Metabolic Clearance RateAndrostanes17-KetosteroidsIodine IsotopesGlucoseBlood GlucoseHalf-LifeInsulinInfusions, ParenteralGlucose Clamp TechniqueInjections, IntravenousTritiumInfusions, IntravenousKineticsLiverRadioimmunoassayGlucagonTestosteroneCarbon IsotopesDogsGrowth HormoneGlucose Tolerance TestTime FactorsInsulin ResistancePregnancyMicrosomes, LiverMucociliary ClearanceKidneyPharmaceutical PreparationsHepatocytesGlucuronidesAldehyde OxidaseTechnetium Tc 99m PentetateGlucose IntoleranceGlucuronatesCytochrome P-450 Enzyme SystemBiotransformationAntipyrineDealkylationCytochrome P-450 CYP3AFatty Acids, NonesterifiedArea Under CurveC-PeptideDrug InteractionsTissue DistributionAdministration, OralRats, Sprague-DawleyLactic AcidPharmacokineticsModels, BiologicalGlucose OxidaseGlucose Transporter Type 1ThyroxineRats, Inbred StrainsDose-Response Relationship, DrugMononuclear Phagocyte SystemChromatography, High Pressure LiquidBiological AvailabilityMidazolamHormonesGlucose Transporter Type 4Reference ValuesHydrocortisoneIodine RadioisotopesGlucuronosyltransferaseHydroxylationCytochrome P-450 CYP2D6