• mechanism
  • The mechanism by which specific regions of the chromosome are organized and segregated prior to division remains a mystery. (wiley.com)
  • We recently provided evidence from immunofluorescence and electron microscopy studies that merotelic kinetochore orientation is a major mechanism for lagging chromosomes during mitosis in PtK1 cells. (biologists.org)
  • The selected Xi becomes the target of a chromosome‐wide mechanism of transcriptional silencing, which constitutes an exciting paradigm for epigenetic regulations and confirms interest in the molecular dissection of the X‐inactivation centre ( Xic ), a locus on the X chromosome that contains the Xist gene and the elements involved in counting, choice and silencing. (embopress.org)
  • mitotic
  • By using in situ hybridization with alphoid probes to chromosome 7 and 11 we showed that loss of a single sister is much more frequent than loss of both sisters from the same chromosome in anatelophases from human primary fibroblasts released from a nocodazole-induced mitotic arrest, as predicted from merotelic orientation of single kinetochores. (biologists.org)
  • Kinetochores of lagging chromosomes in anaphase human cells were found to be devoid of the mitotic checkpoint phosphoepitopes recognized by the 3F3/2 antibody, suggesting that they attached kinetochore microtubules prior to anaphase onset. (biologists.org)
  • Mitotic chromosome malsegregation produces aneuploidy and genome instability. (biologists.org)
  • Hence, the activation of the mitotic checkpoint prevents the unbalanced distribution of chromosomes during mitosis and the production of aneuploid cells. (biologists.org)
  • boundary
  • Second, the neo-sex chromosome is homologous to the sex chromosomes of mammals, which makes it possible - for the first time - to study mammalian X gene homologs in a novel, avian Z-linked environment where females are the heterogametic sex (ZW), and thus to draw direct parallels over the avian ZW-mammalian XY boundary. (lu.se)
  • appear
  • Most likely this suppression was the result of a series of chromosomal inversions on the Y chromosome, which would also explain why the genes appear to be in order on the X but scrambled on the Y," Page explains. (abc.net.au)
  • regions
  • We observe that genetic diversity in the PAR1 is significantly greater than the non-recombining regions (nonPARs). (genetics.org)
  • play
  • This suggests that chromosome instability and aneuploidy may play a critical role in tumor development and progression ( Sen, 2000 ). (biologists.org)
  • Science
  • Research published in this week's Science reveals that the Y chromosome developed from an X-like ancestor around 300 million years ago. (abc.net.au)