPx1 polymorphism and KD, we analyzed GPx1 polymorphism, blood selenium levels and GPx activity in KD patients and healthy controls in Heilongjiang Province. (geneticsmr.com)
Phospholipid1
- Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. (ymdb.ca)
GSSG2
- Is instrumental in reduction of the oxidized form of Glutathione (GSSG) to its reduced form (GSH). (relumins.com)
- Vitamin B2, 5mg: -helps to convert the oxidised form of glutathione (GSSG) to the reduced form (GSH). (skinsolutionstore.in)
Catalase1
- Glutathione peroxidase (GPx) activity decreased whereas catalase activity increased with RL in muscles from young and aged rats. (cdc.gov)
Hydrogen2
- As a glutathione peroxidase, GPx1 functions in the detoxification of hydrogen peroxide, specifically by catalyzing the reduction of hydrogen peroxide to water. (wikipedia.org)
- More specifically, GPx1 neutralises and protects against damage from one ROS in particular - hydrogen peroxide (H2O2). (fitnessgenes.com)
Antioxidants1
- Some antioxidants, such as glutathione , Vitamin E (alpha-tocopherol) and Vitamin C (ascorbic acid), work by binding to and immobilising (or 'scavenging') ROS. (fitnessgenes.com)
Protein2
- This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. (wikipedia.org)
- Free and protein bound glutathione in normal and cataractous human lens. (aaem.pl)
Deficiency1
- Experimental GPX1 deficiency amplifies certain aspects of aging, namely endothelial dysfunction, vascular remodeling, and invasion of leukocytes in cardiovascular tissue. (wikipedia.org)
CDNA2
- 10.4194/1303-2712-v21_11_02 Viewed : 1352 - Downloaded : 812 In this study, full-length cDNA of glutathione peroxidases 1 (GPX1) of Onychostoma macrolepis was cloned by RACE, and expression of GPX1 and activity of GPX in O. macrolepis suffered from heat stress were analyzed. (trjfas.org)
- A novel cDNA encoding glutathione peroxidase of tea plant (Camellia sinensis) was isolated by rapid amplification of cDNA ends (RACE) method and designated as CsGPX2 (GenBank Accession No. JQ247186). (springeropen.com)
Lipid peroxidation2
- RL increased H2O2 in tibialis anterior muscles of young and aged rats and decreased the ratio of reduced/oxidized glutathione and lipid peroxidation in aged but not young adult animals. (cdc.gov)
- Vitamin E, 100IU: Glutathione levels are directly associated to Vitamin E levels, and treatment with Vitamin E (100 IU/day) dramatically enhances Glutathione while decreasing lipid peroxidation and HbA1c concentrations in type 1 diabetic patients' erythrocytes. (skinsolutionstore.in)
Serum3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutathione Peroxidase 1 (GPX1) in serum, plasma and other biological fluids. (jsce-ip.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutathione Peroxidase 1 (GPX1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
- Description: A sandwich ELISA kit for detection of Glutathione Peroxidase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
Genes3
- sought to investigate connections between oxidative stress genes, including GPX1, and Panic Disorder, an anxiety disorder characterized by random and unexpected attacks of intense fear. (wikipedia.org)
- Certain genetic variations in the GPX1 (Glutathione peroxidase) and EPHX1 (Epoxide hydrolase) genes are among the few that have been studied by researchers. (livemint.com)
- Concomitance of Polymorphisms in Glutathione Transferase Omega Genes Is Associated with Risk of Clear Cell Renal Cell Carcinoma. (cancerindex.org)
Reactive Oxygen4
- GPx-1 stands for Glutathione peroxidase 1 - an important enzyme involved in protecting our cells from damage caused by harmful substances called Reactive Oxygen Species ( ROS ). (fitnessgenes.com)
- GPx-1 (glutathione peroxidase 1) is an enzyme that protects cells against damage from harmful substances called Reactive Oxygen Species (ROS). (fitnessgenes.com)
- Both drugs significantly restored the gonadal redox imbalances in diabetic mice by decreasing reactive oxygen species accumulation and increasing glutathione levels. (bvsalud.org)
- This oleic acid increased the low-level reactive oxygen species (ROS) in BCSCs while decreasing expression of glutathione peroxidase 1 (GPx1). (jejunu.ac.kr)
Organic hydroperoxides1
- The glutathione peroxidase also catalyzes the reduction of other organic hydroperoxides, such as lipid peroxides, to the corresponding alcohols. (wikipedia.org)
Activity5
- Rathbun WB, Bovis MG. Activity of glutathione peroxidase and glutathione reductase in the human lens related to age. (aaem.pl)
- In vitro studies showed H295R cells with knockdown of GPX1 had 50% less basal GPX activity and were less viable than wild-type when exposed to oxidative stress. (qmul.ac.uk)
- By supplementing the diet of Vitamin E deficient rats with salicylic acid (1 g/kg diet), this study assessed effects of salicylic acid on cytosolic glutathione peroxidase activity in the colon. (elsevierpure.com)
- Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. (geneticsmr.com)
- However, the mutation frequency of exon 474 was higher in the KD group (7/36) than in controls (2/41), and GPx activity was lower in the mutation group (90.475 ± 23.757 U/L) than in the non-mutation group (93.947 ± 17.463 U/L). Further investigation is necessary to clarify a possible causality between GPx1 exon 474 mutation and KD. (geneticsmr.com)
H2O21
- therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. (nih.gov)
Ascorbate1
- 2011 ). On the other side, plants have developed some enzymatic systems including superoxide dismutases (SOD), catalases (CAT), ascorbate peroxidases (APX), peroxiredoxins and non-enzymatic mechanisms to protect against oxidative damage caused by these ROS (Agrawal et al. (springeropen.com)
Reduction1
- Mechanistically, reduction of GPx1 expression by oleic acid inhibited FAK/NF-κB activation. (jejunu.ac.kr)
Significantly3
- The GPx1 allele with five Ala repeats is significantly associated with breast cancer risk. (wikipedia.org)
- Adrenals from Gpx1-/- mice showed no gross morphological changes and corticosterone levels were not significantly different from their wild-type counterparts (in contrast to the Nnt mutants). (qmul.ac.uk)
- Glutathione level is significantly related to Vitamin E level, and supplementation with Vitamin E (100 IU/day) significantly increases Glutathione and lowers lipid per-oxidation and HbA1c concentrations in the erythrocytes of type 1 diabetic patients. (relumins.com)
Mice2
- Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo. (wikipedia.org)
- In GPX1 (-/-) mice, oxidant formation is increased, endothelial NO synthase is deregulated, and adhesion of leukocytes to cultured endothelial cells is increased. (wikipedia.org)
Protects cells1
- GPX1 is ubiquitously expressed in many tissues, where it protects cells from oxidative stress. (wikipedia.org)
Tissues1
- Compared with the control group (24°C), the experimental fish were stressed for 0, 1, 3, 6, 12, 24, and 48 hours at the heated water (30°C). Liver had highest level and response speed in GPX1 expression among various tissues after heat stress, indicated that liver was the highest sensitive tissue to heat stress. (trjfas.org)
Supplementation1
- Evidence suggests that alpha Lipoic Acid may assist Glutathione levels remain elevated following supplementation. (skinsolutionstore.in)
Booster1
- The most advanced oral Glutathione boosting medication available is Relumins Glutathione booster. (skinsolutionstore.in)
Mutation1
- My data suggest that loss of PRDX3 alone is insufficient to cause adrenal failure and further that mutation in GPX1, either alone or in combination with PRDX3 mutation, may tip the redox balance to cause FGD. (qmul.ac.uk)
Levels1
- Supports High Levels of Glutathione in the Body. (relumins.com)
Sequence1
- The deduced amino acid sequence showed high homology with glutathione peroxidases of angiosperms and contained the characteristic conserved motifs of ILAFPCNQF and FTVKD, the highest level of similarity was 85% to a glutathione peroxidase from Ricinus communis (Accession NO. XP_002509790.1). (springeropen.com)
Level1
- Kisić B, Mirić D, Žorić L, Ilić A, Dragojević I. Reduced glutathione level and GSH-dependent enzyme activities in corticonuclear blocks of lenses in patients with senile cataract. (aaem.pl)