• The major pathologic manifestations of rheumatoid arthritis (RA) and osteoarthritis (OA) are joint inflammation and articular cartilage resorption by proinflammatory cytokine-stimulated matrix metalloproteinases (MMPs) and aggrecanases. (aspetjournals.org)
  • Therefore, besides its anti-inflammatory activity, this agent may also be effective in blocking cartilage matrix resorption by MMPs by impairing AP-1 and NF-κB binding activities. (aspetjournals.org)
  • Matrix metalloproteinases (MMPs) are enzymes capable of breaking down various connective tissue elements. (scite.ai)
  • This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), ECM degrading enzymes (matrix metalloproteinases [MMPs]) and their tissue inhibitors of metalloproteinase (TIMPs), and POP. (scite.ai)
  • Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, and there are 23 different types of human MMPs. (molcells.org)
  • Some molecules are involved in several stages of the process of alveolar repair, for example matrix metalloproteinases (MMPs) 2 , among others. (bvsalud.org)
  • MMPs are an important family of metal-dependent endopeptidases and represent the major class of enzymes responsible for the degradation or resorption of all components of the extra-cellular matrix (ECM) 38 . (bvsalud.org)
  • Matrix metalloproteinases (MMPs) are a large family of mostly secreted, extracellularly acting proteolytic enzymes. (nature.com)
  • Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. (nature.com)
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
  • A critical step in this process is degradation of the basement membrane, which contains extracellular matrix (ECM) proteins and functions as a barrier to surrounding tissues. (aacrjournals.org)
  • Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
  • Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12 signaling and cancer progression. (biomedcentral.com)
  • An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
  • Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). (prostate.net)
  • Consistent with an unexpected role for MMP-12 in clearing systemic IFN-α, treatment of coxsackievirus type B3-infected wild-type mice with a membrane-impermeable MMP-12 inhibitor elevates systemic IFN-α levels and reduces viral replication in pancreas while sparing intracellular MMP-12. (nih.gov)
  • 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent . (cardiff.ac.uk)
  • Western blot analysis and real-time PCR showed that celastrol dose-dependently suppressed TNF-α-induced MMP-9 gene expression at both the mRNA and protein levels in MDA-MB-231 cells. (spandidos-publications.com)
  • Jin ML, Park SY, Kim YH, Park G and Lee SJ: Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9. (spandidos-publications.com)
  • Park SK, Hwang YS, Park KK, Park HJ, Seo JY and Chung WY: Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • Interferon-α (IFN-α) is essential for antiviral immunity, but in the absence of matrix metalloproteinase-12 (MMP-12) or IκBα (encoded by NFKBIA) we show that IFN-α is retained in the cytosol of virus-infected cells and is not secreted. (nih.gov)
  • We show here that after macrophage secretion, MMP-12 is transported into virus-infected cells. (nih.gov)
  • In HeLa cells MMP-12 is also translocated to the nucleus, where it binds to the NFKBIA promoter, driving transcription. (nih.gov)
  • The present study evaluated cell viability, expression levels of collagen II (Col II) and matrix metalloproteinase‑13 (MMP‑13), and activity of the Wnt/β‑catenin and NF‑κB signaling pathways in treated SW1353 cells. (spandidos-publications.com)
  • In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. (molcells.org)
  • Stem Cells 32(1):301-12, 2014. (mdanderson.org)
  • The MMP20 gene mutations involved in this condition prevent cells from producing functional enamelysin. (medlineplus.gov)
  • In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
  • Indeed expression of a dominant-negative form of CREB (KCREB) in metastatic melanoma cells sensitizes them to thapsigargin-induced apoptosis (12). (antiviralbiologic.com)
  • It is a 40-kDa cysteine-rich heparin-binding protein that either localizes intracellularly or is usually secreted into the extracellular milieu where it associates with the extracellular matrix and cell surfaces (27 28 Here we demonstrate that inhibits Helicid tumor growth and metastasis decreases angiogenesis and induces apoptosis of melanoma cells as a tumor suppressor in. (antiviralbiologic.com)
  • Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. (wikipedia.org)
  • Tissue samples collected from the anterior glenohumeral joint capsule during surgery will undergo RNA-seq to determine differences in gene expression between the study groups. (biomedcentral.com)
  • A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)
  • Caries research 2016 Nov 51 (1): 12-16. (cdc.gov)
  • However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. (wikipedia.org)
  • We also identified dual-regulated substrates that are repressed both by MMP-12 binding to the substrate's gene exons and by MMP-12-mediated cleavage of the substrate protein itself. (nih.gov)
  • Matrix metalloproteinase-7 and adam-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy. (ualberta.ca)
  • Association of MBL2 Gene Polymorphism with Dental Caries in Saudi Children. (cdc.gov)
  • Polymorphism in the human 2'-5'-oligoadenylate synthetase genes (OAS), associated with predisposition to severe forms of tick-borne encephalitis, in populations from North Eurasia]. (cdc.gov)
  • Single nucleotide polymorphism in the promoter region of the CD209 gene is associated with human predisposition to severe forms of tick-borne encephalitis. (cdc.gov)
  • Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population. (cdc.gov)
  • Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population. (cdc.gov)
  • Analysis of the relationship between single nucleotide polymorphism of the CD209, IL-10, IL-28 and CCR5 D32 genes with the human predisposition to developing tick-borne encephalitis. (cdc.gov)
  • Genetic polymorphism studies demonstrated that the can develop immediate, late or dual asthmatic reactions glutathione-S-transferase gene family is associated with after chemical exposure. (cdc.gov)
  • Introduction and hypothesis Extracellular matrix (ECM) synthesis and metabolism abnormalities may influence the pelvic supporting system and lead to the occurrence and development of pelvic organ prolapse (POP). (scite.ai)
  • Identification of a novel heart/liver axis: Matrix metalloproteinases-2 negatively regulates cardiac secreted phospholipase a2 to modulate lipid metabolism and inflammation in the liver. (ualberta.ca)
  • Numerous genes transcribed in oocytes are involved in multiple aspects of cell maintenance and protection, including metabolism, signal perception and transduction, RNA processing, cell cycle, defense against pathogens and DNA damage. (biomedcentral.com)
  • Orthologous to human MMP9 (matrix metallopeptidase 9). (nih.gov)
  • Whereas intracellular MMP-12 mediates NFKBIA transcription, leading to IFN-α secretion and host protection, extracellular MMP-12 cleaves off the IFN-α receptor 2 binding site of systemic IFN-α, preventing an unchecked immune response. (nih.gov)
  • Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. (ualberta.ca)
  • The 1,25(OH)2D3 induced striking upregulation of genes involved in immune and inflammatory response processes such as chemokines and cytokines, complement system genes and HLA genes, and the cell cycle pathway genes such as DNA polymerases, cyclin-dependent kinases, and mini chromosome maintenance genes. (cancer.org)
  • At least seven mutations in the MMP20 gene have been identified in people with an autosomal recessive form of a disorder of tooth development called amelogenesis imperfecta. (medlineplus.gov)
  • Autosomal recessive inheritance means that two copies of the MMP20 gene in each cell are altered. (medlineplus.gov)
  • As matrix metalloproteinase-9 (MMP-9) plays a critical role in tumor metastasis, we analyzed its expression with celastrol treatment. (spandidos-publications.com)
  • Single-nucleotide polymorphisms (SNPs) in regulatory areas of MMP-encoding genes can alter their transcription rate, and therefore the possible effect on pelvic floor supporting structures. (scite.ai)
  • Genetic polymorphisms of such related genes have been increasingly studied. (scite.ai)
  • We studied the association between four MMP polymorphisms within three MMP genes and esophageal adenocarcinoma (EA) risk and prognosis. (mcmaster.ca)
  • Polymorphisms in chemokine receptor 5 and Toll-like receptor 3 genes are risk factors for clinical tick-borne encephalitis in the Lithuanian population. (cdc.gov)
  • Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population. (cdc.gov)
  • The 1,25(OH)2D3 also induced striking upregulation of genes that are targets of transcriptional factors known to play key roles in inflammation, immune response, proliferation, and extracellular matrix function (Figure 3 and Supplemental Table 5). (cancer.org)
  • We found that signaling through the Gα12 in MDA-MB-231 and MCF10A breast cancer cell lines enhances expression of interleukins (IL)-6 and −8, and matrix metalloproteinase (MMP)-2, and that these secreted factors play a role in G12-stimulated cell invasion. (biomedcentral.com)
  • The organ tropism is different depending on the infiltration parameters, vascular cell adhesion molecule to splenomegaly, matrix metalloprotease-2 to hepatomegaly and to extramedullary infiltration other than spleen, liver or lymph node. (karger.com)
  • The expression levels of dentin sialo-phosphoprotein (DSPP), dentin matrix protein-1 (DMP1), enamelysin/matrix metalloproteinase 20 (MMP20) and phosphate-regulating gene with homologies to endopeptidases on X chromosome (PHEX) were analysed using RT-PCR. (scielo.br)
  • Although there was a decrease in the expression of enamelysin/ MMP20 in PLDL and HA/TCP at 12 weeks, all other expressions increased and reached their highest level at 12 weeks. (scielo.br)
  • The MMP20 gene provides instructions for making a protein called enamelysin, which is essential for normal tooth development. (medlineplus.gov)
  • In the new research, investigators are studying the role that an enzyme, matrix metalloproteinase (MMP)-9, plays in vasospasm and what effect minocycline has on MMP-9 and vasospasm. (wustl.edu)
  • which are all enrolled in extracellular matrix (ECM) pathways. (scite.ai)
  • By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
  • Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
  • The matrix metalloproteinase (MMP) family degrade extracellular matrix and mediate pathways including apoptosis, angiogenesis and immunity. (mcmaster.ca)
  • Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. (prostate.net)
  • Results We identified a homozygous 2 bp deletion in MMP21, encoding matrix metalloproteinase-21, as the sole coding mutation that segregated with the phenotype. (bmj.com)
  • Khan F, Liu H, Reyes A, Witkowska HE, Martinez-Avila O, Zhu L, Li W, Habelitz S. The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions. (medlineplus.gov)
  • The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (wikipedia.org)
  • The MMP20 gene is found on chromosome 11 . (medlineplus.gov)
  • Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M and Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. (spandidos-publications.com)
  • Twelve mice were infected by placing 15 µl of sucrose-phosphate-glutamic acid (SPG) buffer containing 10 6 inclusion forming units (IFUs) of C. muridarum into the vaginal vault. (bmj.com)
  • At day 10, organs from infected animals showed significantly higher MMP-2 and MMP-9 genes expression than organs obtained from non-infected mice. (bmj.com)
  • Yan C and Boyd DD: Regulation of matrix metalloproteinase gene expression. (spandidos-publications.com)
  • Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals. (bmj.com)
  • Metalloproteinases in hypertension and cardiac disease: Differential expression and mutual regulation. (ualberta.ca)
  • Regulation of gene expression plays a central role in embryonic development. (biomedcentral.com)
  • We found that CREB silencing resulted in the up-regulation of cysteine-rich protein 61 (is usually a member of the growth factor-inducible immediate-early gene family consisting of was the first cloned member of the CCN family. (antiviralbiologic.com)
  • Matrix metalloproteinases gene variants and dental caries in Czech children. (cdc.gov)
  • Decock J, Thirkettle S, Wagstaff L and Edwards DR: Matrix metalloproteinases: protective roles in cancer. (spandidos-publications.com)
  • Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)
  • Although the fine points of the definition can be debated, it is reasonable to think of asthma as a pulmonary disorder characterized by the generalized reversible obstruction of airflow and to define reversibility as a greater than 12% increase in the patient's forced expiratory volume in 1 second (FEV 1 ) that occurs either spontaneously or with therapy. (jci.org)
  • Gene Set Enrichment Analysis will be used to further understand the pathogenesis of AC as well as guide serum and urine biomarker analysis. (biomedcentral.com)
  • Targeting a Single Pathway to Treat Peripheral Neuropathy Dr Alan Jacobs reviews the results of a recent study finding that overactivation of matrix-metalloproteinase-13 is a key mechanism underlying peripheral neuropathy. (medscape.com)
  • Variability in the 2'-5'-oligoadenylate synthetase gene cluster is associated with human predisposition to tick-borne encephalitis virus-induced disease. (cdc.gov)
  • Klatt AR, Klinger G, Paul-Klausch B, Kühn G, Renno JH, Wagener R, Paulsson M, Schmidt J, Malchau G and Wielckens K: Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes. (spandidos-publications.com)
  • In humans, the MMP-8 protein is encoded by the MMP8 gene. (wikipedia.org)
  • Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
  • It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
  • Kim Y, Kang H, Jang SW and Ko J: Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • Ling H, Zhang Y, Ng KY and Chew EH: Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
  • To interrogate the pathogenic potential of the discovered variant, we used an in vivo system in which the potential of the candidate gene to induce L-R asymmetry was tested by transient suppression and CRISPR/Cas9-induced deletions. (bmj.com)
  • The Journal of infectious diseases 2010 Dec 202 (12): 1813-8. (cdc.gov)