• Specifically, the authors found that genetic variants of ROBO1 in young children are associated with grey matter volume in the right parietal cortex, which in turn predicts mathematical test scores in second grade. (sciencedaily.com)
  • The authors analyzed 18 single nucleotide polymorphisms (SNPs) -- genetic variants affecting a single DNA building block -- in 10 genes previously implicated in mathematical performance. (sciencedaily.com)
  • Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. (nature.com)
  • Research from Rutgers, published in The Journal of Dietary Supplements , provides the first solid clue: two genetic variants that predict some of the risk. (sciencedaily.com)
  • Gene chip studies are popular nowadays and are effective at finding relationships between common genetic variants and disease. (scienceblog.com)
  • Scientists have long suspected that both common and rare genetic variants contribute to many diseases, but the study from the Robarts group now definitively shows that this is the case. (scienceblog.com)
  • It means that to get a full picture of a patient's genetic risk, you need to consider both common and rare variants in many genes simultaneously, and to use methods that will detect both types of variation. (scienceblog.com)
  • In brief, traditional GWAS methods can be used to identify large numbers of common genetic variants, usually single-nucleotide polymorphisms (SNPs), to determine the genetic basis of bacterial phenotypes of interest. (cdc.gov)
  • However, considering the high genomic plasticity of many species of bacteria, traditional GWAS methods can only partially identify the phenotype-associated genetic variants. (cdc.gov)
  • One of the key outcomes was the discovery of more than three million new genetic variants. (theconversation.com)
  • Variants that cause serious genetic diseases are often rare in the general population, mostly because their effect is so severe that a person with such a variant often does not reach adulthood. (theconversation.com)
  • Background Several studies suggest that multiple rare genetic variants in genes causing monogenic forms of neurodegenerative disorders interact synergistically to increase disease risk or reduce the age of onset, but these studies have not been validated in large sporadic case series. (bmj.com)
  • Genetic variants were assessed using the American College of Medical Genetics criteria for pathogenicity. (bmj.com)
  • Conclusions A priori, individuals with AD, PD-DLB and FTD-ALS are more likely to harbour a known genetic risk factor, and it is the burden of these variants in combination with rare benign alleles that is likely to be responsible for some oligogenic associations. (bmj.com)
  • 1-5 Some of the known risk alleles are common in the general population, raising the possibility that multiple interacting genetic variants might enhance the risk of developing disease or modify the disease phenotype. (bmj.com)
  • Despite these obese-specific variants, overall viral genetic diversity did not differ significantly between obese and lean hosts. (bvsalud.org)
  • There's also genetic variation within dengue virus types, with some variants showing higher levels of virulence. (cdc.gov)
  • Genetic variation is the difference in DNA among individuals or the differences between populations among the same species. (wikipedia.org)
  • Differences between populations resulting from geographic separation is known as geographic variation. (wikipedia.org)
  • A variety of factors maintain genetic variation in populations. (wikipedia.org)
  • Information from several large experiments to measure genetic variation in different populations is available through Ensembl's new linkage disequilibrium view. (news-medical.net)
  • Recent natural selection took the genetic code in different directions as different populations adapted to their local environments, the scientists found. (stanford.edu)
  • The sequence in Han Chinese populations had an evolutionarily new variation, perhaps reflecting that premature birth would have been especially costly for the small group of ancestral humans who migrated from Africa to East Asia. (stanford.edu)
  • The findings also predict that the genetic forms of the progesterone receptor seen in East Asians would not necessarily protect against premature birth in other populations. (stanford.edu)
  • Studying African genomes not only fills a gap in the current understanding of human genetic variation, but also reveals new insights into the history of African populations. (theconversation.com)
  • The aim of this study was to examine the structure of common variation ascertained in major U.S. populations by resequencing the exons and flanking regions of 3,873 genes in 154 chromosomes from European, Latino/Hispanic, Asian, and African Americans generated by the Genaissance Resequencing Project. (blogspot.com)
  • Evolutionary theory suggests that populations with low genetic variation are more vulnerable to changing environmental conditions than are diverse populations. (berkeley.edu)
  • Genetic diversity was lower in the Tsushima population than in three geographic populations on the main islands: heterozygosity was 0.189-0.364 in the former, compared to 0.457-0.747 in the latter. (bioone.org)
  • In addition, high pairwise Fst values (0.485-0.682) and Nei's standard distance (0.550-1.183) between the Tsushima and main-island populations indicated a high degree of genetic differentiation. (bioone.org)
  • Finally, a Bayesian clustering analysis showed that the Tsushima population is apparently differentiated from the main-island populations and comprises two genetic clusters. (bioone.org)
  • Our results suggest that restricted gene flow or inbreeding may have reduced genetic diversity in the Tsushima population, which has been geographically isolated from the main-island populations since the formation of Tsushima Strait. (bioone.org)
  • In natural populations, local mate selection and dispersal create correlations between geographic location and genetic variation - each individual's genome is a mosaic of material inherited from recent ancestors that are usually geographically nearby. (elifesciences.org)
  • and also offers a way to analyze variation in geographic ancestry without assuming the existence of discrete ancestral populations. (elifesciences.org)
  • Our results show that genetic variation in the ability to preferentially reduce associations with an exploitative partner exists within mutualisms and is under selection, indicating that micro-evolutionary responses in mutualism-stabilizing traits in the face of rapidly evolving mutualistic and exploitative symbiotic bacteria can occur in natural host populations. (datadryad.org)
  • Genetic Variation in Field and Laboratory Populations of the Spined So" by Kathleen Kneeland, Thomas A. Coudron et al. (unl.edu)
  • However, virtually nothing is known of its genetic variation, in natural or domesticated populations. (unl.edu)
  • To address this lacuna, we used amplified fragment length polymorphism (AFLP) to assess the genetic variability of field and laboratory populations. (unl.edu)
  • The AFLP results showed greater genetic variability between populations from Missouri and Mississippi (both USA), and relatively low variability within Missouri populations. (unl.edu)
  • We infer little genetic isolation among Missouri field populations and within laboratory populations but a significant genetic isolation between Missouri and Mississippi populations. (unl.edu)
  • Geographic distance among sampled populations, plant frequency and three plant traits (life span, mating system and pollination mode) were included into the models, to account for their potential effects on level of genetic variation. (uni-regensburg.de)
  • Genetic differentiation was significantly higher among populations of species from the alpine than subalpine, montane or lowland zone. (uni-regensburg.de)
  • In contrast, genetic diversity was significantly lower within populations from the alpine zone compared to the other zones. (uni-regensburg.de)
  • We argue that the observed pattern of genetic variation most likely results from restricted gene flow, both past and present, among spatially and environmentally isolated populations in alpine habitats. (uni-regensburg.de)
  • Host obesity impacts genetic variation in influenza A viral populations. (bvsalud.org)
  • Enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations. (cdc.gov)
  • citation needed] Ultimately, genetic variation is caused by variation in the order of bases in the nucleotides in genes. (wikipedia.org)
  • Examination of DNA has shown genetic variation in both coding regions and in the noncoding intron region of genes. (wikipedia.org)
  • Genetic variations that lie outside of any known genes can lead to disease. (nih.gov)
  • Optherion licensed from the University of Pittsburgh the worldwide rights to develop diagnostic products for age-related macular degeneration (AMD) associated with specific variations in genes on Chromosome 10. (genengnews.com)
  • It's also instructive that one single gene is not solely responsible for high triglyceride levels but rather a mosaic of both common and rare variations in several genes. (scienceblog.com)
  • Genomewide association studies (GWAS) are increasingly used to detect novel genes and genetic elements associated with bacterial phenotypes, which may provide insight for future preventive strategies and control measures ( 9 - 12 ). (cdc.gov)
  • Later, scientists identified resistance genes in a potato from South America, where farmers have preserved the genetic variation of potatoes by growing many cultivated varieties alongside the potato's wild cousins. (berkeley.edu)
  • Genetic variation in over 50 genes contributes to the risk of developing neurodegenerative diseases. (bmj.com)
  • There are genetic variations in the same genetic region in women with cervical carcinoma caused by Human Papillomavirus," Antczak said, referring to where the genes for papillomavirus susceptibility was discovered in horses. (cornellsun.com)
  • Our findings provide evidence of host genetic influences on upper airway microbial composition in humans and implicate mucosal immunity genes in this relationship. (biomedcentral.com)
  • In fact, quantitative trait locus (QTL) approaches have successfully identified variation in candidate host genes that influence the RA of specific bacteria not only in Drosophila and mice but also in humans [ 22 ]. (biomedcentral.com)
  • This is likely due to the high supply rate of de novo variation and common evolutionary adaptations to the ferret host regardless of obesity status, which we show are mediated by variation in the hemagglutinin (HA) and polymerase genes (PB2 and PB1). (bvsalud.org)
  • I agree that my blood may be kept for future studies using my genes to help understand genetic links to medical conditions. (cdc.gov)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • Genetic diversity, disease resistance and pest control are highlighted. (berkeley.edu)
  • This study contributes a major, new source of African genomic data, which showcases the complex and vast diversity of African genetic variation. (theconversation.com)
  • This is significant because we are learning more about human genetic diversity in general, and discovering more differences that could be linked to disease or traits in the future. (theconversation.com)
  • This book provides a state-of-the-art view of human genetic variation and what we can infer from it, surveying the genetic diversity seen in Africa, Europe, the Americas, and India. (cshlpress.com)
  • Research in humans and animal models points to potential biological and genetic mechanisms contributing to the diversity of behaviors seen in autism. (neurosciencenews.com)
  • The aim of the current study was to estimate the genetic diversity of F. graminearum and F. culmorum isolated from wheat in Adana province of Turkey by investigating by RAPD-PCR polymorphisms. (scialert.net)
  • Then, we compared genetic diversity and differentiation between species occurring in the lowland, montane, subalpine and alpine vegetation zone with the help of linear models. (uni-regensburg.de)
  • HCV-6 has considerable genetic diversity with 23 subtypes (a to w). (tropmedres.ac)
  • Additionally, both sexes discriminated absolute and relative MHC- 39 DRB diversity in the genital odors of opposite-sex conspecifics, supporting previous findings that 40 lemur genital odors function as advertisement of genetic quality. (readkong.com)
  • Because genetic diversity at the MHC is fundamentally linked to 48 parasite resistance, survivorship, and reproductive success (Sommer 2005a, Piertney & Oliver 49 2006), an individual's MHC genotype is hypothesized to be an important predictor of its quality 50 as a mate. (readkong.com)
  • During viral replication in a host, the negative sense single stranded RNA genome of IAV accumulates genetic diversity that may have important consequences for viral evolution and transmission . (bvsalud.org)
  • Our study provides the first insight into the consequences of host obesity on viral genetic diversity and adaptation, suggesting that host factors associated with obesity alter the selective environment experienced by a viral population , thereby impacting the spectrum of genetic variation . (bvsalud.org)
  • We report on the incidence, genetic diversity, and molecular epidemiology of sapoviruses detected in domestic pigs in a comprehensive study conducted in six European countries (Denmark, Finland, Hungary, Italy, Slovenia, and Spain) between 2004 and 2007. (lu.se)
  • Variation and recombination can be facilitated by transposable genetic elements, endogenous retroviruses, LINEs, SINEs, etc.[citation needed] For a given genome of a multicellular organism, genetic variation may be acquired in somatic cells or inherited through the germline. (wikipedia.org)
  • HIV), damage in the RNA genome appears to be avoided during reverse transcription by strand switching, a form of genetic recombination. (wikipedia.org)
  • Human geneticists can now see which variations on the human genome are inherited together, thanks to a new way of viewing genetic variations in the latest release of the Ensembl genome browser [a joint project between EMBL's EBI and the Wellcome Trust Sanger Institute ]. (news-medical.net)
  • A human genome refers to the complete set of genetic information found in a human cell. (theconversation.com)
  • We sequenced the whole genome of each of these individuals - this means we could read every part of the genome to look for variation. (theconversation.com)
  • Our data has shown that we have not yet found all the variation in the human genome. (theconversation.com)
  • New Breeding Techniques (NBTs) include several new technologies for introduction of new variation into crop plants for plant breeding, in particular the methods that aim to make targeted mutagenesis at specific sites in the plant genome (NBT mutagenesis). (frontiersin.org)
  • Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as well. (wikipedia.org)
  • Random mutations are the ultimate source of genetic variation. (wikipedia.org)
  • citation needed] Genetic variation will result in phenotypic variation if variation in the order of nucleotides in the DNA sequence results in a difference in the order of amino acids in proteins coded by that DNA sequence, and if the resultant differences in amino-acid sequence influence the shape, and thus the function of the enzyme. (wikipedia.org)
  • We studied the associations between the stem quality, phenology, and genetic structure by genotyping the phenotypic variation at 15 genomic SSR makers of 208 mature European beech trees in four artificially established stands in Lithuania. (mdpi.com)
  • Through phenotypic identification, genetic analysis, main ingredients measurement and embryo rescue, development of genetic mapping population from A0178, the endosperm mutant gene was located. (techscience.com)
  • The variations in the progesterone receptor gene - consisting of single nucleotide polymorphisms, or one-letter changes in the genetic code - were found in regions of the gene that regulate when it is switched on and off. (stanford.edu)
  • A new analysis showed that early signs of liver damage from high-dose green tea extract were somewhat predicted by one variation in a genotype and strongly predicted by another variation. (sciencedaily.com)
  • An analysis by researchers showed that early signs of liver damage were somewhat more common than normal in women with one variation in the catechol-O-methyltransferase (COMT) genotype and strongly predicted by a variation in the uridine 5'-diphospho-glucuronosyltransferase 1A4 (UGT1A4) genotype. (sciencedaily.com)
  • Variations in this one genotype don't completely explain the variations in liver enzyme changes among study participants. (sciencedaily.com)
  • To elucidate the genetic structure of the Tsushima population, we genotyped 101 individuals from the Tsushima Islands and 43 individuals from Honshu and Kyushu using 10 microsatellite loci, and performed population genetic analyses on the genotype data. (bioone.org)
  • Hepatitis C virus genotype 6: virology, epidemiology, genetic variation and clinical implication. (tropmedres.ac)
  • These results give researchers a framework for uncovering genetic regulators that could be potential targets for drug development. (nih.gov)
  • Researchers led by Laura Acosta, then a doctoral student, now a graduate, selected two genetic variations in question because each controls the synthesis of an enzyme that breaks EGCG down. (sciencedaily.com)
  • The researchers found that a person's genetic makeup affects how an enzyme found in the liver metabolizes methadone, making a person more or less susceptible to an overdose. (cottonwooddetucson.com)
  • Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia (AML) patients will benefit or not benefit from one of the newest antileukemic agents. (medicalxpress.com)
  • In the latest study, U of M researchers evaluated how inherited genetic polymorphisms in CD33, a protein that naturally occurs in most leukemia cells , could affect clinical outcomes of patients treated with an existing chemotherapy drug, gemtuzumab ozogamicin (GO), an immuno-conjugate between anti-CD33 antibody and a cytotoxin known as calicheamicin, which binds to CD33 on leukemic cells. (medicalxpress.com)
  • In this study, researchers discovered rare variations in the ABCB6 gene, also called Lan . (stjude.org)
  • Because cytochrome P450 oxidoreductase helps regulate the activity of these enzymes, researchers suspect that normal variations in the POR gene may influence a person's response to particular drugs (drug metabolism). (medlineplus.gov)
  • Genetic variation can be divided into different forms according to the size and type of genomic variation underpinning genetic change. (wikipedia.org)
  • By using a 2-stage genomewide association study process, we compared genomic differences between infection and carriage isolates to address genomic variation associated with pathogenicity. (cdc.gov)
  • Furthermore, over time, antigenic variation (antigenic drift) within a subtype may be so marked that infection or vaccination with one strain may not induce immunity to distantly related strains of the same subtype. (cdc.gov)
  • Although influenza B viruses have shown more antigenic stability than influenza A viruses, antigenic variation does occur. (cdc.gov)
  • DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a new study. (sciencedaily.com)
  • DNA variation in a gene called ROBO1 is associated with early anatomical differences in a brain region that plays a key role in quantity representation, potentially explaining how genetic variability might shape mathematical performance in children, according to a study published October 22nd in the open-access journal PLOS Biology by Michael Skeide of the Max Planck Institute for Human Cognitive and Brain Sciences, and colleagues. (sciencedaily.com)
  • As a result, it is an open question how genetic variation could give rise to differences in mathematical ability. (sciencedaily.com)
  • To determine whether genetic variation is unevenly enriched in S. pneumoniae infection isolates, we used multiple GWAS analyses to compare genomic differences between infection and carriage isolates. (cdc.gov)
  • We use published estimates to test the hypotheses that there are systematic differences in the rate of evolution among trait types, and that these differences are in part due to genetic architecture. (biorxiv.org)
  • Despite considerable variation, they do not explain the observed differences in evolutionary rates. (biorxiv.org)
  • Analyses focused on behavioral and genomic differences between sibling pairs reveal genetic locations that could prove relevant to autism-related social difficulties. (neurosciencenews.com)
  • Studies like those presented today confirm that autism is driven by sources of genetic variation that naturally exist in the human population," says Nicola Grissom, an assistant professor of psychology at the University of Minnesota who studies individual and sex differences in motivated behavior and executive function in mouse models. (neurosciencenews.com)
  • The team proposed that genetic differences in horse species could allow for papillomavirus-induced sarcoid (skin) tumors to grow in some horses and not others. (cornellsun.com)
  • Genetic variability is being discussed as a source of inter‐individual differences in Theory of Mind development. (mpg.de)
  • Studying the variations in different people's genomes gives important clues to how genetic information influences people's appearance and health. (theconversation.com)
  • A person's genetic makeup influences how an enzyme in the liver metabolizes methadone," said principal investigator Dr. Evan Kharasch, professor of biochemistry and molecular biophysics at Washington University School of Medicine in St. Louis, in a news release . (cottonwooddetucson.com)
  • Our latest findings lead us to believe that genetic variation in CD33 influences how AML patients ' leukemic cell responds to GO. (medicalxpress.com)
  • We conclude that these limitations currently prevent firm conclusions on genetic influences on Theory of Mind development. (mpg.de)
  • Similar to the traits it influences, the microbiome itself can be considered a complex phenotype with environmental and genetic factors contributing to its composition [ 9 ]. (biomedcentral.com)
  • as a product of directional selection acting on them ( β ) and the genetic variance-covariance matrix for those traits ( G ). Despite being empirically challenging to estimate, there are enough published estimates of G and β to allow for synthesis of general patterns across species. (biorxiv.org)
  • Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance, skin color, food tolerance, and susceptibility to different diseases. (cshlpress.com)
  • Plant breeding is dependent on genetic variation, and new variation is fundamentally important for introduction of new traits in breeding programs. (frontiersin.org)
  • Variation in neutralization epitopes of human rotaviruses in relation to genomic RNA polymorphism. (microbiologyresearch.org)
  • Abiotic stresses like low temperatures are contributory factors to the variations observed among species during plant germination, growth, and development. (mendeley.com)
  • It utilizes the genetic variation between individuals within a plant species and combines the desired properties into new and improved varieties. (frontiersin.org)
  • However, in cases where a specific genetic trait is not immediately available to be crossed into breeding materials, the genetic variation in a crop species can be expanded by other means. (frontiersin.org)
  • Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. (elifesciences.org)
  • In this study, we compared the genetic variation of plant species occurring in different altitudinal zones. (uni-regensburg.de)
  • We first compiled a data set on genetic variation of 179 plant species occurring in Central Europe and the European Alps measured by AFLPs from the literature. (uni-regensburg.de)
  • Our analysis revealed different patterns of genetic variation in plant species occurring in the alpine and non‐alpine zone. (uni-regensburg.de)
  • This information will be extremely useful to human geneticists who are looking for genetic markers for disease. (news-medical.net)
  • We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density ( r g = 0.15) and pancreatic β-cell function ( r g = 0.12). (nature.com)
  • In both replication attempts, we did not find any evidence for associations between the sampled genetic markers and Theory of Mind ability in a series of analyses. (mpg.de)
  • This comprehensive non‐replication is important to balance current research on genetic markers of Theory of Mind. (mpg.de)
  • Eliminating this opportunistic pathogenic bacterium requires knowledge of the pathogenicity-associated genetic elements that distinguish infection from carriage isolates. (cdc.gov)
  • Genetic distances of F. graminearum and F. culmorum isolates appeared more intense in wheat fields in Adana region were determined by RAPD-PCR (10 primers). (scialert.net)
  • Our results indicated that temporal genetic variation of the VP7 of serotype G1 rotaviruses was associated with changes in the antigenicity of these isolates. (microbiologyresearch.org)
  • S. zooepidemicus displays a wide genetic variation between different isolates. (cdc.gov)
  • Our findings suggest that S. pneumoniae pathogenicity is complex and multifactorial, and we provide genetic evidence for precise targeted interventions. (cdc.gov)
  • The findings indicate that blacks have a genetic variation associated with slower methadone metabolism. (cottonwooddetucson.com)
  • Findings provide a better understanding of how natural genetic variations impact brain development and give rise to the spectrum of autism-associated behaviors. (neurosciencenews.com)
  • Any two people share 99.9% of their DNA sequence but tiny variations, often in a single letter of the DNA code, can greatly affect an individual's susceptibility to disease. (news-medical.net)
  • The new view in Ensembl allows you to work out which cards you need to look at in any region of the sequence to predict which cards are in any individual's genetic 'hand. (news-medical.net)
  • According to the authors, the results suggest that genetic variability might shape mathematical ability by influencing the early development of the brain's basic quantity processing system. (sciencedaily.com)
  • Furthermore, random fertilization also contributes to variation. (wikipedia.org)
  • A high mutation rate caused by the lack of a proofreading mechanism appears to be a major source of the genetic variation that contributes to RNA virus evolution. (wikipedia.org)
  • New technology now allows scientists to directly sequence DNA, which has identified even more genetic variation than was previously detected by protein electrophoresis. (wikipedia.org)
  • Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties. (embl.org)
  • Humans have unexpectedly high genetic variation in the receptor for a key pregnancy-maintaining hormone, according to research led by scientists at the Stanford University School of Medicine . (stanford.edu)
  • It's a tumor, it's an infection which causes a tumor, there's a genetic basis, there's lots of variation that we don't understand and it's an important disease in humans, of course. (cornellsun.com)
  • The degree to which host genetic variation can modulate microbial communities in humans remains an open question. (biomedcentral.com)
  • Using a model mutualism-the interaction between legumes and nitrogen-fixing soil symbionts-we tested for quantitative genetic variation in plant responses to mutualistic and exploitative symbiotic rhizobia in controlled greenhouse conditions. (datadryad.org)
  • Now that we have to tools to track variation effectively, we're much closer to fulfilling the promise of genomics, in terms of better ways of diagnosing and treating disease. (news-medical.net)
  • Crossing over (genetic recombination) and random segregation during meiosis can result in the production of new alleles or new combinations of alleles. (wikipedia.org)
  • Genetic variation and recombination by transposable elements and endogenous retroviruses sometimes is supplemented by a variety of persistent viruses and their defectives which generate genetic novelty in host genomes. (wikipedia.org)
  • Genetic recombination also has been shown to play a key role in generating the genetic variation that underlies RNA virus evolution. (wikipedia.org)
  • Numerous RNA viruses are capable of genetic recombination when at least two viral genomes are present in the same host cell. (wikipedia.org)
  • The distributions of the total number of recombination events per gamete, among the eight mothers of the CEPH families, were significantly different, and this variation was not due to maternal age. (nih.gov)
  • citation needed] Genetic variation can also be identified by examining variation at the level of enzymes using the process of protein electrophoresis. (wikipedia.org)
  • An international research team has linked rare variations in a cell membrane protein to the wide variation in symptom severity that is a hallmark of porphyria, a rare disorder that often affects the skin, liver and nervous system. (stjude.org)
  • Genetic variation within a population is commonly measured as the percentage of polymorphic gene loci or the percentage of gene loci in heterozygous individuals. (wikipedia.org)
  • New research is offering better understanding of how natural genetic variation impacts brain development and gives rise to the spectrum of behaviors associated with autism and may contribute to more individualized approaches for supporting people with autism. (neurosciencenews.com)
  • New research has found that genetic variations can influence the risk of a methadone overdose, HealthDay reports. (cottonwooddetucson.com)
  • The overall goal of our study was to use genetic data to predict beneficial or adverse response to a specific drug, thus opening up opportunities to use this information for drug optimization to achieve maximum therapeutic efficacy and minimum toxicity. (medicalxpress.com)
  • This allows us to predict the location of origin of a genetic sample by comparing it to a set of samples of known geographic origin. (elifesciences.org)
  • Natural selection can also maintain genetic variation in balanced polymorphisms. (wikipedia.org)
  • Also an interesting view of the genetic structure of the main US population groups. (blogspot.com)
  • The full analysis behind this unique view of the genetic activities determining our appearance, function and behaviour is published today in Nature Biotechnology . (embl.org)
  • Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait. (nature.com)
  • The genetic variance in relative viability increases with density, but not significantly. (bioone.org)
  • Large-scale DNA sequencing is now allowing us to map the patterns of human genetic variation more accurately than ever before, trace our ancestries, and develop personalized therapies for particular diseases. (cshlpress.com)
  • A frequent claim about human population structure is that most common variation is shared among all populations11-13. (blogspot.com)
  • They found that specific genetic variation in CD33 that significantly affected the clinical outcome of AML patients who received GO based chemotherapy. (medicalxpress.com)
  • In recent clinical trials GO has been shown to induce remission and improve survival in subset of patients with AML, however there is wide inter-patient variation in response. (medicalxpress.com)
  • Relating enhancer genetic variation across mammals to complex phenotypes using machine learning. (umassmed.edu)
  • 1 kb) can be either copy number variation (loss or gain), or chromosomal rearrangement (translocation, inversion, or Segmental acquired uniparental disomy). (wikipedia.org)
  • One of the mysteries of this disease has been why some individuals with the same genetic defect have mild symptoms while others have severe symptoms and require hospitalization in the intensive care unit," said corresponding author John Schuetz, Ph.D ., a member of the St. Jude Department of Pharmaceutical Sciences. (stjude.org)
  • Understanding how host genetic variation shapes the microbiome and how the microbiome ultimately functions to modulate host immunity are fundamental questions that are central to fully characterizing the architecture of many common diseases that occur at mucosal surfaces, including those involving the airway. (biomedcentral.com)
  • The extent of genetic variation in fitness and its components and genetic variation's dependence on environmental conditions remain key issues in evolutionary biology. (bioone.org)
  • A fundamental question in evolutionary biology is the relative importance of selection and genetic architecture in determining evolutionary rates. (biorxiv.org)
  • Using data from the Minnesota Green Tea Trial, a large study of green tea's effect on breast cancer, the research team investigated whether people with certain genetic variations were more likely than others to show signs of liver stress after a year of ingesting 843 milligrams per day of the predominant antioxidant in green tea, a catechin called epigallocatechin gallate (EGCG). (sciencedaily.com)
  • In a combined evaluation of our own and previous studies, we point to substantial methodological issues that research on the genetic basis of Theory of Mind development faces. (mpg.de)
  • More information on genetic variation will be added to Ensembl in the near future because the HapMap consortium, an international group of scientists that is doing a global study of genetic variation, has just lifted all restrictions on the use of its data, allowing it to be incorporated into the major public databases for the first time. (news-medical.net)
  • The high-dimensional genomic data can provide unprecedented resolution for identifying subtle genomic variations. (cdc.gov)