• The herpes simplex virus type 1 (HSV-1) glycoprotein N (gN/UL49.5) is a type I transmembrane protein conserved throughout the herpesvirus family. (mdpi.com)
  • Myelin associated glycoprotein (MAG) is a 100 kDa transmembrane glycoprotein found in the periaxonal membranes of Schwann cells and oligodendrocytes of myelin sheaths. (loinc.org)
  • Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (nih.gov)
  • Thus, findings of our 1st year project supported the possibility of origin specific detection of glycoproteins by lectin specific extraction coupled to a normal immunoassay instruments that commonly used by all WADA laboratories. (wada-ama.org)
  • Identification of the Abundant Hydroxyproline-Rich Glycoproteins in th" by Yuning Chen, Dening Ye et al. (umass.edu)
  • The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. (nih.gov)
  • The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (nih.gov)
  • Gene organization of the pregnancy-specific glycoprotein region on human chromosome 19: assembly and analysis of a 700-kb cosmid contig spanning the region. (nih.gov)
  • We confirmed that all recombinant glycoproteins from CHO cell line studied were lacking certain human type glycanes, which are not always identifiable by mass spectrometry. (wada-ama.org)
  • Our first year results represented that recombinant and human glycoprotein hormone can be isolated by stereo specific lectin-glycane interactions, and the recombinant fraction does not show any human type glycane specific lectin interactions. (wada-ama.org)
  • Glycoproteins from human show a strong lectin-glycan interaction with certain lectins whereas those expressed in CHO-cell lines do not show any interaction with the selected lectins. (wada-ama.org)
  • The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. (bvsalud.org)
  • Here we have cloned 113 human monoclonal antibodies (mAbs) specific for LASV glycoproteins from memory B cells of Lassa fever survivors from West Africa . (bvsalud.org)
  • Cloning and expression of a new pregnancy-specific beta 1-glycoprotein member. (nih.gov)
  • Productive folding of the protein moiety is facilitated during this period by the calnexin/calreticulin cycle in mammalian cells, which relies on G1M9-specific lectin-type chaperones (calnexin and calreticulin) associated with the oxidoreductase ERp57, and UDP-glucose:glycoprotein glucosyltransferases 1 and 2, which are capable of re-adding glucose to M9 if the protein moiety is not yet folded. (elifesciences.org)
  • One-half bind the GP2 fusion subunit, one-fourth recognize the GP1 receptor-binding subunit and the remaining fourth are specific for the assembled glycoprotein complex, requiring both GP1 and GP2 subunits for recognition. (bvsalud.org)
  • Urinary glycoproteins associated with aggressive prostate cancer. (nih.gov)
  • Glycoproteins play essential roles in cancer development, while urine is a noninvasive and easily obtainable biological fluid that contains secretory glycoproteins from the urogenital system. (nih.gov)
  • Therefore, here we aimed to identify urinary glycoproteins that are capable of differentiating aggressive from non-aggressive prostate cancer. (nih.gov)
  • We have identified glycopeptides of urinary glycoproteins associated with aggressive prostate cancer using a quantitative mass spectrometry-based glycoproteomic approach and demonstrated their potential to serve as noninvasive urinary glycoprotein biomarkers worthy of further validation by a multi-center study. (nih.gov)
  • Kit contains all enzymes and reagents needed to remove all N-linked, all simple O-linked, and virtually all-complex O-linked oligosaccharides from glycoproteins in a single reaction at neutral pH. (sigmaaldrich.com)
  • Platelets play a primary role in this process, interacting with subendothelium-bound von Willebrand factor (vWf) via the membrane glycoprotein (GP) Ib complex. (medscape.com)
  • Notably, of the 16 mAbs that neutralize LASV, 13 require the assembled glycoprotein complex for binding, while the remaining 3 require GP1 only. (bvsalud.org)
  • Prohibited glycoprotein hormones are currently tested by immunological methods with the result evaluation using the applicable threshold or by comparing the isoform profile with that of the reference standard as no procedure yet available to identify their origins. (wada-ama.org)
  • It is composed of three glycoproteins with various functions during fertilization and preimplantation development. (nih.gov)
  • ORCID: 0000-0002-6857-1614 and Clarke, Paul A. (2012) Recombinant prokaryotic lectins : enhanced tools for glycoprotein analysis and purification. (dcu.ie)
  • Recombinant Prokaryotic Lectins (RPL's) offer new opportunities to develop enhanced glycoselective tools for glycoprotein analysis and purification and to overcome the limitations that have restricted the applications of plant lectins. (dcu.ie)
  • Recombinant vaccinia virus expressing PrM and E glycoproteins of louping ill virus: induction of partial homologous and heterologous protection in mice. (curehunter.com)
  • Protein homologs of only 4 herpes simplex virus (HSV) glycoproteins, gB, gH, gL and gM, have been identified, and potential functions have been postulated based on studies of specific glycoprotein null mutants of HSV and other herpesviruses. (nih.gov)
  • Glycoproteins are frequently isolated and purified from protein mixtures using columns of agarose-bound lectins. (vectorlabs.com)
  • After applying a protein mixture, the agarose-lectin column is washed free of unwanted proteins and the glycoprotein bound to the lectin is eluted with a sugar that inhibits binding. (vectorlabs.com)
  • Alpha-2-HS-Glycoprotein is a protein coding gene type that is a negatively charged serum. (prospecbio.com)
  • These autoantibodies are directed against beta2-glycoprotein antigens, a plasmatic protein that displays an intense tropism for endothelial cell membrane phospholipids [ 10 , 15 - 17 ]. (hindawi.com)
  • The deletion of the C-terminal hydrophobic domain of the envelope glycoprotein resulted in the secretion of E protein into the supernatant culture medium. (curehunter.com)
  • Finally, recent findings have also provided evidence that HCMV glycoproteins may contribute to evasion of host cellular immune responses by limiting viral antigen presentation. (nih.gov)
  • Understanding the initial events of infection will require a further analysis of the glycoprotein components of the virion envelope as well as their expression in the membranes of the infected cell. (nih.gov)
  • Several of the envelope glycoproteins elicit strong host immune responses, including the production of virus-neutralizing antibodies. (nih.gov)
  • 1) Wyatt R and Sodroski J. The human immunodeficiency virus (HIV-1) envelope glycoproteins: Fusogens, antigens and immunogens. (nih.gov)
  • 2) Wyatt R, Kwong PD, Desjardins E, Sweet R, Robinson J, Hendrickson W and Sodroski J. The antigenic structure of the human immunodeficiencyv irus gp120 envelope glycoprotein. (nih.gov)
  • Papers relevant to this lecture: 1) Wyatt R and Sodroski J. The human immunodeficiency virus (HIV-1) envelope glycoproteins: Fusogens, antigens and immunogens. (nih.gov)
  • Our aim is to investigate a possible association of circulating anti-beta2-glycoprotein I antibodies (ABGPI) with the endothelial dysfunction, nitric oxide bioactivity dysregulation, and the inflammatory status that surrounds peripheral arterial disease. (hindawi.com)
  • In this context, circulating anti-beta2-glycoprotein I antibodies (ABGPI) have been associated with peripheral arterial disease (PAD) and coronary arterial disease [ 12 - 14 ]. (hindawi.com)
  • The glycoprotein eluting solutions are largely comprised of specific sugars and defined salts that are usually required to remove bound material from agarose conjugated lectins. (vectorlabs.com)
  • Vector Laboratories has developed five Glycoprotein Elution Solutions in the neutral pH range that maximize the yield of eluted glycoproteins and preserve the activity of the agarose-bound lectins for repeated use. (vectorlabs.com)
  • There is a need for tools that enable efficient isolation of glycoproteins from biological samples, where they are usually only present at low levels, to enable their identification and analysis. (dcu.ie)
  • N-linked glycoproteins play important roles in biological processes, including cell-to-cell recognition, growth, differentiation, and programmed cell death. (nih.gov)
  • In this review, we summarize common strategies for N-linked glycoprotein characterization and applications of these strategies to identification of glycoprotein changes associated with disease states. (nih.gov)
  • We also review the N-linked glycoproteins altered in diseases such as breast cancer, lung cancer, and prostate cancer. (nih.gov)
  • These results may not be typical for other glycoproteins, since oligosaccharide structures of glycoproteins vary significantly.The eluting solution has a high osmolarity.If downstream applications are adversely affected by salt, eluted glycoproteins may require dialysis or gel filtration. (vectorlabs.com)
  • All components of these ready-to-use Glycoprotein Eluting Solutions can be subsequently removed by dialysis. (vectorlabs.com)
  • These Glycoprotein Eluting Solutions offer researchers convenience and superior recovery over standard sugar solutions. (vectorlabs.com)
  • Additional glycoproteins have been analyzed but to date their function in the replicative cycle of this virus is unknown. (nih.gov)
  • Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus. (nih.gov)