ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
Description: A competitive ELISA for quantitative measurement of Canine Arachidonate 15 lipoxygenase (ALOX15/LOG15) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (myelisakit.com)
ALOX53
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans is encoded by the ALOX5 gene. (wikipedia.org)
The ALOX5 gene, which occupies 71.9 kilobase pairs (kb) on chromosome 10 (all other human lipoxygenases are clustered together on chromosome 17), is composed of 14 exons divided by 13 introns encoding the mature 78 kilodalton (kD) ALOX5 protein consisting of 673 amino acids. (wikipedia.org)
Description: A competitive ELISA for quantitative measurement of Human Cross Linked C Telopeptide Of Type II Collagen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (elisastrip.com)
Description: A competitive ELISA for quantitative measurement of Rat Cross Linked C Telopeptide Of Type II Collagen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (elisastrip.com)
Pathways2
They are part of a much larger group of compounds, the eicosanoids, which, although ubiquitous as a group, are produced by a variety of cell type-, tissue-, and species-specific biosynthetic pathways. (jci.org)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
Protein1
In response to the presence of certain activating substances, including oxidized LDL, monocyte chemoattractant protein 1 (MCP-1), interleukin (IL)-8, and platelet-derived growth factor (PDGF), leukocytes migrate into the wall of the artery (see the image below). (medscape.com)
Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)
What is the relationship between ferroptosis and other types of cell death? (nature.com)
Arachidonic acid6
12-Hydroxyeicosatetraenoic acid (12-HETE) is a derivative of the 20 carbon polyunsaturated fatty acid, arachidonic acid, containing a hydroxyl residue at carbon 12 and a 5Z,8Z,10E,14Z Cis-trans isomerism configuration (Z=cis, E=trans) in its four double bonds. (wikipedia.org)
It was first found as a product of arachidonic acid metabolism made by human and bovine platelets through their 12S-lipoxygenase (i.e. (wikipedia.org)
ALOX12 metabolizes arachidonic acid almost exclusively to 12(S)-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12(S)-HpETE or 12S-HpETE). (wikipedia.org)
Mouse e-12LO metabolizes arachidonic acid predominantly to 12(S)-HETE and to a lesser extent 15(S)-HETE. (wikipedia.org)
Arachidonic acid ( AA ), i.e. 5 Z , 8 Z ,11 Z ,14 Z -eicosatetraenoic acid is an ω-6 fatty acid with four double bonds in the cis configuration (see Cis-trans isomerism ), each located between carbons 5-6, 8-9, 11-12, and 14-15. (thcscience.wiki)
ALOX12B1
Recent studies indicate that the metabolism by ALOXE3 of the R stereoisomer of 12-HpETE made by ALOX12B and therefore possibly the S stereoisomer of 12-HpETE made by ALOX12 or ALOX15 is responsible for forming various hepoxilins in the epidermis of human and mouse skin and tongue and possibly other tissues. (wikipedia.org)
ELISA Kit1
Description: A sandwich ELISA kit for detection of Ephrin Type A Receptor 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (elisastrip.com)
Metabolites1
e.g., isoleucylglycine) plus 8 metabolites from four other classes (e.g., hypoxanthine, 12-hydroxyeicosatetraenoic acid). (nih.gov)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Ephrin Type A Receptor 1 (EPHA1) in Tissue homogenates, cell lysates and other biological fluids. (elisastrip.com)