• Mitochondrially encoded tRNA asparagine also known as MT-TN is a transfer RNA which in humans is encoded by the mitochondrial MT-TN gene. (wikipedia.org)
  • The MT-TN gene is located on the p arm of the non-nuclear mitochondrial DNA at position 12 and it spans 73 base pairs. (wikipedia.org)
  • MT-TN is a small 73 nucleotide RNA (human mitochondrial map position 5657-5729) that transfers the amino acid asparagine to a growing polypeptide chain at the ribosome site of protein synthesis during translation. (wikipedia.org)
  • [ 3 ] However, other mitochondrial DNA (mtDNA) mutations are observed, including the m.3244 G → A, m.3258 T → C, m.3271 T → C, and m.3291 T → C in the mitochondrial tRNA Leu(UUR) gene. (medscape.com)
  • The mitogenome is 18,680 bp in length, and includes the 37 typical mitochondrial genes and a large control region (length: 1,997 bp). (researchsquare.com)
  • People with mutations in the MT-TL1 , MT-TH , or MT-TS1 gene typically have signs and symptoms of other mitochondrial disorders as well as those of MERRF. (medlineplus.gov)
  • The MT-TK , MT-TL1 , MT-TH , and MT-TS1 genes are contained in mitochondrial DNA (mtDNA). (medlineplus.gov)
  • A small percentage of MERRF cases are caused by mutations in other mitochondrial genes, and in some cases the cause of the condition is unknown. (medlineplus.gov)
  • In most cases, people with MERRF inherit an altered mitochondrial gene from their mother, who may or may not show symptoms of the disorder. (medlineplus.gov)
  • Less commonly, the disorder results from a new mutation in a mitochondrial gene and occurs in people with no family history of MERRF. (medlineplus.gov)
  • Is the tRNA(Leu(UUR)) gene an etiologic hot spot? (wikipedia.org)
  • Approximately 80% of patients with the clinical characteristics of MELAS syndrome have a heteroplasmic A-to-G point mutation in the dihydrouridine loop of the transfer RNA (tRNA) Leu (UUR) gene at base pair (bp) 3243 (ie, 3243 A → G mutation). (medscape.com)
  • One basic problem is how a decrease in tRNA levels, by downregulating Pol III efficiency, influences the expression pattern of protein-coding genes. (mdpi.com)
  • F o For as long as living things have been building proteins based on the code of messenger RNA molecules, there have been aminoacyl-tRNA synthetases. (fascea.pics)
  • Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs. (utah.edu)
  • Phosphorylation-resistant site mutations in PIF7 result in increased nuclear localization and shade-induced gene expression, and consequently augment hypocotyl elongation. (elifesciences.org)
  • Mutations in the MT-TK gene are the most common cause of MERRF, occurring in more than 80 percent of all cases. (medlineplus.gov)
  • Less frequently, mutations in the MT-TL1 , MT-TH , and MT-TS1 genes have been reported to cause the signs and symptoms of MERRF. (medlineplus.gov)
  • This has further implications for understanding the patho-aetiology of HCM-causing mutations in the genes encoding cMyBPC and cTNI, and raises the question of whether MMGL might itself be considered a candidate HCM-causing or modifying factor. (biomedcentral.com)
  • X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia, is an inherited immunodeficiency disease caused by mutations in the gene coding for Bruton tyrosine kinase (BTK). (medscape.com)
  • Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)
  • Pertinence of glioma and single nucleotide polymorphism of TERT, CCDC26, CDKN2A/B and RTEL1 genes in glioma: a meta-analysis. (cdc.gov)
  • Molecular formula of common RNA modifications. (beds.ac.uk)
  • Cellular respiration (oxidative phosphorylation) occurs in the mitochondria, where a series of enzymes catalyze the transfer of electrons to molecular oxygen and the generation of energy-storing adenosine triphosphate (ATP). (msdmanuals.com)
  • It may be an important candidate gene for molecular breeding of drought- tolerant plants. (biomedcentral.com)
  • Some examples include delivering DNA-free gene editing reagents such as ribonucleoproteins or mRNA, relying on reagent expression from non-integrated DNA, using novel delivery mechanisms such as viruses or nanoparticles, using unconventional selection methods to avoid integration of transgenes, and/or avoiding tissue culture altogether. (frontiersin.org)
  • In addition, steady-state mRNA levels of nine stress-responsive genes coding for either functional or regulatory proteins were induced to higher levels in the transgenic lines with or without drought stress. (biomedcentral.com)
  • TF constitutes the key regulon that plays crucial roles in various biological processes, including stress response, through binding to the cis -acting element in the promoters of target genes [ 7 ]. (biomedcentral.com)
  • With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)
  • The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)
  • Transcriptomics focuses on gene transcription and regulation of transcription in cells [ 25 , 26 ]. (hindawi.com)
  • My research interest centers around understanding gene expression regulation in both stem cells and cancer cells. (nih.gov)
  • ABA-responsive element (ABRE, PyACGTGGC), an important cis -element, is implicated in the transcriptional regulation of ABA- and/or stress-responsive genes [ 8 ]. (biomedcentral.com)
  • NF-κB is a transcription factor that plays a pivotal role in the highly specific pattern of gene expression observed for immune, inflammatory and acute phase response genes, including interleukin 1, interleukin 8, tumor necrosis factor and certain cell adhesion molecules. (justia.com)
  • These genes can be generally classified into two main groups based on their products, effector molecules or regulator molecules, which are also correspondingly designated as delayed-response genes or early-response genes based on their response timing [ 4 - 6 ]. (biomedcentral.com)
  • All 13 protein-coding genes use ATN or TTG as start codon, and end with TAA/G or incomplete stop codons (single T-). Twenty-one transfer RNA genes have the typical clover-leaf structures, while the dihydrouridine (DHU) arm of trnS1 is missing. (researchsquare.com)
  • These enzymes, abbreviated as AARS, link transfer RNAs (tRNAs) with the corresponding amino acids. (fascea.pics)
  • Sequencing of a 2.5-kb chromosomal Sma I- Pst I fragment containing the structural gene revealed an open reading frame encoding 537 amino acids, homologous to known pckA genes. (asm.org)
  • The BTK gene defect has been mapped to the long arm of the X chromosome at band Xq21.3 to Xq22, spanning 37.5kb with 19 exons forming 659 amino acids to complete the BTK cytosolic tyrosine kinase. (medscape.com)
  • The decreased protein synthesis may ultimately lead to the observed decrease in respiratory chain activity by reduced translation of UUG-rich genes such as ND6 (component of complex I). (medscape.com)
  • In addition, cells can produce more than 300 different protein variants from AARS genes through alternative splicing of their mRNAs or post-translational protein fragmentation. (fascea.pics)
  • Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
  • Products of the former group function directly in protecting cells against damage derived from stresses and sustaining cell viability, and the latter is composed of regulatory proteins, such as transcription factors (TFs), protein kinases and protein phosphatases, that are responsible for transducing stress signaling and regulating expression of stress-responsive genes [ 5 ]. (biomedcentral.com)
  • The definitive determinant of XLA is the complete absence of BTK ribonucleic acid (RNA) or protein. (medscape.com)
  • In addition, STARD12/14 could regulate the ferroptosis related genes. (medsci.org)
  • Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)
  • Our research has shown that p53 plays an essential role in regulating ESC differentiation after DNA damage by down-regulating the transcription of many ES cell critical genes (Li et al. (nih.gov)
  • There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)
  • fl agellin gene polymorphism. (cdc.gov)
  • The main tool used in transcriptomics is total RNA sequencing, which is a powerful tool for analyzing gene expression changes in response to various environmental stresses [ 27 ]. (hindawi.com)
  • ABA responsive element binding factor (ABF) plays an important role in stress responses via regulating the expression of stress-responsive genes. (biomedcentral.com)
  • TFs are known as master switch in plant stress response, and genetic transformation of the genes encoding TFs has been suggested as a possible approach for engineering stress tolerance as manipulation of a single TF can alter expression of a wide array of target genes [ 7 ]. (biomedcentral.com)
  • How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)
  • M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. (beds.ac.uk)
  • Transferred mitochondria accumulate reactive oxygen species, promoting proliferation. (utah.edu)
  • Simultaneous Occurrence of Multiple Neoplasms in Children with Cancer Predisposition Syndromes: Collaborating with Abnormal Genes. (cdc.gov)
  • Prognostic and immunomodulatory roles of schizophrenia-associated genes HTR2A, COMT, and PRODH in pan-cancer analysis and glioma survival prediction model. (cdc.gov)
  • Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)
  • Infections begin once transferred maternal immunoglobulin G (IgG) antibodies have been catabolized, typically at about 6 months of age. (medscape.com)
  • Keisuke Wakasugi I was curious about the sequence of the gene that codes for TyrRS, the AARS for tyrosine. (fascea.pics)
  • In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
  • Prognosis and immunoinfiltration analysis of angiogene-related genes in grade 4 diffuse gliomas. (cdc.gov)
  • Increased understanding of plant genetics and the development of powerful and easier-to-use gene editing tools over the past century have revolutionized humankind's ability to deliver precise genotypes in crops. (frontiersin.org)
  • Plant transformation techniques are well developed for making transgenic varieties in certain crops and model organisms, yet reagent delivery and plant regeneration remain key bottlenecks to applying the technology of gene editing to most crops. (frontiersin.org)
  • We find that the potato genome substantially expanded its repertoire of disease-resistance genes when compared with closely related seed-propagated solanaceous crops, indicative of the effect of tuber-based propagation strategies on the evolution of the potato genome. (nature.com)
  • Early stages of B-cell differentiation can be identified by the status of the immunoglobulin genes and by the cell surface markers CD34, CD19, and surface immunoglobulin (sIg). (medscape.com)
  • Single-cell RNA sequencing reveals localized tumour ablation and intratumoural immunostimulant delivery potentiate T cell mediated tumour killing. (utah.edu)
  • STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)
  • Genes required for B cell development. (medscape.com)
  • In this study, a gene coding for ABF ( PtrABF ) was isolated from Poncirus trifoliata (L.) Raf. (biomedcentral.com)
  • Studies of a pckA-lacZ gene fusion indicated that when cells were grown in minimal media with various carbon sources, such as succinate, malate, pyruvate, lactate, or ethanol, under both anaerobic light and aerobic dark conditions, the pckA gene was induced in log phase, irrespective of the carbon source. (asm.org)
  • High-throughput sequencing refers to the use of antibody immunoprecipitation or chemical methods to accurately locate the site of m7G modification in RNA. (beds.ac.uk)
  • With the rapid development of sequencing technology, m7G has become a new research hotspot of RNA modification. (beds.ac.uk)
  • As a first step towards improvement of drought tolerance via genetic engineering in plant, genes with functions in drought tolerance should be cloned and characterized. (biomedcentral.com)
  • This review highlights diverse strategies to deliver CRISPR/Cas gene editing reagents to regenerable plant cells and to recover edited plants without unwanted integration of transgenes. (frontiersin.org)
  • Not only is m7G involved in the normal physiological metabolism of RNA, but recent research also shows that m7G and related regulators appear to be considerably dysregulated in tumors [ 12 ]. (beds.ac.uk)
  • Esherichia coli strain that expresses MutaT7, a fusion of rat APOBEC1 and the T7 RNA polymerase. (addgene.org)
  • The disease was first elucidated by Bruton in 1952, for whom the gene is named. (medscape.com)