Genes repressor proteins. Medical search. Frequent questions

TCF1 is inactivated by association with the transcriptional repressor TLE proteins. (biolegend.com)
During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. (biolegend.com)
can function as a transcriptional repressor. (atlasgeneticsoncology.org)
This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. (thermofisher.com)
The cellular factor, CCAAT displacement protein (CDP), is a transcriptional repressor of MMTV. (utexas.edu)
Studies with mouse embryo fibroblasts lacking endogenous nuclear CDP confirmed that CDP150 lacks transcriptional repressor or activator function for the MMTV LTR and β-casein. (utexas.edu)
In differentiating neuroblastoma cells, HASH-1 is down-regulated, and there is coincident up-regulation of the transcriptional repressor HES-1, which is known to bind the HASH-1 promoter. (lu.se)

that is, they inhibit the transcription of messenger RNA from their target genes. (proteopedia.org)
Interaction with CTNNB1 results in transactivation of TCF1 target genes. (biolegend.com)
The analysis of both authentic Dorsal target genes and defined synthetic promoters suggests that the ectopic gradient is sufficient to generate the full repertory of DV patterning responses along the AP axis of the embryo. (sdbonline.org)
KDM5A-mediated histone H3 lysine 4 demethylation contributes to silencing of retinoblastoma target genes (Chicas et al. (atlasgeneticsoncology.org)
The researchers, headed by Stephen Small, chair of NYU's biology department, examined a large number of target genes that are directly activated by Bcd. (livescience.com)
By examining DNA sequences associated with these target genes, the researchers discovered binding sites for three other proteins-Runt, Capicua, and Kruppel-which all act as repressors. (livescience.com)

Alterations in DNA methylation, lncRNAs and multiple genes may be involved in the regulation of FTLs . (nature.com)
DRB2 has been remarkably conserved throughout plant evolution, raising the possibility that translational repression is the ancient form of miRNA-directed gene regulation in plants, and that Dicer partnering proteins, such as human TRBP, might play a similar role in other eukaryotic systems. (nature.com)
The microarray analysis of drb2 also revealed a large set of gene transcripts that were significantly different from wild-type levels, but which are not thought to be the primary targets of miRNA-directed regulation ( Supplementary Fig. 3 ). (nature.com)
Figure 4: Translational and post-translational regulation of DRB1 and DCL1, and evolutionary conservation of DRB1 and DRB2 proteins. (nature.com)
We now confirm those findings, as complementation of a csrS mutant restored Mg(2+)-dependent gene regulation. (lu.se)
The effect of Mg(2+) on regulation of global gene expression was evaluated using genomic microarrays in an M-type 3 strain of GAS and in an isogenic csrS mutant. (lu.se)
We observed CsrS-dependent regulation of 72 of the 73 genes whose expression changed in response to elevated extracellular Mg(2+) in wild-type bacteria, a result that identifies CsrS as the principal, if not exclusive, sensor for extracellular Mg(2+) in GAS. (lu.se)
To our knowledge, this study is the first to characterize global gene regulation by a GAS two-component system in response to a specific environmental stimulus. (lu.se)
who also correctly proposed the general mechanism of regulation by the lac repressor. (proteopedia.org)
Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
The Huang (1997) paper also clearly summarizes what is known about the regulation of genes involved in dorsal/ventral patterning. (sdbonline.org)
Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. (thermofisher.com)
Our in silico findings report that there is cross-regulation between both pathways at the level of gene transcription regulation, mediated by the presence of binding sites for both factors in promoters of genes essential for these pathways. (biomedcentral.com)
The rat HMGCS2 gene contains elements that control its multihormonal regulation and tissue specificity ( 11 - 14 ). (aacrjournals.org)
Cadmium coordinates up-regulation of cytoprotective genes and protection agains metal toxicity by inhibiting the ubiquitination of Nrf2 and disrupting the Nrf2/Keap1 complex. (cdc.gov)
To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain. (lu.se)
The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. (lu.se)

The lactose ("lac") repressor controls the expression of bacterial enzymes involved in the metabolism of of the sugar lactose. (proteopedia.org)

In many organs, cell proliferation and differentiation are antagonistically regulated by multiple basic helix-loop-helix (bHLH) activator and repressor genes. (biologists.com)
Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. (bvsalud.org)

In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. (wikipedia.org)
The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. (sinica.edu.tw)
It's the breaking of a molecular feature - a repressor switch. (evolutionnews.org)
A molecular repressor switch has been broken, and another protein has been overexpressed. (evolutionnews.org)
Molecular characterization and gene expression of lhcb5 gene encoding CP26 in the light-harvesting complex II of Chlamydomonas reinhardtii. (bio.net)
Here, we use an in vitro assay of protein synthesis in the hippocampus of male Fmr1 knock-out (KO) mice to explore the molecular mechanisms involved in this core biochemical phenotype under conditions where aberrant synaptic physiology has been observed. (jneurosci.org)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. (origene.com)

An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. (wikipedia.org)
A repressor that binds with a co-repressor is termed an aporepressor or inactive repressor. (wikipedia.org)
In contrast, an active repressor binds directly to an operator to repress gene expression. (wikipedia.org)
When SAM is present, it binds to the MetJ protein, increasing its affinity for its cognate operator site, which halts transcription of genes involved in methionine synthesis. (wikipedia.org)
When the lac repressor binds lactose, it changes to an inactive conformation that cannot repress the production of these enzymes. (proteopedia.org)
N binds to the two Nut sites, one in the N gene, and one in the cro gene. (wikidoc.org)
Under Cu stress, Cu(I) binds to CsoR and de-represses genes under its transcriptional control. (bl.uk)
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. (thermofisher.com)

The lambda repressor is a dimer also known as the cI protein . (wikidoc.org)

In particular,the Hes bHLH repressor genes play an essential role in the development of many organs by maintaining progenitor cells and by regulating binary cell fate decisions. (biologists.com)
The type II target gene snail contains a series of low-affinity Dl-binding sites, as well as binding sites for the bHLH activator, Twist. (sdbonline.org)
Mesectoderm differentiation is controlled by the bHLH-PAS gene, sim . (sdbonline.org)
It is assumed that the Id helix-loop-helix (HLH) proteins act by associating with ubiquitously expressed basic HLH (bHLH) transcription factors, such as E47 and E2-2, which prevents these factors from forming functional hetero- or homodimeric DNA binding complexes. (lu.se)
Several tissue-specific bHLH proteins, including HASH-1, dHAND, and HES-1, are important for development of the nervous system. (lu.se)

But a mutation in the citrate-eaters allowed them to make an "antiporter" protein, CitT, that allows citrate to cross the membrane and enter the cell. (evolutionnews.org)

The operon consists of a regulatory repressor gene (araC), three control sites (ara02, ara01, araI1, and araI2), two promoters (Parac/ParaBAD) and three structural genes (araBAD). (wikipedia.org)
Here we show that the form of regulatory action directed by a plant miRNA is determined by DRB2, a DICER-LIKE1 (DCL1) partnering protein. (nature.com)
Repressor proteins are coded for by regulatory genes. (proteopedia.org)
The lac repressor, and the group of genes it controls, which is called an operon , were the first such gene regulatory system to be discovered. (proteopedia.org)
Among them a promoter, exons, introns, and regulatory elements, which together help to determine protein expression in a cell. (jove.com)
Stimulation of TLRs (Toll-Like Receptors) by a pathogen induces activation of signal transduction cascades, which leads to translocation of nuclear factor-κB (NF-κB) to the nucleus [ 1 ], activation of interferon regulatory factors 3/7 (IRF3/7) and/or activator protein-1 (AP-1), which cooperate to induce transcription of various cytokines such as alpha/beta interferon (IFN-α/β) to counteract infection [ 2 - 4 ]. (biomedcentral.com)

Here we show that the AN gene encodes a C-terminal binding proteins/brefeldin A ADP-ribosylated substrates (CtBP/BARS) related protein. (nih.gov)
The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae regulates the expression of the gene on corynebacteriophages that encodes diphtheria toxin (DT). (rcsb.org)
The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation. (bio.net)

The lacZYA operon houses genes encoding proteins needed for lactose breakdown. (wikipedia.org)
The lacI gene codes for a protein called "the repressor" or "the lac repressor", which functions to repressor of the lac operon. (wikipedia.org)
The lac repressor is constitutively expressed and usually bound to the operator region of the promoter, which interferes with the ability of RNA polymerase (RNAP) to begin transcription of the lac operon. (wikipedia.org)
The L-arabinose operon houses genes coding for arabinose-digesting enzymes. (wikipedia.org)
In S. lividans the GlxA gene is part of the cslA/glxA operon that contains genes encoding putative enzymes involved in glycan processing. (bl.uk)
The Cu sensitive operon repressor (CsoR) protein determines the set point of Cu(I) concentration in the cytosol. (bl.uk)

If an inducer, a molecule that initiates the gene expression, is present, then it can interact with the repressor protein and detach it from the operator. (wikipedia.org)
A co-repressor is a molecule that can bind to the repressor and make it bind to the operator tightly, which decreases transcription. (wikipedia.org)
For a general introduction to the lac repressor, please see David Goodsell's Introduction to the lac repressor in his series Molecule of the Month , and the article in Wikipedia on the lac repressor . (proteopedia.org)
An amino acid is the fundamental molecule that serves as the building block for proteins. (genome.gov)
Each time an amino acid is added to a growing polypeptide during protein synthesis, a tRNA anticodon pairs with its complementary codon on the mRNA molecule, ensuring that the appropriate amino acid is inserted into the polypeptide. (genome.gov)

The ATN1 gene variants that cause CHEDDA syndrome occur in one of the two copies of the gene in each cell and lead to a change in single protein building blocks (amino acids) in atrophin 1. (medlineplus.gov)
A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
Sequencing of a 2.5-kb chromosomal Sma I- Pst I fragment containing the structural gene revealed an open reading frame encoding 537 amino acids, homologous to known pckA genes. (asm.org)

Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
and the University of California, Santa Cruz, Genome Browser, to look for genes or genomic regions of chromosomes 1 and 19 thought to produce proteins that interact with Xist. (sciencedaily.com)

In a cell, antisense DNA serves as the template for producing messenger RNA (mRNA), which directs the synthesis of a protein. (genome.gov)
miRNAs comprise a large group of endogenous non-coding RNAs that can block mRNA translation or negatively regulate mRNA stability and thereby play a central role in regulating gene expression [10] , [11] . (plos.org)
Introns are excised once the sequence is transcribed to mRNA, leaving only exons to code for proteins. (jove.com)
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. (jneurosci.org)
Our data suggest that elevated protein synthesis in the Fmr1 KO is due to saturation of mRNA translation downstream of the MAP kinase ERK1/2 which is basally activated by mGluR5. (jneurosci.org)
In rats, hepatic ketogenic capacity increases rapidly during postnatal development ( 4 ) or fasting ( 5 ) when the mRNA, protein, and activity of HMGCS2 increase in liver ( 6 - 8 ). (aacrjournals.org)
Administration of dibutyryl-cyclic AMP to adult rats increases mRNA, protein levels, and enzymatic activity of HMGCS2 in the liver ( 6, 9 ). (aacrjournals.org)
In MEF cells with wild type Nrf2 and mouse hepa 1c1c7 cells, Cd increased the Nrf2 protein level but not the Nrf2 mRNA level dose-dependently. (cdc.gov)

The researchers hunted for genes responsible for adding or subtracting so-called epigenetic marks, which attach to DNA and affect whether a cell can use a given gene. (sciencedaily.com)

Other genes regulated by DtxR include those that encode proteins involved in siderophore-mediated iron uptake. (rcsb.org)
Dispersed between the chromosomes are over 20,000 genes, sometimes separated by vast stretches of non-coding DNA, or that which does not encode proteins. (jove.com)

A transcriptional co-repressor is a protein that interacts with other DNA-binding proteins to suppress the activity of certain genes, although it cannot attach (bind) to DNA by itself. (medlineplus.gov)
The extended CAG region changes the structure of atrophin 1 and how the protein interacts with other proteins to control gene function. (medlineplus.gov)

Although the exact function of this protein is unknown, it appears to play an important role in nerve cells (neurons) in many areas of the brain. (medlineplus.gov)
This altered protein accumulates in neurons and interferes with normal cell functions. (medlineplus.gov)
Without Hes genes such as Hes1 , however, progenitor cells prematurely differentiate into certain types of neurons only, and are depleted before they have proliferated sufficiently and generated all neuronal and glial cell types. (biologists.com)

In these processes, Hes genes function as effectors of Notch signaling, which coordinates cellular events via cell-cell interactions. (biologists.com)
This study demonstrated that reduction of full-length CDP levels in two independent strains of CDP knockout mice increased endogenous MMTV and other mammary-specific cellular genes in undifferentiated mammary glands, suggesting a critical role for CDP in the MMTV life cycle. (utexas.edu)

On average, we identify 43 mutations per tumour, excluding four cases with a mutator phenotype that harboured inactivating mutations in mismatch repair genes. (nih.gov)
A strong rationale for taking this approach is that slice has been shown to accurately reproduce the in vivo phenotype of elevated basal protein synthesis in the Fmr1 KO hippocampus (cf. (jneurosci.org)
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes. (yeastgenome.org)

One type of aporepressor is the trp repressor, an important metabolic protein in bacteria. (wikipedia.org)
Each repressor targets a specific co-regulated group of genes by recognizing a specific sequence of DNA, called the operator in bacteria . (proteopedia.org)
Transcriptional regulator proteins are closely involved in essential survival strategies in bacteria. (rcsb.org)

Silencers can be located several bases upstream or downstream from the actual promoter of the gene. (wikipedia.org)
c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)

These are DNA sequences that bind to repressors to partially or fully repress a gene. (wikipedia.org)
We analyzed respective gene promoters' sequences using in silico methods for identification of transcription binding sites, mainly in the NF-κB- and IRF-coding genes. (biomedcentral.com)
However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. (origene.com)

Protein phosphorylation regulates actomyosin-driven vesicle movement in cell extracts isolated from the green algae, Chara corallina. (bio.net)
It regulates the transcription of the cI protein and the Cro protein. (wikidoc.org)
HMGCS2 , the gene that regulates ketone body production, is expressed in liver and several extrahepatic tissues, such as the colon. (aacrjournals.org)

Furthermore, most known eukaryotic repressors are found in simple organisms (e,g. yeast), and act by interacting directly with activators. (wikipedia.org)
These proteins work as activators or repressors of growth-stimulating genes. (hightimes.com)
Essentially, activators and repressors act like the stop and start pedals on a car. (hightimes.com)
When a repressor is present, it stops the formation of growth-stimulating genes, in parallel activators start the transcription of growth-stimulating genes. (hightimes.com)

In eukaryotic genomes, genes are separated by large stretches of DNA that do not code for proteins. (jove.com)

AN is expressed at low levels in all organs and the AN protein is localized in the cytoplasm. (nih.gov)

Characterization and mapping of human genes encoding zinc finger proteins. (nih.gov)
Along with the complex arrangement of genetic material in a cell's nucleus, human genes also demonstrate their own unique organization. (jove.com)

aegypti L5 annotated physical map has allowed interrogation of the exome for genes and single nucleotide polymorphisms (SNPs) associated with pyrethroid resistance. (cdc.gov)
Exome capture enrichment for coding regions and the AaegL5 annotation were used to identify genes statistically associated with resistance. (cdc.gov)

Thus, a gene consists of various components. (jove.com)

A repressor is a DNA binding protein (in the case of Sr9011 an artificial one) that inhibits gene expression. (thecni.org)

As a result, silencers help to regulate gene expression. (jove.com)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)
Once processed by the liver, SR9011 works in the same way as Sr9009, by increasing the constitutive repression of genes regulated by Rev-ErbA and Rev-ErbAB (Beta). (thecni.org)

Replacing either of the salt-bridge partners with an alanine reduces repressor activity substantially and it has been inferred that the salt bridge could possibly control the wedge angle between the DNA-binding domain and the dimerization domain, thereby modulating repressor activity. (rcsb.org)

In the high association group (n = 1,053 genes), several genes were identified that also genetically or physically interact with the voltage-gated sodium channel (VGSC). (cdc.gov)

This protein and the product of a second closely related gene, CTBP2, can dimerize. (thermofisher.com)
Studying interactions, we noted that all four Id proteins could dimerize with E47 or E2-2, but not with HASH-1 or dHAND. (lu.se)

Transcription factor Nrf2 is a key regulator of genes encoding phase II detoxification enzymes and antioxidant proteins in response to environmental chemical insults. (cdc.gov)

The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. (sinica.edu.tw)
Translocation of EWSR1 (Ewing sarcoma breakpoint region 1) with an ETS (E26 transformation-specific) transcription factor gene occurs in more than 95% of Ewing sarcomas. (medscape.com)

In addition to mutations in TP53 and KRAS, we identify genetic alterations in chromatin remodelling genes, ARID1A and ARID1B, in histone methyltransferase MLL3, in histone deacetylase modifier SPOP and in chromatin assembly factor BAZ1A, in nearly two thirds of cases. (nih.gov)
Variants (also called mutations) in the ATN1 gene can cause a very rare condition called congenital hypotonia, epilepsy, developmental delay, and digital anomalies (CHEDDA) syndrome. (medlineplus.gov)
RS is related to various mutations on the MECP2 gene, which codes for methyl-CpG binding protein-2 (MECP2). (medscape.com)
aegypti is associated with mutations in the vgsc gene and a large assortment of genes. (cdc.gov)

According to the metabotropic glutamate receptor (mGluR) theory of FXS, excessive protein synthesis downstream of mGluR5 activation causes the synaptic pathophysiology that underlies multiple aspects of FXS. (jneurosci.org)
We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). (jneurosci.org)
These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS. (jneurosci.org)
Although it is now clear that mGluR5 participates in the pathogenesis of FXS, at least in animal models, it is still poorly understood how Gp1 mGluRs trigger protein synthesis and how this process is altered in the absence of FMRP to disrupt synaptic function. (jneurosci.org)
One source of confusion may be that proxy measures of protein synthesis, such as mGluR-LTD or phosphorylation of signaling molecules, have been used in intact hippocampal slice preparations, whereas metabolic labeling experiments have been performed in synaptoneurosome preparations of cortex that are not easily related to altered hippocampal synaptic plasticity. (jneurosci.org)

Alternative splicing of transcripts from this gene results in multiple transcript variants. (thermofisher.com)
Studies done elsewhere identified the mechanism behind the silencing of X chromosomes: a gene called Xist, short for X-inactive specific transcript. (sciencedaily.com)

Nol3 has been shown to be induced in multiple cancer types and acts as a repressor of apoptosis leading to resistance and proliferation. (wikipedia.org)
AcrR is a one-component allosteric repressor of the genes associated with lipid transport and antibiotic resistance. (rcsb.org)
Vgsc-interacting proteins are genetically associated with pyrethroid resistance in Aedes aegypti. (cdc.gov)
Association mapping of factors that condition pyrethroid resistance in Aedes aegypti has consistently identified genes in multiple functional groups. (cdc.gov)

Located on the X chromosome itself, Xist produces a protein that spreads up and down the chromosome during female embryonic development, turning off its genes. (sciencedaily.com)
The most likely explanation for this phenomenon, Migeon reasons, was that a protein that represses the X chromosome silencing activity of Xist was working overtime, allowing more than one X chromosome to remain activated. (sciencedaily.com)
To identify the likely location of the repressor protein and the gene that codes for it, the researchers started by looking at cells from human embryos with different forms of chromosomal trisomy, a condition in which cells carry three copies of a particular chromosome instead of two. (sciencedaily.com)
The vgsc on chromosome 3 had the highest association, followed by genes proximal to vgsc. (cdc.gov)
HPX8C) or within clusters in chromosome 2 (three esterase clusters, two of CYP) and chromosome 3 (one cluster of 16 CYP325 and seven CYP9 genes). (cdc.gov)

As part of the cslA-glxA gene cluster are two genes encoding for putative polysaccharide degrading enzymes. (bl.uk)

In the presence of the inducer allolactose, the repressor changes conformation, reduces its DNA binding strength and dissociates from the operator DNA sequence in the promoter region of the lac operong. (wikipedia.org)

For example, mesoderm determinants are activated in the anterior third of the embryo, whereas neurogenic genes are expressed in central regions. (sdbonline.org)
They focused on one protein, Bicoid (Bcd), which is expressed in a gradient with highest levels at the end of the embryo that will become the mature fly's head. (livescience.com)
Each target gene is expressed in a region of the embryo with a boundary that corresponds to a specific structure. (livescience.com)
All three proteins are expressed in gradients with highest levels in the middle part of the embryo, and thus are positioned in exactly the opposite orientation compared to the Bcd activation gradient. (livescience.com)
By changing the spatial distribution of the repressors and by manipulating their binding sites, Small and his colleagues showed that these repressors antagonize Bcd-dependent activation and are absolutely critical for establishing the correct order of boundaries that are found in a normal embryo. (livescience.com)

Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. (sigmaaldrich.com)
Cys102 is a key residue of metal site 2 and its substitution into a serine abolishes repressor activity. (rcsb.org)
These results confirm the importance of the hinge motion for repressor activity. (rcsb.org)
There are five distinct thresholds of gene activity in response to the Dorsal nuclear gradient in early embryos. (sdbonline.org)
However, these intergenic regions carry important elements that regulate gene activity, for instance, the promoter where transcription starts, and enhancers and silencers that fine-tune gene expression. (jove.com)
This study reveals a novel posttranslational cleavage event that controls CDP activity and gene expression during normal development of the mammary gland. (utexas.edu)
However, the Id proteins did complex with HES-1, and increased levels of Id2 reduced the DNA binding activity of HES-1. (lu.se)

We identified potential detoxification genes located singly (e.g. (cdc.gov)

Results in deregulation of HOXA genes through recruitment of the histone acetyltransferase CBP / p300 (Thiollier et al. (atlasgeneticsoncology.org)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

The Dl and Twist proteins appear to make synergistic contact with the basal transcription complex, so that snail is activated throughout the presumptive mesoderm in response to both peak and high levels of the Dl gradient. (sdbonline.org)
However, prior to commitment, it has been cells, it is evident that GATA-1 and PU.1 are able to specify observed that many genes are expressed at intermediate or basal erythroid and myeloid cell fates (see [16] and references therein). (lu.se)

Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. (nih.gov)
Synthetic biology goes further than genetic engineering, which usually involves adding a single gene to a cell so that it will do something it wouldn't normally do. (technologyreview.com)
We develop a computational model for the hematopoietic erythroid-myeloid lineage decision, which is determined by a genetic switch involving the genes PU.1 and GATA-1. (lu.se)

While repressors are more commonly found in prokaryotes, they are rare in eukaryotes. (wikipedia.org)

Autosomal" means that the gene in question is located on one of the numbered, or non-sex, chromosomes. (genome.gov)
Trisomies of these chromosomes were missing, suggesting that the repressor might be located on one of them," says Migeon. (sciencedaily.com)
The team reasoned that if the repressor was in a region that was duplicated, it would work overtime and turn off Xist on both X chromosomes, leaving both the X chromosomes active and selectively changing the survival of male vs. female embryos. (sciencedaily.com)

A two-dimensional hierarchical clustered matrix, covering 383 of the most highly regulated genes, was constructed from 46 diverse experimental conditions. (nih.gov)

The gene lacI is situated immediately upstream of lacZYA but is transcribed from a lacI promoter. (wikipedia.org)
The latter pair inherits the state of its upstream master genes and further reinforces the decision due to several feedback loops, thereby leading to irreversible commitment. (lu.se)

The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. (biologists.com)
The DNA of the prophage that is expressed in that state codes for proteins that look out for signs of stress in the host cell. (wikidoc.org)
In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)

Anatomy3

Organisms3

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes30

Information Science3

Transcriptional repressor7

Target genes6

Regulation17

Metabolism1

Activator and repressor2

Molecular9

Binds8

Lambda repressor1

BHLH5

Mutation1

Regulatory6

Encodes3

Operon6

Molecule5

Amino acids3

Genomic2

MRNA8

Epigenetic1

Encode proteins2

Interacts2

Neurons3

Cellular2

Phenotype4

Bacteria3

Promoter of the gene2

Sequences3

Regulates3

Activators4

Eukaryotic1

Localized in the cytoplasm1

Human genes2

Exome2

Consists1

Inhibits1

Regulate gene expression1

Repression2

Dimerization1

Interact1

Dimerize2

Regulator1

Transcription factor2

Mutations4

Synthesis5

Transcript2

Resistance4

Chromosome5

Putative1

Conformation1

Embryo5

Activity8

Detoxification1

Histone1

Structural1

Basal2

Genetic3

Eukaryotes1

Chromosomes3

Highly regulated1

Upstream2

Cell3