Genes biological membranes cell compartmentation. Medical search. Frequent questions

Magnesium transporters are proteins that transport magnesium across the cell membrane. (wikipedia.org)
In the last major development before the cloning of the genes encoding the transporters, it was discovered that there was a second Mg2+ uptake system that showed similar affinity and transport kinetics to the first system, but had a different range of sensitivities to interfering cations. (wikipedia.org)
We envision that our work will serve as a stepping stone for future studies of the biological function and the identification of the natural substrates of the many under-explored SLC transporters, as well as for the development of new therapeutic applications, including strategies for personalized medicine and drug delivery. (bvsalud.org)
The uptake and efflux of solutes across a plasma membrane is controlled by transporters. (bvsalud.org)
In the brain, SLC transporters are involved in transporting various solutes across the blood-brain barrier, blood-cerebrospinal fluid barrier, astrocytes, neurons, and other brain cell types including oligodendrocytes and microglial cells. (bvsalud.org)
Hence, mutations in the genes that encode SLC transporters can cause a variety of neurological disorders. (bvsalud.org)
The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. (edu.pl)
A membrane assay that indirectly measures the activity of efflux transporters. (atpasepathway.com)
These factors include sugar transporters and invertases as well as metabolites, including sucrose and glucose, which function as signalling molecules to modulate gene expression. (sun.ac.za)
Transgenic lines overproducing the yeast-derived invertase in either the vacuole (Vac-Inv) or apoplast (Apo-Inv) were utilised to analyse the effect of the altered sugar levels in sink and source organs on the expression of sugar transporters, as well as the endogenous cell wall invertase and inhibitors in these plants. (sun.ac.za)

This bacterial system might also be able to provide some utility for the analysis of eukaryotic Mg2+ transport proteins, but differences in biological systems of prokaryotes and eukaryotes will have to be considered in any experiment. (wikipedia.org)
Comparing the functions of the characterised Mg2+ transport proteins is currently almost impossible, even though the proteins have been investigated in different biological systems using different methodologies and technologies. (wikipedia.org)
If the proteins could be shown to be functional in bacteria (S. typhimurium), then a combination of the techniques of mag-fura 2, quantification of protein in the envelope membrane, and structure of the proteins (X-ray crystal or cryo-TEM) might allow the determination of the basic mechanisms involved in the recognition and transport of the Mg2+ ion. (wikipedia.org)
A further six years of postdoctoral research at the University of Manchester allowed me to advance my research skills and to tackle fundamental questions about how proteins are organised within cells. (shu.ac.uk)
Our common theme is investigating how proteins and RNA are delivered to their correct destination within cells, a universal process that can result in disease when it malfunctions. (shu.ac.uk)
Membrane proteins in translational control: characterisation of membrane-bound protein complexes associated with eIF2B, which regulates protein synthesis, and is important in neurological disease. (shu.ac.uk)
Tail-anchored membrane proteins: investigating the targeting and membrane insertion mechanisms, which is important due to the wide range of core cellular functions performed by these proteins. (shu.ac.uk)
The advent of high throughput -omics has made the accumulation of comprehensive data sets possible, consisting of changes in genes, transcripts, proteins and metabolites. (mdpi.com)
Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
Endocytic/exocytic CELL MEMBRANE STRUCTURES rich in glycosphingolipids, cholesterol, and lipid-anchored membrane proteins that function in ENDOCYTOSIS (potocytosis), transcytosis, and SIGNAL TRANSDUCTION. (lookformedical.com)
Proteins which are found in membranes including cellular and intracellular membranes. (lookformedical.com)
This novel trafficking/chaperoning pathway underpins neurotransmission, as secretory vesicles rely on the zippering of SNARE proteins such as syntaxin-1 to undergo fusion with the plasma membrane. (edu.au)
Engineered constructs were compared to human SAS and assessed for specific cell-cell interaction markers as well as for extracellular matrix proteins found in human meninges. (biomedcentral.com)
They stained positively for specific cell-cell interaction markers indicative of a functional meningeal tissue, as well as extracellular matrix proteins found in human meninges. (biomedcentral.com)
I am a plant cell biologist and protein biochemist at Oxford Brookes University with expertise in the structure and function of the plant endoplasmic reticulum (ER), membrane proteins and auxin biosynthesis using biochemical techniques as well as high-resolution live cell imaging. (brookes.ac.uk)
I further investigated membrane proteins and the targeting of tail-anchored proteins at Sheffield Hallam University. (brookes.ac.uk)
A combination of methods, including the isobaric tags for relative and absolute quantification (iTRAQ), quantitative real-time polymerase chain reaction, gas chromatography, and high-performance liquid chromatography, was used to identify proteins, measure gene expression levels, volatiles, sugars, organic acids and carotenoids. (biomedcentral.com)
His research area of expertise includes growth-related heat shock proteins, translational control of gene expression, molecular mechanisms of stress-dependent signal transduction, nucleo-cytoplasmic signalling, role of stress-activated protein kinase MK2 in vivo using knockout mouse models, regulation of gene expression by protein phosphorylation at the post-transcriptional level and new ERK3/MK5 signalling modules. (hoajonline.com)

8. Melchers, F.: Biosynthesis, transport and secretion of immunoglobulin in plasma cells. (uni-mainz.de)
Identification and expression analysis of genes involved in anthocyanin and proanthocyanidin biosynthesis in the fruit of blackberry. (udca.edu.co)
Genes coding for defense-related transcription activators, reactive oxygen species metabolism, terpene biosynthesis, and energy conversion pathways were upregulated in inoculated samples of L. dendroidea , indicating an integrated defensive system in seaweeds. (asm.org)
For instance, the transformation of plants with a yeast-derived invertase targeted to different subcellular compartments has led to the elucidation of several key aspects of sugar metabolism, including phloem loading mechanisms, the regulation of photosynthesis by sugars, the importance of sugar-metabolism compartmentation with regards to sucrose biosynthesis, storage and distribution, as well as the role of cell-wall invertase in phloem unloading and sink strength. (sun.ac.za)

Background Colorectal cancer (CRC) is the major subtype of gastrointestinal malignancy and involves cancer-related genes and signaling pathways to regulate ferroptosis. (bvsalud.org)
The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways focused on the plant hormone signal transduction and mitogen-activated protein kinase signaling pathway. (researchsquare.com)
His research is focused on Cell surface receptors, Ligand-receptor networks, Signalling pathways and inhibition, Signal transduction, Trafficking mechanisms. (hoajonline.com)
Transcriptomic changes in L. dendroidea in the presence of V. madracius include the upregulation of genes that participate in signaling pathways described here for the first time as a response of seaweeds to microbes. (asm.org)
Somatic mutations in genes involved in oncogenic signaling pathways, including KRAS and TP53, rewire the metabolic machinery in cancer cells. (biomed.news)

Our discoveries have led to a deep understanding of how secretory vesicles interact with the cortical actin network prior to fusing with the plasma membrane to release the neurotransmitter. (edu.au)
We have identified a critical role of the phospholipid phosphatidylinositol (4,5) bisphosphate in coordinating the actin-mediated recruitment of secretory vesicles to the plasma membrane. (edu.au)
This active mechanism allows secretory vesicles to dock with the plasma membrane prior to fusion and is controlled by the effector cdc42. (edu.au)
We demonstrated that the protein Munc18-1 was responsible for the transport of syntaxin-1 to the plasma membrane. (edu.au)
Following exocytosis, the process of endocytosis is required for neurons to replenish their pools of synaptic vesicles by pinching off vesicles from the plasma membrane. (edu.au)
We demonstrated that Munc18-1 and syntaxin-1A and are organised in nanodomains on the plasma membrane of neurons and neurosecretory cells that control SNARE-dependent neuroexocytosis through lateral trapping in these nanoclusters. (edu.au)
Is phenol oxidation responsible for the short term effect of boron deficiency on plasma-membrane permeability and function in squash root? (udca.edu.co)

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. (lookformedical.com)
Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products. (ebsco.com)
This study aimed to investigate the role of intracellular glutathione (GSH) levels in the induction of Nrf2-mediated gene expression by α-dicarbonyl compounds. (ebsco.com)

Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
Program access grant to the STFC Harwell Laser Facility 'The Plant Cell Initiative: Protein interactions in the higher plant secretory pathway' 2017-2021 (approximate value of £200K). (brookes.ac.uk)
This transcriptome analysis provides a valuable resource for elucidating the signaling pathway of NaCl and KCl stress and is a substantial genetic resource for discovering genes related to the NaCl and KCl stress response of M. hupehensis . (researchsquare.com)
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation. (stanford.edu)
Keep flux low until the cell needs a given end product of the pathway. (flashcardmachine.com)

As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or on breaking them down and using them to obtain energy, by their digestion. (wikipedia.org)
Lipids are usually defined as hydrophobic or amphipathic biological molecules but will dissolve in organic solvents such as ethanol, benzene or chloroform. (wikipedia.org)
The claim is that such structures would display minimal life-like behavior (reproductive and potentially evolutive) if the intravesicle ribozymes catalyze their own replication and the production of membrane molecules at the expenses of certain precursors available in the environment. (frontiersin.org)
The major theme will be devoted to describe and analyze the molecules of life, light microscopy, fine cell structure and function, cell membranes structure and function, cell division and staining procedures. (uaeu.ac.ae)

Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. (lookformedical.com)
Analysis by RNA sequencing revealed altered expression of genes associated with extracellular matrix remodeling, endo-lysosomal processing, and mitochondrial energy metabolism under pathophysiological flow conditions. (biomedcentral.com)
Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death. (uni-bielefeld.de)
Specifically, we explored how somatic mutations in these genes and substrate availability (lactate, glucose, substrate deprivation) from the extracellular microenvironment affect bioenergetic parameters, including cellular ATP, NADH and mitochondrial membrane potential dynamics. (biomed.news)
Intriguingly, cytosolic, mitochondrial and overall cellular ATP measurements revealed that, in WT KRAS cells, TP53 deficiency leads to an enhanced ATP production in the presence of extracellular lactate and glucose, and to the greatest increase in ATP following a starvation period. (biomed.news)

Grape berries are extremely rich in K, which is involved in several physiological processes: enzyme activation, cellular membrane transport processes and translocation of assimilates, anion neutralisation, which is essential to the maintenance of membrane potential, and osmotic potential regulation, which controls the plant water relations, turgor maintenance and growth. (benthambooks.com)
Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
These attempts share a common anti-vitalistic viewpoint: synthesizing (cellular) life from scratch should be possible, and it would demonstrate that the biological phenomenology follows a "continuity principle" with respect to physics and chemistry. (frontiersin.org)
Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. (lookformedical.com)
To overcome the lack of suitable in vitro models that faithfully recapitulate the intricate three-dimensional architecture, complex cellular interactions, and fluid dynamics within the SAS, we have developed a perfusion bioreactor-based 3D in vitro model using primary human meningothelial cells (MECs) to generate meningeal tissue constructs. (biomedcentral.com)
The SAS imposes a unique environment to its cellular component, the meningothelial cells (MECs) which are a key constituent of the dura mater and the leptomeninges (arachnoid and pia mater). (biomedcentral.com)
Develop a biological knowledge base common to contemporary biologists, encompassing microscopy, cell structure, cellular membranes, and nucleic acids biology. (uaeu.ac.ae)
Use a biological knowledge base common to contemporary biologists in cellular, sub-organismic, organismic, and systems levels of biological organization. (uaeu.ac.ae)
On the other hand, oncogenic KRAS in TP53-deficient cells reversed the alterations in cellular ATP levels. (biomed.news)

9. Melchers, F., Köhler, G., Messer, W.: Stabilization of conformations of Escherichia coli beta-galactosidase by specific antibodies.In: 23rd Mossbach Colloquium of the Germany Society for Biological Chemistry on Protein-Protein Interactions, pp. 409-425, Springer, Berlin, 1972. (uni-mainz.de)
I am committed to interdisciplinary research, and an example of the successes gained from this approach is the project with Prof A Nabok (Engineering Sheffield Hallam University) using total internal reflection ellipsometry to quantify protein-membrane interactions on native plant membranes and human cell lines. (brookes.ac.uk)
We also study the alterations of these interactions and their biological consequences in the context of co-infections, with pathogens which display opposite sensitivities towards autophagy. (cfatg.org)
This presents a starting point for studies into the underlying mechanisms of AD including interactions with other AD-associated genes, like Rho1, Ankyrin, Tau and APP with the potential to identify new targets for treatment. (sdbonline.org)

20. Melchers, F.: Biochemical characterization of immunoglobulin-producing B-lymphocytes at different stages of their differentiation.In: 'Regulation of Growth and Differentiated Function in Eukaryotic Cells,' eds. (uni-mainz.de)
In: 'Regulation of the Immune System: Genes and the Cells in which They Function,' Vol. VI, eds. (uni-mainz.de)
Enzymes act as catalysts - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction, for example in response to changes in the cell's environment or to signals from other cells. (wikipedia.org)
The diseases where cures or at least treatments are sought are complex ones involving many potential defects in the structure, function, or regulation of the cells involved. (springeropen.com)
A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)

We also screened out 28 candidate genes from 762 DEGs and verified their expression by quantitative reverse transcription polymerase chain reaction (qRT-PCR). (researchsquare.com)
To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)

In: 'Perspectives in Membrane Biology,' eds. (uni-mainz.de)
2016 ( Journal of Cell Biology ) we found that the Munc18-1 domain 3a hinge-loop controls syntaxin-1A engagement into the SNARE complex during priming. (edu.au)
2016 Journal of Cell Biology ). (edu.au)
Define the basis of eukaryotic cell biology. (uaeu.ac.ae)
Dr. Paul Robert Fisher holds the Chair in Microbiology at La Trobe University, where he leads the Microbial Cell Biology Group. (hoajonline.com)

We here set out to determine, at the single cell level, metabolic signatures in human colon cancer cells engineered to express combinations of activating KRAS gene mutations and TP53 gene deletions. (biomed.news)
Employing cytosolic and mitochondrial FRET-based ATP probes, fluorescent NADH sensors, and the membrane-permeant cationic fluorescent probe TMRM in HCT-116 cells as a model system, we observed that TP53 deletion and KRAS mutations drive a shift in metabolic signatures enabling lactate to become an efficient metabolite to replenish both ATP and NADH following nutrient deprivation. (biomed.news)

Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). (mdpi.com)
What % of genes encode enzymes? (flashcardmachine.com)

The carbohydrate composition of a myeloma protein from different subcellular fractions of plasma cells. (uni-mainz.de)

Our lab focuses on the molecular events that govern vesicular trafficking within presynaptic nerve terminals and neurosecretory cells. (edu.au)
This has allowed us to probe the nanoscopic environment of neurons and neurosecretory cells undergoing communication. (edu.au)

Alterations of these biological processes may not only interfere with critical MEC functions impacting CSF and hence optic nerve homeostasis, but may likely alter SAS structure, thereby further impeding cerebrospinal fluid flow. (biomedcentral.com)
Stat3-mediated alterations in lysosomal membrane protein composition. (uni-bielefeld.de)

In: 'Biochemistry of Gene Expression in Higher Organisms,' Sydney, eds. (uni-mainz.de)
One feature of inflammation-associated gut microbiotas is enrichment of motile bacteria, which can facilitate microbiota encroachment into the mucosa and activate pro-inflammatory gene expression. (nature.com)
The link between elevated microbiota flagellin levels and intestinal inflammation is thought to involve flagellin's ability to activate pro-inflammatory gene expression via TLR5 and the NLRC4 inflammasome. (nature.com)
Aging, the cruel fate from which no one can escape, is associated with drastic physiological changes amplified by the increased expression of genes related to cell damage. (thesciencebreaker.org)
Furthermore, in a cell-based reporter gene assay MGO, GO, and 3-DG were able to induce Nrf2-mediated gene expression in a dose-dependent manner. (ebsco.com)
Our results reveal subtle differences in the role of GSH in protection against the three typical α-dicarbonyl compounds and in their induction of Nrf2-mediated gene expression, and point at a dual biological effect of the α-dicarbonyl compounds, being reactive toxic electrophiles and -as a consequence- able to induce Nrf2-mediated protective gene expression, with MGO being most reactive. (ebsco.com)
The seaweed RNA was sequenced, providing an unprecedentedly high coverage of the transcriptome of Laurencia , and the gene expression levels were compared between control and inoculated samples after 24, 48, and 72 h. (asm.org)
Using four different cancer cell lines, we report that, at clinically relevant concentrations (100-500 nM), MitoQ selectively repressed mesenchymal pancreatic cancer cell respiration, which involved the inhibition of the expression of PGC-1α, NRF1 and a reduced expression of electron-transfer-chain complexes I to III. (biomed.news)
Phenotypically, MitoQ further inhibited pancreatic cancer cell migration, invasion, clonogenicity and the expression of stem cell markers. (biomed.news)

The compartmentation and distribution of metabolites between mitochondria and the rest of the cell is a key parameter of cell signalling and pathology. (biomed.news)
Using this procedure revealed the in vivo compartmentation of mitochondrial metabolites and will enable assessment of the distribution of metabolites between the cytosol and mitochondria during a range of situations in vivo. (biomed.news)

Furthermore, cells possessing oncogenic KRAS, independently of TP53 status, showed less pronounced mitochondrial membrane potential changes in response to metabolic nutrients. (biomed.news)

We have identified a novel mechanism by which dynamin and actin coordinate a series of membrane events that culminate in the formation of bulk endosomes from which new synaptic vesicles emanate at the neuromuscular junction. (edu.au)

their enzymatic repertoire is highly variable among species, individual cell types and under different physiological conditions. (biorxiv.org)

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. (lookformedical.com)
A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc. (lookformedical.com)

However, few studies focus on the analysis of primary cells, although in humans, many diseases are associated with polymorphisms of autophagic genes. (cfatg.org)
High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. (uni-bielefeld.de)

However, it is important that the amount of transporter present in the membrane is accurately determined if comparisons of transport capability are to be made. (wikipedia.org)
The Gene Ontology (GO) terms were enriched in ion transmembrane transporter and oxidoreductase activity under NaCl and KCl stress. (researchsquare.com)
Transcript levels of the sucrose transporter NtSUT1 and hexose transporter NtMST1 encoding genes increased significantly in the source leaves and roots of Vac-Inv lines, whereas increased NtMst1 transcript levels were also detected in the roots of Apo-Inv lines. (sun.ac.za)

17. Melchers, F., Andersson, J.: Immunoglobulin production in B-lymphocytes: synthesis of the membrane-bound receptor and the secreted serum glycoprotein immunoglobulin M. Biochem. (uni-mainz.de)

Lysosomes in nutrient signalling: A focus on pancreatic β-cells. (uni-bielefeld.de)
Prior studies have shown which mutation within the dermokine-β (DMKN-β) gene causes pancreatic and colorectal cancer. (atpasepathway.com)

11. Melchers, F.: Synthesis, transport and secretion of immunoglobulin in lymphoid cells. (uni-mainz.de)
Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. (springeropen.com)
Despite the complexity of causative factors that can lead to these disease states, the tools of modern drug discovery have the power to cover millions of compounds or fragments and determine their potential association with a target before specific chemical synthesis and biological testing is done. (springeropen.com)

In: 'Control of Proliferation in Animal Cells', Cold Spring Harbor Laboratory, pp. 393-410, 1974. (uni-mainz.de)
The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line Cancer Cell International. (nottingham.ac.uk)

It binds CHOLESTEROL and is involved in LIPIDS transport, membrane traffic, and SIGNAL TRANSDUCTION. (lookformedical.com)

However, perhaps the best advance would be the development of methods allowing the measurement of the protein's function in the patch-clamp system using artificial membranes. (wikipedia.org)
which can be considered a sort of foundational paper for (or even the manifesto of) the modern approaches for constructing living artificial cells from scratch. (frontiersin.org)
Autopoiesis thus becomes a convenient and elegant theoretical framework to guide the variegate experimental efforts to fabricate synthetic (artificial) cells (SCs/ACs), especially with respect to studies oriented at the origins and emergence of life. (frontiersin.org)

Methods The transcriptional and protein levels of ALKBH5 and solute carrier family 7 members 11 (SLC7A11) in tissues and cells were determined by qRT-PCR and Western blot assay. (bvsalud.org)
HCT116 and SW620 cells were transfected with ALKBH5 overexpression vectors to determine cell viability and levels of reactive oxygen species (ROS), Fe+, glutathione, and glutathione peroxidase 4 using cell counting kit-8, colony formation, fluorescence probe, assay kits, and Western blot assay. (bvsalud.org)

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)-How Does the Endoplasmic Reticulum Membrane Influence Their Function? (mdpi.com)
Is such compartmentalization necessary for optimal cell function? (biorxiv.org)
This is consistent with early specification of the cumulus and suggests that cell-cell interaction with other deep layer cells is not required for its function. (biomedcentral.com)

To date, only a few GGR genes have been confirmed to reduce polyprenyl substrates in vitro or in vivo. (biomedcentral.com)

MitoQ consequently decreased the mitochondrial membrane potential and mitochondrial superoxide production by these cells. (biomed.news)

The following year, the same group and another group, Silver, independently described the uptake and efflux of Mg2+ in metabolically active E. coli cells using 28Mg2+. (wikipedia.org)

The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. (wikipedia.org)
The metabolism of cancer cells is also different from the metabolism of normal cells, and these differences can be used to find targets for therapeutic intervention in cancer. (wikipedia.org)
Progress in gene isolation related to volatile production has been impeded by the lack of information concerning plant secondary metabolism, with flavor-associated volatiles [ 17 ]. (biomedcentral.com)
Moreover, cell population measurements of mitochondrial and glycolytic metabolism using a Seahorse analyzer demonstrated that WT KRAS TP53-silenced cells display an increase of the basal respiration and tightly-coupled mitochondria, in the presence of glucose as substrate, compared to TP53 competent cells. (biomed.news)

Our past review established that distinct Foxo1 gene erasure in osteoblasts inside small rats leads to bone tissue loss that can be a inside previous these animals exhibits the other influence. (atpasepathway.com)
In small rodents, Foxo1 gene erasure stops osteoblast difference, bringing about a decreased osteoblast quantity along with reduced navicular bone formation bionic robotic fish price due to the weakened power to fight oxidative strain, at some point producing bone fragments decline and postponed curing involving bone fragments problems. (atpasepathway.com)

Moreover, we identify a distinct, N-terminal, higher affinity interaction interface between LRRK2 phosphorylated Rab8 and Rab10 termed 'Site #2', that can retain LRRK2 on membranes in cells to catalyze multiple, subsequent phosphorylation events. (stanford.edu)

Viroid trafficking in plant cells: determining the mechanisms of RNA import into the chloroplast, which is a crucial step in the lifecycle of viroids. (shu.ac.uk)
Plant, Cell and Environment. (rothamsted.ac.uk)
The Plant Cell. (rothamsted.ac.uk)

Several distinct genes for caveolins have been identified. (lookformedical.com)
We show that there are two distinct regions of internalization: most cells enter the deep layer via the central blastopore but many additional cells ingress via an extra-blastoporal ring, either at the periphery of the germ disc ( Latrodectus spp. (biomedcentral.com)

Cell signalling and Trafficking emphasize current knowledge and information regarding cell response and reaction to signalling mechanisms and molecular transport system within the cell. (hoajonline.com)

However, demonstration of whether and how these genes cause pathology is largely lacking. (sdbonline.org)

Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)

The paradigm of water transport across the biological membrane has recently changed, when the molecular basis (aquaporins) was first identified by the team of Peter Agre. (benthambooks.com)
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. (lookformedical.com)
Transport and membrane trafficking in cells Lundsbrunn Spa, Sweden, 7 - 9 May 2004. (edu.pl)

While many of them play key biological roles, their systematic analysis has been hampered by their functional and structural heterogeneity. (bvsalud.org)
The single membrane-bound peroxisomes exhibit great functional versatility. (biorxiv.org)

We seek to understand the molecular connections between autophagy and antigen presentation and to measure their impact on the diversity of the presentation, especially in the context of self antigens (those of the cell), and non-self antigens (those from pathogens). (cfatg.org)
Autophagy is particularly decrypted and analyzed using immortalized cell lines and appropriate animal models. (cfatg.org)
We seek to standardize the study of autophagy in immune cells from healthy donors to better understand autophagy failures under pathological conditions. (cfatg.org)
We pay a special attention to inflammatory bowel diseases, in particular Crohn's disease for which many genes of susceptibility are linked to autophagy. (cfatg.org)

The cumulus cells begin migration before other cells enter the deep layer. (biomedcentral.com)

Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane. (wikipedia.org)

Anatomy37

Organisms17

Diseases1

Chemicals and Drugs102

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes62

Disciplines and Occupations7

Technology, Industry, Agriculture10

Information Science8

Health Care1

Transporters10

Proteins19

Biosynthesis4

Pathways5

Plasma membrane7

Intracellular4

Pathway5

Molecules4

Extracellular5

Cellular9

Interactions4

Regulation5

Candidate genes2

Biology5

Mutations2

Enzymes2

Subcellular1

Neurosecretory cells2

Alterations2

Expression9

Metabolites2

Metabolic1

ENDOSOMES1

Physiological1

Selectively2

Autophagic2

Transporter3

Receptor1

Pancreatic2

Synthesis3

Proliferation2

Lipids1

Artificial3

Assay2

Function3

Vivo1

Superoxide1

Efflux1

Metabolism4

FOXO12

Catalyze1

Plant3

Distinct2

Mechanisms1

Pathology1

Vitro1

Transport3

Functional2

Autophagy4

Migration1

Main structural1