• Anti-α1-acid glycoprotein antibodies react with antigen in the sample to form an antigen/antibody complex. (cdc.gov)
  • The present invention discloses a pharmaceutical composition containing antibodies or antigen-binding fragments of antibodies that bind to SSEA3, SSEA4, and globo H. It also describes methods for using the composition. (patentpc.com)
  • It is so rare to find the T antigen in healthy tissue, that we actually have antibodies against it. (dadamo.com)
  • All humans normally possess antibodies that react with the Thomsen-Friedenreich (T) and the Tn antigens. (dadamo.com)
  • Transmembrane or otherwise tumor-associated polypeptides specifically expressed on the surface of cancer cells as compared to normal, non-cancerous cell(s) have been identified as cellular targets for cancer diagnosis and therapy with antibodies. (justia.com)
  • She is particularly interested in the immunological foundation of anti-carbohydrate antibodies, their effects on cancer and heart diseases, and the development of innovative diagnostics and treatments for these diseases. (glycanage.com)
  • Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates , however they are not considered lectins . (lookformedical.com)
  • Lectins, or proteins that bind carbohydrates, can recognize specific oligosaccharides and provide useful information for cell recognition based on oligosaccharide binding. (wikipedia.org)
  • These proteins called tumour-associated antigens may be present in higher than usual concentrations in other tissues serum urine or body fluids of patients with cancer. (scienceexhibitions.org)
  • We identified a total of 587 glycoproteins, including 1239 glycopeptides, 526 monosaccharide components, and 8326 intact glycopeptides in glycoproteomics, as well as a total of 4496 proteins identified in proteomic analysis. (frontiersin.org)
  • Glycosylation is an important post-translational modification of proteins, and glycoproteins are widely involved in various important cellular biological processes and diseases ( 1 ). (frontiersin.org)
  • Changes in glycan structures and the interactions of these structures with endogenous carbohydrate- binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tu- mor progression. (fdocuments.net)
  • At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
  • Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. (lookformedical.com)
  • The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. (lookformedical.com)
  • Proteins that share the common characteristic of binding to carbohydrates . (lookformedical.com)
  • PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). (lookformedical.com)
  • The addition of any one tumor marker assay consistently improved the diagnostic value of cytology. (nih.gov)
  • The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. (hindawi.com)
  • This session will focus on hCG's functions as a tumor marker. (aacc.org)
  • SCC antigen is a tumor marker for cervical, vaginal, lung, brain a nd esophageal cancer. (xhfhj.com)
  • The structure of Gal beta 1,3GalNAc alpha occurs on the surface of tumor cells as a mucin-associated antigenic marker, termed as T-antigen. (biotrend.com)
  • Many malignant cells (such as those found in breast and stomach cancer) develop a tumor marker called the Thomsen-Friedenreich (T) antigen. (dadamo.com)
  • We also investigated serum CA 15-3 activity to establish whether its expression could be assigned WIKI4 to several tumour characteristics to evaluate its potential use as a serum tumour marker in the canine mammary oncology field. (scienceexhibitions.org)
  • 0.0019) between serum CA 15-3 levels and the degree of tumour proliferation and differentiation was shown which indicates that the values of this serum marker increase as the tumour stage progresses. (scienceexhibitions.org)
  • Tumor marker levels must be used in conjunction with the history, physical examination, and diagnostic imaging. (medscape.com)
  • A decrease in marker levels during treatment can indicate tumor response, whereas stable or increasing levels despite adequate treatment can indicate that the tumor is not responding to treatment or that the tumor is recurring. (medscape.com)
  • If the tumor produces CA 15-3, marker levels will increase as the tumor grows. (medscape.com)
  • One or the other tumor marker is ordered, typically not both. (medscape.com)
  • Carbohydrate antigen 19-9 - tumor marker: Past, present, and future World J Gastrointest Surg. (moleculardepot.com)
  • Persistently high AFP after surgery may indicate incomplete removal of the tumor or the presence of metastasis. (aacc.org)
  • A significant increase in AFP in post-surgery tumor-free patients may also indicate metastasis. (aacc.org)
  • Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)
  • There can, however, be few similarities between the two, as the bone marrow is a common site of metastasis of solid tumors too [6]. (fortunejournals.com)
  • However, the impact of M6P/IGF2R on tumour invasion and metastasis is so far only poorly understood. (boku.ac.at)
  • Future studies will aim at the identification of these anti-invasive M6P-modified protein(s) followed by a comprehensive assessment of their involvement in tumour invasion and metastasis. (boku.ac.at)
  • It may play a role in tumor cell metastasis. (nsjbio.com)
  • sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
  • Several tumor markers have been evaluated in pleural fluid, but their clinical role has not been firmly established. (nih.gov)
  • The aim of this study is to determine the diagnostic value of carbohydrate antigen 549 (CA 549) levels in pleural fluid, and to compare it with another previously studied tumor markers: carcinoembryonic antigen (CEA), CA 15.3 and CA 72.4. (nih.gov)
  • The levels of the tumor markers were measured by immunoradiometric assays (RIA). (nih.gov)
  • The best combination of tumor markers for differentiating malignant from benign effusions was CA 549+CEA+CA 15.3, with a sensitivity of 0.65, specificity of 0.99 and accuracy of 0.85. (nih.gov)
  • In our study, none of the tumor markers was organ-specific. (nih.gov)
  • The best combination of tumor markers in this series with a high relative frequency of mesothelioma and low frequency of breast carcinoma was CA 549+CEA+CA 15.3. (nih.gov)
  • Individual tumor markers or their combination increased the sensitivity of pleural cytology. (nih.gov)
  • This slide summarizes how AFP and hCG function as tumor markers. (aacc.org)
  • Abstract: The aim of this study was to investigate the prognostic value of tumor markers in operable non-small cell lung cancer (NSCLC) patients. (pdffox.com)
  • Patients with all three tumor markers elevated presented the worst prognosis (p (pdffox.com)
  • [ 35 ] Tumor markers such as CA125 are not good discriminators of benign lesions from malignant lesions in premenopausal women but have better accuracy in postmenopausal women. (medscape.com)
  • Many studies are using a combination of ultrasound, serum CA125 testing, and other tumor markers. (medscape.com)
  • In this example, the T and Tn antigens are the stumps found in cancer, while the well-groomed yard has bushes, shrubs, and flowers, that correspond to the ABO markers and other antigens found on healthy cells. (dadamo.com)
  • So the hypothesis goes that because of the lower level of antibody against T and Tn antigens or stumps, and because of this tendency for the immune system of A's to be a bit confused or disinclined to attack Tn antigens, blood type A is at an immunologic disadvantage in attacking any cell bearing these T and Tn antigenic markers. (dadamo.com)
  • Several histopathological variables such as tumour size lymph node status lymphatic or vascular invasion and the tumour grade of differentiation form have been widely used parameters in prognostic evaluations [2 3 In human breast cancer and other malignancies serum tumour markers play an important role in patient management [4 5 Tumour cells display protein molecules on their surfaces. (scienceexhibitions.org)
  • Currently CA 15-3 the circulating form of CACNG4 DF3 antigen is one of the most widely used WIKI4 serum biochemical markers in breast cancer. (scienceexhibitions.org)
  • Currently there is a lack of scientific documentation regarding the application of serum tumour markers in the canine mammary oncology WIKI4 field and only one preliminary report describing the possible use of serum CA 15-3 in dogs has been published [15]. (scienceexhibitions.org)
  • After five cycles of chemotherapy, the general condition of the patient improved and tumor markers (CEA, CA125, CA199) decreased. (biomedcentral.com)
  • Tumor markers were elevated (CEA 6.21 ng/mL, CA125 115.80 u/mL, and CA199 659.93 u/mL). (biomedcentral.com)
  • Consideration may be given to ordering multiple tumor markers due to the heterogeneity in cell composition of each tumor. (medscape.com)
  • Other tumor markers for epithelial-derived carcinomas include CEA, CA 19-9, and CA 125. (medscape.com)
  • ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
  • This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
  • These 2 theranostic approaches, as well as the therapy of osseous metastases of prostate cancer with 223 Ra ( 4 , 9 , 10 ), have unequivocally demonstrated that radionuclide therapy can be applied not only to thyroid cancer but also to other solid tumors. (snmjournals.org)
  • The complexity of the human bone marrow, with context to haematological malignancies, is more difficult to elucidate with the present strategies compared to the niche of solid tumors. (fortunejournals.com)
  • Relevant information has now been established on solid tumors and their micro-environments, which include immune, endothelial and mesenchymal cells. (fortunejournals.com)
  • Other malignancies have occurred, including skin cancers and other solid tumors. (drugs.com)
  • Therefore, a person with A blood type will have the A antigen and H antigen present on the glycolipids of the red blood cell plasma membrane. (wikipedia.org)
  • Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
  • More recently, the prostate-specific membrane antigen (PSMA) has been established as a theranostic target for prostate cancer. (snmjournals.org)
  • However, membrane receptors that are recognized by SRL in normal resting PBMCs were totally different and are high molecular weight glycoproteins. (bvsalud.org)
  • Treatment of membrane receptors with glycosidases prior to lectin probing, revealed that fucosylated Thomsen-Friedenreich(TF) antigen glycans are increasingly expressed on transformed Molt-4 leukemic cells compared to other cells. (bvsalud.org)
  • The difference between the yards is largely because a cancer cell is unable to completely assemble a normal, healthy cell membrane structure like a blood type ABO antigen. (dadamo.com)
  • The MUC1 protein, also known as polymorphic epithelial mucin or epithelial membrane antigen, has a large extracellular region, a transmembrane sequence, and a cytosolic domain. (medscape.com)
  • Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. (unige.ch)
  • Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain. (unige.ch)
  • LAMP2 is a member of a family of membrane glycoproteins. (nsjbio.com)
  • CA242 is a sialylated carbohydrate antigen that can be recognized by CA242 monoclonal antibody.It is a mucin-type glycoprotein that is low in the serum of healthy people and patients with benign diseases. (xhfhj.com)
  • most of these tumors are adenocarcinomas containing pools of mucin. (biomedcentral.com)
  • Cancer antigen 15-3, or CA 15-3, is an epitope of a large transmembrane glycoprotein named MUC1 that is derived from the MUC1 gene. (medscape.com)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11R1-deficient mice), a transmembrane receptor that is required conjointly with glycoprotein 130 to transduce IL-11 signaling. (cdc.gov)
  • Glycoproteins are relevant as cell-surface receptors, cell-adhesion molecules, immunoglobulins, and tumor antigens. (wikipedia.org)
  • Their response involves antigen capture, enhancing their MHC-II presentation receptors and production of chemokines and/or cytokines at the site of inflammation [9]. (fortunejournals.com)
  • Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors. (unige.ch)
  • Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors. (unige.ch)
  • Carbohydrate antigen 125 (CA-125) is a high molecular-weight glycoprotein expressed by epithelial ovarian tumors as well as on the surface of cells of mesothelial origin [ 10 ]. (hindawi.com)
  • AFP is a single-chain glycoprotein with a molecular weight of around 70 KDa and 4% carbohydrate content. (aacc.org)
  • HE4 antigen is a glycoprotein with a molecular weight of about 20-25 KD. (xhfhj.com)
  • In malignant or pre-malignant cells, the ability to synthesize the polysaccharides which normally cover the T antigen is often lost, which causes T to be 'expressed' or uncovered, much like a falling tide will often uncover previously hidden rocks at a low tide. (dadamo.com)
  • The CA 15-3 antigen (also known as MUC1, from which it is derived) represents sequences of mucins that are often overexpressed in malignant glandular cells, such as breast cancer. (medscape.com)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • In 1994, a joint effort by several investigators in the field led to a new nomenclature in which the term "galectins" was used to define lectins with an affinity for - galactosides and with sequence similarity in the carbohydrate-binding site [3]. (fdocuments.net)
  • However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition. (lookformedical.com)
  • During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
  • These cells participate in pathogen recognition, apoptotic cell clearance, and antigen presentation ( 14 ). (frontiersin.org)
  • Our data showed the involvement of TLR4 in the hemocyanin-mediated proinflammatory response in APCs, which could cooperate with MR in innate immune recognition of these glycoproteins. (exeter.ac.uk)
  • The 15 members of the family are normally classified according to their struc- ture and number of carbohydrate recognition domains (CRDs). (fdocuments.net)
  • The current study aimed to explore its exquisite carbohydrate specificity on human peripheral blood mononuclear cells (PBMCs) and leukemic T-cells. (bvsalud.org)
  • The carbohydrate specificity of either type of subunit appears to be the same, preferring α-linked N-acetylgalactosamine structures. (biotrend.com)
  • Additional experiments also showed that the selected aptamers could detect similarly glycosylated lipocalin-2 (NGAL), indicating specificity for the glycan structure that could become general reagents for protein carbohydrate side chains. (aptamergroup.com)
  • Carbohydrate xenoantigens and xenoantibody epitope-specificity, the removal of xenoantibodies by plasmapheresis, and antibody neutralization using soluble saccharides, were all explored. (gu.se)
  • The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is a multifunctional tumour suppressor which binds a variety of factors that impinge on the proliferation, migration and invasiveness of cancer cells. (boku.ac.at)
  • Molecular mechanisms exhibit alterations in the expression of multiple genes usually involve: (proto) oncogenes, tumour suppressor genes, and DNA repair genes that contribute to the development of cancer genotype and phenotype with a state of cell proliferation dysregulation events. (lifepronow.com)
  • In accordance, attempts have been made to establish a link between the immune system and the tumor microenvironment, to comprehend tumor progression and achieve effective therapeutic approaches. (fortunejournals.com)
  • Prostate-specific antigen (PSA), is a glycoprotein enzyme secreted by the prostate gland that is often used for diagnosing and predicting progression of prostate cancer in men. (aptamergroup.com)
  • Identification of such tumor-associated cell surface antigen polypeptides, i.e. tumor associated antigens (TAA), allows specific targeting of cancer cells for destruction via antibody-based therapies. (justia.com)
  • High levels of neuron-specific enolase (NSE), carbohydrate antigen 125 (CA125) and squamous cell carcinoma antigen (SCC) were detected in 306 (63.6%), 89 (18.5%) and 125 (26.0%) patients, respectively. (pdffox.com)
  • The Thomsen-Friedenreich (T) antigen and Tn antigen show some structural similarity to the A antigen (even though it is derived from the M blood type antigen). (dadamo.com)
  • Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. (lookformedical.com)
  • Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • All cells are coated in either glycoproteins or glycolipids, both of which help determine cell types. (wikipedia.org)
  • However, tumor cell-derived AFP has various carbohydrate compositions depending on the saccharide transferase activity within the tumor cells. (aacc.org)
  • Human chorionic gonadotropin (hCG) is also a glycoprotein secreted by the syncytiotrophoblastic cells of the normal placenta. (aacc.org)
  • A trophoblastic tumor is a proliferation of cells derived from the placenta. (aacc.org)
  • In the case of immunoglobulins, these carbohydrate chains help in various functions, including binding to specific antigens and signaling immune cells. (proprofs.com)
  • In the current study we show that designer glycopeptides containing the Thomsen-Freidenreich (TF) antigen (β-Gal-[1→3]-α-GalNAc- O -serine) are immunogenic in vivo and generate TF-specific CTL capable of recognizing a variety of tumor cells in vitro including a MUC1-expressing tumor. (silverchair.com)
  • This antigen is suppressed in normal healthy cells, much like a rock is covered over by water at high tide. (dadamo.com)
  • Healthy cells do not normally express the T or Tn antigen, which are 'encrypted' or covered up by polysaccharides much the same way that a rock is covered by water at high tide. (dadamo.com)
  • One of the functions of these T and Tn antigens is to promote cancer cell adhesion----the ability for the cancer cell to stick to other cells including healthy cells. (dadamo.com)
  • Discrimination of MUC1 mucins from other sialyl-Le(a)-carrying glycoproteins produced by colon carcinoma cells using a novel monoclonal antibody Cancer Res. (moleculardepot.com)
  • Recent advances in the field of glycobiology have demonstrated that during tumorigenesis subtle changes in the glycan structure of PSA occur which may allow to distinguish PSA from normal and tumor cells. (aptamergroup.com)
  • The use of antibody-drug conjugates (ADC), i.e. immunoconjugates, for the local delivery of cytotoxic or cytostatic agents, i.e. drugs to kill or inhibit tumor cells in the treatment of cancer (Lambert, J. (2005) Curr. (justia.com)
  • No. 4,975,278) allows targeted delivery of the drug moiety to tumors, and intracellular accumulation therein, where systemic administration of these unconjugated drug agents may result in unacceptable levels of toxicity to normal cells as well as the tumor cells sought to be eliminated (Baldwin et al (1986) Lancet pp. (justia.com)
  • TLR4, but Neither Dectin-1 nor Dectin-2, Participates in the Mollusk Hemocyanin-Induced Proinflammatory Effects in Antigen-Presenting Cells from Mammals. (exeter.ac.uk)
  • Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
  • Cancer biomarkers (CB) are biomolecules produced in response to the tumour by either the tumour cells or other cells within the body. (lifepronow.com)
  • Cancer biomarkers (CB) are biomolecules formed in response to the tumour by either the tumour cells or other cells in the body, and CB may be used as a screening / early warning method for cancer, diagnosis , prognosis, or indicator of a patient's overall outcome. (lifepronow.com)
  • Acid-labile linkage, catering for the pH difference between tumor cells and normal tissue, has been utilized to release drugs at tumor tissue. (eurekaselect.com)
  • This lectin has a high affinity for tumor-associated T-antigen disaccharide (Gal beta 1,3GalNAc alpha) and many O-linked glycopeptide structures. (biotrend.com)
  • Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. (unige.ch)
  • In recent years, however, theranostics has been successfully applied to a whole range of other malignancies, including neuroendocrine tumors (NETs) and prostate cancer in particular. (snmjournals.org)
  • Glycoprotein refers to a protein that has carbohydrate chains attached to it. (proprofs.com)
  • The oligosaccharide chains of glycoprotein and glycolipid are often terminated by sialic acids, which play intensely important role in regulating physiologically and pathologically interactions with ligands [ 9 ]. (biomedcentral.com)
  • It is made up of a polypeptide chain having 5 carbohydrate chains N-glycosidically bonded to it (molar mass of 41,000 daltons). (cdc.gov)
  • When imaging studies demonstrate an adnexal mass, the decision whether to observe the patient with repeat imaging or to proceed to surgical evaluation must take into account not only the imaging characteristics but also the patient's medical history, physical examination results, and cancer antigen 125 (CA125) level. (medscape.com)
  • The determination is used in the assessment of the activity of acute and recurring inflammations as well as of tumors with cell necrosis (Schmid, 1975). (cdc.gov)
  • TACA-containing glycopeptides are appealing cytotoxic T cell (CTL)-based vaccines to prevent or treat cancer because the same sugar moieties are expressed in a variety of tumors, rendering a vaccination strategy applicable in a large population. (silverchair.com)
  • Because of these encouraging results, we applied the same antigenic strategy to TACA-containing glycopeptides because induction of a degenerate T cell response against this class of tumor antigens may be of great advantage in cancer immunotherapy ( 10 - 12 ). (silverchair.com)
  • Cancer antigen 15-3 (CA 15-3) is used to monitor response to breast cancer treatment and disease recurrence. (medscape.com)
  • Glycoproteins have distinct Oligosaccharide structures which have significant effects on many of their properties, affecting critical functions such as antigenicity, solubility, and resistance to proteases. (wikipedia.org)
  • The oligosaccharides found on the A, B, and H antigen occur on the non-reducing ends of the oligosaccharide. (wikipedia.org)
  • T antigen only becomes 'unsuppressed' as a cell moves towards malignancy, much like the covered rock in our example becomes uncovered as the tide moves out. (dadamo.com)
  • It is even more rare to find a Tn antigen on a healthy cell. (dadamo.com)
  • As a general rule, an orderly expression of T antigens on a cancer cell usually indicates a cancer with a relatively favorable outlook. (dadamo.com)
  • However, a prevalence of Tn antigens (Note: Tn Antigen is actually a precursor to T antigen or a less well developed T antigen) on a cancer cell usually denotes a highly aggressive, metastatic cancer irrespective of organ or type of cancer. (dadamo.com)
  • However, as a cancer cell becomes poorly differentiated, Tn antigen expression predominates. (dadamo.com)
  • Conclusions The results of this study reveal that CA 15-3 is expressed in both canine mammary tumour cell lines and tissues and that serum levels significantly correlate with the histological grade of the malignancy. (scienceexhibitions.org)
  • CREG is a glycoprotein expressed in most mammalian tissues and cell types. (boku.ac.at)
  • These results have high potential for immunotherapy against a broad range of tumors. (silverchair.com)
  • The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. (lookformedical.com)
  • Using the sandwich assay approach with anti-PSA aptamer secures the selectivity of the assay against glycoproteins other than PSA. (aptamergroup.com)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Cancer antigen 27.29 (CA 27.29) measures the same antigen in the blood as CA 15-3. (medscape.com)
  • Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer. (aptamergroup.com)
  • La présente étude prospective à Yazd (République islamique d'Iran) a évalué la valeur des marqueurs tumoraux tels que l'antigène carcino-embryonaire et l'antigène carbohydrate 15-3 chez 159 patientes ayant reçu un premier diagnostic de cancer du sein. (who.int)
  • The H antigen (which indicates an O blood type) serves as a precursor for the A and B antigen. (wikipedia.org)
  • Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. (gu.se)
  • Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. (gu.se)
  • CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein. (unige.ch)
  • And that's why we get auto xeno antigens that can be recognised by xeno-autoantibodies that bind to these non-human sugars. (glycanage.com)
  • It is one of the oncofetal antigens produced during fetal life and has a high concentration in the sera of fetuses. (aacc.org)
  • He has published more than 150 scientific articles in the fields of carbohydrate biochemistry, glycobiology, allo- and xeno-transplantation, and regeneratvie medicine. (gu.se)