Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme ( EC 5.3.1.9) that in humans is encoded by the GPI gene on chromosome 19. (wikipedia.org)
Conformational changes in phosphoglucose isomerase induced by ligand binding. (weizmann.ac.il)
Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps. (weizmann.ac.il)
Cytosolic phosphoglucose isomerase catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate (Tsuboi et al. (reactome.org)
Phosphoglucose isomerase, purification and properties. (reactome.org)
The mechanism that GPI uses to interconvert glucose 6-phosphate and fructose 6-phosphate (aldose to ketose) consists of three major steps: opening the glucose ring, isomerizing glucose into fructose through an enediol intermediate, and closing the fructose ring. (wikipedia.org)
To complete the isomerization, Glu357 donates its proton to C1, the C2 hydroxyl group loses its proton and the open-chain ketose fructose 6-phosphate is formed. (wikipedia.org)
When going from fructose-6-phosphate toward glucose-6-phosphate, the result could be mannose-6-phosphate if carbon C2 is given the wrong chirality, but the enzyme does not permit that result except at a very low, non-physiological, rate. (wikipedia.org)
glucose 6-phosphate ↔ fructose 6-phosphate The protein has different functions inside and outside the cell. (wikipedia.org)
These proteins were L-lactate dehydrogenase B(LDHB), glyceraldehyde-3-phosphate dehydrogenase, glucose-6-phosphate isomerase (GPI), phosphoglycerate mutase 2 (PGAM2), gelsolin and isoform 8 of titin. (biomedcentral.com)
Protein to protein interaction network analysis showed glycolytic enzymes, such as isoform alpha-enolase of alpha-enolase, isoform 1 of triosephosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase, had more connections than other proteins in myocardial metabolism during ischemia. (biomedcentral.com)
Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds. (cdc.gov)
In the course of 14 weeks exposure to mercury (7439976) compounds, including MetHg (a fluid seed dressing), mercuric-chloride (7487947), ethyl mercuric-chloride (107277) and phenyl-mercuric- chloride (100561), in doses corresponding to 5 percent of the median lethal dose three times a week, enhanced levels of activity of malate-dehydrogenase and glucose-phosphate isomerase in blood serum were observed. (cdc.gov)
After 7 weeks of exposure about a four fold increase of malate-dehydrogenase (9001643) and two to three fold enhancement of glucose-phosphate isomerase activities were found relative to controls. (cdc.gov)
Enzyme1
Several residues in the small domain serve to bind phosphate, while other residues, particularly His388, from the large and C-terminal domains are crucial to the sugar ring-opening step catalyzed by this enzyme. (wikipedia.org)
Deficiency2
Glucose phosphate isomerase (GPI) deficiency is a rare autosomal recessive disorder that causes hereditary nonspherocytic hemolytic anemia (HNSHA). (biomedcentral.com)
Glucose-6-phosphate isomerase (GPI) deficiency (MIM 613470), one of hereditary nonspherocytic hemolytic anemias (HNSHA), is a rare autosomal recessive hereditary disease caused by homozygous or compound heterozygous mutations of GPI gene on chromosome 19q13 [ 1 ]. (biomedcentral.com)
Protein3
This gene encodes a member of the glucose phosphate isomerase protein family. (wikipedia.org)
Among these antibiotics Ribostamycin was identified as a potent drug against the Protein Disulphide Isomerase with a significant binding energy of -7.35Kcal/mol with formation of 5 hydrogen bonds. (ijpsr.com)
It involves a sequence of enzymatic reactions that break down glucose (glycolysis) into pyruvate, creating the energy sources adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH). (msdmanuals.com)
The genome-based cg3035 modulated strain was further engineered by attenuating the expression of pta and cat , inserting a strong P eftu promoter in the upstream region of glycolytic enzymes such as pfkA , gap , and pyk , and redirecting carbon flux to the pentose phosphate pathway. (biomedcentral.com)
Proteins1
The brain, heart, skeletal muscle, and liver depend on ketone bodies or on glucose for energy and for carbon chains to synthesize cellular proteins (see the images below). (medscape.com)
Reaction 3 (2nd kinase reaction) uses phosphofructokinase 1 to transfers a phosphorus from ATP to C-1 of fructose-6-Pi to make fructose-1,6-bis-phosphate. (flashcardmachine.com)
Nervous and muscle tissues preferentially oxidize ketones over fatty acids, glucose, or amino acids under normal conditions. (medscape.com)
Saline1
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. (researchgrade.com)
Besides, HSF1-EVs greatly inhibited the production of inflammatory cytokines (IL-1ß, IL-6, MCP-1 and HMGB1), and constrained the pulmonary neutrophilic infiltration induced by HS. (bvsalud.org)
The hemozoin and other toxic factors such as glucose phosphate isomerase (GPI) stimulate macrophages and other cells to produce cytokines and other soluble factors which act to produce fever and rigors and probably influence other severe pathophysiology associated with malaria. (cdc.gov)
Glucose and galactose increase postprandially and several other carbohydrates contained in milk do not. (medscape.com)
Form1
Glucose 6-phosphate binds to GPI in its pyranose form. (wikipedia.org)
Strain3
The final strain with all the exploratory metabolic engineering manipulations produced 32.3 g/L of ʟ-ornithine, a yield of 0.395 g ornithine per g glucose, which was 35.7% higher than that produced by the original strain (23.8 g/L). (biomedcentral.com)
constructed a metabolically engineered C. glutamicum strain that could produce 0.524 g ʟ-ornithine per g glucose in CgXII medium through disruption of argFRG and overexpression of gdh and argCJBD [ 10 ]. (biomedcentral.com)
This strain produced 51.5 g/L ʟ-ornithine from glucose in a fed-batch culture in a 6.6-L fermenter [ 12 ]. (biomedcentral.com)
Reports1
The study sites were determined by reports try [ 1-6 ]. (who.int)