GAGsBiosynthesisProteoglycansHeparinProteoglycanCell-surface glycosaminoglycansCharacterizationChondroitin sulfatePolysaccharidesCartilageHeparanChemokineVivoChainsMoleculesVascularKeratanMucopolysaccharidosesInflammationFuture therapeuticMass spectrometryPathwaysInhibitCollagenAdequanChemokinesAnticoagulantTherapeutic strategyMembranesBiochemicalBiomechanicalSulfationMechanismsMicePhysiologicalHumanResearchersMajor
GAGs22
- Glycosaminoglycans (GAGs) or mucopolysaccharides are long, linear polysaccharides consisting of repeating disaccharide units (i.e. two-sugar units). (wikipedia.org)
- Glycosaminoglycans (GAGs), known to be present in airway mucus, are macromolecules with a variety of structural and biological functions. (nih.gov)
- Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
- Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
- Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
- Glycosaminoglycans (GAGs) are essential functional components of the extracellular matrix (ECM). (degruyter.com)
- Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
- In recent years, glycosaminoglycans (GAGs) have emerged into the focus of biochemical and biomedical research due to their importance in a variety of physiological processes. (fu-berlin.de)
- Articular cartilage undergoes severe loss of proteoglycan and its constituent glycosaminoglycans (GAGs) in osteoarthritis. (cardiff.ac.uk)
- [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
- Hyaluronic acid belongs to a family of molecules known as glycosaminoglycans or GAGs for short. (sapienskinseattle.com)
- Glycosaminoglycans (GAGs) are routinely found associated with amyloid deposits in most amyloidosis diseases, and there is evidence to support an active role of GAGs in amyloid fibril formation in some cases. (usf.edu)
- Glycosaminoglycans (GAGs) are linear mucopolysaccharides with repeating disaccharide units. (biomedcentral.com)
- Scaffolds based on chitosan (CTS), collagen (Coll), and glycosaminoglycans (GAGs) cross-linked by sodium alginate (SA) were obtained with the use of the freeze-drying method. (ac.rs)
- TY - JOUR AU - Kaczmarek, B. AU - Sionkowska, A. AU - Stojkovska, Jasmina PY - 2018 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3866 AB - Scaffolds based on chitosan (CTS), collagen (Coll), and glycosaminoglycans (GAGs) cross-linked by sodium alginate (SA) were obtained with the use of the freeze-drying method. (ac.rs)
- article{ author = "Kaczmarek, B. and Sionkowska, A. and Stojkovska, Jasmina", year = "2018", abstract = "Scaffolds based on chitosan (CTS), collagen (Coll), and glycosaminoglycans (GAGs) cross-linked by sodium alginate (SA) were obtained with the use of the freeze-drying method. (ac.rs)
- Glycosaminoglycans (GAGs) constitute the main building blocks of the endothelial glycocalyx (GLX), and disruption of GLX initiates and promotes endothelial dysfunction. (uni-luebeck.de)
- Here, we aimed to develop a novel, specific and accurate LC-SRM/MS-based method for glycosaminoglycans (GAGs) profiling. (uni-luebeck.de)
- It remains uncertain how brain glycosaminoglycans (GAGs) contribute to the progression of inflammatory disorders like multiple sclerosis (MS). We investigated here neuroinflammation-mediated changes in GAG composition and metabolism using the mouse model of experimental autoimmune encephalomyelitis (EAE) and sham-immunized mice as controls. (mdc-berlin.de)
- We quantitatively and structurally characterize primary stored HS and other glycosaminoglycans (GAGs) possibly accumulated through a secondary storage in brain, liver, kidney and lung of MPS IIIA mouse model. (unimore.it)
- Immune cell invasion after the transplantation of solid organs is directed by chemokines binding to glycosaminoglycans (GAGs), creating gradients that guide immune cell infiltration. (elsevierpure.com)
- GALNS deficiency induces the accumulation of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate (C6S) in multiple tissues, particularly bone, cartilage, heart valves, and cornea, whereas β-galactosidase deficiency induces the accumulation of only KS in those tissues. (medscape.com)
Biosynthesis3
- By confocal microscopy of A549 cells, we showed that the xylosides were taken up by the cells, but did not enter the Golgi apparatus where most of the glycosaminoglycan biosynthesis occurs. (lu.se)
- Xyloside analogues with substitution of the endocyclic oxygen atom by sulfur or carbon were investigated as substrates for β-1,4-galactosyltransferase 7 (β4GalT7), a key enzyme in the biosynthesis of glycosaminoglycan chains. (lu.se)
- We are presently mainly working on the biosynthesis of glycosaminoglycans and bacterial sialic acid uptake mechanisms. (lu.se)
Proteoglycans5
- Glycosaminoglycans (GAG) and proteoglycans (PG) were extracted from both relatively uninflamed and severly inflamed human gingiva. (eurekamag.com)
- Changes in glycosaminoglycans and related proteoglycans in intrinsically aged human skin in vivo. (sapienskinseattle.com)
- Proteoglycans are comprised of a core protein and one or more covalently attached glycosaminoglycan (GAG) chains. (openbiochemistryjournal.com)
- Proteoglycans are complex macromolecules comprised of a core protein and one or more covalently attached glycosaminoglycans (GAG) chains so that structurally they are both proteins and carbohydrates. (openbiochemistryjournal.com)
- Currently, he is research interests include investigating the role of glycosaminoglycans and proteoglycans on the development of placental pathology and breast cancer. (mdx.ac.uk)
Heparin5
- Sulodexide is a mixture of glycosaminoglycans: heparin and dermatan sulphate, which on one hand suppresses the intravascular inflammation and on the other hand have protective effect towards the endothelium. (viamedica.pl)
- Heparin and Other Glycosaminoglycans Stimulate The Formation of Amyloi" by Jeffrey A. Cohlberg, Jie Li et al. (usf.edu)
- Lymphotactin, the unique member of the "C" chemokine subclass, is a highly basic protein that binds heparin, a glycosaminoglycan, with high affinity (∼10 nM). (elsevierpure.com)
- Substitutions in and around this binding site and surface plasmon resonance analysis of heparin binding affinity identified two arginine residues of lymphotactin as critical for glycosaminoglycan binding. (elsevierpure.com)
- SpyCEP-cleaved CXCL8 had similarly impaired binding to the glycosaminoglycan heparin . (bvsalud.org)
Proteoglycan1
- Glycosaminoglycan and proteoglycan in skin aging. (sapienskinseattle.com)
Cell-surface glycosaminoglycans1
- Chemokine-mediated recruitment of leukocytes in vivo depends on interactions with cell surface glycosaminoglycans. (elsevierpure.com)
Characterization1
- Characterization of glycosaminoglycans and glycoproteins of the bovine prolactin matrix. (rupress.org)
Chondroitin sulfate2
- Among glycosaminoglycans, the major component is heparan sulfate, while hyaluronic acid and chondroitin sulfate ar present in smaller amounts. (rupress.org)
- Glycosaminoglycan from Apostichopus japonicus (AHG) and its depolymerized fragments (DAHGs) are anticoagulant fucosylated chondroitin sulfate. (myjournals.org)
Polysaccharides2
- Glycosaminoglycan (GAG) is a class of highly sulfated, negatively charged and dispersed linear polysaccharides, usually composed of a backbone of repeating disaccharide units formed by uronic acid and glycosamine residue. (bioglyco.com)
- Glycosaminoglycans (long-chain polysaccharides) are major components of the extracellular matrix, glycocalyx, and synovial fluid. (ku.dk)
Cartilage2
- Starting treatment with Adequan® i.m. (polysulfated glycosaminoglycan) at the early signs of arthritis can help slow the progression of cartilage deterioration in horses' joints. (adequan.com)
- gagCEST is a promising MRI method that has the potential to directly reflect the glycosaminoglycan (GAG) depletion within early degeneration of articular cartilage. (lu.se)
Heparan3
- The glycosaminoglycan (heparan sulfate) component of glomerular basement membranes from human kidneys of diabetic and nondiabetic subjects has been quantitated after isolation from protease digests of the membranes on OEAE-cellulose microcolumns. (diabetesjournals.org)
- Heparan sulfate was identified as the predominant glycosaminoglycan in both diabetic and control subjects and the extent of its sulfation appeared to be similar. (diabetesjournals.org)
- We observed that dermatan sulfate is the major anticoagulant and antithrombotic among the vessel wall glycosaminoglycans while the bulk of heparan sulfate is a poorly sulfated glycosaminoglycan, devoid of anticoagulant and antithrombotic activities. (qjbchina.com)
Chemokine3
- Both arginine mutant proteins and the combined double mutant had dramatically diminished in vivo activity in a leukocyte recruitment assay, suggesting that the lymphotactin-glycosaminoglycan interactions detected in vitro are important for the function of this chemokine. (elsevierpure.com)
- A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP. (bvsalud.org)
- We conclude, therefore, that SpyCEP cleavage of CXCL8 results in chemokine inactivation because of a requirement for glycosaminoglycan binding in productive chemokine receptor interactions. (bvsalud.org)
Vivo1
- These glycosaminoglycans markedly prevented thrombosis formation and thrombin-induced platelet aggregation in a dose- and molecular weight-dependent manner in vitro and in vivo. (myjournals.org)
Chains1
- Schematic representation of glycosaminoglycan chains (Merida-de-Barros, D.A. (bioglyco.com)
Molecules1
- Mucopolysaccharidoses occur when the body lacks enzymes needed to break down and store complex sugar molecules (glycosaminoglycans). (msdmanuals.com)
Vascular1
- In view of these results we discuss a possible balance between the two glycosaminoglycan-dependent anticoagulant pathways present in the vascular wall. (qjbchina.com)
Keratan1
- The repeating two-sugar unit consists of a uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose unit. (wikipedia.org)
Mucopolysaccharidoses2
- Mucopolysaccharidoses are a group of metabolic disorders in which abnormal accumulations of glycosaminoglycans occur due to enzyme deficiencies. (wikipedia.org)
- Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders that affect regulation of glycosaminoglycan (GAG) processing. (nih.gov)
Inflammation2
- Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C . Frontiers in cardiovascular medicine , 9 , [866751]. (helsinki.fi)
- Kohli S, Shahzad K, Jouppila A , Holthöfer H , Isermann B, Lassila R. Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C . Frontiers in cardiovascular medicine . (helsinki.fi)
Future therapeutic1
- Leishmaniasis and glycosaminoglycans: a future therapeutic strategy? (bioglyco.com)
Mass spectrometry1
- During the past few years, in the field of glycosaminoglycomics, mass spectrometry (MS) emerged as one of the most efficient analytical techniques due to its valuable contribution to compositional and structural determination of various glycosaminoglycan (GAG) classes. (molecular-life.org)
Pathways1
- Five novel xylosides tagged with the fluorescent probe Pacific Blue™ were synthesized and found to act as substrates for β4GalT7, a bottleneck enzyme in the biosynthetic pathways leading to glycosaminoglycans. (lu.se)
Inhibit1
- Glycosaminoglycan, CaG can strengthen ECM by increasing activity of TIMP-2 and adhesion activity on collagen known to inhibit changes of ECM, leading to tumor cell invasion and progression. (biomedcentral.com)
Collagen3
- The reduced level of glycosaminoglycan in the diabetic glomerular basement membrane was accompanied by a significant elevation of hexoses, which are primarily associated with the collagen component, suggesting that a redistribution of basement membrane macromolecules occurs in the diabetic state. (diabetesjournals.org)
- We show that fibromodulin deficiency decreased collagen fibril thickness but glycosaminoglycan content and composition were unchanged. (lu.se)
- The results showed that the scaffolds based on chitosan, collagen, and glycosaminoglycans cross-linked by sodium alginate are stable in aqueous environment. (ac.rs)
Adequan2
- My colleagues and I have the pleasure of talking with a lot of veterinarians about Adequan i.m. (polysulfated glycosaminoglycan), and we often get into conversations about the dosing regimen. (adequan.com)
- To begin with, as the only FDA-approved equine polysulfated glycosaminoglycan (or PSGAG), Adequan i.m. has a mode of action that helps treat degenerative joint disease in multiple ways. (adequan.com)
Chemokines1
- Our results demonstrate that like other chemokines, lymphotactin utilizes highly specific glycosaminoglycan-binding sites that represent potential targets for drug development. (elsevierpure.com)
Anticoagulant1
- 5% of the total arterial glycosaminoglycans) with high anticoagulant activity were also observed, as assessed by its retention on an antithrombin-affinity column. (qjbchina.com)
Therapeutic strategy1
- Targeting this glycosaminoglycan complex biomolecules might be a novel therapeutic strategy to treat disorders such as cancers, neurodegenerative diseases, and infections associated with receptor for advanced glycation end-products (RAGE) containing disaccharide units (CS-E) [ 2 ]. (biomedcentral.com)
Membranes2
- 0.005) in the glycosaminoglycan content of diabetic membranes was observed. (diabetesjournals.org)
- 2] In a last example, we use model membranes carrying glycosaminoglycans, to elucidate the molecular mechanisms modulating attachment and release of the herpes simplex virus. (lu.se)
Biochemical1
- 1) Yamada S, Sugahara K, Ozbek S. Evolution of glycosaminoglycans: Comparative biochemical study. (sapienskinseattle.com)
Biomechanical1
- With this in mind, three decellularization protocols were compared in terms of their effectiveness to extract cellular materials, their effect on glycosaminoglycan (GAG) content and, finally, their effect on tensile biomechanical behavior. (upm.es)
Sulfation1
- Glycosaminoglycans vary greatly in molecular mass, disaccharide structure, and sulfation. (wikipedia.org)
Mechanisms1
- One of the mechanisms of your skin that you can thank for wound healing, hydration, and support is this family of glycosaminoglycans. (sapienskinseattle.com)
Mice2
- The objective of this study was to evaluate the anti-cancer effect of insect-derived polymer dung beetle glycosaminoglycan (GAG) after intraperitoneally injecting it to melanoma mice induced by B16F10 cells. (biomedcentral.com)
- Mice with induced melanoma were then treated with Catharsius molossus (dung beetle) GAG (CaG) at 5 mg/kg for 8 weeks to investigate its anti-cancer effects compared to bumblebee ( Bombus ignitus ) queen glycosaminoglycan (IQG) and Huechys sanguinea glycosaminoglycan (HEG). (biomedcentral.com)
Physiological1
- The role of different glycosaminoglycan species from the vessel walls as physiological antithrombotic agents remains controversial. (qjbchina.com)
Human2
- The acid glycosaminoglycans (AG) were isolated from small quantities of human tissue (1.0 gm wet weight or less) and were separated, identified, and measured by zone electrophoresis on cellulose acetate. (northwestern.edu)
- To further investigate this aspect we extracted glycosaminoglycans from human thoracic aorta and saphenous vein. (qjbchina.com)
Researchers2
- This set of researchers wanted to find out what happens to the glycosaminoglycan if the disc is damaged. (coxtechnic.com)
- CD BioGlyco has provided glycosaminoglycan related services to researchers, and our quality and efficiency have been confirmed by numerous clients. (bioglyco.com)
Major1
- Glycosaminoglycan is a component of aggrecan, a major component of the disc's make-up. (oldingchiropractic.com)