Genome gene. Medical search. Frequent questions

Such studies are complicated by the fact that teleost genomes have undergone a whole-genome duplication event, as well as individual gene-duplication events. (washington.edu)
In contrast, whole-genome and tandem duplications have generated two zebrafish protocadherin clusters comprised of at least 97 genes. (washington.edu)
Researchers from The Hospital for Sick Children (SickKids) have uncovered new genes and genetic changes associated with autism spectrum disorder (ASD) in the largest autism whole genome sequencing analysis to date, providing better understanding into the 'genomic architecture' that underlies this disorder. (medicalxpress.com)
The study, published today in Cell, used whole genome sequencing (WGS) to examine the entire genomes of over 7,000 individuals with autism as well as an additional 13,000 siblings and family members . (medicalxpress.com)
The majority of data was drawn from the Autism Speaks MSSNG database, the world's largest autism whole genome dataset, which provides autism researchers with free, open access to thousands of sequenced genomes. (medicalxpress.com)
Stephen W. Scherer, Genomic Architecture of Autism From Comprehensive Whole-Genome Sequence Annotation, Cell (2022). (medicalxpress.com)
Whole genome sequencing has, however, not been employed to look for all off-target effects in living animals. (biosafety-info.net)
Dr Michael Antoniou, a London-based molecular geneticist, believes that not only is it necessary to conduct whole genome sequencing to identify all off-target mutations from CRISPR-based genome editing, but it is also essential to ascertain the effects of these unintended changes on global patterns of gene function (Item 2). (biosafety-info.net)
Therefore one needs to follow up whole genome sequencing with other molecular profiling analyses or "omics": transcriptomics - gene expression profiling, proteomics - protein composition profiling, metabolomics - profiling of metabolites, and miR-omics - microRNA profiling. (biosafety-info.net)
These predictive algorithms seem to do a good job when CRISPR is performed in cells or tissues in a dish, but whole genome sequencing has not been employed to look for all off-target effects in living animals," says co-author Alexander Bassuk, MD, PhD, professor of pediatrics at the University of Iowa. (biosafety-info.net)
They have been actively engaged in studies of human genetic variation and natural selection, and have used whole-genome sequencing to uncover disease-causing mutations and to estimate the human mutation rate. (utah.edu)
It also supports the feasibility of the ultra-high-density whole-genome association approach to the study of AD and other heritable phenotypes. (psychiatrist.com)
These whole-genome association studies show great promise to identify additional genes that contribute to the risk of AD. (psychiatrist.com)
When available, the information provided by whole-genome sequencing projects provides an entry into an understanding of genome structure and evolution and gene discovery, and function. (biomedcentral.com)
The project will rely on published whole genome assemblies and gene annotations of various qualities. (lu.se)
We have extensive whole genome and RNA sequencing data taken from whole samples of flies at three life stages: larva, pupa and adult. (lu.se)

Timothy Close, plant geneticist at the University of California in Riverside and corresponding author on the newly published paper, told GenomeWeb this week that the team's goal was to sequence the gene-rich regions of the genome to discover more genes than previous research had been able to uncover. (genomeweb.com)
Over many years, Close and colleagues were able to generate approximately 1.7 Gb of genomic sequence containing an estimated two-thirds of all barley genes. (genomeweb.com)
Close worked closely with his colleague, Stefano Lonardi, a computer scientist at UC Riverside, to develop new algorithms to sequence these smaller gene-rich areas of the barley genome. (genomeweb.com)
They also used published sequence from goat grass ( Aegilops tauschii ) to develop a synteny viewer that allowed them to compare sequences from the barley genome with data from the ancestor of the wheat D genome. (genomeweb.com)
Most of the human genome is uncharted territory -- entire stretches of sequence with no clear function or purpose," said Jason Lieb, Ph.D., associate professor of biology at UNC, a member of the UNC Lineberger Comprehensive Cancer Center and one of the senior authors of the study. (sciencedaily.com)
In addition to the data collection efforts, KEGG develops and provides various computational tools, such as for reconstructing biochemical pathways from the complete genome sequence and for predicting gene regulatory networks from the gene expression profiles. (nih.gov)
Epigenetics refers to the study of heritable changes in gene function without alterations in DNA sequence ( Bird, 2007 ). (frontiersin.org)
The first tomato genome sequence was released in 2012, revealing approximately 35,000 genes and facilitating crop improvement efforts. (isaaa.org)
Here, we demonstrate the value of coelacanth genome sequence by complete sequencing and analysis of the protocadherin gene cluster of the Indonesian coelacanth, Latimeria menadoensis. (washington.edu)
Our results indicate that coelacanth provides the ideal outgroup sequence against which tetrapod genomes can be measured. (washington.edu)
This research project attempts to identify the genetic determinants of SHRSP/Gla phenotypes by using mRNA and micro(mi)RNA expression profiling data, in combination with the genome sequence of the SHRSP/Gla and WKY/Gla, to facilitate human translational studies for hypertension and vice versa. (gla.ac.uk)
Many EST libraries were constructed from RNA extracted from various genetic backgrounds, thus gene identification from these sources is complicated by the existence of both gene and allele sequence differences. (biomedcentral.com)
using a redundancy criterion to identify reproducible sequence differences between related genes within gene families. (biomedcentral.com)
Analysis of these sequences revealed single base substitutions and single base indels are the most frequently observed form of sequence variation between genes within families in the dataset. (biomedcentral.com)
The more recent duplication event in particular would be expected to result in many paralogous pairs of genes differing by relatively few sequence differences, thus complicating gene identification using ESTs. (biomedcentral.com)
Another way the exposome interacts with the genome is through epigenetics , the process of altering gene expression without changing the DNA Sequence. (cdc.gov)
Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1. (medlineplus.gov)
Therefore, in this study, we conducted a genome -wide identification of ZFP genes in three species of grapevine, namely Vitis vinifera , Vitis riparia, and Vitis amurensis, based on the sequence databases and phylogenetic and their conserved domains. (bvsalud.org)
The clustered gene analysis showed that the motif distribution was similar and the sequence of genes was highly conserved. (bvsalud.org)
Genome Sequence of Geobacillus sp. (lu.se)

The database was originally used to support gene function analyses and oligonucleotide design, but has since grown to handle additional activities including microarray content design, SNP identification, genotyping platform design, comparative genomics, and the coupling of physical and genetic maps. (genomeweb.com)
In this thesis, I present a novel genome data visualization targeting an important area of genomics research: comparative bacterial gene neighborhood analysis. (uic.edu)
an award winning podcast from Genome British Columbia , is back with a thought-provoking Season 3, exploring the many ways genomics impacts the world. (genomebc.ca)
Genome BC is a not-for-profit organization supporting world-class genomics research and innovation to grow globally competitive life sciences sectors and deliver sustainable benefits for British Columbia, Canada and beyond. (genomebc.ca)
In addition to scientific programming, Genome BC works to integrate genomics into society by supporting responsible research and innovation and foster an understanding and appreciation of the life sciences among educators, students, and the public. (genomebc.ca)
Silver Age of GOLD Introduces New Features The Genomes OnLine Database makes curated microbiome metadata that follows community standards freely available and enables large-scale comparative genomics analysis initiatives. (doe.gov)
Recent advances in genomics and computational biology are enabling construction of large-scale models of gene-regulatory networks. (biomedcentral.com)
The complete sequencing of the human genome, announced in 2001, marked the culmination of unprecedented advances in the science of genomics, the study of the genome and its functions. (who.int)
And, more significantly, the progress achieved recently in human genomics research,1 the creation of genetically-modified foods2 and the gene therapy3 have added to the major bioethical issues the Region is likely to face in the near future. (who.int)

Although gradual changes in trait complexity appear to have been facilitated by allelic turnover, key innovations are associated with gene and genome duplications. (lu.se)
These findings provide an important connection between the origins of biodiversity, coevolution, and the role of gene and genome duplications as a substrate for novel traits. (lu.se)

By acquiring Boston Genetics, we can start building off-the-shelf datasets by curating the entire genome that can be available for researchers. (pharmavoice.com)
In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide. (biosafety-info.net)
Genome-wide association studies (GWAS) survey single nucleotide polymorphisms (SNPs), or specific genetic variations, across the entire genome. (medscape.com)

Here we have developed a map that can guide scientists to regions of the genome that do appear to be functionally relevant, instead of a dead end. (sciencedaily.com)
As CRISPR-Cas9, a new gene-editing technology, moves into gene therapy clinical trials, a new study published in Nature Methods has reported that it can introduce hundreds of unintended mutations into the genome of mice, including single nucleotide mutations and mutations in non-coding regions of the genome (Item 1). (biosafety-info.net)

In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
The researchers found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single-nucleotide mutations and more than 100 larger deletions and insertions. (biosafety-info.net)
New York- As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome. (biosafety-info.net)
For some diseases, such as cystic fibrosis , specific mutations in a single gene may be the main influence for disease development. (cdc.gov)
This analysis identifies resistance genes and mutations. (cdc.gov)
A catch-all term that includes both resistance genes and resistance mutations that give a microbe the ability to resist the effects of one or more drugs. (cdc.gov)
A small number of mutations in the TYRP1 gene have been found to cause oculocutaneous albinism type 3. (medlineplus.gov)
Manga P, Kromberg JG, Box NF, Sturm RA, Jenkins T, Ramsay M. Rufous oculocutaneous albinism in southern African Blacks is caused by mutations in the TYRP1 gene. (medlineplus.gov)
Rooryck C, Roudaut C, Robine E, Musebeck J, Arveiler B. Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient. (medlineplus.gov)

We describe here an anatomically comprehensive digital atlas containing the expression patterns of approximately 20,000 genes in the adult mouse brain. (nih.gov)
Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)
We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. (lu.se)
and (4) how dynamic modeling of DNA-binding and gene expression data can be used to infer regulatory logic of TF circuitry. (lu.se)
Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
Audic S, Claverie JM: The significance of digital gene expression profiles. (karger.com)
Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
The report says profiles of DNAm can alter gene expression and have other impacts, "all of which have potential health implications. (evanstonroundtable.com)
We recently reported a procedure for inferring gene-regulatory network models by integrating gene-expression profiles with high-throughput measurements of protein interactions [ 18 ]. (biomedcentral.com)
In the present set of experiments, using gene-expression microarray technology that allowed us to quantify the expression of ~25,000 genes simultaneously, we assessed the gene expression profiles of the best and worst learners from a sample of 60 mice (in two replications). (rutgers.edu)
The most consistent pattern of differential expression was found in the prefrontal cortex, here a set of genes associated with the efficacy of dopamine functioning (i.e. (rutgers.edu)
This relationship was further verified through a quantitative PCR analysis where we demonstrated a significant correlation between the expression of these prefrontal dopamine genes and the general learning abilities of 48 mice. (rutgers.edu)
The initial GWAS in asthma incorporated a unique approach by combining gene expression with genetic association to find ORMDL3 , a novel locus on chromosome 17q21. (medscape.com)
Finally, the expression of VvZFP genes was determined using real- time quantitative PCR , which confirmed that the identified genes were involved in response to methyl jasmonate (MeJA), abscisic acid (ABA), salicylic acid (SA), and low- temperature (4 °C) stress. (bvsalud.org)
VvZFP10-GFP and VvZFP46-GFP fusion proteins were localized in the nucleus of tobacco cells , and VvZFP10 is the most responsive gene among all VvZFPs with the highest relative expression level to MeJA, ABA, SA and low- temperature (4 °C) stress. (bvsalud.org)
miRNAs are small noncoding RNAs that have broad regulatory functions on gene expression. (lu.se)
Changes in gene expression mediate growth and development in all living organisms. (lu.se)
Strong selection pressures experienced during one stage of development may differ from those experienced in other stages, and with consequences for the underlying patterns of gene expression. (lu.se)
We want to understand differences in life stage-specific gene expression in the peacock fly and relate these patterns to signatures of selection across the genome. (lu.se)
The student will analyze gene expression in a reference-based pipeline using existing RNA sequencing data from larvae, pupae, and adult flies from each of the two host forms. (lu.se)
This will include co-expression network analyses to identify groups of genes that are expressed similarly and might belong to the same or linked gene regulatory networks. (lu.se)
The student will evaluate gene expression in relation to measures of genetic diversity, differentiation, and neutrality across the genome to evaluate whether the sequences or the flanking regions of genes with stage-specific expression demonstrate signs of selection. (lu.se)

In an Advanced Online Publication in Nature Genetics Carolina Perez-Iratxeta and colleagues at the EMBL in Heidelberg describe using a bioinformatics approach to link genes to diseases (13 May 2002, DOI:10.1038/ng895). (biomedcentral.com)
Dr. Brett Trost, lead author of the paper and a Research Associate in the Genetics & Genome Biology program at SickKids, notes the use of WGS allowed researchers to uncover variant types that would not have otherwise been detectable. (medicalxpress.com)
As researchers understand more about genetics and the human genome, the sheer amount of data can be overwhelming. (pharmavoice.com)
We had already decided we're going to go all in on curating the genome - I think Boston Genetics looked at that as being very intriguing, as well as the opportunity to scale that part of the business much faster by combining forces," Klein said. (pharmavoice.com)
Their target was Myriad Genetics, a University of Utah spinout company that controlled the patents on the BRCA1/2 genes. (utah.edu)
In "The Genome Defense" , Professor Jorge Contreras describes the circuitous path of this remarkable lawsuit, from genetics labs to corporate boardrooms to the highest reaches of the White House. (utah.edu)
Murisier F, Beermann F. Genetics of pigment cells: lessons from the tyrosinase gene family. (medlineplus.gov)

Thousands of complete genome sequences have been compiled on public databases and even larger volumes of data have been generated privately by independent research groups. (uic.edu)
In this thesis, I present Bacterial Gene Neighborhood Investigation Environment, or BactoGeNIE, a new comparative gene neighborhood visualization designed to address large volumes of bacterial genome sequences and explore the design decisions that best take advantage of large, high-resolution environments. (uic.edu)
Large scale gene analysis of most organisms is hampered by incomplete genomic sequences. (biomedcentral.com)
The identification of potential gene sequences (pHaps) from soybean allows us to begin to get a picture of the genomic history of the organism as well as begin to observe the evolutionary fates of gene copies in this highly duplicated genome. (biomedcentral.com)
We identified approximately 45,000 potential gene sequences (pHaps) from EST sequences of Williams/Williams82, an inbred genotype of soybean ( Glycine max L. Merr. (biomedcentral.com)
Functional annotation of gene sequences indicate functional classifications are not randomly distributed among gene families containing few or many genes. (biomedcentral.com)
The availability of genome sequences for many living organisms clearly has important implications for health improvement, and it has been widely predicted that elucidation of the sequences will lead to a revolution in medical research and patient care. (who.int)

The completion of the human genome project has spurred a flurry of research into the exact genetic changes underlying disease. (sciencedaily.com)
Genetic engineering has been used to clone this growth hormone gene, which has enabled the production of growth hormone used in the treatment of pituitary dwarfism. (pearson.com)
Now, scientists from the USDA Agricultural Research Service (ARS) and the Boyce Thompson Institute (BTI) have created a pan-genome that captures all of the genetic information of 725 cultivated and closely related wild tomatoes, mapping 4,873 genes that were absent from the original reference genome . (isaaa.org)
To identify common genetic markers that may modify this association, we tested gene-caffeine intake interaction on BCC risk in a genome-wide analysis. (harvard.edu)
The team found 134 genes linked with ASD and discovered a range of genetic changes , most notably gene copy number variations (CNVs), likely to be associated with autism, including ASD-associated rare variants in about 14 percent of participants with autism. (medicalxpress.com)
Towards this goal, we describe an automated procedure for prioritizing genetic perturbations in order to discriminate optimally between alternative models of a gene-regulatory network. (biomedcentral.com)
We used the ESTminer suite of programs to identify potential soybean gene transcripts from a single genetic background allowing us to observe functional classifications between gene families as well as structural differences between genes and gene paralogs within families. (biomedcentral.com)
Candidate gene studies represent the most common form of genetic association study performed to find asthma-susceptibility genes. (medscape.com)
Thus, unlike the candidate gene studies, GWAS are adequately powered to discover common genetic variations associated with complex disorders such as asthma. (medscape.com)
The Trans-National Asthma Genetic Consortium (TAGC) made up of worldwide groups of investigators with genome-wide data available published a meta-analysis of worldwide asthma GWAS (23,948 cases, 118,538 controls) from ethnically diverse populations. (medscape.com)
A genome is an organism's complete set of genes that carry the genetic instructions for building and maintaining that organism. (cdc.gov)

Genomes Fish, Aspergillus, Diatom new gene-finding parameters for FGENESH suit A new parameter set for gene annotation in Fish, Diatom, Aspergillus genomes is presented for FGENESH program suit. (bio.net)
The workshop was organized around breakout sessions in which participants discussed research challenges associated with gene function discovery and accurate annotation across taxa. (energy.gov)
This report presents the challenges, knowledge gaps, and opportunities for accelerated gene function discovery and accurate gene annotation in four areas: technology, computation, microorganisms, and plants. (energy.gov)

Twenty of these genes are known to harbor gene variants associated with type II diabetes. (sciencedaily.com)
Surprising to the team was that the "polygenic score"-an estimation of the likelihood of an individual having autism, calculated by aggregating the effects of thousands of common variants throughout the genome -was not higher among multiplex families. (medicalxpress.com)
What we've typically done with our pharma customers is deliver what we call genomic landscapes as they build clinical trials or companion diagnostics - an understanding of every gene and every variant, the pathogenicity of those variants, the functionality or loss of function and the drivers behind those variants. (pharmavoice.com)
Individuals with certain variants of these genes have a high risk of contracting breast or ovarian cancer, but Myriad's test for these variants was unaffordable to many. (utah.edu)
The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. (cdc.gov)

We also generated genome-wide maps of PARIS occupancy using ChIP-seq in human SH-SY5Y cells. (nature.com)

RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)

NEW YORK (GenomeWeb) - After more than a decade of collaborative work, a team led by researchers at the University of California in Riverside has published details of its successful efforts in sequencing large gene-rich portions of the barley genome. (genomeweb.com)
The researchers contributing to and using the HarvEST:Barley database have helped fill in many information gaps for the barley genome, but the International Barley Sequencing Consortium (IBSC) is leading the efforts to produce a whole sequenced genome. (genomeweb.com)
Researchers have generated a complete map of the areas of the genome that control which genes are "turned on" or "off. (sciencedaily.com)
Together with colleagues in Barcelona, researchers at the University of North Carolina at Chapel Hill have generated a complete map of the areas of the genome that control which genes are "turned on" or "off. (sciencedaily.com)
The researchers decided to continue their studies on the variant most strongly associated with the disease, a single nucleotide polymorphism -- or SNP -- occurring in the TCF7L2 gene. (sciencedaily.com)
JBEI researchers have developed the first genome-scale model for predicting the functions of genes and gene networks in a grass species. (jbei.org)
The goal is to improve curation of their human genome database to help pharma companies and researchers review past studies more thoroughly and quickly. (pharmavoice.com)
In 2005, two MIT researchers observed that 20% of the human genome was claimed by patents. (utah.edu)
Genome Insider: Methane Makers in Yosemite's Lakes Meet researchers who sampled the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains to see how climate change affects freshwater ecosystems, and how those ecosystems work. (doe.gov)
But with two projects, communities are forming to generate high quality genomes to benefit researchers. (doe.gov)

Finally, we tested the associations between caffeine consumption-related SNPs reported by previous genome-wide association studies and risk of BCC, both individually and jointly, but found no significant association. (harvard.edu)
An individualized genome-wide association study using 502,627 SNPs was performed in 1086 histopathologically verified AD cases and controls to determine the OR associated with genes predisposing to Alzheimer's disease. (psychiatrist.com)
[ 5 ] As all SNPs in the genome correlate with each other, one could conceivably type as few as 500,000 SNPs to obtain information on most of the 13 million SNPs across the genome. (medscape.com)
Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and 8 (rs908084, p = 8.59 × 10(-9) and rs2514805, p = 1.22 × 10(-8), respectively). (cdc.gov)
This study identified SNPs mapping to the HERC2, CDH17, and ODZ3 genes as potential susceptibility loci for DA. (cdc.gov)
Overlap of 2 suggestive SNPs with likely TF binding sites suggests possible roles in disruption of gene regulation. (cdc.gov)

The pathway information is also represented by the ortholog group tables summarizing orthologous and paralogous gene groups among different organisms. (nih.gov)
KEGG maintains the GENES database for the gene catalogs of all organisms with complete genomes and selected organisms with partial genomes, which are continuously re-annotated, as well as the LIGAND database for chemical compounds and enzymes. (nih.gov)
Indeed, all sequenced genomes, both microbes and plants, contain large numbers of genes of "unknown function" that significantly limit scientists' ability to model, predict, and engineer organisms with enhanced functions relevant to DOE. (energy.gov)
However, if we are to accurately model large gene networks in complex organisms, including fly, worm, mouse, and human, automated procedures will be essential for analyzing the network, choosing the best new experiments to test the model, conducting the experiments, and integrating the resulting data. (biomedcentral.com)
namely, metabolic pathways, regulatory pathways, and molecular assemblies, and maintains gene catalogs for all the organisms that have be. (bvsalud.org)

Newly developed image-based informatics tools allow global genome-scale structural analysis and cross-correlation, as well as identification of regionally enriched genes. (nih.gov)
They found that the chromatin is more open in the presence of the high risk version of the gene (a T) than in the presence of the non-risk version (an A). Further analysis demonstrated that the risk variant enhanced the activity of the gene, indicating that it may possess functional characteristics that could contribute to disease. (sciencedaily.com)
Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. (nih.gov)
The report says, "Our analysis identified 2,546 sites across 1,537 genes where DNAm differed significantly in association with SES, suggesting that DNAm is an important mechanism through which SES becomes biologically embedded across a large proportion of the genome. (evanstonroundtable.com)
The study titled, "Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood," was recently published in the American Journal of Physical Anthropology. (evanstonroundtable.com)
This workshop brought together leaders in microbiology, plant sciences, technology, and computation, who collectively identified the experimental and data analysis gaps preventing large-scale gene function determination as well as opportunities for overcoming these gaps. (energy.gov)
Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. (asm.org)
The antimicrobial resistance expected based on analysis of an organism's genome. (cdc.gov)
Genome-Wide Identification and Analysis of the Genes Encoding Q-Type C2H2 Zinc Finger Proteins in Grapevine. (bvsalud.org)
Exon and intron structure analysis showed that 118 genes of ZFPs were intron deletion types, and the remaining genes had variable numbers of introns , ranging from 2 to 15. (bvsalud.org)
Pathway analysis indicated that these genes are associated with antigen processing and presentation, and other immune pathways. (cdc.gov)

Decreases in genome sequencing costs have driven a proliferation in the volume of genomic data. (uic.edu)
My high-density genome data visualization approach relies on interactive visual queries to transform large data volumes into high-resolution comparative genomic maps, that use pre-attentive visual cues to address analytic tasks for comparative gene neighborhood investigations across large volumes of complete bacterial genomes. (uic.edu)
Our results resolve the outstanding question of how hybrids in native genomic contexts interact with replication to cause mutagenesis and shape genome organization. (biorxiv.org)
The close genomic locations of these two genes as well as their functional similarity have hindered efforts to define whether each gene independently influences human triglyceride concentrations. (doe.gov)
To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516. (asm.org)
Such EST data form a valuable foundation for the understanding of the gene composition and genomic biology of yet-to-be fully sequenced genomes [ 3 ]. (biomedcentral.com)

The overall IFN-related gene panel annotated by gene ontology (GO) showed an excellent diagnostic capacity in CD4+ T cells (Sensitivity = 0.82, specificity = 0.82 and AUC = 0.90), while IFI44L , another IFN-related gene not annotated by GO, showed high prediction ability in both CD4+ (AUC = 0.86) and CD8+ (AUC = 0.75) T cells. (frontiersin.org)
They integrated information from multiple databases to establish relationships between Medical Subject Headings (MeSH terms) related to diseases, or drugs, and Gene Ontology terms. (biomedcentral.com)
Gene ontology: tool for the unification of biology. (biomedcentral.com)
Clustering of gene ontology terms in genomes. (lu.se)

This gene, DCP1, located at 17q23, codes for an enzyme that plays an important role in blood pressure regulation. (pearson.com)
As genome-scale measurements lead to increasingly complex models of gene regulation, systematic approaches are needed to validate and refine these models. (biomedcentral.com)

However, as high-throughput omic technologies and integrative systems biology efforts have improved our understanding of some biological systems, analyzing and finding meaningful answers within these massive datasets remain extremely challenging, in large part due to the lack of fundamental knowledge of gene function. (energy.gov)

In conclusion, our study demonstrated that hypomethylation of IFN-related genes is a common feature of GD/RA/SLE/SSc patients in CD4+ T cells, and the DNA methylation profile of IFN-related genes could be promising biomarkers for the diagnosis of GD, RA, SLE, and SSc. (frontiersin.org)
DNA methylation is one of the major epigenetic mechanisms, and it plays an important role in determining gene function ( Hedrich and Tsokos, 2011 ). (frontiersin.org)
A new Northwestern University study has found that low socioeconomic status (SES) is associated with the level of DNA methylation (DNAm) in a large number of genes in the genome. (evanstonroundtable.com)
This is the largest genome-wide DNA methylation study of its kind, using samples of oesophageal squamous cell carcinoma from nine countries with high incidence of this disease, including countries in Africa, Asia, and South America. (who.int)

When this approach was tested against known disease-linked genes, the score could predict promising candidate genes. (biomedcentral.com)

The Human Genome Project: Genes on Human Chromosome 17 The location of genes is designated by an established labeling system for chromosomes. (pearson.com)

Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
Genes carry information that determine traits, such as eye color in humans and resistance to antibiotics in bacteria. (cdc.gov)

Each cluster typically encompassed single genes that are active specifically in islet cells. (sciencedaily.com)
This region of the chromosome has a cluster of genes that encode the hard proteins, which are involved in the formation of hair and nails. (pearson.com)
We found that coelacanth has 49 protocadherin cluster genes organized in the same three ordered subclusters, alpha, beta, and gamma, as the 54 protocadherin cluster genes in human. (washington.edu)
Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)

Sequencing the whole barley genome has been a challenge because barley possesses a large and highly repetitive genome of 5.1 Gb - almost twice the size of the human genome (3.2 Gb). (genomeweb.com)
In particular, rates of bacterial genome sequencing have accelerated, due to low sequencing costs. (uic.edu)
This "bottleneck" in genome understanding could be broken with new, innovative, and transformative experimental tools, datasets, and computation that can define gene function on a massive and high-throughput scale compatible with the pace of DNA sequencing. (energy.gov)
PGML has led in the sequencing of the sorghum genome and the cotton genome. (wikipedia.org)

Hi all, I just made this video showing you how to use UCSC genome browser https://genome.ucsc.edu/ to check ChIP-seq data. (biostars.org)

Using this procedure, we evaluate 38 candidate regulatory networks in yeast and perform four high-priority gene knockout experiments. (biomedcentral.com)
These data have spawned a variety of methods to infer the structure of gene-regulatory networks or to study their high-level properties, as recently reviewed [ 5 ]. (biomedcentral.com)
First, we use the previously described modeling procedure to generate a library of models corresponding to different gene-regulatory systems in yeast. (biomedcentral.com)

This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome. (psychiatrist.com)
Fifty-three genes have been identified and replicated in more than one study, and 20 genes have been replicated in more than 10 separate investigations. (medscape.com)

Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
Also repeats, transfer RNA (tRNA) and ribosomal RNA (rRNA) genes were annotated. (escholarship.org)

There is a much higher chance of selecting neighboring genes in the region that will have unknown and possibly unwanted effects, whether it's barley, rice, or some other species. (genomeweb.com)
Unfortunately, the size and complexity of the genomes of many agronomically important species currently hinders the undertaking of such projects. (biomedcentral.com)
Finally, genes of B. retrofracta and 6 other Brassicaceae species were used for phylogenetic tree reconstruction. (escholarship.org)
An assembled genome of B. retrofracta will help in the challenging assembly of the highly heterozygous genomes of hybrid apomictic species. (escholarship.org)
Basically, if miRNA repression is evolutionarily important for a gene, we expect the miRNA binding sites to be shared across closely related species. (lu.se)

However, the genes encoding this transcription factor family have not been explored in grapevine genomes . (bvsalud.org)

Patients with alterations in this gene can experience a progressive visual loss with onset of night blindness between 4 and 10 years of age. (pearson.com)
Other alterations in this gene have been reported in a few affected people of non-African heritage. (medlineplus.gov)

A gene that gives microbes the ability to resist the effects of one or more drugs. (cdc.gov)
The gene may be naturally present in the microbe, or it may be transferred from other microbes. (cdc.gov)

The discussions included the breadth of diverse, high-throughput technologies needed for characterizing genes of unknown function and how the diverse data from these technologies could be integrated with new and existing computational platforms to accurately propagate these annotations to newly sequenced genomes. (energy.gov)
The student will be responsible for improving the annotations, especially for the untranslated regions that lie up and downstream of protein coding genes. (lu.se)

We found that the most significant differentially methylated sites had a remarkable enrichment in type I interferon (IFN) pathway genes. (frontiersin.org)
NEIL3, a gene belonging to the base excision DNA repair pathway, encodes a DNA glycosylase that recognizes and removes lesions produced by oxidative stress. (harvard.edu)

The research team, which comprises investigators from more than two dozen public and private organizations, started shortly after the first library of the barley genome was created back in 2000. (genomeweb.com)
Genome Res 10:344-349 (2000). (karger.com)

Yet, dopaminergic (DA) neuron-specific mechanistic underpinnings and genome-wide PARIS binding landscape has not been explored. (nature.com)

The database includes not only the research published by Close and his team, but the rest of the available mapping and gene data. (genomeweb.com)
The purpose of this funding opportunity is to provide support for investigative groups to conduct genome-wide association (GWA) genotyping and/or replication studies using data and samples from human subjects on whom information is available for conditions/traits of public health importance and relevant environmental exposures. (nih.gov)
It includes support for sharing the samples and data and analyzing the resulting data as part of the NIH-wide Genes and Environment Initiative (GEI). (nih.gov)

Single nucleotide polymorphism (SNP) rs142310826 near the NEIL3 gene showed a genome-wide significant interaction with caffeine consumption (P = 1.78 x 10(-8) for interaction) on BCC risk. (harvard.edu)
The predominance of single nucleotide insertion/deletions and substitution events between genes within families (individual genes and gene paralogs) is consistent with a model of gene amplification followed by single base random mutational events expected under the classical model of duplicated gene evolution. (biomedcentral.com)
Genome-wide single nucleotide polymorphism (SNP) genotyping was performed in 74 diisocyanate -exposed workers with DA and 824 healthy controls using Omni-2.5 and Omni-5 SNP microarrays. (cdc.gov)

In mice, this gene is absolutely essential for sustained growth and expected longevity. (pearson.com)

While the apolipoprotein E (APOE) e4 allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19. (psychiatrist.com)

The protein encoded by this gene is one of a family of related proteins that transports glucose into cells by facilitated diffusion. (pearson.com)
Q-type C2H2 zinc finger proteins (ZFPs), the largest family of transcription factors , have been extensively studied in plant genomes . (bvsalud.org)

5'-untranslated region (5'UTR), the hypervariable region 1 (HVR1), non-structural gene 5a (NS5a) and non-structural gene 5b (NS5b). (cdc.gov)

This website is a comprehensive collection of information relevant to the Human Genome Project (HGP). (bvsalud.org)

Recent work suggests that other changes in this gene may contribute to panic disorder. (pearson.com)
This suggests that not only does feeding on the wrong host plant have large fitness costs for these flies, but the genes that are expressed during this life stage are under strong selection. (lu.se)

The pan-genome helps identify additional genes that might be available for crop breeding and improvement. (isaaa.org)
Fine genotype mapping in the region is then used to identify the actual gene(s) responsible for the linkage peak. (medscape.com)
The team found that seven alterations affecting three genes could identify tumours with high sensitivity and specificity. (who.int)

In addition, we identified several loci with P value for interaction <5 x 10(-7) in gender-specific analyses (P for heterogeneity between genders <0.001) including those mapping to the genes LRRTM4, ATF3 and DCLRE1C in women and POTEA in men. (harvard.edu)

Genome Res 7:986-995 (1997). (karger.com)

Anatomy15

Organisms33

Diseases3

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes142

Disciplines and Occupations5

Technology, Industry, Agriculture3

Information Science15

Health Care5

Whole-genome16

Sequence20

Genomics9

Duplications2

Entire genome3

Regions of the genome2

Mutations9

Expression31

Genetics7

Sequences7

Genetic11

Annotation3

Variants5

Generated genome-wide1

Target genes1

Researchers10

SNPs6

Organisms5

Analysis11

Genomic6

Ontology4

Regulation2

Biology1

Methylation4

Disease-linked genes1

Chromosomes1

Bacteria2

Cluster4

Sequencing4

Https1

Regulatory3

Study2

Ribosomal2

Species5

Transcription factor1

Alterations in this gene2

Microbes2

Annotations2

Pathway2

20002

Mechanistic1

Data3

Single-nucleotide3

Mice1

Alzheimer's1

Proteins2

Structural1

Human genome1

Suggests2

Identify3

Analyses1

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